Detailed information for compound 1060314

Basic information

Technical information
  • TDR Targets ID: 1060314
  • Name: 2,3-dihydro-1,3-benzothiazol-2-amine
  • MW: 152.217 | Formula: C7H8N2S
  • H donors: 2 H acceptors: 0 LogP: 1.51 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC1Nc2c(S1)cccc2
  • InChi: 1S/C7H8N2S/c8-7-9-5-3-1-2-4-6(5)10-7/h1-4,7,9H,8H2
  • InChiKey: PVOBHWZVXBTENP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2,3-dihydro-1,3-benzothiazol-2-ylamine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0194 0.0245
Schistosoma mansoni ap endonuclease 0.0018 0.0257 0.0661
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0589 0.1517
Onchocerca volvulus 0.0016 0.0194 0.0283
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0799 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0035
Loa Loa (eye worm) hypothetical protein 0.0036 0.0799 0.1066
Loa Loa (eye worm) cysteine protease 0.0016 0.0194 0.0258
Loa Loa (eye worm) hypothetical protein 0.0036 0.0799 0.1066
Onchocerca volvulus 0.0048 0.1197 0.1751
Echinococcus granulosus lamin 0.0026 0.0516 0.0516
Echinococcus granulosus intermediate filament protein 0.0026 0.0516 0.0516
Onchocerca volvulus 0.0026 0.0516 0.0754
Brugia malayi Cathepsin L-like precursor 0.0011 0.0027 0.0035
Onchocerca volvulus 0.0016 0.0194 0.0283
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0799 0.0831
Onchocerca volvulus 0.0016 0.0194 0.0283
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.1693 1
Mycobacterium leprae Probable lipase LipE 0.0036 0.0799 0.5
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0131 0.0175
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0799 0.1134
Onchocerca volvulus 0.0016 0.0194 0.0283
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.1693 0.1693
Onchocerca volvulus 0.0029 0.0589 0.0862
Loa Loa (eye worm) hypothetical protein 0.0026 0.0516 0.0688
Loa Loa (eye worm) hypothetical protein 0.0029 0.0589 0.0786
Onchocerca volvulus 0.0011 0.0027 0.0039
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0194 0.0498
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0799 0.0831
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1614 1
Plasmodium vivax SET domain protein, putative 0.0029 0.0589 0.6537
Schistosoma mansoni intermediate filament proteins 0.0026 0.0516 0.1328
Entamoeba histolytica hypothetical protein 0.0073 0.1962 1
Brugia malayi Cathepsin L-like precursor 0.0011 0.0027 0.0035
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.1614 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0194 0.0245
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0589 0.1517
Echinococcus multilocularis tumor protein p63 0.033 1 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0556 0.0556
Entamoeba histolytica hypothetical protein 0.0073 0.1962 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0194 0.0245
Leishmania major hypothetical protein, conserved 0.0036 0.0799 0.4037
Loa Loa (eye worm) hypothetical protein 0.0012 0.0072 0.0097
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0589 0.0589
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1614 1
Brugia malayi Cathepsin L-like precursor 0.0016 0.0194 0.0258
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0257 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.1693 0.1693
Loa Loa (eye worm) hypothetical protein 0.0026 0.0501 0.0668
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0194 0.0245
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0194 0.0194
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0589 0.1517
Brugia malayi beta-lactamase family protein 0.0036 0.0799 0.1066
Brugia malayi beta-lactamase family protein 0.0036 0.0799 0.1066
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.1693 0.4359
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0194 0.0245
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0257 0.0338
Echinococcus multilocularis cysteine protease 0.0016 0.0194 0.0194
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0194 0.0245
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0194 0.0245
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0799 0.3775
Schistosoma mansoni cathepsin F (C01 family) 0.0011 0.0027 0.0068
Brugia malayi Cathepsin L-like precursor 0.0016 0.0194 0.0258
Mycobacterium tuberculosis Conserved protein 0.0036 0.0799 0.0831
Schistosoma mansoni thyroid hormone receptor 0.0134 0.3884 1
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.1693 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0257 0.0444
Brugia malayi hypothetical protein 0.0073 0.1962 0.2618
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0088 0.0088
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0194 0.0258
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.1962 0.1962
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0194 0.0245
Schistosoma mansoni lamin 0.0026 0.0516 0.1328
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0799 0.1066
Onchocerca volvulus 0.0036 0.0799 0.1168
Loa Loa (eye worm) hypothetical protein 0.0013 0.0088 0.0117
Trichomonas vaginalis set domain proteins, putative 0.0229 0.6839 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0056 0.1447 0.8824
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0194 0.0245
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0194 0.0863
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.1614 1
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0124 0.3573 0.3573
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0257 0.0342
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0194 0.0245
Onchocerca volvulus 0.0016 0.0194 0.0283
Echinococcus multilocularis cysteine protease 0.0016 0.0194 0.0194
Onchocerca volvulus 0.0016 0.0194 0.0283
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0194 0.0194
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0124 0.3573 0.3573
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0194 0.0863
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1614 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0194 0.0194
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0799 0.1134
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0257 0.0421
Brugia malayi Cathepsin L-like precursor 0.0016 0.0194 0.0258
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0194 0.0283
Echinococcus multilocularis survival motor neuron protein 1 0.025 0.7496 0.7496
Brugia malayi intermediate filament protein 0.0026 0.0516 0.0688
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0799 0.2057
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.1281 0.1709
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0799 0.0831
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0799 0.0799
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0799 0.1134
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0194 0.0245
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1614 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.1693 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0134 0.3884 0.3884
Echinococcus granulosus cathepsin l1 0.0016 0.0194 0.0194
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0516 0.0688
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0194 0.0245
Brugia malayi hypothetical protein 0.025 0.7496 1
Entamoeba histolytica hypothetical protein 0.0073 0.1962 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1614 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0035
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0194 0.0245
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0194 0.0245
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0799 0.4262
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.1693 0.4359
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0589 0.2639
Echinococcus multilocularis musashi 0.0026 0.0516 0.0516
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0257 0.5
Echinococcus multilocularis lamin 0.0026 0.0516 0.0516
Loa Loa (eye worm) hypothetical protein 0.0048 0.1197 0.1598
Echinococcus granulosus lamin dm0 0.0026 0.0516 0.0516
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0799 0.1134
Trypanosoma cruzi major cysteine proteinase, putative 0.0048 0.1202 0.7098
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0799 0.1134
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0194 0.0245
Leishmania major cathepsin L-like protease 0.0062 0.1614 0.9473
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0227 0.6785 1
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0799 0.0831
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.1693 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0257 0.0257
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0257 0.5
Echinococcus multilocularis lamin dm0 0.0026 0.0516 0.0516
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0194 0.0245
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0257 0.1042
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0194 0.0258
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0799 0.0831
Loa Loa (eye worm) beta-lactamase 0.0036 0.0799 0.1066
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1614 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0035
Loa Loa (eye worm) hypothetical protein 0.0036 0.0799 0.1066
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0799 0.0831
Onchocerca volvulus 0.0036 0.0799 0.1168
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0036 0.0799 0.1066
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1614 1
Leishmania major cathepsin L-like protease 0.0062 0.1614 0.9473
Loa Loa (eye worm) hypothetical protein 0.025 0.7496 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0201 0.5971 0.7966
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0194 0.0245
Brugia malayi beta-lactamase 0.0036 0.0799 0.1066
Brugia malayi cathepsin L-like precursor 0.0011 0.0027 0.0035
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0799 0.1066
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0131 0.0175
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.1693 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1614 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0257 0.0342
Schistosoma mansoni lamin 0.0026 0.0516 0.1328
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0799 0.3775
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1614 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0194 0.0245
Brugia malayi Cathepsin L-like precursor 0.0016 0.0194 0.0258
Schistosoma mansoni hypothetical protein 0.0051 0.1281 0.3297
Toxoplasma gondii exonuclease III APE 0.0018 0.0257 0.0421
Onchocerca volvulus 0.0036 0.0799 0.1168
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0799 0.2057
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0257 0.0257
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0516 0.0688
Entamoeba histolytica cysteine protease, putative 0.0016 0.0194 0.0863
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0799 0.0831
Mycobacterium ulcerans lipase LipD 0.0036 0.0799 0.3775
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0589 0.0589
Brugia malayi Cathepsin L-like precursor 0.0016 0.0194 0.0258
Mycobacterium tuberculosis Conserved protein 0.0036 0.0799 0.0831
Loa Loa (eye worm) ctsf protein 0.0016 0.0194 0.0258
Loa Loa (eye worm) hypothetical protein 0.0036 0.0799 0.1066
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0194 0.0283
Toxoplasma gondii ABC1 family protein 0.0036 0.0799 0.4037
Brugia malayi Pre-SET motif family protein 0.0029 0.0589 0.0786
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0194 0.0194
Schistosoma mansoni hypothetical protein 0.0124 0.3573 0.9197
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0799 0.4262
Onchocerca volvulus 0.0016 0.0194 0.0283
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0516 0.0688
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0257 0.1189
Trichomonas vaginalis esterase, putative 0.0036 0.0799 0.1134
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1614 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0194 0.0245
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0257 0.0338
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0194 0.0283
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0799 0.5
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0799 0.0799
Brugia malayi Cathepsin L-like cysteine proteinase 0.0011 0.0027 0.0035
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0194 0.0245
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.1962 0.1962
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0194 0.0194
Onchocerca volvulus 0.0229 0.6839 1
Entamoeba histolytica hypothetical protein 0.0073 0.1962 1
Onchocerca volvulus 0.0051 0.1281 0.1873
Schistosoma mansoni ap endonuclease 0.0018 0.0257 0.0661
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.1614 1
Mycobacterium tuberculosis Conserved protein 0.0036 0.0799 0.0831
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0194 0.0245
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0194 0.0498
Schistosoma mansoni survival motor neuron protein 0.0051 0.1281 0.3297
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0194 0.0245
Echinococcus granulosus survival motor neuron protein 1 0.025 0.7496 0.7496
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0194 0.0245
Onchocerca volvulus 0.0026 0.0516 0.0754
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0194 0.0245
Schistosoma mansoni thyroid hormone receptor 0.0134 0.3884 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0257 0.0444
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0589 0.0589
Loa Loa (eye worm) hypothetical protein 0.0036 0.0799 0.1066
Schistosoma mansoni hypothetical protein 0.0073 0.1962 0.5051
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0799 0.3995
Brugia malayi Cathepsin L-like precursor 0.0016 0.0194 0.0258
Brugia malayi Pre-SET motif family protein 0.0201 0.5971 0.7966
Mycobacterium ulcerans beta-lactamase 0.0036 0.0799 0.3775
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.1197 0.3083
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1614 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0194 0.0258
Mycobacterium ulcerans hypothetical protein 0.0036 0.0799 0.3775
Echinococcus granulosus cathepsin l1 0.0011 0.0027 0.0027
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.1693 0.22
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.1962 0.5051
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0194 0.0194
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0589 0.1517
Leishmania major cathepsin L-like protease 0.0062 0.1614 0.9473
Loa Loa (eye worm) fibroinase 0.0016 0.0194 0.0258
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0194 0.0245
Loa Loa (eye worm) hypothetical protein 0.0012 0.0072 0.0097
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0194 0.0258
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.1614 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0257 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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