Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0039 | 0.0917 | 0.5 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0039 | 0.0917 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0039 | 0.0917 | 0.8735 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0128 | 0.454 | 0.5776 |
Schistosoma mansoni | hypothetical protein | 0.0193 | 0.7189 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0041 | 0.0997 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0041 | 0.0997 | 0.5 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0039 | 0.0917 | 0.5 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0041 | 0.0997 | 0.0087 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.1221 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.1221 | 0.0483 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0041 | 0.0997 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0041 | 0.0997 | 0.7368 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0041 | 0.0997 | 0.8166 |
Onchocerca volvulus | 0.0041 | 0.0997 | 0.5 | |
Trypanosoma brucei | hypothetical protein, conserved | 0.0041 | 0.0997 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0041 | 0.0997 | 0.8166 |
Plasmodium vivax | hypothetical protein, conserved | 0.0041 | 0.0997 | 1 |
Brugia malayi | hypothetical protein | 0.0026 | 0.037 | 0.3031 |
Loa Loa (eye worm) | beta-lactamase | 0.0041 | 0.0997 | 0.7368 |
Toxoplasma gondii | exonuclease III APE | 0.0039 | 0.0917 | 0.8735 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0.0997 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0138 | 0.4959 | 0.6444 |
Mycobacterium ulcerans | hypothetical protein | 0.0041 | 0.0997 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1221 | 0.0483 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1221 | 0.0483 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0997 | 0.7368 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0041 | 0.0997 | 0.0087 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0039 | 0.0917 | 0.8735 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0041 | 0.0997 | 0.0087 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.1221 | 0.0483 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.1221 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0041 | 0.0997 | 0.8166 |
Mycobacterium leprae | Probable lipase LipE | 0.0041 | 0.0997 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0138 | 0.4959 | 0.6444 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0041 | 0.0997 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0039 | 0.0917 | 0.7517 |
Leishmania major | hypothetical protein, conserved | 0.0041 | 0.0997 | 1 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0041 | 0.0997 | 0.0087 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.1221 | 0.0483 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0041 | 0.0997 | 0.0087 |
Echinococcus multilocularis | geminin | 0.0193 | 0.7189 | 1 |
Trichomonas vaginalis | esterase, putative | 0.0041 | 0.0997 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0138 | 0.4959 | 0.6444 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0039 | 0.0917 | 0.6437 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0997 | 0.7368 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1221 | 0.0483 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0.0997 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0041 | 0.0997 | 0.0087 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0.0997 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0041 | 0.0997 | 0.0087 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.1221 | 0.0483 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0041 | 0.0997 | 0.0087 |
Mycobacterium ulcerans | beta-lactamase | 0.0041 | 0.0997 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0193 | 0.7189 | 1 |
Onchocerca volvulus | 0.0041 | 0.0997 | 0.5 | |
Brugia malayi | beta-lactamase | 0.0041 | 0.0997 | 0.8166 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0041 | 0.0997 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0039 | 0.0917 | 0.8735 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0041 | 0.0997 | 0.0126 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0039 | 0.0917 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0041 | 0.0997 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0041 | 0.0997 | 0.0087 |
Mycobacterium ulcerans | lipase LipD | 0.0041 | 0.0997 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0041 | 0.0997 | 0.0126 |
Toxoplasma gondii | ABC1 family protein | 0.0041 | 0.0997 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0039 | 0.0917 | 0.8735 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0041 | 0.0997 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0128 | 0.454 | 0.5776 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0041 | 0.0997 | 0.0087 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0128 | 0.454 | 0.5776 |
Echinococcus granulosus | geminin | 0.0193 | 0.7189 | 1 |
Onchocerca volvulus | 0.0041 | 0.0997 | 0.5 | |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0041 | 0.0997 | 0.0126 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0997 | 0.7368 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0041 | 0.0997 | 0.0126 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0997 | 0.7368 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0039 | 0.0917 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0997 | 0.7368 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0997 | 0.7368 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0039 | 0.0917 | 0.8735 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 100 uM | Antileishmanial activity against Leishmania donovani LV9 promastigotes after 72 hrs by MTT assay | ChEMBL. | 19819695 |
IC50 (functional) | > 100 uM | Antitrypanosomal activity against Trypanosoma brucei brucei GVR 35 trypomastigotes after 72 hrs by MTT assay | ChEMBL. | 19819695 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.