Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | leukotriene A4 hydrolase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | leukotriene A 4 hydrolase | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Candida albicans | leukotriene A4 hydrolase/leucyl aminopeptidase | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Schistosoma japonicum | ko:K01254 leukotriene-A4 hydrolase [EC3.3.2.6], putative | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Candida albicans | leukotriene A4 hydrolase/leucyl aminopeptidase | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | leukotriene A4 hydrolase | 611 aa | 508 aa | 22.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | importin beta-1 subunit, putative | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0376 | 0.0188 |
Trichomonas vaginalis | importin beta-1, putative | 0.0023 | 0 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.0931 | 0.2027 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.0931 | 0.0753 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0376 | 0.0506 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0931 | 0.0753 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0298 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.0931 | 0.2027 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0023 | 0 | 0.5 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0028 | 0.0192 | 0.5 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0028 | 0.0192 | 0.5 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0028 | 0.0192 | 0.5 |
Plasmodium vivax | importin-beta 2, putative | 0.0028 | 0.0192 | 0.5 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0279 | 0.9313 | 0.9299 |
Entamoeba histolytica | hypothetical protein | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0298 | 1 | 1 |
Plasmodium falciparum | importin beta, putative | 0.0028 | 0.0192 | 0.5 |
Echinococcus multilocularis | snurportin 1 | 0.0298 | 1 | 1 |
Brugia malayi | RNA, U transporter 1 | 0.0079 | 0.2061 | 0.5127 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0279 | 0.9313 | 0.9299 |
Brugia malayi | hypothetical protein | 0.0128 | 0.3837 | 1 |
Echinococcus granulosus | leukotriene A 4 hydrolase | 0.0279 | 0.9313 | 0.9299 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0279 | 0.9313 | 0.9299 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0376 | 0.0188 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 23 nM | Inhibition of human LTA4H hydrolysis assessed as inhibition of Ca2+ ionophore-stimulated LTB4 formation in human whole blood by ELISA | ChEMBL. | 19950900 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.