TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 528.912 | Formula: C27H31BrClN3O
H donors: 1 H acceptors: 2 LogP: 8.65 Rotable bonds: 9
Rule of 5 violations (Lipinski): 2
SMILES: C[C@@H]([C@H](c1cccc(c1)Br)Cc1ccc(cc1)Cl)Nc1ncnc(c1)OCC1CCCCC1
InChi: 1S/C27H31BrClN3O/c1-19(32-26-16-27(31-18-30-26)33-17-21-6-3-2-4-7-21)25(22-8-5-9-23(28)15-22)14-20-10-12-24(29)13-11-20/h5,8-13,15-16,18-19,21,25H,2-4,6-7,14,17H2,1H3,(H,30,31,32)/t19-,25+/m0/s1
InChiKey: GRZKPAYHMMHEOB-UQBPGWFLSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Cannabinoid CB1 receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0489	0.1095
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0137	0.3518	1
Entamoeba histolytica	cysteine protease, putative	0.0073	0.1624	0.4498
Entamoeba histolytica	cysteine proteinase, putative	0.0073	0.1624	0.4498
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.002	0.0075	0.5
Plasmodium vivax	serine-repeat antigen (SERA)	0.0029	0.0332	0.0868
Trypanosoma cruzi	cysteine peptidase, putative	0.0044	0.0782	0.1151
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0107	0.2644	0.6237
Entamoeba histolytica	cysteine protease, putative	0.0073	0.1624	0.4498
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0029	0.0332	0.0259
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0025	0.0212	0.0396
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0029	0.0332	0.0746
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.002	0.0075	0.034
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0029	0.0332	0.0259
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0029	0.0332	0.0259
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0212	0.0222
Leishmania major	cathepsin L-like protease	0.0137	0.3518	0.5604
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0029	0.0332	0.0746
Giardia lamblia	Cathepsin L precursor	0.0029	0.0332	0.176
Giardia lamblia	Encystation-specific protease	0.0029	0.0332	0.176
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0029	0.0332	0.0868
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0137	0.3518	0.5604
Onchocerca volvulus		0.0137	0.3518	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0029	0.0332	0.062
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0212	0.0329
Echinococcus granulosus	citrate lyase subunit beta protein	0.0026	0.0266	0.0192
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0137	0.3518	1
Loa Loa (eye worm)	hypothetical protein	0.0093	0.2226	0.5241
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0029	0.0332	0.0259
Giardia lamblia	Cathepsin L precursor	0.0029	0.0332	0.176
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0018	0.0029	0.5
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0107	0.2644	0.6195
Entamoeba histolytica	cysteine proteinase, putative	0.0137	0.3518	1
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0029	0.0332	0.0868
Brugia malayi	Cathepsin L-like precursor	0.0093	0.2226	0.5188
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0332	0.0722
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0029	0.0332	0.0868
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0029	0.0332	0.0868
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0029	0.0332	0.0746
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0073	0.1624	0.2521
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0137	0.3518	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.007	0.1535	0.1471
Brugia malayi	Cathepsin L-like precursor	0.0137	0.3518	0.8303
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0025	0.0212	0.1536
Schistosoma mansoni	aldehyde dehydrogenase	0.0064	0.1377	0.1312
Schistosoma mansoni	aldehyde dehydrogenase	0.0064	0.1377	0.1312
Entamoeba histolytica	cysteine protease, putative	0.0073	0.1624	0.4498
Brugia malayi	fibroinase precursor	0.0029	0.0332	0.062
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0029	0.0332	0.0722
Mycobacterium tuberculosis	Conserved protein	0.0026	0.0266	0.1929
Plasmodium falciparum	serine repeat antigen 5	0.0029	0.0332	0.0868
Onchocerca volvulus		0.0137	0.3518	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0212	0.0222
Plasmodium falciparum	serine repeat antigen 9	0.0029	0.0332	0.0868
Echinococcus multilocularis	GPCR, family 2	0.0034	0.0489	0.0417
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0137	0.3518	1
Entamoeba histolytica	cysteine protease, putative	0.0073	0.1624	0.4498
Trypanosoma cruzi	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative	0.0026	0.0266	0.031
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0029	0.0332	0.0746
Entamoeba histolytica	cysteine protease, putative	0.0137	0.3518	1
Brugia malayi	Papain family cysteine protease containing protein	0.0029	0.0332	0.062
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0029	0.0332	0.0746
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0212	0.0222
Trypanosoma cruzi	cruzipain precursor, putative	0.0137	0.3518	0.5604
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0782	0.1796
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.1624	0.2521
Plasmodium vivax	unspecified product	0.0029	0.0332	0.0868
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0029	0.0332	0.062
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0137	0.3518	0.5604
Leishmania major	cathepsin L-like protease	0.0137	0.3518	0.5604
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0137	0.3518	1
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0025	0.0212	0.1352
Giardia lamblia	Hypothetical protein	0.0029	0.0332	0.176
Echinococcus granulosus	cathepsin b	0.0161	0.4222	0.4178
Giardia lamblia	Cysteine protease	0.0029	0.0332	0.176
Entamoeba histolytica	cysteine proteinase, putative	0.0073	0.1624	0.4498
Schistosoma mansoni	cathepsin F (C01 family)	0.0137	0.3518	0.3469
Echinococcus granulosus	cathepsin L cysteine protease	0.0073	0.1624	0.156
Brugia malayi	cathepsin L-like precursor	0.0093	0.2226	0.5188
Brugia malayi	cathepsin F-like cysteine proteinase	0.0029	0.0332	0.062
Toxoplasma gondii	cathepsin CPL	0.0137	0.3518	1
Entamoeba histolytica	cysteine protease, putative	0.0029	0.0332	0.0746
Trichomonas vaginalis	Citrate lyase beta chain, putative	0.0026	0.0266	0.0553
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0034	0.0489	0.0417
Trypanosoma brucei	hypothetical protein, conserved	0.0229	0.6219	1
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0161	0.4222	0.4178
Loa Loa (eye worm)	hypothetical protein	0.0161	0.4222	1
Plasmodium vivax	unspecified product	0.0044	0.0782	0.2159
Brugia malayi	Papain family cysteine protease containing protein	0.0073	0.1624	0.3735
Plasmodium vivax	vivapain-2	0.0137	0.3518	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.0044	0.0782	0.1706
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0073	0.1624	0.156
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0029	0.0332	0.0259
Toxoplasma gondii	aldehyde dehydrogenase	0.0064	0.1377	0.3782
Toxoplasma gondii	cathepsin B	0.007	0.1535	0.4241
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0029	0.0332	0.0259
Schistosoma mansoni	cathepsin C	0.0029	0.0332	0.0259
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0782	0.1796
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0029	0.0332	0.0868
Onchocerca volvulus		0.0137	0.3518	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0161	0.4222	0.6749
Mycobacterium ulcerans	citrate (pro-3S)-lyase subunit beta	0.0026	0.0266	0.1753
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0073	0.1624	0.4498
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0073	0.1624	0.4498
Giardia lamblia	Cysteine protease	0.0029	0.0332	0.176
Brugia malayi	cathepsin B-like cysteine proteinase	0.0161	0.4222	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0137	0.3518	1
Brugia malayi	Papain family cysteine protease containing protein	0.0029	0.0332	0.062
Echinococcus granulosus	cathepsin L	0.0029	0.0332	0.0259
Echinococcus multilocularis	cathepsin L	0.0029	0.0332	0.0259
Toxoplasma gondii	cathepsin CPC1	0.0029	0.0332	0.0746
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0018	0.0029	0.0214
Leishmania major	cysteine peptidase A (CPA)	0.0137	0.3518	0.5604
Leishmania major	cathepsin L-like protease	0.0137	0.3518	0.5604
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0137	0.3518	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0137	0.3518	0.5604
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0332	0.0746
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0212	0.0435
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0212	0.0435
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0137	0.3518	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0137	0.3518	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0073	0.1624	0.2521
Brugia malayi	Cathepsin L-like precursor	0.0093	0.2226	0.5188
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0029	0.0332	0.176
Leishmania major	cathepsin L-like protease	0.0137	0.3518	0.5604
Giardia lamblia	Cathepsin B precursor	0.0029	0.0332	0.176
Onchocerca volvulus	Cathepsin L homolog	0.0137	0.3518	1
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0025	0.0212	0.0396
Loa Loa (eye worm)	hypothetical protein	0.0107	0.2644	0.6237
Plasmodium falciparum	serine repeat antigen 1	0.0029	0.0332	0.0868
Entamoeba histolytica	cysteine protease, putative	0.0073	0.1624	0.4498
Plasmodium vivax	serine-repeat antigen (SERA)	0.0029	0.0332	0.0868
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0034	0.0489	0.0417
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0137	0.3518	0.3469
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0093	0.2226	0.3502
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0034	0.0489	0.1095
Leishmania major	cathepsin L-like protease	0.0137	0.3518	0.5604
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.002	0.0075	0.0109
Schistosoma mansoni	cathepsin S (C01 family)	0.0029	0.0332	0.0259
Trypanosoma cruzi	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative	0.0026	0.0266	0.031
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0137	0.3518	0.3469
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0029	0.0332	0.0746
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0161	0.4222	0.4178
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0212	0.1352
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0137	0.3518	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0212	0.0435
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0137	0.3518	1
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0064	0.1377	0.1312
Echinococcus granulosus	cysteine protease	0.0073	0.1624	0.156
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0782	0.1796
Onchocerca volvulus		0.0137	0.3518	1
Schistosoma mansoni	hypothetical protein	0.0034	0.0489	0.0417
Brugia malayi	cathepsin L-like cysteine proteinase	0.0029	0.0332	0.062
Schistosoma mansoni	hypothetical protein	0.0358	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0137	0.3518	1
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0025	0.0212	0.1352
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0025	0.0212	0.1352
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0029	0.0332	0.0259
Schistosoma mansoni	cathepsin B (C01 family)	0.0029	0.0332	0.0259
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0137	0.3518	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0137	0.3518	0.5604
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0029	0.0332	0.0259
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0044	0.0782	0.1796
Echinococcus granulosus	cathepsin b	0.0161	0.4222	0.4178
Entamoeba histolytica	cysteine protease, putative	0.0073	0.1624	0.4498
Brugia malayi	Cathepsin L-like precursor	0.0137	0.3518	0.8303
Entamoeba histolytica	cysteine protease, putative	0.0029	0.0332	0.0746
Onchocerca volvulus		0.0093	0.2226	0.6094
Brugia malayi	Cathepsin L-like precursor	0.0137	0.3518	0.8303
Brugia malayi	Latrophilin receptor protein 2	0.0034	0.0489	0.0997
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0029	0.0332	0.0259
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0029	0.0332	0.0722
Plasmodium falciparum	serine repeat antigen 7	0.0029	0.0332	0.0868
Brugia malayi	Papain family cysteine protease containing protein	0.0073	0.1624	0.3735
Giardia lamblia	Cathepsin L-like protease	0.0029	0.0332	0.176
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0029	0.0332	0.0746
Mycobacterium ulcerans	hypothetical protein	0.0026	0.0266	0.1753
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0029	0.0332	0.0746
Trypanosoma cruzi	cysteine peptidase, putative	0.0137	0.3518	0.5604
Mycobacterium ulcerans	citrate (pro-3S)-lyase subunit beta	0.0026	0.0266	0.1753
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.002	0.0075	0.0546
Entamoeba histolytica	hypothetical protein	0.0029	0.0332	0.0746
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0212	0.0329
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0137	0.3518	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0137	0.3518	0.5604
Schistosoma mansoni	hypothetical protein	0.0073	0.1646	0.1583
Echinococcus multilocularis	cathepsin L	0.0073	0.1624	0.156
Entamoeba histolytica	cysteine protease, putative	0.0029	0.0332	0.0746
Echinococcus multilocularis	cathepsin L cysteine protease	0.0137	0.3518	0.3469
Plasmodium falciparum	serine repeat antigen 4	0.0029	0.0332	0.0868
Loa Loa (eye worm)	cysteine protease	0.0137	0.3518	0.8321
Trypanosoma brucei	cysteine peptidase C (CPC)	0.007	0.1535	0.2376
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0107	0.2644	0.6195
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.007	0.1535	0.4241
Loa Loa (eye worm)	hypothetical protein	0.0137	0.3518	0.8321
Trypanosoma cruzi	major cysteine proteinase, putative	0.0029	0.0332	0.0418
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0064	0.1377	1
Giardia lamblia	Cathepsin B precursor	0.0029	0.0332	0.176
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0029	0.0332	0.0868
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0332	0.0722
Brugia malayi	Cathepsin L-like precursor	0.0137	0.3518	0.8303
Trypanosoma cruzi	major cysteine proteinase, putative	0.0029	0.0332	0.0418
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0029	0.0332	0.0746
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0029	0.0332	0.0746
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0029	0.0332	0.176
Plasmodium falciparum	serine repeat antigen 2	0.0029	0.0332	0.0868
Echinococcus granulosus	cathepsin l1	0.0093	0.2226	0.2168
Echinococcus multilocularis	geminin	0.0358	1	1
Brugia malayi	Cathepsin L-like precursor	0.0044	0.0782	0.1706
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0025	0.0212	0.1352
Entamoeba histolytica	cysteine proteinase, putative	0.0073	0.1624	0.4498
Entamoeba histolytica	cysteine protease, putative	0.0029	0.0332	0.0746
Onchocerca volvulus	Cathepsin L homolog	0.0029	0.0332	0.0365
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0029	0.0332	0.0746
Leishmania major	cathepsin L-like protease	0.0137	0.3518	0.5604
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0064	0.1377	1
Entamoeba histolytica	cysteine protease, putative	0.0073	0.1624	0.4498
Giardia lamblia	Cysteine protease	0.0029	0.0332	0.176
Giardia lamblia	Cathepsin L precursor	0.0029	0.0332	0.176
Echinococcus multilocularis	citrate lyase subunit beta protein	0.0026	0.0266	0.0192
Brugia malayi	cathepsin L precursor	0.0029	0.0332	0.062
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0034	0.0489	0.0417
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0029	0.0332	0.0746
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0137	0.3518	1
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0064	0.1377	1
Entamoeba histolytica	cysteine proteinase, putative	0.0093	0.2226	0.6249
Trypanosoma cruzi	cysteine peptidase, putative	0.0137	0.3518	0.5604
Echinococcus granulosus	cathepsin l1	0.0137	0.3518	0.3469
Plasmodium vivax	unspecified product	0.0073	0.1624	0.457
Echinococcus granulosus	cathepsin L	0.0073	0.1624	0.156
Trypanosoma cruzi	cysteine protease, putative	0.0073	0.1624	0.2521
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0029	0.0332	0.0722
Giardia lamblia	Cathepsin B precursor	0.0029	0.0332	0.176
Echinococcus multilocularis	cysteine protease	0.0137	0.3518	0.3469
Leishmania major	cathepsin L-like protease	0.0137	0.3518	0.5604
Onchocerca volvulus		0.0137	0.3518	1
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0029	0.0332	0.0868
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0029	0.0332	0.0746
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0137	0.3518	0.5604
Trypanosoma cruzi	hypothetical protein, conserved	0.0229	0.6219	1
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0064	0.1377	0.1312
Entamoeba histolytica	cysteine protease, putative	0.0073	0.1624	0.4498
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0137	0.3518	1
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0044	0.0782	0.1706
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0332	0.0746
Echinococcus multilocularis	cathepsin b	0.0161	0.4222	0.4178
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0064	0.1377	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0029	0.0332	0.0746
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1646	0.3857
Trypanosoma cruzi	cruzipain precursor, putative	0.0044	0.0782	0.1151
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0137	0.3518	0.3469
Plasmodium vivax	vivapain-2	0.0137	0.3518	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0161	0.4222	0.4178
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0029	0.0332	0.0868
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0137	0.3518	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0073	0.1646	0.3789
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0137	0.3518	0.5604
Loa Loa (eye worm)	cathepsin B	0.007	0.1535	0.3592
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0212	0.1352
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0073	0.1624	0.457
Giardia lamblia	Cysteine protease	0.0029	0.0332	0.176
Schistosoma mansoni	hypothetical protein	0.0358	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0073	0.1624	0.4498
Plasmodium vivax	vivapain-3	0.0073	0.1624	0.457
Echinococcus multilocularis	cathepsin L cysteine protease	0.0137	0.3518	0.3469
Giardia lamblia	Cathepsin B precursor	0.007	0.1535	1
Plasmodium vivax	vivapain-1	0.0073	0.1624	0.457
Giardia lamblia	Cathepsin L precursor	0.0029	0.0332	0.176
Giardia lamblia	Cathepsin B precursor	0.007	0.1535	1
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0064	0.1377	0.2119
Mycobacterium tuberculosis	Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase)	0.0026	0.0266	0.1929
Entamoeba histolytica	cysteine protease, putative	0.0029	0.0332	0.0746
Brugia malayi	Cathepsin L-like precursor	0.0137	0.3518	0.8303
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0093	0.2226	0.5188
Schistosoma mansoni	cathepsin F (C01 family)	0.0093	0.2226	0.2168
Loa Loa (eye worm)	hypothetical protein	0.0093	0.2226	0.5241
Giardia lamblia	Cathepsin L precursor	0.0029	0.0332	0.176
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0332	0.0722
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0137	0.3518	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0137	0.3518	0.5604
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0137	0.3518	0.5604
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0029	0.0332	0.0868
Leishmania major	cathepsin L-like protease	0.0137	0.3518	0.5604
Giardia lamblia	Hypothetical protein	0.0029	0.0332	0.176
Mycobacterium ulcerans	hypothetical protein	0.0026	0.0266	0.1753
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0137	0.3518	0.8321
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0137	0.3518	0.8321
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0093	0.2226	0.6249
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0029	0.0332	0.062
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0137	0.3518	0.5604
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0029	0.0332	0.0746
Entamoeba histolytica	cysteine protease, putative	0.0029	0.0332	0.0746
Giardia lamblia	Cathepsin B precursor	0.0029	0.0332	0.176
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0029	0.0332	0.0746
Entamoeba histolytica	cysteine proteinase, putative	0.0137	0.3518	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0029	0.0332	0.0746
Entamoeba histolytica	acyl-coA synthetase, putative	0.0025	0.0212	0.0396
Loa Loa (eye worm)	hypothetical protein	0.0093	0.2226	0.5241
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0137	0.3518	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0034	0.0489	0.0417
Leishmania major	hypothetical protein, conserved	0.0229	0.6219	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0029	0.0332	0.0746
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0029	0.0332	0.176
Treponema pallidum	exodeoxyribonuclease (exoA)	0.002	0.0075	0.5
Onchocerca volvulus	Cathepsin L homolog	0.0137	0.3518	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0137	0.3518	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0332	0.0722
Mycobacterium ulcerans	hypothetical protein	0.0025	0.0212	0.1352
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0137	0.3518	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0137	0.3518	1
Brugia malayi	Papain family cysteine protease containing protein	0.0029	0.0332	0.062
Onchocerca volvulus		0.0137	0.3518	1
Schistosoma mansoni	cathepsin s	0.0044	0.0782	0.0713
Plasmodium falciparum	serine repeat antigen 3	0.0029	0.0332	0.0868
Entamoeba histolytica	cysteine proteinase 1, putative	0.0073	0.1624	0.4498
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0029	0.0332	0.0868
Onchocerca volvulus	Cathepsin F homolog	0.0137	0.3518	1
Loa Loa (eye worm)	ctsf protein	0.0137	0.3518	0.8321
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0029	0.0332	0.0746
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0137	0.3518	0.3469
Loa Loa (eye worm)	fibroinase	0.0137	0.3518	0.8321
Toxoplasma gondii	cathepsin CPC2	0.0029	0.0332	0.0746
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0137	0.3518	1
Onchocerca volvulus		0.0029	0.0332	0.0365
Entamoeba histolytica	cysteine proteinase 2	0.0073	0.1624	0.4498
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0025	0.0212	0.5
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0029	0.0332	0.0868
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0137	0.3518	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0073	0.1624	0.156
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.0075	0.0131
Giardia lamblia	Cathepsin L precursor	0.0029	0.0332	0.176
Trypanosoma cruzi	cysteine proteinase, putative	0.0073	0.1624	0.2521
Plasmodium falciparum	serine repeat antigen 6	0.0029	0.0332	0.0868
Entamoeba histolytica	cysteine protease, putative	0.0073	0.1624	0.4498
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.0075	0.0131
Echinococcus multilocularis	cysteine protease	0.0137	0.3518	0.3469
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.007	0.1535	0.2376
Onchocerca volvulus		0.0137	0.3518	1
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0029	0.0332	0.176
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0034	0.0489	0.0997
Entamoeba histolytica	cysteine protease, putative	0.0073	0.1624	0.4498
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.007	0.1535	0.2376
Trypanosoma cruzi	cysteine peptidase, putative	0.0137	0.3518	0.5604
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0161	0.4222	0.4178
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0073	0.1624	0.156
Entamoeba histolytica	cysteine protease, putative	0.0073	0.1624	0.4498
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0212	0.0329
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0212	0.1352
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0029	0.0332	0.0746
Schistosoma mansoni	cathepsin F (C01 family)	0.0137	0.3518	0.3469
Entamoeba histolytica	cysteine protease, putative	0.0073	0.1624	0.4498
Trypanosoma cruzi	cysteine proteinase, putative	0.0073	0.1624	0.2521
Giardia lamblia	Cathepsin B precursor	0.0029	0.0332	0.176
Giardia lamblia	Cathepsin L-like protease	0.0029	0.0332	0.176
Schistosoma mansoni	hypothetical protein	0.0034	0.0489	0.0417
Brugia malayi	Papain family cysteine protease containing protein	0.0137	0.3518	0.8303
Trypanosoma cruzi	hypothetical protein, conserved	0.0229	0.6219	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0332	0.0722
Brugia malayi	Cathepsin L-like precursor	0.0137	0.3518	0.8303
Giardia lamblia	Cathepsin B precursor	0.007	0.1535	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0137	0.3518	1
Echinococcus multilocularis	cathepsin b	0.0161	0.4222	0.4178
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0137	0.3518	1
Schistosoma mansoni	hypothetical protein	0.0034	0.0489	0.0417
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.1624	0.2521
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0137	0.3518	0.5604
Plasmodium falciparum	serine repeat antigen 8	0.0029	0.0332	0.0868
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0029	0.0332	0.0868
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0332	0.0722
Leishmania major	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative	0.0026	0.0266	0.031
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0137	0.3518	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0093	0.2226	0.6249
Schistosoma mansoni	hypothetical protein	0.0034	0.0489	0.0417
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0137	0.3518	1
Echinococcus granulosus	GPCR family 2	0.0034	0.0489	0.0417
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0025	0.0212	0.1536
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0029	0.0332	0.0868
Trypanosoma cruzi	cysteine peptidase, putative	0.0137	0.3518	0.5604
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0025	0.0212	0.5
Mycobacterium ulcerans	citrate lyase beta subunit, CitE_2	0.0026	0.0266	0.1753
Entamoeba histolytica	cysteine protease, putative	0.0073	0.1624	0.4498

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 136 nM	Displacement of [3H]CP-55940 from cannabinoid CB1 receptor in Sprague-Dawley rat cerebellar membrane by liquid scintillation spectrometry	ChEMBL.	19596576

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL564279

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1060896