Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | glycogen phosphorylase | 0.0125 | 0.619 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.324 | 0.319 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0029 | 0.0768 | 0.1241 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0125 | 0.619 | 0.5 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0125 | 0.619 | 0.6161 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0029 | 0.0768 | 0.1241 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.1189 | 0.1921 |
Brugia malayi | RNA binding protein | 0.0069 | 0.3001 | 0.4848 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.2222 | 0.359 |
Entamoeba histolytica | glycogenphosphorylase, putative | 0.0054 | 0.2173 | 0.1327 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.3001 | 0.2949 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0074 | 0.012 |
Schistosoma mansoni | hypothetical protein | 0.0192 | 1 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0017 | 0.0074 | 0.012 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0073 | 0.324 | 0.319 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0125 | 0.619 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.3001 | 0.2949 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2222 | 0.2164 |
Loa Loa (eye worm) | intermediate filament protein | 0.0029 | 0.0768 | 0.1241 |
Echinococcus granulosus | glycogen phosphorylase | 0.0125 | 0.619 | 0.6161 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.1189 | 0.1123 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.2222 | 0.2164 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.1559 | 0.1495 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 0.215 | 0.3474 |
Schistosoma mansoni | hypothetical protein | 0.0192 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 0.215 | 0.3474 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0069 | 0.3001 | 0.4848 |
Brugia malayi | TAR-binding protein | 0.0069 | 0.3001 | 0.4848 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0125 | 0.619 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0069 | 0.3001 | 0.4848 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.3001 | 0.2949 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2222 | 0.2164 |
Echinococcus granulosus | lamin dm0 | 0.0029 | 0.0768 | 0.0699 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0073 | 0.324 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.2222 | 0.2164 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0017 | 0.0074 | 0.012 |
Schistosoma mansoni | lamin | 0.0029 | 0.0768 | 0.0699 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.324 | 1 |
Schistosoma mansoni | lamin | 0.0029 | 0.0768 | 0.0699 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.2222 | 0.2164 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.2222 | 0.359 |
Brugia malayi | carbohydrate phosphorylase | 0.0125 | 0.619 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0054 | 0.215 | 0.3474 |
Loa Loa (eye worm) | RNA binding protein | 0.0069 | 0.3001 | 0.4848 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0738 | 0.1192 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0054 | 0.2173 | 0.1327 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0073 | 0.324 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0073 | 0.324 | 0.319 |
Echinococcus multilocularis | tar DNA binding protein | 0.0069 | 0.3001 | 0.2949 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0054 | 0.2173 | 0.1327 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.1559 | 0.1495 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0125 | 0.619 | 0.6161 |
Echinococcus multilocularis | lamin dm0 | 0.0029 | 0.0768 | 0.0699 |
Echinococcus granulosus | tar DNA binding protein | 0.0069 | 0.3001 | 0.2949 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.215 | 0.3474 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.1559 | 0.1495 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0125 | 0.619 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2222 | 0.2164 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0017 | 0.0074 | 0.012 |
Schistosoma mansoni | intermediate filament proteins | 0.0029 | 0.0768 | 0.0699 |
Brugia malayi | intermediate filament protein | 0.0029 | 0.0768 | 0.1241 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.3001 | 0.2949 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0125 | 0.619 | 1 |
Echinococcus multilocularis | lamin | 0.0029 | 0.0768 | 0.0699 |
Schistosoma mansoni | glycogen phosphorylase | 0.0054 | 0.2173 | 0.2114 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0125 | 0.619 | 1 |
Schistosoma mansoni | glycogen phosphorylase | 0.0125 | 0.619 | 0.6161 |
Echinococcus granulosus | glycogen phosphorylase | 0.0125 | 0.619 | 0.6161 |
Giardia lamblia | Glycogen phosphorylase | 0.0125 | 0.619 | 0.5 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0125 | 0.619 | 0.6161 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.324 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0073 | 0.324 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1189 | 0.1921 |
Echinococcus granulosus | intermediate filament protein | 0.0029 | 0.0768 | 0.0699 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.1559 | 0.1495 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0125 | 0.619 | 0.6161 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0768 | 0.1241 |
Schistosoma mansoni | glycogen phosphorylase | 0.0125 | 0.619 | 0.6161 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.324 | 1 |
Brugia malayi | hypothetical protein | 0.0043 | 0.1559 | 0.2518 |
Loa Loa (eye worm) | TAR-binding protein | 0.0069 | 0.3001 | 0.4848 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.324 | 0.319 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.2222 | 0.2164 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.3001 | 0.2949 |
Echinococcus multilocularis | geminin | 0.0192 | 1 | 1 |
Echinococcus granulosus | lamin | 0.0029 | 0.0768 | 0.0699 |
Echinococcus multilocularis | musashi | 0.0029 | 0.0768 | 0.0699 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -6.435 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.081 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.798 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.794 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.747 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.736 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.722 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.713 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.7 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.7 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.686 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.