Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | thyroid hormone receptor | 0.0011 | 0.0048 | 0.0058 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0011 | 0.0048 | 0.0058 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0011 | 0.0048 | 0.0035 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0048 | 0.0035 |
Trypanosoma cruzi | ISWI complex protein | 0.0016 | 0.0292 | 0.6423 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0011 | 0.0048 | 0.0058 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0018 | 0.0374 | 0.0456 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0011 | 0.0048 | 0.0058 |
Echinococcus granulosus | ATP dependent DNA helicase Q1 | 0.002 | 0.0445 | 0.0487 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.002 | 0.0445 | 1 |
Trichomonas vaginalis | set domain proteins, putative | 0.0236 | 1 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.003 | 0.0886 | 0.1029 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0035 | 0.1137 | 0.1336 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.002 | 0.0445 | 0.0457 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0063 | 0.238 | 0.2862 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.002 | 0.0445 | 0.5017 |
Schistosoma mansoni | bromodomain containing protein | 0.0067 | 0.2548 | 0.3108 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0048 | 0.0035 |
Echinococcus granulosus | methyl CpG binding domain protein 2 | 0.0018 | 0.0374 | 0.0401 |
Brugia malayi | Pre-SET motif family protein | 0.003 | 0.0886 | 0.0966 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0024 | 0.0632 | 0.0771 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0011 | 0.0048 | 0.0058 |
Echinococcus multilocularis | GPCR, family 2 | 0.0035 | 0.1137 | 0.1336 |
Schistosoma mansoni | zinc finger protein | 0.0016 | 0.0292 | 0.0356 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0048 | 0.0035 |
Entamoeba histolytica | recQ family DNA helicase | 0.001 | 0.0017 | 0.0381 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0011 | 0.0048 | 0.0035 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0112 | 0.4517 | 0.5145 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0024 | 0.0632 | 0.0718 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0035 | 0.1137 | 0.1254 |
Treponema pallidum | ATP-dependent DNA helicase | 0.001 | 0.0017 | 0.5 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0048 | 0.1688 | 0.2013 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.003 | 0.0886 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1137 | 0.1285 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0035 | 0.1137 | 0.1254 |
Schistosoma mansoni | hypothetical protein | 0.0076 | 0.2952 | 0.3601 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0011 | 0.0048 | 0.0035 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.0018 | 0.0374 | 0.0401 |
Echinococcus multilocularis | zinc finger protein | 0.0021 | 0.0493 | 0.0546 |
Schistosoma mansoni | hypothetical protein | 0.0022 | 0.0543 | 0.0662 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.1137 | 0.1387 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0886 | 0.1081 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.1578 | 0.1791 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0048 | 0.0035 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0011 | 0.0048 | 0.0035 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0048 | 0.0035 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0035 | 0.1137 | 0.1336 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0011 | 0.0048 | 0.0058 |
Echinococcus granulosus | GPCR family 2 | 0.0035 | 0.1137 | 0.1336 |
Schistosoma mansoni | DNA helicase recq5 | 0.002 | 0.0445 | 0.0542 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1488 | 0.1687 |
Echinococcus multilocularis | ATP dependent DNA helicase Q5 | 0.002 | 0.0445 | 0.0487 |
Schistosoma mansoni | thyroid hormone receptor | 0.0011 | 0.0048 | 0.0058 |
Brugia malayi | Pre-SET motif family protein | 0.0207 | 0.8734 | 1 |
Onchocerca volvulus | 0.003 | 0.0886 | 0.0843 | |
Schistosoma mansoni | zinc finger protein | 0.0021 | 0.0493 | 0.0601 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.001 | 0.0017 | 0.0191 |
Schistosoma mansoni | coup transcription factor | 0.0011 | 0.0048 | 0.0058 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.002 | 0.0445 | 0.5017 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.002 | 0.0445 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0011 | 0.0048 | 0.0058 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.002 | 0.0445 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0011 | 0.0048 | 0.0058 |
Loa Loa (eye worm) | RecQ helicase | 0.002 | 0.0445 | 0.0491 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0038 | 0.1262 | 0.149 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0048 | 0.1688 | 0.2013 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0048 | 0.0035 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.1688 | 0.1917 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0035 | 0.1137 | 0.1336 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0011 | 0.0048 | 0.0035 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0048 | 0.1688 | 0.206 |
Entamoeba histolytica | recQ family helicase, putative | 0.002 | 0.0445 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0011 | 0.0048 | 0.0035 |
Schistosoma mansoni | nuclear hormone receptor | 0.0011 | 0.0048 | 0.0058 |
Echinococcus multilocularis | bloom syndrome protein | 0.002 | 0.0445 | 0.0487 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.002 | 0.0445 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0112 | 0.4517 | 0.5162 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.002 | 0.0445 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0292 | 0.0356 |
Echinococcus granulosus | bloom syndrome protein | 0.002 | 0.0445 | 0.0487 |
Schistosoma mansoni | hypothetical protein | 0.0195 | 0.8197 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0195 | 0.8197 | 1 |
Echinococcus granulosus | geminin | 0.0195 | 0.8197 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0112 | 0.4517 | 0.5145 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0048 | 0.0035 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0011 | 0.0048 | 0.0058 |
Echinococcus granulosus | ATP dependent DNA helicase Q5 | 0.002 | 0.0445 | 0.0487 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0017 | 0.00000000041269 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0011 | 0.0048 | 0.0058 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0048 | 0.1688 | 0.206 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.003 | 0.0886 | 0.1081 |
Echinococcus multilocularis | ATP dependent DNA helicase Q1 | 0.002 | 0.0445 | 0.0487 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0035 | 0.1137 | 0.1285 |
Trypanosoma cruzi | ISWI complex protein | 0.0016 | 0.0292 | 0.6423 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0076 | 0.2952 | 0.3344 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.002 | 0.0445 | 0.0457 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.1137 | 0.1387 |
Brugia malayi | Bromodomain containing protein | 0.0041 | 0.1373 | 0.1526 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0038 | 0.1262 | 0.149 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0063 | 0.238 | 0.2862 |
Schistosoma mansoni | DNA helicase recq1 | 0.002 | 0.0445 | 0.0542 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0011 | 0.0048 | 0.0035 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0022 | 0.0543 | 0.0603 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.002 | 0.0445 | 0.0491 |
Plasmodium vivax | SET domain protein, putative | 0.003 | 0.0886 | 1 |
Plasmodium falciparum | ATP-dependent DNA helicase Q1 | 0.002 | 0.0445 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0445 | 0.0491 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.4517 | 0.5162 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0207 | 0.8734 | 1 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0018 | 0.0374 | 0.0456 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1377 | 0.156 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0019 | 0.0403 | 0.0443 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.1137 | 0.1387 |
Echinococcus granulosus | zinc finger protein | 0.0021 | 0.0493 | 0.0546 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.0017 | 0.0191 |
Brugia malayi | Bloom's syndrome protein homolog | 0.002 | 0.0445 | 0.0457 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.2898 | 0.3305 |
Brugia malayi | Bromodomain containing protein | 0.008 | 0.3099 | 0.3513 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.2952 | 0.3367 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0011 | 0.0048 | 0.0035 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.001 | 0.0017 | 0.0021 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.1137 | 0.1387 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0024 | 0.0632 | 0.0718 |
Brugia malayi | PHD-finger family protein | 0.0026 | 0.0744 | 0.0801 |
Echinococcus multilocularis | geminin | 0.0195 | 0.8197 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0048 | 0.0035 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0029 | 0.0838 | 0.097 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0035 | 0.1137 | 0.1336 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | Antimalarial activity against erythrocytic stage of Plasmodium falciparum 3D7 at 115 uM | ChEMBL. | 20584608 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.