TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 341.351 | Formula: C15H14F3N3OS
H donors: 0 H acceptors: 2 LogP: 3.22 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1ccccc1C(F)(F)F)N1CCN(CC1)c1nccs1
InChi: 1S/C15H14F3N3OS/c16-15(17,18)12-4-2-1-3-11(12)13(22)20-6-8-21(9-7-20)14-19-5-10-23-14/h1-5,10H,6-9H2
InChiKey: GEQZFSCFWGCHOX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	stearoyl-CoA desaturase (delta-9-desaturase)	Starlite/ChEMBL	References
Rattus norvegicus	Acyl-CoA desaturase 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Plasmodium vivax	stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative	Get druggable targets OG5_126939	All targets in OG5_126939
Trypanosoma cruzi	fatty acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania donovani	stearic acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Trypanosoma cruzi	fatty acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Trypanosoma brucei gambiense	fatty acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Plasmodium knowlesi	stearoyl-CoA desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania major	fatty-acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Trypanosoma cruzi	fatty acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania braziliensis	stearic acid desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Plasmodium berghei	stearoyl-CoA desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Trypanosoma brucei	fatty acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania mexicana	fatty-acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Trypanosoma congolense	fatty acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania major	stearic acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania donovani	fatty-acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania braziliensis	fatty-acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Loa Loa (eye worm)	acyl-CoA desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Candida albicans	one of two potential fatty acid desaturase genes similar to S. cerevisiae OLE1 (YGL055W) delta-9-fatty acid desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Neospora caninum	fatty acyl-CoA desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania mexicana	stearic acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Onchocerca volvulus		Get druggable targets OG5_126939	All targets in OG5_126939
Plasmodium yoelii	delta-9 fatty acid desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania infantum	stearic acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Plasmodium falciparum	stearoyl-CoA desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Candida albicans	one of two potential fatty acid desaturase genes similar to S. cerevisiae OLE1 (YGL055W) delta-9-fatty acid desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania infantum	fatty-acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Brugia malayi	acyl-CoA desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Onchocerca volvulus		Get druggable targets OG5_126939	All targets in OG5_126939

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Candida albicans	one of two potential fatty acid desaturase genes similar to S. cerevisiae OLE1 (YGL055W) delta-9 fatty acid desaturase	Acyl-CoA desaturase 1	358 aa	317 aa	27.1 %
Candida albicans	one of two potential fatty acid desaturase genes similar to S. cerevisiae OLE1 (YGL055W) delta-9 fatty acid desaturase	Acyl-CoA desaturase 1	358 aa	317 aa	27.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	tar DNA-binding protein	0.0127	0.4739	1
Brugia malayi	RNA binding protein	0.0127	0.4739	0.4739
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0112	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0112	0.0112
Schistosoma mansoni	lamin	0.0027	0.0528	0.0901
Onchocerca volvulus		0.0027	0.0528	0.048
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0112	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0112	0.0112
Brugia malayi	neuropeptide F receptor	0.0017	0.0112	0.0112
Trypanosoma cruzi	fatty acid desaturase, putative	0.0205	0.8036	0.9119
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0112	0.0112
Echinococcus multilocularis	Peptidase M, neutral zinc metallopeptidases, zinc binding site	0.0018	0.0152	0.0086
Brugia malayi	Dopamine receptor	0.0017	0.0112	0.0112
Loa Loa (eye worm)	RNA binding protein	0.0127	0.4739	0.4739
Brugia malayi	acyl-CoA desaturase	0.0205	0.8036	0.8036
Schistosoma mansoni	rab6-interacting	0.002	0.0222	0.0239
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0112	0.0112
Brugia malayi	hypothetical protein	0.002	0.0222	0.0222
Schistosoma mansoni	hypothetical protein	0.002	0.0222	0.0239
Brugia malayi	hypothetical protein	0.0037	0.0937	0.0937
Onchocerca volvulus		0.0223	0.8797	1
Brugia malayi	TAR-binding protein	0.0127	0.4739	0.4739
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0508	0.0508
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0112	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0112	0.0112
Brugia malayi	intermediate filament protein	0.0027	0.0528	0.0528
Mycobacterium ulcerans	electron transfer protein FdxB	0.0018	0.0152	0.5
Schistosoma mansoni	polycystin 1-related	0.002	0.0222	0.0239
Trypanosoma cruzi	fatty acid desaturase, putative	0.0223	0.8797	1
Brugia malayi	hypothetical protein	0.0017	0.0112	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0112	0.0112
Schistosoma mansoni	fatty acid desaturase	0.0018	0.0152	0.0086
Brugia malayi	RNA recognition motif domain containing protein	0.0127	0.4739	0.4739
Brugia malayi	G protein-coupled receptor F59B2.13	0.0017	0.0112	0.0112
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0017	0.0112	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0112	0.0112
Echinococcus multilocularis	lipoxygenase domain containing protein	0.002	0.0222	0.0239
Echinococcus multilocularis	musashi	0.0027	0.0528	0.0901
Mycobacterium tuberculosis	Possible electron transfer protein FdxB	0.0018	0.0152	0.5
Mycobacterium ulcerans	linoleoyl-CoA desaturase, DesA3	0.0018	0.0152	0.5
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0112	0.0112
Schistosoma mansoni	tar DNA-binding protein	0.0127	0.4739	1
Echinococcus granulosus	Sphingolipid delta4 desaturase DES1	0.0018	0.0152	0.0086
Brugia malayi	Doublecortin family protein	0.002	0.0222	0.0222
Brugia malayi	putative neuropeptide receptor	0.0017	0.0112	0.0112
Brugia malayi	hypothetical protein	0.0017	0.0112	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0112	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0112	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0112	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0112	0.0112
Echinococcus multilocularis	Peptidase M, neutral zinc metallopeptidases, zinc binding site	0.0018	0.0152	0.0086
Echinococcus granulosus	lipoxygenase domain containing protein	0.002	0.0222	0.0239
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0017	0.0112	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0112	0.0112
Entamoeba histolytica	hypothetical protein	0.0037	0.0937	0.5
Brugia malayi	Delta5 fatty acid desaturase	0.0018	0.0152	0.0152
Loa Loa (eye worm)	fatty acid desaturase	0.0018	0.0152	0.0152
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0017	0.0112	0.0112
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0017	0.0112	0.0112
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.0528	0.0528
Brugia malayi	Melatonin receptor type 1A	0.0017	0.0112	0.0112
Schistosoma mansoni	rab6-interacting	0.002	0.0222	0.0239
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.0528	0.0528
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0152	0.0152
Mycobacterium tuberculosis	Probable transmembrane alkane 1-monooxygenase AlkB (alkane 1-hydroxylase) (lauric acid omega-hydroxylase) (omega-hydroxylase) (f	0.0018	0.0152	0.5
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0112	0.0112
Onchocerca volvulus		0.002	0.0222	0.0127
Echinococcus granulosus	lamin	0.0027	0.0528	0.0901
Brugia malayi	Fatty acid desaturase family protein	0.0018	0.0152	0.0152
Echinococcus multilocularis	RUN	0.002	0.0222	0.0239
Schistosoma mansoni	intermediate filament proteins	0.0027	0.0528	0.0901
Echinococcus multilocularis	Polycystic kidney disease protein	0.002	0.0222	0.0239
Mycobacterium ulcerans	hypothetical protein	0.0018	0.0152	0.5
Toxoplasma gondii	sphingolipid delta 4 desaturase/c-4 hydroxylase protein des2 family protein	0.0018	0.0152	0.5
Mycobacterium ulcerans	transmembrane alkane 1-monooxygenase AlkB	0.0018	0.0152	0.5
Leishmania major	fatty-acid desaturase, putative	0.0223	0.8797	1
Schistosoma mansoni	lamin	0.0027	0.0528	0.0901
Plasmodium vivax	stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative	0.0205	0.8036	1
Echinococcus multilocularis	lamin dm0	0.0027	0.0528	0.0901
Entamoeba histolytica	hypothetical protein	0.0037	0.0937	0.5
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0112	0.0112
Brugia malayi	RE15519p	0.0017	0.0112	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0112	0.0112
Loa Loa (eye worm)	acyl-CoA desaturase	0.0205	0.8036	0.8036
Loa Loa (eye worm)	fatty acid desaturase	0.0018	0.0152	0.0152
Brugia malayi	hypothetical protein	0.0017	0.0112	0.0112
Brugia malayi	hypothetical protein	0.0017	0.0112	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0112	0.0112
Loa Loa (eye worm)	FAT-3 protein	0.0018	0.0152	0.0152
Brugia malayi	hypothetical protein	0.0017	0.0112	0.0112
Brugia malayi	hypothetical protein	0.0017	0.0112	0.0112
Entamoeba histolytica	hypothetical protein	0.0037	0.0937	0.5
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0112	0.0112
Echinococcus granulosus	lamin dm0	0.0027	0.0528	0.0901
Plasmodium falciparum	stearoyl-CoA desaturase	0.0205	0.8036	1
Leishmania major	stearic acid desaturase, putative	0.0223	0.8797	1
Schistosoma mansoni	hypothetical protein	0.0037	0.0937	0.1783
Schistosoma mansoni	tar DNA-binding protein	0.0127	0.4739	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0112	0.0112
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0017	0.0112	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0112	0.0112
Brugia malayi	G-protein coupled receptor	0.0017	0.0112	0.0112
Schistosoma mansoni	lipoxygenase	0.0055	0.172	0.3476
Onchocerca volvulus		0.0018	0.0152	0.0046
Mycobacterium tuberculosis	Probable conserved membrane protein	0.0018	0.0152	0.5
Echinococcus granulosus	Polycystic kidney disease protein	0.002	0.0222	0.0239
Schistosoma mansoni	loxhd1	0.002	0.0222	0.0239
Brugia malayi	hypothetical protein	0.0017	0.0112	0.0112
Brugia malayi	hypothetical protein	0.0017	0.0112	0.0112
Loa Loa (eye worm)	melatonin receptor type 1A	0.0017	0.0112	0.0112
Echinococcus multilocularis	tar DNA binding protein	0.0127	0.4739	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0112	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0112	0.0112
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.0528	0.0528
Brugia malayi	Serotonin receptor	0.0017	0.0112	0.0112
Brugia malayi	ORL1-like opioid receptor	0.0017	0.0112	0.0112
Loa Loa (eye worm)	neuropeptide F receptor	0.0017	0.0112	0.0112
Onchocerca volvulus		0.0223	0.8797	1
Echinococcus multilocularis	lipoxygenase domain containing protein	0.002	0.0222	0.0239
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0112	0.0112
Echinococcus granulosus	lipoxygenase domain containing protein	0.002	0.0222	0.0239
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0112	0.0112
Brugia malayi	AKH receptor	0.0017	0.0112	0.0112
Schistosoma mansoni	lipoxygenase	0.002	0.0222	0.0239
Echinococcus multilocularis	Fatty acid desaturase, type 1	0.0018	0.0152	0.0086
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0017	0.0112	0.0112
Trypanosoma cruzi	fatty acid desaturase, putative	0.0205	0.8036	0.9119
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0055	0.172	0.3476
Loa Loa (eye worm)	hypothetical protein	0.002	0.0222	0.0222
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0017	0.0112	0.0112
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0017	0.0112	0.0112
Loa Loa (eye worm)	TAR-binding protein	0.0127	0.4739	0.4739
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0112	0.0112
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0127	0.4739	0.4739
Onchocerca volvulus		0.0027	0.0528	0.048
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0528	0.0528
Brugia malayi	sulfakinin receptor protein	0.0017	0.0112	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0112	0.0112
Loa Loa (eye worm)	doublecortin family protein	0.002	0.0222	0.0222
Trypanosoma brucei	fatty acid desaturase, putative	0.0223	0.8797	1
Mycobacterium ulcerans	hypothetical protein	0.0018	0.0152	0.5
Brugia malayi	putative neuropeptide receptor NPR1	0.0017	0.0112	0.0112
Schistosoma mansoni	tar DNA-binding protein	0.0127	0.4739	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0112	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0112	0.0112
Mycobacterium ulcerans	linoleoyl-CoA desaturase, DesA3_2	0.0018	0.0152	0.5
Brugia malayi	GnHR receptor homolog	0.0017	0.0112	0.0112
Brugia malayi	Fatty acid desaturase family protein	0.0018	0.0152	0.0152
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.0937	0.1783
Loa Loa (eye worm)	G-protein coupled receptor	0.0017	0.0112	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0112	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0112	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0112	0.0112
Brugia malayi	G protein-coupled receptor	0.0017	0.0112	0.0112
Echinococcus granulosus	tar DNA binding protein	0.0127	0.4739	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0112	0.0112
Echinococcus granulosus	intermediate filament protein	0.0027	0.0528	0.0901
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0017	0.0112	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0112	0.0112
Entamoeba histolytica	hypothetical protein	0.0037	0.0937	0.5
Loa Loa (eye worm)	TYRA-2 protein	0.0017	0.0112	0.0112
Brugia malayi	Dopamine receptor protein 1	0.0017	0.0112	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0112	0.0112
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0017	0.0112	0.0112
Brugia malayi	G-protein coupled receptor	0.0017	0.0112	0.0112
Loa Loa (eye worm)	G-protein coupled receptor	0.0017	0.0112	0.0112
Brugia malayi	Serotonin receptor	0.0017	0.0112	0.0112
Loa Loa (eye worm)	neuropeptide F receptor	0.0017	0.0112	0.0112
Echinococcus multilocularis	lamin	0.0027	0.0528	0.0901
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.0937	0.1783
Schistosoma mansoni	tar DNA-binding protein	0.0127	0.4739	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0112	0.0112
Brugia malayi	neuropeptide F receptor	0.0017	0.0112	0.0112
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0251	1	1
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0055	0.172	0.3476
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0112	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0112	0.0112
Echinococcus granulosus	Fatty acid desaturase type 1	0.0018	0.0152	0.0086
Mycobacterium ulcerans	linoleoyl-CoA desaturase, DesA3	0.0018	0.0152	0.5
Brugia malayi	hypothetical protein	0.002	0.0222	0.0222
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0112	0.0112
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.0937	0.1783
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0112	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0112	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0112	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0112	0.0112
Brugia malayi	Dopamine receptor protein 2	0.0017	0.0112	0.0112
Loa Loa (eye worm)	hypothetical protein	0.002	0.0222	0.0222
Onchocerca volvulus		0.002	0.0222	0.0127
Echinococcus granulosus	RUN	0.002	0.0222	0.0239
Brugia malayi	hypothetical protein	0.0017	0.0112	0.0112
Brugia malayi	hypothetical protein	0.0017	0.0112	0.0112
Brugia malayi	larval opioid receptor	0.0017	0.0112	0.0112

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 3 uM	Inhibition of SCD1 in rat liver microsomes assessed as formation of oleoyl-CoA from 9,10-3H-steroyl-CoA	ChEMBL.	19632834
IC50 (binding)	= 13 uM	Inhibition of SCD1 in human HepG2 cells by whole cell assay	ChEMBL.	19632834

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL566052

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1061046