TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 280.321 | Formula: C17H16N2O2
H donors: 3 H acceptors: 2 LogP: 2.93 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Oc1ccc(cc1)C(=O)NCCc1c[nH]c2c1cccc2
InChi: 1S/C17H16N2O2/c20-14-7-5-12(6-8-14)17(21)18-10-9-13-11-19-16-4-2-1-3-15(13)16/h1-8,11,19-20H,9-10H2,(H,18,21)
InChiKey: MLKONJPJJSFXFY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0166	0.1393
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0056	0.0956	0.1028
Trichomonas vaginalis	alpha-glucosidase, putative	0.0015	0.0091	0.0568
Loa Loa (eye worm)	PHD-finger family protein	0.0023	0.0256	0.0248
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0105	0.1983	0.2144
Brugia malayi	Cathepsin L-like precursor	0.0012	0.0039	0.0039
Loa Loa (eye worm)	runx1	0.0061	0.1062	0.1054
Schistosoma mansoni	DNA helicase recq1	0.0011	0.0009	0.001
Leishmania major	cathepsin L-like protease	0.007	0.1252	0.9583
Loa Loa (eye worm)	beta-lactamase	0.0039	0.0605	0.0597
Schistosoma mansoni	hypothetical protein	0.0033	0.0472	0.0512
Schistosoma mansoni	cpg binding protein	0.0036	0.0525	0.0569
Brugia malayi	PHD-finger family protein	0.0032	0.0453	0.0453
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0933	0.0925
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.007	0.1252	0.9607
Toxoplasma gondii	PHD-finger domain-containing protein	0.0032	0.0453	0.4154
Loa Loa (eye worm)	hypothetical protein	0.0489	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0012	0.0039	0.0042
Echinococcus granulosus	cathepsin l1	0.0012	0.0039	0.0033
Plasmodium vivax	vivapain-2	0.0018	0.0166	0.2234
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0018	0.0166	0.3551
Schistosoma mansoni	hypothetical protein	0.0072	0.1276	0.1384
Leishmania major	cathepsin L-like protease	0.0018	0.0166	0.0737
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0056	0.0956	0.7169
Trichomonas vaginalis	sucrase-isomaltase, putative	0.004	0.0614	0.6276
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0033	0.0472	0.0503
Schistosoma mansoni	alpha-glucosidase	0.0155	0.3016	0.3272
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0166	0.0166
Echinococcus granulosus	neutral alpha glucosidase AB	0.004	0.0614	0.0658
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0105	0.1968	0.1961
Echinococcus granulosus	lysine specific demethylase 5A	0.0043	0.0676	0.0725
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0453	0.0444
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0166	0.1393
Loa Loa (eye worm)	RecQ helicase	0.0026	0.0334	0.0326
Trypanosoma cruzi	ISWI complex protein	0.0017	0.0133	0.0465
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0039	0.0605	0.0597
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0018	0.0166	0.3551
Loa Loa (eye worm)	ctsf protein	0.0018	0.0166	0.0158
Brugia malayi	Bloom's syndrome protein homolog	0.0026	0.0334	0.0334
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0015	0.0091	0.0568
Brugia malayi	Bromodomain containing protein	0.0085	0.1548	0.1548
Trypanosoma cruzi	glycosyl hydrolase-like protein, putative	0.0015	0.0091	0.012
Brugia malayi	Bromodomain containing protein	0.0035	0.0507	0.0507
Entamoeba histolytica	cysteine protease, putative	0.0018	0.0166	0.101
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0605	0.0597
Schistosoma mansoni	hypothetical protein	0.0037	0.055	0.0597
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0166	0.1393
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0166	0.0166
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0033	0.0472	0.0503
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0166	0.1393
Brugia malayi	Glycosyl hydrolases family 31 protein	0.018	0.3539	0.3539
Trichomonas vaginalis	alpha-glucosidase, putative	0.0015	0.0091	0.0568
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0732	0.0794
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0166	0.1393
Trichomonas vaginalis	penicillin-binding protein, putative	0.0039	0.0605	0.6173
Echinococcus granulosus	beta LACTamase domain containing family member	0.0039	0.0605	0.0647
Trypanosoma cruzi	cysteine peptidase, putative	0.007	0.1252	0.9583
Echinococcus granulosus	lysosomal alpha glucosidase	0.018	0.3539	0.3834
Loa Loa (eye worm)	fibroinase	0.0018	0.0166	0.0158
Onchocerca volvulus		0.0018	0.0166	0.0128
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.002	0.0188	0.0195
Echinococcus multilocularis	bloom syndrome protein	0.0026	0.0334	0.0353
Giardia lamblia	Kinase, CMGC MAPK	0.0056	0.0956	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0732	0.0785
Brugia malayi	Cathepsin L-like precursor	0.0012	0.0039	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0039	0.003
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0027	0.0338	0.0358
Echinococcus multilocularis	Protein lozenge	0.0061	0.1062	0.1144
Trypanosoma cruzi	cruzipain precursor, putative	0.007	0.1252	0.9583
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.007	0.1252	0.9607
Toxoplasma gondii	ABC1 family protein	0.0039	0.0605	0.5548
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.007	0.1252	0.9607
Echinococcus multilocularis	neutral alpha glucosidase AB	0.004	0.0614	0.0658
Trichomonas vaginalis	CMGC family protein kinase	0.0056	0.0956	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0166	0.1393
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0018	0.0166	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0082	0.0073
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0056	0.0956	0.7169
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.004	0.0609	0.0652
Loa Loa (eye worm)	bromodomain containing protein	0.0019	0.0188	0.0179
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0605	0.6173
Echinococcus granulosus	jumonji domain containing protein	0.0045	0.0716	0.0768
Onchocerca volvulus	Alhambra homolog	0.0032	0.0453	0.0416
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0018	0.0166	0.1393
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.004	0.0614	0.6276
Loa Loa (eye worm)	hypothetical protein	0.0045	0.072	0.0712
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0032	0.0453	0.0491
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0073	0.1303	1
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0014	0.0076	0.0584
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0472	0.0464
Echinococcus granulosus	peregrin	0.0035	0.0507	0.0541
Brugia malayi	beta-lactamase family protein	0.0039	0.0605	0.0605
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0018	0.0166	0.0158
Loa Loa (eye worm)	cysteine protease	0.0018	0.0166	0.0158
Trypanosoma brucei	glycosyl hydrolase-like protein	0.0015	0.0091	0.0697
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0166	0.0158
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0019	0.0174	0.0188
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0014	0.0079	0.0076
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0056	0.0956	0.0948
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.007	0.1252	0.9607
Schistosoma mansoni	hypothetical protein	0.0032	0.0453	0.0491
Mycobacterium ulcerans	esterase/lipase LipP	0.0039	0.0605	0.5
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0091	0.0082
Leishmania major	cathepsin L-like protease	0.0018	0.0166	0.0737
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0166	0.1393
Echinococcus granulosus	zinc finger protein	0.0023	0.027	0.0283
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0043	0.0676	0.0734
Trichomonas vaginalis	DNA helicase recq, putative	0.0014	0.0076	0.0407
Schistosoma mansoni	jumonji domain containing protein	0.0084	0.153	0.166
Echinococcus multilocularis	GPCR, family 2	0.0033	0.0472	0.0503
Plasmodium vivax	vivapain-2	0.0018	0.0166	0.2234
Echinococcus granulosus	histone lysine methyltransferase setb	0.002	0.0188	0.0195
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0605	0.4309
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0056	0.0956	0.7169
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.007	0.1252	0.9607
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0039	0.003
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0043	0.0676	0.0734
Entamoeba histolytica	cysteine proteinase, putative	0.0018	0.0166	0.101
Mycobacterium leprae	Probable lipase LipE	0.0039	0.0605	0.5
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0018	0.0166	0.0171
Brugia malayi	jmjC domain containing protein	0.0105	0.1983	0.1983
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.007	0.1252	0.9607
Mycobacterium ulcerans	beta-lactamase	0.0039	0.0605	0.5
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.004	0.0614	0.6276
Echinococcus multilocularis	cysteine protease	0.0018	0.0166	0.0171
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0068	0.1195	0.1289
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0015	0.0091	0.0412
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0166	0.0166
Plasmodium falciparum	phd finger protein, putative	0.0032	0.0453	1
Echinococcus multilocularis	lysosomal alpha glucosidase	0.018	0.3539	0.3834
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0033	0.0472	0.0472
Onchocerca volvulus		0.0039	0.0605	0.0568
Trypanosoma cruzi	cysteine peptidase, putative	0.007	0.1252	0.9583
Echinococcus granulosus	dnaJ subfamily B	0.0451	0.9218	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0105	0.1968	0.1968
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0033	0.0472	0.0503
Brugia malayi	CXXC zinc finger family protein	0.0032	0.0443	0.0443
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0067	0.1186	0.1286
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.002	0.0188	0.0204
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.004	0.0614	0.5635
Mycobacterium ulcerans	hypothetical protein	0.0039	0.0605	0.5
Echinococcus granulosus	GPCR family 2	0.0033	0.0472	0.0503
Mycobacterium ulcerans	lipase LipD	0.0039	0.0605	0.5
Schistosoma mansoni	alpha glucosidase	0.004	0.0614	0.0666
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0166	0.1393
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0023	0.0267	0.581
Entamoeba histolytica	recQ family helicase, putative	0.0014	0.0076	0.0295
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0018	0.0165	0.0179
Brugia malayi	PHD-finger family protein	0.0014	0.0082	0.0082
Onchocerca volvulus	Uncharacterized family 31 glucosidase KIAA1161 homolog	0.0015	0.0091	0.0052
Echinococcus multilocularis	zinc finger protein	0.0023	0.027	0.0283
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0732	0.0724
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0166	0.0166
Trypanosoma cruzi	glycosyl hydrolase-like protein, putative	0.0015	0.0091	0.012
Trichomonas vaginalis	CMGC family protein kinase	0.0056	0.0956	1
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0056	0.0956	0.8768
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0018	0.0166	0.1393
Trichomonas vaginalis	alpha-glucosidase, putative	0.0015	0.0091	0.0568
Plasmodium falciparum	conserved Plasmodium membrane protein, unknown function	0.0012	0.004	0.0712
Trichomonas vaginalis	DNA helicase recq1, putative	0.0026	0.0334	0.322
Schistosoma mansoni	bromodomain containing protein	0.0072	0.1278	0.1386
Trypanosoma brucei	glucosidase, putative	0.004	0.0614	0.4714
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0166	0.1393
Schistosoma mansoni	hypothetical protein	0.0017	0.0133	0.0144
Echinococcus multilocularis	transcription factor Dp 1	0.0042	0.0662	0.0709
Echinococcus granulosus	bloom syndrome protein	0.0026	0.0334	0.0353
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.007	0.1252	0.9607
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.0614	0.4386
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0166	0.1393
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0018	0.0166	0.0158
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0018	0.0166	0.3551
Trichomonas vaginalis	DNA helicase recq, putative	0.0026	0.0334	0.322
Brugia malayi	hypothetical protein	0.0037	0.055	0.055
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1276	0.1268
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0039	0.0605	0.0605
Brugia malayi	Papain family cysteine protease containing protein	0.0018	0.0166	0.0166
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0802	0.0794
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0032	0.0453	0.0482
Mycobacterium leprae	conserved hypothetical protein	0.0039	0.0605	0.5
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.055	0.0588
Loa Loa (eye worm)	hypothetical protein	0.0133	0.2568	0.2562
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0732	0.0732
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0605	0.6173
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0011	0.0009	0.0081
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0039	0.0605	0.5
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0011	0.0009	0.0009
Schistosoma mansoni	blooms syndrome DNA helicase	0.0021	0.0217	0.0236
Trichomonas vaginalis	penicillin-binding protein, putative	0.0039	0.0605	0.6173
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.007	0.1252	0.9607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0166	0.1393
Onchocerca volvulus		0.0039	0.0605	0.0568
Trypanosoma cruzi	ISWI complex protein	0.0017	0.0133	0.0465
Giardia lamblia	PHD finger protein 15	0.0032	0.0453	0.4689
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0252	0.5049	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0105	0.1968	0.1968
Onchocerca volvulus		0.0018	0.0166	0.0128
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.007	0.1252	0.9607
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.055	0.0597
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.018	0.3539	0.3534
Trichomonas vaginalis	CMGC family protein kinase	0.0056	0.0956	1
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0068	0.1195	0.1289
Onchocerca volvulus		0.0032	0.0443	0.0406
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0605	0.0597
Echinococcus granulosus	mitogen activated protein kinase	0.0056	0.0956	0.1028
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0019	0.0174	0.0179
Leishmania major	hypothetical protein, conserved	0.0017	0.0133	0.0465
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.0614	0.4386
Leishmania major	cathepsin L-like protease	0.007	0.1252	0.9583
Echinococcus multilocularis	cysteine protease	0.0018	0.0166	0.0171
Trichomonas vaginalis	alpha-glucosidase, putative	0.0015	0.0091	0.0568
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0032	0.0443	0.0434
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.007	0.1252	0.9607
Plasmodium vivax	hypothetical protein, conserved	0.0032	0.0453	0.7306
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0014	0.0079	0.0076
Trichomonas vaginalis	alpha-glucosidase, putative	0.0015	0.0091	0.0568
Loa Loa (eye worm)	hypothetical protein	0.0078	0.1412	0.1404
Onchocerca volvulus		0.0018	0.0166	0.0128
Leishmania major	glycosyl hydrolase-like protein	0.0015	0.0091	0.012
Plasmodium vivax	hypothetical protein, conserved	0.0039	0.0605	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0018	0.0166	0.0171
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0166	0.1393
Leishmania major	cathepsin L-like protease	0.007	0.1252	0.9583
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0166	0.1393
Brugia malayi	cathepsin L-like precursor	0.0012	0.0039	0.0039
Leishmania major	cysteine peptidase A (CPA)	0.0018	0.0166	0.0737
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0073	0.1303	0.1303
Trichomonas vaginalis	alpha-glucosidase, putative	0.004	0.0614	0.6276
Echinococcus multilocularis	dnaJ subfamily B	0.0451	0.9218	1
Echinococcus granulosus	PHD finger protein rhinoceros	0.0032	0.0453	0.0482
Trypanosoma cruzi	major cysteine proteinase, putative	0.0055	0.0937	0.7016
Leishmania major	cathepsin L-like protease	0.0018	0.0166	0.0737
Schistosoma mansoni	zinc finger protein	0.0023	0.027	0.0292
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0018	0.0166	0.0171
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0732	0.0794
Schistosoma mansoni	lozenge	0.0061	0.1062	0.1152
Trypanosoma cruzi	cysteine peptidase, putative	0.007	0.1252	0.9583
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0011	0.0009	0.0009
Echinococcus multilocularis	mitogen activated protein kinase	0.0056	0.0956	0.1028
Onchocerca volvulus	Cathepsin L homolog	0.0018	0.0166	0.0128
Onchocerca volvulus		0.0018	0.0166	0.0128
Schistosoma mansoni	hypothetical protein	0.0033	0.0472	0.0512
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0605	0.6173
Echinococcus multilocularis	jumonji domain containing protein	0.0045	0.0716	0.0768
Brugia malayi	MAP kinase sur-1	0.0056	0.0956	0.0956
Trypanosoma brucei	ISWI complex protein	0.0017	0.0133	0.1022
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.0018	0.0155	0.2024
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0732	0.0785
Loa Loa (eye worm)	PHD-finger family protein	0.0032	0.0453	0.0444
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0073	0.1303	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0605	0.0597
Brugia malayi	latrophilin 2 splice variant baaae	0.0072	0.1276	0.1276
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0019	0.0174	0.0188
Schistosoma mansoni	DNA helicase recq5	0.0011	0.0009	0.001
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0064	0.1124	0.8542
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0166	0.1393
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.0605	0.0656
Echinococcus multilocularis	lysine specific demethylase 5A	0.0039	0.0594	0.0636
Trypanosoma cruzi	cysteine peptidase, putative	0.0018	0.0166	0.0737
Onchocerca volvulus		0.0018	0.0166	0.0128
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0605	0.0597
Trichomonas vaginalis	CMGC family protein kinase	0.0056	0.0956	1
Entamoeba histolytica	hypothetical protein	0.0037	0.055	0.4043
Echinococcus multilocularis	cathepsin L cysteine protease	0.0018	0.0166	0.0171
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0039	0.0605	0.0647
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0605	0.0597
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0166	0.1393
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0665	0.0657
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0732	0.0794
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0732	0.0785
Leishmania major	cathepsin L-like protease	0.0018	0.0166	0.0737
Schistosoma mansoni	hypothetical protein	0.0033	0.0472	0.0512
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0605	0.0597
Schistosoma mansoni	hypothetical protein	0.0451	0.9218	1
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0056	0.0956	0.7169
Echinococcus granulosus	fetal alzheimer antigen falz	0.0027	0.0338	0.0358
Schistosoma mansoni	hypothetical protein	0.0033	0.0472	0.0512
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.007	0.1252	0.9607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0166	0.1393
Schistosoma mansoni	alpha-glucosidase	0.0155	0.3016	0.3272
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0166	0.1393
Echinococcus multilocularis	peregrin	0.0035	0.0507	0.0541
Brugia malayi	Latrophilin receptor protein 2	0.0033	0.0472	0.0472
Schistosoma mansoni	serine/threonine protein kinase	0.0056	0.0956	0.1037
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0605	0.4309
Echinococcus multilocularis	lysosomal alpha glucosidase	0.018	0.3539	0.3834
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0073	0.1303	1
Onchocerca volvulus		0.0104	0.1954	0.1923
Leishmania major	hypothetical protein, conserved	0.0039	0.0605	0.4309
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0027	0.0338	0.0367
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0039	0.003
Onchocerca volvulus		0.0039	0.0605	0.0568
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0056	0.0956	0.7334
Entamoeba histolytica	hypothetical protein	0.0037	0.055	0.4043
Loa Loa (eye worm)	hypothetical protein	0.0489	1	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.004	0.0614	0.6276
Brugia malayi	beta-lactamase family protein	0.0039	0.0605	0.0605
Leishmania major	cathepsin L-like protease	0.0018	0.0166	0.0737
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0732	0.0785
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.055	0.0588
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.0605	0.0656
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0166	0.1393
Entamoeba histolytica	hypothetical protein	0.0037	0.055	0.4043
Echinococcus granulosus	cpg binding protein	0.0036	0.0525	0.056
Schistosoma mansoni	cathepsin F (C01 family)	0.0018	0.0166	0.0181
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0073	0.1303	0.1296
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0015	0.0091	0.0568
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.004	0.0609	0.0652
Trichomonas vaginalis	alpha-glucosidase, putative	0.004	0.0614	0.6276
Brugia malayi	Glycosyl hydrolases family 31 protein	0.004	0.0614	0.0614
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0166	0.0166
Trypanosoma brucei	protein kinase, putative	0.0056	0.0956	0.7334
Loa Loa (eye worm)	jmjC domain-containing protein	0.0066	0.1169	0.1161
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0056	0.0956	0.7169
Onchocerca volvulus		0.0018	0.0166	0.0128
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0056	0.0956	0.7169
Schistosoma mansoni	zinc finger protein	0.0017	0.0133	0.0144
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0015	0.0091	0.0568
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0166	0.1393
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0073	0.1303	1
Trichomonas vaginalis	maltase-glucoamylase, putative	0.004	0.0614	0.6276
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0073	0.1303	0.1414
Schistosoma mansoni	hypothetical protein	0.0023	0.0256	0.0278
Toxoplasma gondii	PHD-finger domain-containing protein	0.0032	0.0453	0.4154
Brugia malayi	Bromodomain containing protein	0.0042	0.0664	0.0664
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0012	0.0039	0.0039
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0063	0.109	1
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0166	0.0166
Echinococcus granulosus	mitogen activated protein kinase 3	0.0056	0.0956	0.1028
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.004	0.0614	0.4552
Schistosoma mansoni	cathepsin F (C01 family)	0.0018	0.0166	0.0181
Brugia malayi	beta-lactamase	0.0039	0.0605	0.0605
Echinococcus granulosus	transcription factor Dp 1	0.0042	0.0662	0.0709
Onchocerca volvulus	Cathepsin L homolog	0.0018	0.0166	0.0128
Trypanosoma brucei	hypothetical protein, conserved	0.0039	0.0605	0.4641
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0073	0.1303	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.004	0.0614	0.6276
Entamoeba histolytica	hypothetical protein	0.0037	0.055	0.4043
Schistosoma mansoni	cpg binding protein	0.0036	0.0525	0.0569
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0073	0.1303	0.1406
Onchocerca volvulus	Cathepsin F homolog	0.0018	0.0166	0.0128
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0166	0.1393
Onchocerca volvulus		0.0018	0.0166	0.0128
Brugia malayi	PHD-finger family protein	0.0029	0.0393	0.0393
Loa Loa (eye worm)	hypothetical protein	0.0105	0.1968	0.1961
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0166	0.1393
Loa Loa (eye worm)	hypothetical protein	0.002	0.0188	0.0179
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0033	0.0472	0.0503
Onchocerca volvulus		0.0489	1	1
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.004	0.0614	0.0606
Echinococcus multilocularis	cathepsin L cysteine protease	0.0018	0.0166	0.0171
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.002	0.0188	0.0204
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0166	0.1393
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0011	0.0009	0.0081
Trichomonas vaginalis	esterase, putative	0.0039	0.0605	0.6173
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0019	0.0174	0.0179
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0018	0.015	0.1378
Echinococcus multilocularis	cpg binding protein	0.0036	0.0525	0.056
Loa Loa (eye worm)	jmjC domain-containing protein	0.0043	0.0676	0.0668
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0166	0.1393
Trichomonas vaginalis	alpha-glucosidase, putative	0.004	0.0614	0.6276
Echinococcus granulosus	cathepsin l1	0.0018	0.0166	0.0171
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0015	0.0091	0.0091
Entamoeba histolytica	cysteine proteinase, putative	0.0018	0.0166	0.101
Schistosoma mansoni	cpg binding protein	0.0032	0.0443	0.048
Brugia malayi	F/Y-rich N-terminus family protein	0.0022	0.0246	0.0246
Toxoplasma gondii	cathepsin CPL	0.0018	0.0166	0.1527
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0033	0.0472	0.0464
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0105	0.1983	0.2144
Brugia malayi	jmjC domain containing protein	0.0043	0.0676	0.0676
Leishmania major	alpha glucosidase II subunit, putative	0.004	0.0614	0.4386
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.004	0.0614	0.4552
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0073	0.1303	0.1406

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (binding)	= 0 %	Inhibition of catecholase activity of tyrosinase in human HMVII cells assessed as dopachrome formation at 100 uM	ChEMBL.	19524439
Activity (binding)	= 0 %	Inhibition of catecholase activity of tyrosinase in mouse B16 cells assessed as dopachrome formation at 100 uM	ChEMBL.	19524439
Activity (ADMET)	= 94 %	Cytotoxicity against mouse B16 cells assessed as cell viability at 20 uM after 2 days by tetrazolium reduction assay	ChEMBL.	19524439
IC50 (functional)	> 30 uM	Antimelanogenic activity in mouse B16 cells assessed as inhibition of intracellular melanin accumulation after 2 days	ChEMBL.	19524439

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL563082

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1061844