Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Ubiquitin carboxyl-terminal hydrolase family protein | 0.0042 | 0.1381 | 0.1594 |
Echinococcus granulosus | tar DNA binding protein | 0.014 | 0.7461 | 0.7461 |
Onchocerca volvulus | 0.0059 | 0.246 | 0.5 | |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0134 | 0.71 | 0.71 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.2005 | 0.2005 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.114 | 0.114 |
Loa Loa (eye worm) | TAR-binding protein | 0.014 | 0.7461 | 0.8608 |
Schistosoma mansoni | ubiquitin-specific peptidase 8 (C19 family) | 0.0042 | 0.1381 | 0.1381 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0059 | 0.246 | 0.2838 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.2061 | 0.2378 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 0.2005 | 0.2005 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0052 | 0.2005 | 0.2313 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0134 | 0.71 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 0.114 | 0.114 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0134 | 0.71 | 1 |
Echinococcus granulosus | Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 | 0.0042 | 0.1381 | 0.1381 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0029 | 0.0541 | 0.0541 |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 8 | 0.0042 | 0.1381 | 0.1381 |
Schistosoma mansoni | lamin | 0.0059 | 0.246 | 0.246 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0134 | 0.71 | 0.71 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.2392 | 0.2759 |
Echinococcus granulosus | lamin dm0 | 0.0059 | 0.246 | 0.246 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.1014 | 0.117 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.2061 | 0.2378 |
Leishmania major | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative | 0.0042 | 0.1381 | 0.1946 |
Echinococcus granulosus | lamin | 0.0059 | 0.246 | 0.246 |
Schistosoma mansoni | tar DNA-binding protein | 0.014 | 0.7461 | 0.7461 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0134 | 0.71 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 0.2005 | 0.2005 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.246 | 0.2838 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 0.2005 | 0.2005 |
Schistosoma mansoni | intermediate filament proteins | 0.0059 | 0.246 | 0.246 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.2061 | 0.2378 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0029 | 0.0541 | 0.0541 |
Schistosoma mansoni | hypothetical protein | 0.018 | 1 | 1 |
Schistosoma mansoni | ubiquitin-specific peptidase 2 (C19 family) | 0.0042 | 0.1381 | 0.1381 |
Echinococcus granulosus | muscleblind protein | 0.0159 | 0.8668 | 0.8668 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 0.114 | 0.114 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0059 | 0.246 | 0.2838 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.2061 | 0.2378 |
Schistosoma mansoni | hypothetical protein | 0.018 | 1 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0134 | 0.71 | 0.71 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.114 | 0.8251 |
Schistosoma mansoni | tar DNA-binding protein | 0.014 | 0.7461 | 0.7461 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0473 | 0.0546 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0059 | 0.246 | 0.2838 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.2005 | 0.2005 |
Echinococcus multilocularis | musashi | 0.0059 | 0.246 | 0.246 |
Echinococcus multilocularis | lamin dm0 | 0.0059 | 0.246 | 0.246 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.114 | 0.8251 |
Brugia malayi | RNA recognition motif domain containing protein | 0.014 | 0.7461 | 0.8608 |
Trypanosoma brucei | ubiquitin carboxyl-terminal hydrolase, putative | 0.0042 | 0.1381 | 1 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0042 | 0.1381 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0134 | 0.71 | 1 |
Brugia malayi | TAR-binding protein | 0.014 | 0.7461 | 0.8608 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0042 | 0.1381 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.014 | 0.7461 | 0.7461 |
Echinococcus multilocularis | geminin | 0.018 | 1 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 0.114 | 0.114 |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.0042 | 0.1381 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0059 | 0.246 | 0.246 |
Brugia malayi | RNA binding protein | 0.014 | 0.7461 | 0.8608 |
Onchocerca volvulus | 0.0059 | 0.246 | 0.5 | |
Schistosoma mansoni | lamin | 0.0059 | 0.246 | 0.246 |
Echinococcus multilocularis | tar DNA binding protein | 0.014 | 0.7461 | 0.7461 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.014 | 0.7461 | 0.8608 |
Echinococcus multilocularis | ubiquitin specific protease 41 | 0.0042 | 0.1381 | 0.1381 |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.0042 | 0.1381 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.014 | 0.7461 | 0.7461 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0042 | 0.1381 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0 | 0.5 |
Echinococcus granulosus | ubiquitin specific protease 41 | 0.0042 | 0.1381 | 0.1381 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0473 | 0.0546 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0032 | 0.0738 | 0.0851 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.1014 | 0.1014 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.114 | 0.8251 |
Echinococcus multilocularis | Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 | 0.0042 | 0.1381 | 0.1381 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0134 | 0.71 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0134 | 0.71 | 0.71 |
Echinococcus multilocularis | muscleblind protein | 0.0159 | 0.8668 | 0.8668 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.8668 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0159 | 0.8668 | 0.8668 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.8668 | 1 |
Brugia malayi | Muscleblind-like protein | 0.0159 | 0.8668 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 0.2005 | 0.2005 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0042 | 0.1381 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0032 | 0.0738 | 0.0851 |
Loa Loa (eye worm) | intermediate filament protein | 0.0059 | 0.246 | 0.2838 |
Loa Loa (eye worm) | RNA binding protein | 0.014 | 0.7461 | 0.8608 |
Brugia malayi | hypothetical protein | 0.0038 | 0.114 | 0.1315 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0541 | 0.0624 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0042 | 0.1381 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.1381 | 0.1594 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0052 | 0.2005 | 0.2313 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.2005 | 0.2005 |
Schistosoma mansoni | tar DNA-binding protein | 0.014 | 0.7461 | 0.7461 |
Echinococcus multilocularis | lamin | 0.0059 | 0.246 | 0.246 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0134 | 0.71 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1014 | 0.117 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.114 | 0.8251 |
Echinococcus granulosus | ubiquitin carboxyl terminal hydrolase 8 | 0.0042 | 0.1381 | 0.1381 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.