Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | potassium voltage-gated channel, subfamily H (eag-related), member 2 | Starlite/ChEMBL | References |
Homo sapiens | melanin-concentrating hormone receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | geminin | 0.0164 | 0.7063 | 1 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0045 | 0.1726 | 0.2357 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0058 | 0.2284 | 0.3155 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1426 | 0.1553 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0045 | 0.1692 | 0.1859 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.1559 | 0.1491 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.035 | 0.0495 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0009 | 0.0081 | 0.0114 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0017 | 0.0453 | 0.0429 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.7063 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0015 | 0.035 | 0.5 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0016 | 0.0426 | 0.0603 |
Trypanosoma brucei | ISWI complex protein | 0.0015 | 0.035 | 0.5 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0201 | 0.8748 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.1876 | 0.2656 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0045 | 0.1726 | 0.2357 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0265 | 0.0213 |
Schistosoma mansoni | zinc finger protein | 0.0019 | 0.0536 | 0.0759 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0035 | 0.1248 | 0.1672 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0045 | 0.1726 | 0.2444 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1541 | 0.1685 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.1559 | 0.1491 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0058 | 0.2284 | 0.3155 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0029 | 0.0984 | 0.1293 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0022 | 0.0665 | 0.0837 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0045 | 0.1692 | 0.2307 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0029 | 0.0984 | 0.1392 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.7063 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1355 | 0.147 |
Echinococcus multilocularis | zinc finger protein | 0.0019 | 0.0536 | 0.0652 |
Trypanosoma cruzi | ISWI complex protein | 0.0015 | 0.035 | 0.5 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0016 | 0.0426 | 0.0603 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0013 | 0.0265 | 0.0264 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.1876 | 0.2656 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.1726 | 0.1899 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0045 | 0.1692 | 0.1859 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0022 | 0.0665 | 0.0837 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0009 | 0.0081 | 0.0114 |
Brugia malayi | Pre-SET motif family protein | 0.0201 | 0.8748 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.2764 | 0.3095 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0009 | 0.0081 | 0.0114 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0013 | 0.0265 | 0.0213 |
Plasmodium vivax | SET domain protein, putative | 0.0029 | 0.0984 | 0.5 |
Schistosoma mansoni | zinc finger protein | 0.0015 | 0.035 | 0.0495 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0009 | 0.0081 | 0.0114 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1458 | 0.1589 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0013 | 0.0265 | 0.0264 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.0665 | 0.0942 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0009 | 0.0081 | 0.0114 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0582 | 0.0824 |
Echinococcus granulosus | voltage gated potassium channel | 0.0013 | 0.0265 | 0.0264 |
Loa Loa (eye worm) | PHD-finger family protein | 0.002 | 0.0582 | 0.0578 |
Echinococcus multilocularis | geminin | 0.0164 | 0.7063 | 1 |
Schistosoma mansoni | bromodomain containing protein | 0.0061 | 0.2439 | 0.3454 |
Brugia malayi | Pre-SET motif family protein | 0.0029 | 0.0984 | 0.1042 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.0016 | 0.0426 | 0.0495 |
Brugia malayi | Bromodomain containing protein | 0.0072 | 0.295 | 0.331 |
Brugia malayi | Bromodomain containing protein | 0.0037 | 0.1351 | 0.1466 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0013 | 0.0265 | 0.0264 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0009 | 0.0081 | 0.0114 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0013 | 0.0265 | 0.0375 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0045 | 0.1726 | 0.2444 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0028 | 0.0936 | 0.1224 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0035 | 0.1248 | 0.1672 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0013 | 0.0265 | 0.0375 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0984 | 0.1392 |
Echinococcus granulosus | zinc finger protein | 0.0019 | 0.0536 | 0.0652 |
Brugia malayi | PHD-finger family protein | 0.0024 | 0.0768 | 0.0793 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0045 | 0.1692 | 0.2307 |
Echinococcus granulosus | methyl CpG binding domain protein 2 | 0.0016 | 0.0426 | 0.0495 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0029 | 0.0984 | 0.5 |
Trypanosoma cruzi | ISWI complex protein | 0.0015 | 0.035 | 0.5 |
Trichomonas vaginalis | set domain proteins, putative | 0.0229 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.