Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Corticotropin releasing factor receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Schistosoma japonicum | IPR001879,Hormone receptor, extracellular,domain-containing | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Corticotropin releasing factor receptor 1 | 415 aa | 359 aa | 21.4 % |
Onchocerca volvulus | Pseudouridine-5 prime-monophosphatase homolog | Corticotropin releasing factor receptor 1 | 415 aa | 401 aa | 27.2 % |
Onchocerca volvulus | Corticotropin releasing factor receptor 1 | 415 aa | 401 aa | 30.2 % | |
Loa Loa (eye worm) | pigment dispersing factor receptor c | Corticotropin releasing factor receptor 1 | 415 aa | 394 aa | 27.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0035 | 0.0741 | 0.0741 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0132 | 0.421 | 0.5481 |
Schistosoma mansoni | thyroid hormone receptor | 0.0132 | 0.421 | 1 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0123 | 0.386 | 0.4974 |
Loa Loa (eye worm) | hypothetical protein | 0.0295 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0026 | 0.0431 | 0.0431 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0741 | 0.082 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.022 | 0.7326 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0035 | 0.0741 | 0.0741 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0741 | 0.082 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0123 | 0.386 | 0.4974 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0741 | 0.082 |
Onchocerca volvulus | 0.0026 | 0.0431 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0431 | 0.0431 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.011 | 0.3415 | 0.3415 |
Onchocerca volvulus | 0.0026 | 0.0431 | 0.5 | |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.011 | 0.3415 | 0.3415 |
Brugia malayi | intermediate filament protein | 0.0026 | 0.0431 | 0.0431 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0035 | 0.0741 | 0.0741 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.0741 | 0.045 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0035 | 0.0741 | 0.0741 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0414 | 0.0414 |
Schistosoma mansoni | thyroid hormone receptor | 0.0132 | 0.421 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0741 | 0.082 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0075 | 0.2177 | 0.2177 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0741 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.2177 | 0.2177 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0026 | 0.0431 | 0.0431 |
Echinococcus granulosus | GPCR family 2 | 0.0035 | 0.0741 | 0.045 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0741 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.0741 | 0.045 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0741 | 0.5 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0035 | 0.0741 | 0.045 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.022 | 0.7326 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0741 | 0.082 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0741 | 0.0741 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0035 | 0.0741 | 0.045 |
Schistosoma mansoni | hypothetical protein | 0.0123 | 0.386 | 0.9074 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0026 | 0.0431 | 0.0431 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0741 | 0.082 |
Schistosoma mansoni | hypothetical protein | 0.0075 | 0.2177 | 0.4621 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0741 | 0.5 |
Echinococcus multilocularis | GPCR, family 2 | 0.0035 | 0.0741 | 0.045 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 150 nM | Displacement of [125I]Tyr-ovine-CRF from CRF1 receptor in rat frontal cortex homogenate by gamma counting | ChEMBL. | 19552437 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.