Detailed information for compound 1062719

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 388.466 | Formula: C22H24N6O
  • H donors: 2 H acceptors: 4 LogP: 3.26 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cn1nc(c2c1c1nc(ncc1CC2)Nc1ccccc1)C(=O)NC1CCCC1
  • InChi: 1S/C22H24N6O/c1-28-20-17(19(27-28)21(29)24-15-9-5-6-10-15)12-11-14-13-23-22(26-18(14)20)25-16-7-3-2-4-8-16/h2-4,7-8,13,15H,5-6,9-12H2,1H3,(H,24,29)(H,23,25,26)
  • InChiKey: JBZSHFMYVGCDBI-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polo-like kinase 1 Starlite/ChEMBL References
Homo sapiens cyclin A1 Starlite/ChEMBL References
Homo sapiens aurora kinase A Starlite/ChEMBL References
Homo sapiens cyclin A2 References
Homo sapiens cyclin-dependent kinase 3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Cryptosporidium hominis protein kinase (EC 2.7.1.-) p46XlEg22 Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum ko:K05868 cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi serine/threonine protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania infantum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium berghei serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania donovani cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Giardia lamblia Aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica serine/threonine- protein kinase 6 , putative Get druggable targets OG5_127024 All targets in OG5_127024
Toxoplasma gondii aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma cruzi cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Cryptosporidium parvum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium vivax serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans likely B-type cyclin similar to S. cerevisiae CLB4 (YLR210W) and CLB3 (YDL155W) involved in G1/S transition Get druggable targets OG5_126649 All targets in OG5_126649
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium knowlesi serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum Serine/threonine-protein kinase 12, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Onchocerca volvulus Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania braziliensis CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense Cyclin, N-terminal domain/Cyclin, C-terminal domain containing protein, putative Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin A, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania mexicana protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma cruzi aurora B kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi serine/threonine-protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica serine/threonine- protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania major cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma congolense aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium yoelii putative protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium falciparum serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi serine/threonine kinase 12 Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania donovani Aurora I-related kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei gambiense cyclin 6,mitotic cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia G2/mitotic-specific cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania mexicana cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania infantum CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania braziliensis cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Neospora caninum hypothetical protein Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum ko:K08850 aurora kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica protein kinase , putative Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania major protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Cryptosporidium parvum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Cryptosporidium hominis mitotic cyclin-CYC2 Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 3 305 aa 303 aa 32.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica recQ family helicase, putative 0.0021 0.0024 0.034
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0022 0.0028
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0024 0.0034
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0024 0.0116
Schistosoma mansoni myelin transcription factor 1 myt1 0.0125 0.023 0.1281
Loa Loa (eye worm) MH2 domain-containing protein 0.0129 0.0237 0.0234
Loa Loa (eye worm) mbt repeat family protein 0.011 0.02 0.0196
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0332 0.0639 1
Entamoeba histolytica cyclin, putative 0.0038 0.0056 0.084
Loa Loa (eye worm) AUR protein kinase 0.0069 0.0119 0.0115
Plasmodium falciparum protein kinase 5 0.0053 0.0087 0.6712
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.021 0.3172
Entamoeba histolytica protein kinase, putative 0.0069 0.0119 0.1822
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.0043 0.0038
Brugia malayi hypothetical protein 0.0024 0.003 0.0026
Trypanosoma cruzi cdc2-related kinase 1 0.0053 0.0087 0.0213
Echinococcus granulosus dnaJ subfamily B 0.0915 0.1794 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0332 0.0639 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0004 0.0025
Schistosoma mansoni lamin 0.0057 0.0095 0.0532
Brugia malayi mbt repeat family protein 0.011 0.02 0.0195
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.000000000017508
Brugia malayi serine/threonine protein kinase 6 0.0069 0.0119 0.0114
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0024 0.0006
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0437 0.0848 0.2538
Echinococcus multilocularis histone acetyltransferase MYST2 0.0125 0.023 0.068
Onchocerca volvulus 0.0057 0.0095 0.2994
Echinococcus granulosus aurora kinase A 0.0069 0.0119 0.0643
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0162 0.0303 1
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0024 0.002
Onchocerca volvulus 0.009 0.016 0.5118
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0136 0.0252 0.1403
Trichomonas vaginalis CAMK family protein kinase 0.0058 0.0096 0.1356
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.021 0.3172
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0024 0.0218
Brugia malayi Cyclin, N-terminal domain containing protein 0.0038 0.0056 0.0052
Echinococcus granulosus cyclin dependent kinase 1 0.0053 0.0087 0.0465
Echinococcus multilocularis musashi 0.0057 0.0095 0.0276
Toxoplasma gondii aldehyde dehydrogenase 0.0071 0.0123 0.5445
Trichomonas vaginalis CAMK family protein kinase 0.0058 0.0096 0.1356
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1691 0.3332 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0001
Entamoeba histolytica hypothetical protein 0.0114 0.0208 0.323
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0024 0.0034
Leishmania major DNA polymerase eta, putative 0.0021 0.0024 0.0006
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0053 0.0087 0.0083
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0162 0.0303 1
Treponema pallidum fructose-bisphosphate aldolase 0.0332 0.0639 1
Schistosoma mansoni kinase 0.0059 0.0099 0.0551
Echinococcus granulosus tissue type plasminogen activator 0.0029 0.004 0.0204
Entamoeba histolytica recQ family DNA helicase 0.0011 0.0003 0.0013
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0004 0.0006
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0024 0.0053
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.009 0.016 0.0354
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0024 0.0053
Trichomonas vaginalis cyclin B3, putative 0.0038 0.0056 0.0724
Echinococcus granulosus cyclin B3 1 0.0038 0.0056 0.0294
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0004 0.0003
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0004 0.0006
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0332 0.0639 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0115 0.021 0.0528
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.021 0.3172
Loa Loa (eye worm) hypothetical protein 0.5057 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0004 0.0001
Schistosoma mansoni DNA helicase recq1 0.0021 0.0024 0.0135
Entamoeba histolytica hypothetical protein 0.0114 0.0208 0.323
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0024 0.0053
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0022 0.0048
Schistosoma mansoni hypothetical protein 0.0114 0.0208 0.116
Trypanosoma cruzi cyclin, putative 0.009 0.016 0.04
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.0043 0.0039
Brugia malayi Latrophilin receptor protein 2 0.007 0.012 0.0115
Giardia lamblia Aurora kinase 0.0069 0.0119 0.1564
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.003 0.0847
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0024 0.0218
Giardia lamblia Cyclin A 0.0038 0.0056 0.0551
Trypanosoma brucei mitotic cyclin 6 0.009 0.016 0.0381
Entamoeba histolytica protein kinase domain containing protein 0.0069 0.0119 0.1822
Echinococcus multilocularis cyclins 0.0038 0.0056 0.0158
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0004 0.0001
Brugia malayi hypothetical protein 0.0114 0.0208 0.0204
Trichomonas vaginalis cyclin B, putative 0.009 0.016 0.2378
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0022 0.0182
Echinococcus multilocularis survival motor neuron protein 1 0.0808 0.1583 0.4745
Trichomonas vaginalis cyclin B, putative 0.009 0.016 0.2378
Onchocerca volvulus 0.0064 0.0109 0.344
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0021 0.0024 0.0021
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0024 0.0034
Echinococcus granulosus GPCR family 2 0.007 0.012 0.0649
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0004 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0024 0.0034
Entamoeba histolytica cyclin family protein 0.0038 0.0056 0.084
Echinococcus multilocularis dnaJ subfamily B 0.0915 0.1794 0.538
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0004 0.0003
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0004 0.0003
Onchocerca volvulus Serine\/threonine kinase homolog 0.0115 0.021 0.6761
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0011 0.00000000027851
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0024 0.0135
Schistosoma mansoni DNA helicase recq5 0.0021 0.0024 0.0135
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0013 0.0074
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0024 0.0081
Echinococcus multilocularis cyclin dependent kinase 1 0.0053 0.0087 0.025
Loa Loa (eye worm) hypothetical protein 0.0027 0.0035 0.0031
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0004 0.0006
Echinococcus granulosus geminin 0.019 0.0359 0.1985
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0004 0.0025
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0021 0.0024 0.0116
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0004 0.0001
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0004 0.0006
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0029 0.004 0.3224
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0024 0.0062
Trypanosoma brucei malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.1987 0.3918 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0004 0.0006
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0332 0.0639 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0024 0.0342
Echinococcus granulosus intermediate filament protein 0.0057 0.0095 0.0514
Schistosoma mansoni hypothetical protein 0.007 0.012 0.0667
Echinococcus multilocularis cyclins 0.0038 0.0056 0.0158
Giardia lamblia Kinase, CMGC CDK 0.0053 0.0087 0.105
Giardia lamblia Hypothetical protein 0.0038 0.0056 0.0551
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0024 0.0034
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0024 0.0081
Loa Loa (eye worm) hypothetical protein 0.0808 0.1583 0.158
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0115 0.021 0.062
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0332 0.0639 1
Loa Loa (eye worm) MBCTL1 0.0125 0.023 0.0226
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0087 0.0484
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0332 0.0639 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0003 0.0037
Entamoeba histolytica protein kinase , putative 0.0069 0.0119 0.1822
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0004 0.0001
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0114 0.0208 0.0615
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0024 0.0034
Echinococcus multilocularis cpg binding protein 0.0068 0.0116 0.0339
Trypanosoma cruzi aurora B kinase, putative 0.0069 0.0119 0.0294
Giardia lamblia Sgs1 DNA helicase, putative 0.0021 0.0024 0.0035
Brugia malayi Intermediate filament tail domain containing protein 0.0057 0.0095 0.0091
Loa Loa (eye worm) hypothetical protein 0.0057 0.0095 0.0092
Echinococcus multilocularis cyclin B 0.009 0.016 0.047
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0021 0.0053
Echinococcus granulosus survival motor neuron protein 1 0.0808 0.1583 0.8821
Echinococcus granulosus SAM and MBT domain containing protein 0.011 0.02 0.1095
Trichomonas vaginalis cyclins, putative 0.009 0.016 0.2378
Trichomonas vaginalis cyclin A, putative 0.009 0.016 0.2378
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0004 0.0025
Loa Loa (eye worm) latrophilin receptor protein 2 0.007 0.012 0.0116
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0013 0.0055
Echinococcus multilocularis tissue type plasminogen activator 0.0029 0.004 0.011
Trichomonas vaginalis cyclins, putative 0.009 0.016 0.2378
Schistosoma mansoni hypothetical protein 0.0011 0.0003 0.0019
Giardia lamblia Kinase, CMGC CDK 0.0053 0.0087 0.105
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0004 0.0003
Trichomonas vaginalis cyclins, putative 0.009 0.016 0.2378
Echinococcus multilocularis lamin dm0 0.0057 0.0095 0.0276
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0022 0.0019
Brugia malayi Kringle domain containing protein 0.0029 0.004 0.0035
Trypanosoma brucei aurora B kinase 0.0069 0.0119 0.0275
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.011 0.02 0.1112
Leishmania major hypothetical protein, conserved 0.0024 0.003 0.0021
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0024 0.002
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.0021
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0004 0.0003
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0437 0.0848 0.4718
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.003 0.0069
Trichomonas vaginalis cyclins, putative 0.0038 0.0056 0.0724
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0071 0.0123 0.0358
Echinococcus multilocularis cyclin dependent kinase 5 0.0053 0.0087 0.025
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0123 0.0683
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.0021
Brugia malayi intermediate filament protein 0.0057 0.0095 0.0091
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0024 0.0081
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0004 0.0025
Toxoplasma gondii histone lysine methyltransferase SET1 0.0122 0.0223 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0001
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0022 0.0056
Loa Loa (eye worm) intermediate filament protein 0.0057 0.0095 0.0092
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0004 0.0003
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0024 0.0053
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.0037 0.0185
Onchocerca volvulus 0.0057 0.0095 0.2994
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0004 0.0006
Echinococcus multilocularis microtubule associated protein 2 0.0768 0.1503 0.4505
Schistosoma mansoni intermediate filament proteins 0.0057 0.0095 0.0532
Giardia lamblia G2/mitotic-specific cyclin B 0.009 0.016 0.2236
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0004 0.0025
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0011 0.0003 0.0071
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0332 0.0639 1
Schistosoma mansoni sex comb on midleg homolog 0.011 0.02 0.1112
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0022 0.0306
Trypanosoma brucei polo-like protein kinase 0.0115 0.021 0.0509
Loa Loa (eye worm) histone methyltransferase 0.002 0.0021 0.0018
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0024 0.0063
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0332 0.0639 1
Plasmodium falciparum cysteine repeat modular protein 1 0.0029 0.004 0.1858
Entamoeba histolytica cyclin family protein 0.0038 0.0056 0.084
Trichomonas vaginalis AGC family protein kinase 0.0069 0.0119 0.1718
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.021 0.3172
Echinococcus granulosus cyclin dependent kinase 0.0053 0.0087 0.0465
Echinococcus granulosus dna polymerase eta 0.0021 0.0024 0.0116
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0024 0.0034
Brugia malayi cell division control protein 2 homolog 0.0053 0.0087 0.0082
Brugia malayi serine/threonine kinase 12 0.0069 0.0119 0.0114
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0024 0.0982
Schistosoma mansoni hypothetical protein 0.019 0.0359 0.2001
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0024 0.0135
Trypanosoma cruzi cdc2-related kinase 3 0.0053 0.0087 0.0213
Schistosoma mansoni coup transcription factor 0.0011 0.0004 0.0025
Loa Loa (eye worm) AUR protein kinase 0.0069 0.0119 0.0115
Schistosoma mansoni protein kinase 0.0069 0.0119 0.0661
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0125 0.023 0.068
Loa Loa (eye worm) CXXC zinc finger family protein 0.0064 0.0109 0.0106
Trypanosoma brucei unspecified product 0.0021 0.0024 0.0034
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0013 0.0055
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0024 0.0034
Plasmodium vivax protein kinase Crk2 0.0053 0.0087 0.7264
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0024 0.0982
Brugia malayi Protein kinase domain containing protein 0.0053 0.0087 0.0082
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0053 0.0087 0.0083
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0332 0.0639 1
Schistosoma mansoni serine/threonine protein kinase 0.0115 0.021 0.117
Echinococcus multilocularis cyclin b3 0.0038 0.0056 0.0158
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0024 0.002
Schistosoma mansoni lamin 0.0057 0.0095 0.0532
Schistosoma mansoni hypothetical protein 0.019 0.0359 0.2001
Entamoeba histolytica serine/threonine protein kinase, putative 0.0115 0.021 0.3258
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0021 0.0016
Leishmania major DNA polymerase kappa, putative 0.0021 0.0024 0.0006
Brugia malayi serine/threonine-protein kinase 6 0.0069 0.0119 0.0114
Trichomonas vaginalis cyclin B, putative 0.009 0.016 0.2378
Schistosoma mansoni cyclin B3 0.0038 0.0056 0.0312
Giardia lamblia Fructose-bisphosphate aldolase 0.0332 0.0639 1
Echinococcus multilocularis dna polymerase eta 0.0021 0.0024 0.0063
Trypanosoma cruzi CYC2-like cyclin, putative 0.009 0.016 0.04
Trichomonas vaginalis cyclins, putative 0.009 0.016 0.2378
Echinococcus granulosus microtubule associated protein 2 0.0768 0.1503 0.8375
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0125 0.023 0.0225
Trypanosoma cruzi malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.1987 0.3918 1
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0087 0.1213
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0024 0.0034
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0038 0.0056 0.0294
Trypanosoma brucei cdc2-related kinase 3 0.0053 0.0087 0.0194
Schistosoma mansoni hypothetical protein 0.0915 0.1794 1
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.021 0.3172
Echinococcus granulosus cyclins 0.0038 0.0056 0.0294
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0114 0.0208 0.1143
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0071 0.0123 0.0665
Brugia malayi hypothetical protein 0.0808 0.1583 0.1579
Echinococcus granulosus cyclins 0.0038 0.0056 0.0294
Echinococcus granulosus cyclins 0.0038 0.0056 0.0294
Schistosoma mansoni cyclin B 0.009 0.016 0.0892
Schistosoma mansoni cpg binding protein 0.0068 0.0116 0.0648
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0071 0.0123 0.3579
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.007 0.012 0.0649
Trichomonas vaginalis cyclin B, putative 0.009 0.016 0.2378
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.003 0.2383
Echinococcus granulosus bloom syndrome protein 0.0021 0.0024 0.0116
Entamoeba histolytica protein kinase, putative 0.0069 0.0119 0.1822
Echinococcus granulosus cyclin B 0.009 0.016 0.0874
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.004 0.0093
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0087 0.0484
Entamoeba histolytica cell division protein kinase 2, putative 0.0053 0.0087 0.1324
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0069 0.0119 0.0346
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0004 0.0001
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0022 0.0048
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.003 0.0049
Echinococcus multilocularis cyclin dependent kinase 0.0053 0.0087 0.025
Plasmodium falciparum cyclin 0.0038 0.0056 0.3525
Brugia malayi Calcitonin receptor-like protein seb-1 0.022 0.0418 0.0413
Onchocerca volvulus 0.0029 0.004 0.1168
Echinococcus multilocularis aurora kinase A 0.0069 0.0119 0.0346
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0004 0.0025
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0001
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0004 0.0025
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0004 0.0003
Echinococcus granulosus cyclins 0.0038 0.0056 0.0294
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0011 0.00000000027851
Giardia lamblia Kinase, PLK 0.0115 0.021 0.3046
Wolbachia endosymbiont of Brugia malayi malonyl-CoA decarboxylase 0.5057 1 1
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.003 0.1255
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.021 0.3172
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0053 0.0087 0.0166
Onchocerca volvulus 0.011 0.02 0.6421
Schistosoma mansoni hypothetical protein 0.007 0.012 0.0667
Loa Loa (eye worm) RecQ helicase 0.0021 0.0024 0.0021
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0022 0.0182
Echinococcus granulosus cyclins 0.0038 0.0056 0.0294
Brugia malayi latrophilin 2 splice variant baaae 0.015 0.028 0.0275
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0087 0.1213
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0013 0.003
Giardia lamblia DINP protein human, muc B family 0.0021 0.0024 0.0037
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0004 0.0025
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0004 0.0025
Trypanosoma cruzi polo-like protein kinase, putative 0.0115 0.021 0.0528
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0024 0.0034
Loa Loa (eye worm) cyclin domain-containing protein 0.0038 0.0056 0.0053
Schistosoma mansoni blooms syndrome DNA helicase 0.0011 0.0003 0.0019
Loa Loa (eye worm) hypothetical protein 0.0027 0.0035 0.0031
Leishmania major protein kinase, putative 0.0069 0.0119 0.0248
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0071 0.0123 0.0258
Echinococcus multilocularis geminin 0.019 0.0359 0.1068
Schistosoma mansoni survival motor neuron protein 0.0165 0.0308 0.1719
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0004 0.0001
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0022 0.1678
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0115 0.021 0.1153
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0053 0.0087 0.0166
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0024 0.0217
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0069 0.0119 0.1822
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0024 0.002
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.011 0.02 0.6421
Echinococcus multilocularis GPCR, family 2 0.007 0.012 0.0349
Loa Loa (eye worm) hypothetical protein 0.0028 0.0037 0.0033
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0069 0.0119 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0021 0.0098
Brugia malayi CXXC zinc finger family protein 0.0064 0.0109 0.0105
Trypanosoma cruzi cdc2-related kinase 3 0.0053 0.0087 0.0213
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0001
Brugia malayi serine/threonine-protein kinase plk-2 0.0115 0.021 0.0206
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.007 0.012 0.0115
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0004 0.0025
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0011 0.00000000027851
Leishmania major malonyl-coa decarboxylase-like protein 0.1987 0.3918 1
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0021 0.0024 0.0225
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0069 0.0119 0.1822
Echinococcus granulosus cyclin dependent kinase 5 0.0053 0.0087 0.0465
Brugia malayi MH2 domain containing protein 0.0129 0.0237 0.0233
Loa Loa (eye worm) hypothetical protein 0.009 0.016 0.0157
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0021 0.0024 0.0116
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0024 0.0217
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0004 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0056 0.0724
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0024 0.0006
Trypanosoma cruzi malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.1987 0.3918 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0004 0.0001
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0024 0.0053
Schistosoma mansoni serine/threonine protein kinase 0.0069 0.0119 0.0661
Echinococcus multilocularis cyclin B3 1 0.0038 0.0056 0.0158
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0001
Loa Loa (eye worm) pigment dispersing factor receptor c 0.022 0.0418 0.0414
Trichomonas vaginalis cyclin D, putative 0.0038 0.0056 0.0724
Schistosoma mansoni hypothetical protein 0.0165 0.0308 0.1719
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0038 0.0056 0.0158
Echinococcus multilocularis SAM and MBT domain containing protein 0.011 0.02 0.0589
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.007 0.012 0.0349
Plasmodium falciparum serine/threonine protein kinase, putative 0.0069 0.0119 1
Brugia malayi Protein kinase domain containing protein 0.0029 0.004 0.0035
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0004 0.0025
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.003 0.0069
Echinococcus granulosus lamin dm0 0.0057 0.0095 0.0514
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0024 0.002
Loa Loa (eye worm) hypothetical protein 0.0056 0.0093 0.009
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0004 0.0003
Trichomonas vaginalis AGC family protein kinase 0.0069 0.0119 0.1718
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0001
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0022 0.0018
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0123 0.3579
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0004 0.0006
Schistosoma mansoni hypothetical protein 0.007 0.012 0.0667
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0001
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0053 0.0087 0.3824
Toxoplasma gondii hypothetical protein 0.0028 0.0038 0.1614
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0053 0.0087 0.0465
Echinococcus granulosus polycomb protein SCMH1 0.011 0.02 0.1095
Loa Loa (eye worm) hypothetical protein 0.0052 0.0084 0.0081
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0011 0.00000000027851
Schistosoma mansoni hypothetical protein 0.0029 0.004 0.0223
Schistosoma mansoni cyclins 0.0038 0.0056 0.0312
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0001
Trypanosoma cruzi cyclin, putative 0.009 0.016 0.04
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0013 0.003
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0057 0.0095 0.0092
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0004 0.0001
Schistosoma mansoni cpg binding protein 0.0064 0.0109 0.0608
Echinococcus multilocularis polycomb protein SCMH1 0.011 0.02 0.0589
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0123 0.0683
Schistosoma mansoni hypothetical protein 0.015 0.028 0.1559
Trypanosoma cruzi cdc2-related kinase 1 0.0053 0.0087 0.0213
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0125 0.023 0.1264
Toxoplasma gondii kringle domain-containing protein 0.0029 0.004 0.1698
Loa Loa (eye worm) hypothetical protein 0.022 0.0418 0.0414
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0024 0.0021
Entamoeba histolytica hypothetical protein 0.0114 0.0208 0.323
Loa Loa (eye worm) AUR protein kinase 0.0069 0.0119 0.0115
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0021 0.0024 0.0062
Schistosoma mansoni DNA polymerase eta 0.0021 0.0024 0.0135
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.0037 0.01
Loa Loa (eye worm) transcription factor SMAD2 0.0129 0.0237 0.0234
Toxoplasma gondii exonuclease III APE 0.002 0.0022 0.0884
Loa Loa (eye worm) hypothetical protein 0.015 0.028 0.0276
Loa Loa (eye worm) hypothetical protein 0.009 0.016 0.0157
Echinococcus multilocularis cyclins 0.0038 0.0056 0.0158
Trichomonas vaginalis cyclin D, putative 0.0038 0.0056 0.0724
Loa Loa (eye worm) hypothetical protein 0.0024 0.003 0.0027
Schistosoma mansoni microtubule-associated protein tau 0.0768 0.1503 0.8378
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.022 0.0418 0.0413
Trichomonas vaginalis cyclin B, putative 0.0038 0.0056 0.0724
Echinococcus multilocularis cyclins 0.0038 0.0056 0.0158
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0024 0.0081
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0053 0.0087 0.0083
Echinococcus multilocularis cyclin dependent kinase 1 0.0053 0.0087 0.025
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0011 0.00000000027851
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0115 0.021 0.0482
Onchocerca volvulus 0.0165 0.0308 1
Toxoplasma gondii aurora kinase 0.0069 0.0119 0.5265
Echinococcus multilocularis lamin 0.0057 0.0095 0.0276
Loa Loa (eye worm) hypothetical protein 0.0029 0.004 0.0037
Schistosoma mansoni transcription factor LCR-F1 0.0114 0.0208 0.116
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0024 0.0063
Schistosoma mansoni sex comb on midleg homolog 0.011 0.02 0.1112
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0004 0.0003
Loa Loa (eye worm) hypothetical protein 0.007 0.012 0.0116
Loa Loa (eye worm) hypothetical protein 0.011 0.02 0.0196
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0022 0.0104
Entamoeba histolytica hypothetical protein 0.0114 0.0208 0.323
Brugia malayi Cyclin, N-terminal domain containing protein 0.009 0.016 0.0156
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0024 0.0225
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0011 0.00000000027851
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.007 0.012 0.0349
Schistosoma mansoni ap endonuclease 0.002 0.0022 0.0123
Loa Loa (eye worm) hypothetical protein 0.0052 0.0086 0.0082
Echinococcus granulosus histone acetyltransferase MYST2 0.0125 0.023 0.1264
Entamoeba histolytica cell division protein kinase 2, putative 0.0053 0.0087 0.1324
Leishmania major cyclin 0.009 0.016 0.0354
Loa Loa (eye worm) hypothetical protein 0.0125 0.023 0.0226
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0024 0.0034
Trichomonas vaginalis cyclins, putative 0.0062 0.0104 0.1481
Echinococcus granulosus dna polymerase kappa 0.0021 0.0024 0.0116
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0011 0.00000000027851
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0024 0.0034
Trypanosoma cruzi cyclin 6, putative 0.009 0.016 0.04
Entamoeba histolytica cyclin, putative 0.009 0.016 0.2474
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.021 0.3172
Schistosoma mansoni hypothetical protein 0.0673 0.1314 0.7325
Loa Loa (eye worm) TK/ROR protein kinase 0.0029 0.004 0.0037
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0332 0.0639 1
Leishmania major hypothetical protein, conserved 0.0029 0.004 0.0046
Schistosoma mansoni ap endonuclease 0.002 0.0022 0.0123
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0024 0.0053
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0123 0.3579
Brugia malayi Cyclin, N-terminal domain containing protein 0.009 0.016 0.0156
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.003 0.0847
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0069 0.0119 0.0643
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0162 0.0303 0.5
Brugia malayi hypothetical protein 0.0016 0.0013 0.0009
Trichomonas vaginalis AGC family protein kinase 0.0069 0.0119 0.1718
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0024 0.0034
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0024 0.0034
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0011 0.00000000027851
Echinococcus granulosus lamin 0.0057 0.0095 0.0514
Schistosoma mansoni blooms syndrome DNA helicase 0.0011 0.0003 0.0014
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0115 0.021 0.0207
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0165 0.0308 0.0304
Echinococcus multilocularis cyclins 0.0038 0.0056 0.0158
Trypanosoma brucei cdc2-related kinase 1 0.0053 0.0087 0.0194
Schistosoma mansoni cpg binding protein 0.0068 0.0116 0.0648
Echinococcus granulosus cyclin b3 0.0038 0.0056 0.0294
Schistosoma mansoni hypothetical protein 0.007 0.012 0.0667
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0022 0.0293
Trichomonas vaginalis AGC family protein kinase 0.0069 0.0119 0.1718
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.007 0.012 0.0649
Echinococcus multilocularis cyclins 0.0038 0.0056 0.0158
Echinococcus multilocularis cyclins 0.0038 0.0056 0.0158
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0024 0.0217
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0021 0.0024 0.0062
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0123 0.3579
Brugia malayi mbt repeat family protein 0.011 0.02 0.0195
Echinococcus granulosus cpg binding protein 0.0068 0.0116 0.063
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0024 0.0034
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0087 0.1213
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0069 0.0119 0.1822
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0004 0.0025

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 3.9 uM Inhibition of CDK2/Cyclin A ChEMBL. 19603809
IC50 (binding) = 3.9 uM Inhibition of CDK2/Cyclin A assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting ChEMBL. 20397705
IC50 (binding) > 10 uM Inhibition of Aurora A ChEMBL. 19603809
IC50 (binding) > 10 uM Inhibition of GST-tagged PLK1 expressed in H5 insect cells assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting ChEMBL. 20397705
IC50 (binding) > 10 uM Inhibition of Aurora A assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting ChEMBL. 20397705
IC50 (functional) > 10 uM Antiproliferative activity against human A2780 cells after 72 hrs by cell Titer_Glo assay ChEMBL. 19603809
IC50 (functional) > 10 uM Antiproliferative activity against human A2780 cells assessed as intracellular ATP level after 72 hrs by luminometry ChEMBL. 20397705

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 19603809

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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