TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 463.638 | Formula: C26H33N5OS
H donors: 0 H acceptors: 2 LogP: 5.45 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: CCc1nc2n(c1N(Cc1cc3c(s1)cccc3)C)cc(cc2)C(=O)N(CCCN(C)C)C
InChi: 1S/C26H33N5OS/c1-6-22-25(30(5)18-21-16-19-10-7-8-11-23(19)33-21)31-17-20(12-13-24(31)27-22)26(32)29(4)15-9-14-28(2)3/h7-8,10-13,16-17H,6,9,14-15,18H2,1-5H3
InChiKey: CTYDGUHUKYMZNS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	isocitrate dehydrogenase 1 (NADP+), soluble	Starlite/ChEMBL	No references
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Neospora caninum	hypothetical protein	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	N terminus of cytosolic NADP-specific isocitrate dehydrogenase.	Get druggable targets OG5_127057	All targets in OG5_127057
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium yoelii	isocitrate dehydrogenase, NADP-dependent, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Brugia malayi	Isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	Mitochondrial NADP-specific isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	C terminus of cytosolic NADP-specific isocitrate dehydrogenase.	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Toxoplasma gondii	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	Mitochondrial NADP-specific isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma japonicum	ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative	Get druggable targets OG5_127057	All targets in OG5_127057
Leishmania braziliensis	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Leishmania infantum	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Theileria parva	isocitrate dehydrogenase (NADP+), putative	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Toxoplasma gondii	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	cytosolic NADP-specific isocitrate dehydrogenase.	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma congolense	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium knowlesi	isocitrate dehydrogenase [NADP], mitochondrial, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Loa Loa (eye worm)	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium berghei	isocitrate dehydrogenase [NADP], mitochondrial, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium yoelii	isocitrate dehydrogenase, NADP-dependent	Get druggable targets OG5_127057	All targets in OG5_127057
Neospora caninum	Isocitrate dehydrogenase-like protein, related	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma congolense	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma cruzi	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Leishmania donovani	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma brucei	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Babesia bovis	isocitrate dehydrogenase, NADP-dependent family protein	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma brucei gambiense	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Leishmania mexicana	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Brugia malayi	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma brucei gambiense	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus	Cathepsin L homolog	0.1792	0.453	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1792	0.453	1
Onchocerca volvulus		0.1792	0.453	1
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0983	0.1865	0.1865
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0983	0.1865	0.4118
Entamoeba histolytica	cysteine proteinase 2	0.0983	0.1865	0.4118
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0487	0.0233	0.0515
Entamoeba histolytica	cysteine protease, putative	0.0983	0.1865	0.4118
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0618	0.0664	0.1467
Brugia malayi	Cathepsin L-like precursor	0.1225	0.2665	0.2665
Trypanosoma brucei	cysteine peptidase C (CPC)	0.1355	0.3093	0.2738
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0618	0.0664	0.0664
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1792	0.453	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1225	0.2665	0.5882
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0603	0.0615	0.0887
Plasmodium falciparum	cysteine proteinase falcipain 3	0.1792	0.453	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.0566	0.0495	0.0495
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2344	0.6349	1
Trypanosoma cruzi	cysteine peptidase, putative	0.1792	0.453	0.453
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1792	0.453	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2344	0.6349	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.1792	0.453	1
Schistosoma mansoni	cathepsin F (C01 family)	0.1225	0.2665	0.2665
Brugia malayi	Cathepsin L-like precursor	0.1225	0.2665	0.2665
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.3453	1	1
Trypanosoma cruzi	cysteine protease, putative	0.0983	0.1865	0.1865
Toxoplasma gondii	cathepsin B	0.1355	0.3093	0.6655
Brugia malayi	Cathepsin L-like precursor	0.0566	0.0495	0.0495
Giardia lamblia	Cathepsin B precursor	0.1355	0.3093	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1792	0.453	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1225	0.2665	0.5882
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0983	0.1865	0.4118
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0566	0.0495	0.0495
Leishmania major	cathepsin L-like protease	0.2344	0.6349	1
Giardia lamblia	Cathepsin B precursor	0.1355	0.3093	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.1225	0.2665	0.2665
Echinococcus granulosus	cathepsin l1	0.1792	0.453	0.453
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0603	0.0615	0.1357
Brugia malayi	Papain family cysteine protease containing protein	0.0983	0.1865	0.1865
Entamoeba histolytica	cysteine protease, putative	0.0983	0.1865	0.4118
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1792	0.453	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1792	0.453	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0566	0.0495	0.0495
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0983	0.1865	0.1865
Entamoeba histolytica	cysteine proteinase 1, putative	0.0983	0.1865	0.4118
Loa Loa (eye worm)	hypothetical protein	0.0566	0.0495	0.0495
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0618	0.0664	0.0664
Brugia malayi	Cathepsin L-like precursor	0.1792	0.453	0.453
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1355	0.3093	0.3093
Leishmania major	cathepsin L-like protease	0.1792	0.453	0.4415
Entamoeba histolytica	cysteine protease, putative	0.0983	0.1865	0.4118
Loa Loa (eye worm)	hypothetical protein	0.0566	0.0495	0.0495
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1792	0.453	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.3453	1	1
Brugia malayi	Cathepsin L-like precursor	0.1792	0.453	0.453
Echinococcus multilocularis	cysteine protease	0.1792	0.453	0.453
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1792	0.453	1
Plasmodium vivax	vivapain-1	0.0983	0.1865	0.4118
Leishmania major	cathepsin L-like protease	0.2344	0.6349	1
Loa Loa (eye worm)	hypothetical protein	0.0566	0.0495	0.0495
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0532	0.0381	0.0842
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1792	0.453	1
Entamoeba histolytica	cysteine proteinase, putative	0.0983	0.1865	0.4118
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1355	0.3093	0.3093
Trypanosoma cruzi	cysteine peptidase, putative	0.2344	0.6349	0.6349
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2344	0.6349	1
Entamoeba histolytica	cysteine protease, putative	0.0983	0.1865	0.4118
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2344	0.6349	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2344	0.6349	1
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0487	0.0233	0.0754
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0618	0.0664	0.1467
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0603	0.0615	0.1357
Loa Loa (eye worm)	fibroinase	0.1792	0.453	0.453
Plasmodium vivax	unspecified product	0.0983	0.1865	0.4118
Echinococcus multilocularis	cathepsin L	0.0983	0.1865	0.1865
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0618	0.0664	0.1467
Echinococcus multilocularis	cathepsin b	0.3453	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1792	0.453	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.1792	0.453	0.453
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.1778	0.4483	0.4483
Plasmodium vivax	vivapain-2	0.1792	0.453	1
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0603	0.0615	0.1357
Echinococcus granulosus	cathepsin L cysteine protease	0.0983	0.1865	0.1865
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0603	0.0615	0.1357
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0618	0.0664	0.0664
Trypanosoma cruzi	cysteine peptidase, putative	0.2344	0.6349	0.6349
Schistosoma mansoni	cathepsin s	0.0566	0.0495	0.0495
Echinococcus granulosus	cathepsin l cysteine peptidase	0.1792	0.453	0.453
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1792	0.453	1
Entamoeba histolytica	cysteine protease, putative	0.0983	0.1865	0.4118
Trypanosoma cruzi	cysteine proteinase, putative	0.0983	0.1865	0.1865
Loa Loa (eye worm)	hypothetical protein	0.1225	0.2665	0.2665
Trypanosoma cruzi	cysteine proteinase, putative	0.0983	0.1865	0.1865
Onchocerca volvulus		0.1792	0.453	1
Entamoeba histolytica	cysteine protease, putative	0.0983	0.1865	0.4118
Schistosoma mansoni	cathepsin F (C01 family)	0.1792	0.453	0.453
Onchocerca volvulus	Cathepsin L homolog	0.1792	0.453	1
Onchocerca volvulus	Cathepsin F homolog	0.1792	0.453	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.1792	0.453	0.453
Echinococcus granulosus	cathepsin l1	0.1225	0.2665	0.2665
Echinococcus granulosus	cathepsin L cysteine proteinase	0.1792	0.453	0.453
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0487	0.0233	0.0515
Echinococcus granulosus	cysteine protease	0.0983	0.1865	0.1865
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1792	0.453	1
Leishmania major	cathepsin L-like protease	0.2344	0.6349	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.3453	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1792	0.453	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2344	0.6349	1
Loa Loa (eye worm)	cathepsin B	0.1355	0.3093	0.3093
Trypanosoma cruzi	cruzipain precursor, putative	0.0566	0.0495	0.0495
Entamoeba histolytica	cysteine protease, putative	0.0983	0.1865	0.4118
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0603	0.0615	0.1987
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1792	0.453	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.3453	1	1
Brugia malayi	Cathepsin L-like precursor	0.1792	0.453	0.453
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1792	0.453	1
Loa Loa (eye worm)	hypothetical protein	0.1225	0.2665	0.2665
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0983	0.1865	0.1865
Entamoeba histolytica	cysteine protease, putative	0.0983	0.1865	0.4118
Echinococcus multilocularis	cathepsin b	0.3453	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.1792	0.453	1
Echinococcus granulosus	cathepsin b	0.3453	1	1
Brugia malayi	Cathepsin L-like precursor	0.1792	0.453	0.453
Leishmania major	cathepsin L-like protease	0.1792	0.453	0.4415
Onchocerca volvulus		0.1792	0.453	1
Entamoeba histolytica	cysteine proteinase, putative	0.1792	0.453	1
Leishmania major	cathepsin L-like protease	0.1792	0.453	0.4415
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1792	0.453	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.1792	0.453	1
Loa Loa (eye worm)	ctsf protein	0.1792	0.453	0.453
Entamoeba histolytica	cysteine protease, putative	0.1792	0.453	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.1792	0.453	1
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0487	0.0233	0.0754
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0618	0.0664	0.1467
Echinococcus multilocularis	cathepsin L cysteine protease	0.1792	0.453	0.453
Plasmodium vivax	vivapain-3	0.0983	0.1865	0.4118
Plasmodium vivax	vivapain-2	0.1792	0.453	1
Leishmania major	cathepsin L-like protease	0.1792	0.453	0.4415
Brugia malayi	Papain family cysteine protease containing protein	0.1792	0.453	0.453
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1792	0.453	1
Entamoeba histolytica	cysteine proteinase, putative	0.1225	0.2665	0.5882
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1792	0.453	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0983	0.1865	0.1865
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.1792	0.453	0.453
Onchocerca volvulus		0.1792	0.453	1
Giardia lamblia	Cathepsin B precursor	0.0618	0.0664	0.2148
Leishmania major	cathepsin L-like protease	0.1792	0.453	0.4415
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.1355	0.3093	0.6827
Entamoeba histolytica	cysteine protease, putative	0.0983	0.1865	0.4118
Entamoeba histolytica	cysteine proteinase, putative	0.0983	0.1865	0.4118
Brugia malayi	Papain family cysteine protease containing protein	0.0983	0.1865	0.1865
Schistosoma mansoni	cathepsin F (C01 family)	0.1792	0.453	0.453
Echinococcus multilocularis	cathepsin L cysteine protease	0.1792	0.453	0.453
Loa Loa (eye worm)	hypothetical protein	0.1225	0.2665	0.2665
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0603	0.0615	0.0615
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.1792	0.453	1
Brugia malayi	Cathepsin L-like precursor	0.1792	0.453	0.453
Loa Loa (eye worm)	cysteine protease	0.1792	0.453	0.453
Trypanosoma cruzi	major cysteine proteinase, putative	0.0968	0.1818	0.1818
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2344	0.6349	1
Leishmania major	cysteine peptidase A (CPA)	0.1792	0.453	0.4415
Toxoplasma gondii	cathepsin CPC1	0.0603	0.0615	0.0887
Trypanosoma cruzi	cysteine peptidase, putative	0.2344	0.6349	0.6349
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0983	0.1865	0.4118
Entamoeba histolytica	cysteine protease, putative	0.0983	0.1865	0.4118
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.1792	0.453	0.453
Loa Loa (eye worm)	hypothetical protein	0.1792	0.453	0.453
Entamoeba histolytica	cysteine proteinase, putative	0.0983	0.1865	0.4118
Plasmodium vivax	unspecified product	0.0566	0.0495	0.1092
Entamoeba histolytica	cysteine protease, putative	0.0983	0.1865	0.4118
Brugia malayi	Cathepsin L-like precursor	0.1792	0.453	0.453
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1792	0.453	1
Echinococcus granulosus	cathepsin L	0.0983	0.1865	0.1865
Onchocerca volvulus		0.1792	0.453	1
Echinococcus granulosus	cathepsin b	0.3453	1	1
Loa Loa (eye worm)	hypothetical protein	0.3453	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2344	0.6349	1
Echinococcus multilocularis	cysteine protease	0.1792	0.453	0.453
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0566	0.0495	0.0495
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.3453	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1792	0.453	1
Onchocerca volvulus		0.1792	0.453	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1792	0.453	1
Onchocerca volvulus		0.1792	0.453	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0983	0.1865	0.1865
Trypanosoma cruzi	cruzipain precursor, putative	0.2344	0.6349	0.6349
Giardia lamblia	Encystation-specific protease	0.0487	0.0233	0.0754
Entamoeba histolytica	cysteine proteinase, putative	0.0983	0.1865	0.4118
Toxoplasma gondii	cathepsin CPL	0.1792	0.453	1
Onchocerca volvulus		0.1225	0.2665	0.5882
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2344	0.6349	1
Giardia lamblia	Cathepsin B precursor	0.1355	0.3093	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1792	0.453	1
Brugia malayi	cathepsin L-like precursor	0.1225	0.2665	0.2665
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1792	0.453	1
Entamoeba histolytica	cysteine protease, putative	0.0983	0.1865	0.4118
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2344	0.6349	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2344	0.6349	1
Entamoeba histolytica	cysteine protease, putative	0.0983	0.1865	0.4118

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	12.5893 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	18.3564 uM	PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	31.6228 uM	PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1865472

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1062909