TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 362.468 | Formula: C22H26N4O
H donors: 2 H acceptors: 2 LogP: 3.57 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1ccccc1c1nc2c([nH]1)cccc2)CCN1CCCCC1C
InChi: 1S/C22H26N4O/c1-16-8-6-7-14-26(16)15-13-21(27)23-18-10-3-2-9-17(18)22-24-19-11-4-5-12-20(19)25-22/h2-5,9-12,16H,6-8,13-15H2,1H3,(H,23,27)(H,24,25)
InChiKey: KJHRMEVJINPYHK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	cytoplasmic intermediate filament protein	0.0048	0.0252	0.0924
Trichomonas vaginalis	set domain proteins, putative	0.0254	0.1676	1
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0017	0.0043	0.0043
Onchocerca volvulus		0.0018	0.0046	0.0275
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.0385	0.5
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0025	0.0101	1
Brugia malayi	Latrophilin receptor protein 2	0.0068	0.039	0.143
Brugia malayi	Cathepsin L-like precursor	0.0012	0.0006	0.0022
Echinococcus granulosus	lamin dm0	0.0089	0.0536	0.0536
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0046	0.0169
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0046	0.0169
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0146	0.0146
Loa Loa (eye worm)	TAR-binding protein	0.0408	0.273	1
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0025	0.0101	0.5
Schistosoma mansoni	hypothetical protein	0.0146	0.093	0.093
Echinococcus multilocularis	cysteine protease	0.0018	0.0046	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0159	0.1018	0.3729
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0214	0.1395	0.511
Onchocerca volvulus		0.0018	0.0046	0.0275
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0046	0.0239
Echinococcus multilocularis	GPCR, family 2	0.0068	0.039	0.039
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0101	1
Schistosoma mansoni	hypothetical protein	0.0135	0.0856	0.0856
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.0385	0.5
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0101	0.0368
Brugia malayi	RNA binding protein	0.0408	0.273	1
Schistosoma mansoni	lamin	0.0089	0.0536	0.0536
Schistosoma mansoni	smad1 5 8 and	0.0017	0.0043	0.0043
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0214	0.1395	0.511
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0043	0.022	0.022
Schistosoma mansoni	hypothetical protein	0.0077	0.0458	0.0458
Brugia malayi	MH2 domain containing protein	0.0017	0.0043	0.0159
Schistosoma mansoni	tar DNA-binding protein	0.0408	0.273	0.273
Entamoeba histolytica	acyl-coA synthetase, putative	0.0025	0.0101	0.2091
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0046	0.0239
Schistosoma mansoni	smad	0.0017	0.0043	0.0043
Brugia malayi	Cathepsin L-like precursor	0.0012	0.0006	0.0022
Echinococcus multilocularis	cathepsin L cysteine protease	0.0018	0.0046	0.0046
Trypanosoma cruzi	cysteine peptidase, putative	0.0067	0.0385	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.0385	0.5
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0025	0.0101	0.2091
Onchocerca volvulus		0.0089	0.0536	0.3198
Plasmodium vivax	SET domain protein, putative	0.0032	0.0146	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0101	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0146	0.0534
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0046	0.0239
Echinococcus multilocularis	lamin	0.0089	0.0536	0.0536
Onchocerca volvulus		0.0018	0.0046	0.0275
Schistosoma mansoni	cathepsin F (C01 family)	0.0012	0.0006	0.0006
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0135	0.0856	0.0856
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0025	0.0101	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0046	0.0239
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.0385	0.5
Brugia malayi	Smad1	0.0017	0.0043	0.0159
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0046	0.0239
Loa Loa (eye worm)	intermediate filament protein	0.0089	0.0536	0.1962
Loa Loa (eye worm)	MH1 domain-containing protein	0.0017	0.0043	0.0159
Echinococcus granulosus	lamin	0.0089	0.0536	0.0536
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.0385	0.5
Mycobacterium ulcerans	hypothetical protein	0.0025	0.0101	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0101	0.1606
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.0385	0.5
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0056	0.0206
Brugia malayi	hypothetical protein	0.0077	0.0458	0.1676
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.0385	0.5
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0101	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0214	0.1395	0.511
Loa Loa (eye worm)	hypothetical protein	0.0043	0.022	0.0805
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0048	0.0252	0.0924
Brugia malayi	Pre-SET motif family protein	0.0224	0.1463	0.5359
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0046	0.0239
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0061	0.0345	0.8824
Brugia malayi	intermediate filament protein	0.0089	0.0536	0.1962
Entamoeba histolytica	cysteine protease, putative	0.0018	0.0046	0.0884
Entamoeba histolytica	hypothetical protein	0.0077	0.0458	1
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0089	0.0536	0.1962
Onchocerca volvulus		0.0032	0.0146	0.0871
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0056	0.0206
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0101	0.0368
Schistosoma mansoni	Smad4	0.0017	0.0043	0.0043
Echinococcus granulosus	cathepsin l1	0.0018	0.0046	0.0046
Schistosoma mansoni	tar DNA-binding protein	0.0408	0.273	0.273
Brugia malayi	cathepsin L-like precursor	0.0012	0.0006	0.0022
Echinococcus multilocularis	tumor protein p63	0.1086	0.7393	0.7393
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0018	0.0046	0.0169
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0068	0.039	0.039
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0068	0.039	0.143
Brugia malayi	TAR-binding protein	0.0408	0.273	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0046	0.0239
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0018	0.0046	0.0046
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0017	0.0043	0.0043
Onchocerca volvulus		0.0018	0.0046	0.0275
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0046	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0056	0.0206
Brugia malayi	latrophilin 2 splice variant baaae	0.0146	0.093	0.3407
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0046	0.0239
Echinococcus granulosus	GPCR family 2	0.0068	0.039	0.039
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0146	0.093	0.093
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0018	0.0046	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0068	0.039	0.143
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0025	0.0101	1
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0224	0.1463	0.5359
Loa Loa (eye worm)	fibroinase	0.0018	0.0046	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0101	0.0368
Trypanosoma cruzi	major cysteine proteinase, putative	0.0053	0.0287	0.7098
Echinococcus granulosus	tar DNA binding protein	0.0408	0.273	0.273
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0056	0.0206
Brugia malayi	Papain family cysteine protease containing protein	0.0018	0.0046	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0146	0.093	0.3407
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0056	0.0206
Entamoeba histolytica	hypothetical protein	0.0077	0.0458	1
Brugia malayi	MH1 domain containing protein	0.0017	0.0043	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0525	0.1921
Schistosoma mansoni	lamin	0.0089	0.0536	0.0536
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0068	0.039	0.039
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0018	0.0046	0.0046
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0018	0.0046	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0006	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0536	0.1962
Brugia malayi	Intermediate filament tail domain containing protein	0.0089	0.0536	0.1962
Echinococcus multilocularis	cysteine protease	0.0018	0.0046	0.0046
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0046	0.0239
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0019	0.0056	0.139
Schistosoma mansoni	smad1 5 8 and	0.0017	0.0043	0.0043
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0018	0.0046	0.0239
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0018	0.0046	0.0169
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0046	0.0239
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0046	0.0239
Schistosoma mansoni	tar DNA-binding protein	0.0408	0.273	0.273
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0209	0.0765
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0046	0.0239
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0046	0.0239
Schistosoma mansoni	intermediate filament proteins	0.0089	0.0536	0.0536
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0019	0.0056	0.5
Loa Loa (eye worm)	hypothetical protein	0.0214	0.1395	0.511
Onchocerca volvulus		0.0159	0.1018	0.6077
Echinococcus granulosus	cathepsin l1	0.0012	0.0006	0.0006
Trypanosoma cruzi	cysteine peptidase, putative	0.0067	0.0385	1
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0046	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0209	0.0765
Schistosoma mansoni	microtubule-associated protein tau	0.1465	1	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0077	0.0458	0.0458
Echinococcus multilocularis	cathepsin L cysteine protease	0.0018	0.0046	0.0046
Loa Loa (eye worm)	MH2 domain-containing protein	0.0252	0.1659	0.6076
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.0385	0.5
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0025	0.0101	0.2091
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0101	0.1606
Brugia malayi	MH2 domain containing protein	0.0017	0.0043	0.0159
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0046	0.0239
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0043	0.022	0.022
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0025	0.0101	0.5
Loa Loa (eye worm)	transcription factor SMAD2	0.0252	0.1659	0.6076
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0046	0.0239
Loa Loa (eye worm)	ctsf protein	0.0018	0.0046	0.0169
Echinococcus granulosus	mothers against decapentaplegic 5	0.0017	0.0043	0.0043
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0046	0.0239
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.0385	0.5
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0017	0.0043	0.0043
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0032	0.0146	0.0146
Leishmania major	cathepsin L-like protease	0.0067	0.0385	1
Onchocerca volvulus		0.0018	0.0046	0.0275
Echinococcus multilocularis	microtubule associated protein 2	0.1465	1	1
Onchocerca volvulus		0.0025	0.0101	0.06
Loa Loa (eye worm)	MH2 domain-containing protein	0.0017	0.0043	0.0159
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0025	0.0101	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0046	0.0239
Leishmania major	cathepsin L-like protease	0.0067	0.0385	1
Echinococcus granulosus	intermediate filament protein	0.0089	0.0536	0.0536
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0032	0.0146	0.0146
Echinococcus granulosus	tumor protein p63	0.1086	0.7393	0.7393
Loa Loa (eye worm)	RNA binding protein	0.0408	0.273	1
Echinococcus multilocularis	tar DNA binding protein	0.0408	0.273	0.273
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0135	0.0856	0.0856
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.0385	0.5
Trypanosoma cruzi	cruzipain precursor, putative	0.0067	0.0385	1
Onchocerca volvulus		0.0018	0.0046	0.0275
Entamoeba histolytica	hypothetical protein	0.0077	0.0458	1
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0046	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0101	0.0368
Loa Loa (eye worm)	Smad1	0.0017	0.0043	0.0159
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0101	0.1606
Onchocerca volvulus		0.0012	0.0006	0.0037
Schistosoma mansoni	transcription factor LCR-F1	0.0077	0.0458	0.0458
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0046	0.0239
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0025	0.0101	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0018	0.0046	0.0046
Brugia malayi	MH2 domain containing protein	0.0252	0.1659	0.6076
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0032	0.0146	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0006	0.0022
Loa Loa (eye worm)	cysteine protease	0.0018	0.0046	0.0169
Brugia malayi	RNA recognition motif domain containing protein	0.0408	0.273	1
Onchocerca volvulus	Cathepsin L homolog	0.0018	0.0046	0.0275
Echinococcus granulosus	Smad4	0.0017	0.0043	0.0043
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0146	0.0146
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0046	0.0239
Echinococcus multilocularis	Smad4	0.0017	0.0043	0.0043
Echinococcus multilocularis	smad	0.0017	0.0043	0.0043
Echinococcus multilocularis	lamin dm0	0.0089	0.0536	0.0536
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.0385	0.5
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0408	0.273	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0146	0.0146
Echinococcus multilocularis	musashi	0.0089	0.0536	0.0536
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0031	0.0138	0.0138
Brugia malayi	MH1 domain containing protein	0.0017	0.0043	0.0159
Plasmodium vivax	acyl-CoA synthetase, putative	0.0019	0.0056	0.1019
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0046	0.0239
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0006	0.0022
Entamoeba histolytica	hypothetical protein	0.0077	0.0458	1
Schistosoma mansoni	thyroid hormone receptor	0.0146	0.093	0.093
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0068	0.039	0.143
Onchocerca volvulus	Cathepsin L homolog	0.0018	0.0046	0.0275
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0101	0.0368
Onchocerca volvulus	Cathepsin F homolog	0.0018	0.0046	0.0275
Schistosoma mansoni	cellular tumor antigen P53	0.0159	0.1018	0.1018
Leishmania major	cathepsin L-like protease	0.0067	0.0385	1
Entamoeba histolytica	cysteine proteinase, putative	0.0018	0.0046	0.0884
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0046	0.0239
Echinococcus granulosus	smad	0.0017	0.0043	0.0043
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0012	0.0006	0.0022
Onchocerca volvulus		0.0018	0.0046	0.0275
Onchocerca volvulus		0.0254	0.1676	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0046	0.0239
Schistosoma mansoni	hypothetical protein	0.0068	0.039	0.039
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0077	0.0458	0.0458
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0101	0.0368
Plasmodium falciparum	acyl-CoA synthetase	0.0019	0.0056	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0018	0.0046	0.0046
Schistosoma mansoni	smad1 5 8 and	0.0017	0.0043	0.0043
Schistosoma mansoni	hypothetical protein	0.0068	0.039	0.039
Brugia malayi	Pre-SET motif family protein	0.0032	0.0146	0.0534
Schistosoma mansoni	hypothetical protein	0.0068	0.039	0.039
Echinococcus granulosus	histone lysine methyltransferase setb	0.0032	0.0146	0.0146
Schistosoma mansoni	thyroid hormone receptor	0.0146	0.093	0.093
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0032	0.0146	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0068	0.039	0.039
Trypanosoma cruzi	cysteine peptidase, putative	0.0067	0.0385	1
Onchocerca volvulus		0.0089	0.0536	0.3198
Schistosoma mansoni	hypothetical protein	0.0068	0.039	0.039
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0046	0.0169
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0025	0.0101	1
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0046	0.0169
Schistosoma mansoni	tar DNA-binding protein	0.0408	0.273	0.273
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0017	0.0043	0.0043
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0018	0.0046	0.0239
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0068	0.039	0.039
Entamoeba histolytica	cysteine proteinase, putative	0.0018	0.0046	0.0884
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0046	0.0239
Schistosoma mansoni	tar DNA-binding protein	0.0408	0.273	0.273

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL563285

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1063098