Detailed information for compound 1063260

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 381.471 | Formula: C21H27N5O2
  • H donors: 2 H acceptors: 4 LogP: 3.04 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CCNC(=O)[C@@H](NC(=O)c1cc(nn1C)C(C)(C)C)Cc1cccc(c1)C
  • InChi: 1S/C21H27N5O2/c1-14-7-6-8-15(11-14)12-16(19(27)23-10-9-22)24-20(28)17-13-18(21(2,3)4)25-26(17)5/h6-8,11,13,16H,10,12H2,1-5H3,(H,23,27)(H,24,28)/t16-/m0/s1
  • InChiKey: UJBBWPQMJVUYPP-INIZCTEOSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin L Starlite/ChEMBL References
Homo sapiens cathepsin B Starlite/ChEMBL References
Homo sapiens cathepsin S Starlite/ChEMBL References
Homo sapiens cathepsin K Starlite/ChEMBL References
Homo sapiens cathepsin V Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin B-like cysteine proteinase Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01363 cathepsin B [EC3.4.22.1], putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin B-like protease (Precursor), related Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni SmCB2 peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania donovani cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei gambiense cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin K 329 aa 349 aa 33.2 %
Plasmodium falciparum dipeptidyl aminopeptidase 1 cathepsin B 339 aa 368 aa 26.9 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin L 333 aa 359 aa 30.1 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin S 281 aa 226 aa 34.1 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin V 334 aa 357 aa 29.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0113 0.147 0.3313
Trypanosoma cruzi cysteine peptidase, putative 0.0061 0.0545 0.154
Loa Loa (eye worm) hypothetical protein 0.0035 0.0089 0.0144
Leishmania major cathepsin L-like protease 0.0113 0.147 0.4143
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0113 0.147 0.3313
Loa Loa (eye worm) phosphatidylinositol 3 0.0048 0.0316 0.051
Loa Loa (eye worm) phosphatidylinositol 3 0.038 0.6198 1
Schistosoma mansoni cathepsin F (C01 family) 0.0113 0.147 0.2101
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0113 0.147 0.3313
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0113 0.147 0.3313
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0186 0.276 0.7795
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0425 0.7 0.7
Mycobacterium tuberculosis Probable dehydrogenase 0.0113 0.148 0.3743
Schistosoma mansoni cathepsin F (C01 family) 0.0113 0.147 0.2101
Schistosoma mansoni RAR-like nuclear receptor 0.0042 0.0215 0.0307
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.054 0.054
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0048 0.0316 0.0893
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0077 0.084 0.1892
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.0215 0.0484
Echinococcus multilocularis cathepsin L cysteine protease 0.0113 0.147 0.147
Entamoeba histolytica cysteine protease, putative 0.0061 0.0545 0.154
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.0215 0.0484
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0139 0.0949
Trypanosoma cruzi cysteine proteinase, putative 0.0061 0.0545 0.154
Echinococcus multilocularis geminin 0.0177 0.2603 0.2603
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0559 0.0798
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0042 0.0215 0.0484
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0113 0.147 0.3313
Schistosoma mansoni cathepsin F (C01 family) 0.0077 0.084 0.12
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0113 0.147 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0036 0.0105 0.017
Echinococcus granulosus cathepsin L cysteine protease 0.0061 0.0545 0.0545
Loa Loa (eye worm) hypothetical protein 0.0038 0.0139 0.0225
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0113 0.148 0.3743
Trypanosoma cruzi cysteine peptidase, putative 0.0113 0.147 0.4152
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0126 0.1704 1
Trypanosoma cruzi cysteine peptidase, putative 0.0113 0.147 0.4152
Echinococcus granulosus cathepsin b 0.0186 0.276 0.276
Schistosoma mansoni steroid hormone receptor ad4bp 0.0042 0.0215 0.0307
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0139 0.0225
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.0354 0.0354
Loa Loa (eye worm) hypothetical protein 0.0042 0.0215 0.0347
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0048 0.0316 0.215
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0082 0.0928 0.2091
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0048 0.0316 0.0452
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0037 0.0126 0.0355
Entamoeba histolytica cysteine protease, putative 0.0061 0.0545 0.154
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0032 0.0047 0.0318
Schistosoma mansoni hypothetical protein 0.0177 0.2603 0.3719
Plasmodium falciparum cysteine proteinase falcipain 3 0.0113 0.147 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0048 0.0316 0.0316
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0042 0.0215 0.0484
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0316 0.0712
Loa Loa (eye worm) hypothetical protein 0.0043 0.0236 0.0381
Entamoeba histolytica cysteine protease, putative 0.0061 0.0545 0.154
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0113 0.147 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0106 0.1356 0.3828
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.0215 0.0484
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0186 0.276 0.3943
Leishmania major cathepsin L-like protease 0.0113 0.147 0.4143
Plasmodium vivax unspecified product 0.0036 0.0105 0.061
Entamoeba histolytica hypothetical protein 0.0185 0.2739 0.7735
Brugia malayi nuclear hormone receptor 0.0042 0.0215 0.0484
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0061 0.0545 0.154
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0113 0.147 0.147
Brugia malayi Cathepsin L-like precursor 0.0113 0.147 0.3313
Echinococcus granulosus histone lysine methyltransferase setb 0.0048 0.0321 0.0321
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0082 0.0928 0.6311
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0048 0.0316 0.215
Plasmodium vivax vivapain-2 0.0113 0.147 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0113 0.147 0.3313
Onchocerca volvulus Protein ultraspiracle homolog 0.0042 0.0215 0.0527
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0113 0.148 0.857
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0139 0.0314
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0316 0.0712
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.023 0.3541 0.7979
Trypanosoma cruzi target of rapamycin kinase 3 0.0048 0.0316 0.0893
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0316 0.0712
Brugia malayi Pre-SET motif family protein 0.0214 0.3254 0.7331
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0316 0.0712
Entamoeba histolytica hypothetical protein 0.0073 0.077 0.2175
Schistosoma mansoni fkbp-rapamycin associated protein 0.003 0.000000022704 0.000000032433
Loa Loa (eye worm) phosphatidylinositol 3 0.0048 0.0316 0.051
Brugia malayi ecdysteroid receptor 0.0042 0.0215 0.0484
Brugia malayi Cathepsin L-like precursor 0.0113 0.147 0.3313
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.077 0.077
Brugia malayi Cathepsin L-like precursor 0.0036 0.0105 0.0237
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0316 0.0712
Loa Loa (eye worm) hypothetical protein 0.0207 0.3138 0.5063
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0042 0.0215 0.0307
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0113 0.147 0.3313
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.023 0.3541 1
Leishmania major cathepsin L-like protease 0.0113 0.147 0.4143
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0321 0.0459
Loa Loa (eye worm) hypothetical protein 0.0077 0.084 0.1355
Onchocerca volvulus Cathepsin L homolog 0.0113 0.147 0.3867
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0037 0.0126 0.0126
Onchocerca volvulus 0.0243 0.3776 1
Trypanosoma cruzi cruzipain precursor, putative 0.0113 0.147 0.4152
Entamoeba histolytica cysteine protease, putative 0.0061 0.0545 0.154
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.023 0.3541 0.7979
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.0215 0.0484
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0316 0.0712
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0037 0.0126 0.0856
Brugia malayi beta-lactamase family protein 0.0038 0.0139 0.0314
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0048 0.0316 0.215
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0061 0.0545 0.0779
Loa Loa (eye worm) hypothetical protein 0.0042 0.0215 0.0347
Echinococcus multilocularis thyroid hormone receptor alpha 0.0042 0.0215 0.0215
Mycobacterium tuberculosis Possible penicillin-binding protein 0.024 0.3722 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0113 0.147 0.3313
Brugia malayi hypothetical protein 0.0073 0.077 0.1735
Entamoeba histolytica cysteine protease, putative 0.0113 0.147 0.4152
Brugia malayi glutathione reductase 0.005 0.0354 0.0798
Loa Loa (eye worm) beta-lactamase 0.0038 0.0139 0.0225
Loa Loa (eye worm) hypothetical protein 0.0042 0.0215 0.0347
Onchocerca volvulus 0.0113 0.147 0.3867
Loa Loa (eye worm) hypothetical protein 0.0152 0.2158 0.3481
Leishmania major phosphatidylinositol 3-kinase, putative 0.0048 0.0316 0.0587
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0047 0.0105
Loa Loa (eye worm) thioredoxin reductase 0.005 0.0354 0.0571
Entamoeba histolytica cysteine protease, putative 0.0061 0.0545 0.154
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0042 0.0215 0.0484
Brugia malayi Thioredoxin reductase 0.005 0.0354 0.0798
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0037 0.0126 0.0355
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0082 0.0928 0.2091
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0152 0.2158 0.4862
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0316 0.0712
Mycobacterium tuberculosis Probable oxidoreductase 0.0126 0.1704 0.4368
Onchocerca volvulus 0.0113 0.147 0.3867
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0037 0.0126 0.0355
Echinococcus multilocularis FTZ F1 alpha 0.0042 0.0215 0.0215
Mycobacterium tuberculosis Probable reductase 0.0113 0.148 0.3743
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0186 0.276 0.3943
Loa Loa (eye worm) hypothetical protein 0.0042 0.0215 0.0347
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0316 0.0712
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0037 0.0126 0.0856
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0075 0.0795 0.2062
Brugia malayi cathepsin F-like cysteine proteinase 0.0036 0.0105 0.0237
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0139 0.0199
Echinococcus granulosus cysteine protease 0.0061 0.0545 0.0545
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0559 0.0798
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0037 0.0126 0.0284
Entamoeba histolytica cysteine proteinase 1, putative 0.0061 0.0545 0.154
Loa Loa (eye worm) hypothetical protein 0.0077 0.084 0.1355
Loa Loa (eye worm) hypothetical protein 0.0077 0.084 0.1355
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0048 0.0316 0.0316
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0037 0.0126 0.0284
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.1177 0.1177
Onchocerca volvulus 0.0038 0.0139 0.0326
Giardia lamblia Cathepsin B precursor 0.0075 0.0795 0.4012
Brugia malayi cathepsin L-like precursor 0.0077 0.084 0.1892
Loa Loa (eye worm) hypothetical protein 0.0038 0.0139 0.0225
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0321 0.0459
Schistosoma mansoni cathepsin s 0.0036 0.0105 0.0151
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0037 0.0126 0.0856
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0042 0.0215 0.0307
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0047 0.0105
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0036 0.0105 0.0237
Toxoplasma gondii target of rapamycin (TOR), putative 0.0048 0.0316 0.215
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.023 0.3541 0.7979
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.005 0.0354 0.0599
Trypanosoma cruzi cruzipain precursor, putative 0.0036 0.0105 0.0298
Entamoeba histolytica cysteine proteinase, putative 0.0061 0.0545 0.154
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0042 0.0215 0.0215
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0042 0.0215 0.0347
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0042 0.0215 0.0484
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0113 0.147 1
Leishmania major cysteine peptidase A (CPA) 0.0113 0.147 0.4143
Plasmodium falciparum thioredoxin reductase 0.005 0.0354 0.1697
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0042 0.0215 0.0484
Brugia malayi beta-lactamase family protein 0.0038 0.0139 0.0314
Schistosoma mansoni survival motor neuron protein 0.0049 0.0336 0.048
Entamoeba histolytica cysteine protease, putative 0.0061 0.0545 0.154
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0096 0.1177 0.1899
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0116 0.0116
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0048 0.0316 0.0316
Onchocerca volvulus 0.0038 0.0139 0.0326
Brugia malayi glutaminase DH11.1 0.0281 0.4438 1
Plasmodium vivax glutathione reductase, putative 0.005 0.0354 0.232
Entamoeba histolytica cysteine protease, putative 0.0061 0.0545 0.154
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0042 0.0215 0.0347
Echinococcus granulosus FTZ F1 alpha 0.0042 0.0215 0.0215
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0316 0.0712
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0559 0.0975
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0186 0.276 0.3943
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0037 0.0126 0.0355
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0082 0.0928 0.1326
Schistosoma mansoni hypothetical protein 0.0073 0.077 0.11
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0017 0.0024
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0126 0.1704 0.4368
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0113 0.147 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0042 0.0215 0.0347
Loa Loa (eye worm) hypothetical protein 0.0113 0.147 0.2372
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0068 0.0672 0.1898
Loa Loa (eye worm) fibroinase 0.0113 0.147 0.2372
Onchocerca volvulus Cathepsin F homolog 0.0113 0.147 0.3867
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0113 0.148 0.3743
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0037 0.0126 0.0126
Leishmania major cathepsin L-like protease 0.0113 0.147 0.4143
Loa Loa (eye worm) hypothetical protein 0.0078 0.0858 0.1385
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0116 0.0116
Brugia malayi Papain family cysteine protease containing protein 0.0061 0.0545 0.1229
Loa Loa (eye worm) hypothetical protein 0.0042 0.0215 0.0347
Loa Loa (eye worm) hypothetical protein 0.0038 0.0139 0.0225
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0082 0.0928 0.2091
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0559 0.117
Schistosoma mansoni glutaminase 0.0281 0.4438 0.634
Loa Loa (eye worm) glutathione reductase 0.005 0.0354 0.0571
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.1177 0.1682
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0425 0.7 1
Plasmodium vivax vivapain-1 0.0061 0.0545 0.3637
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0214 0.3254 0.525
Echinococcus multilocularis cathepsin b 0.0186 0.276 0.276
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0113 0.147 1
Brugia malayi hypothetical protein 0.0239 0.3696 0.8327
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0113 0.147 0.2372
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0316 0.0712
Brugia malayi cathepsin B-like cysteine proteinase 0.0186 0.276 0.6219
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0042 0.0215 0.0307
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0089 0.0201
Trichomonas vaginalis glutaminase, putative 0.0281 0.4438 1
Plasmodium falciparum glutathione reductase 0.005 0.0354 0.1697
Loa Loa (eye worm) ctsf protein 0.0113 0.147 0.2372
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0048 0.0316 0.0893
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0042 0.0215 0.0307
Echinococcus multilocularis ecdysone induced protein 78C 0.0042 0.0215 0.0215
Echinococcus granulosus cathepsin l1 0.0077 0.084 0.084
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0037 0.0126 0.0126
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0215 0.0215
Schistosoma mansoni nuclear hormone receptor 0.0042 0.0215 0.0307
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.016 0.2311 0.5208
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0017 0.0024
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0113 0.148 0.3743
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0152 0.2158 0.2158
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0048 0.0316 0.0893
Brugia malayi Cathepsin L-like precursor 0.0077 0.084 0.1892
Brugia malayi Pre-SET motif family protein 0.0031 0.0017 0.0038
Onchocerca volvulus 0.0042 0.0215 0.0527
Leishmania major hypothetical protein, conserved 0.0038 0.0139 0.0042
Echinococcus multilocularis Zinc finger, PHD finger 0.0037 0.0126 0.0126
Brugia malayi Bromodomain containing protein 0.0039 0.0158 0.0357
Leishmania major cathepsin L-like protease 0.0113 0.147 0.4143
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.1177 0.1682
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0113 0.147 1
Brugia malayi Cathepsin L-like precursor 0.0077 0.084 0.1892
Loa Loa (eye worm) cysteine protease 0.0113 0.147 0.2372
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0113 0.147 1
Loa Loa (eye worm) steroid hormone receptor 0.0042 0.0215 0.0347
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0316 0.0712
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0048 0.0316 0.0316
Entamoeba histolytica cysteine protease, putative 0.0061 0.0545 0.154
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0115 0.1509 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0139 0.0314
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0139 0.0139
Trypanosoma cruzi cysteine protease, putative 0.0061 0.0545 0.154
Toxoplasma gondii thioredoxin reductase 0.005 0.0354 0.2408
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0316 0.0712
Trichomonas vaginalis set domain proteins, putative 0.0243 0.3776 0.8507
Brugia malayi beta-lactamase 0.0038 0.0139 0.0314
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0037 0.0126 0.018
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0082 0.0928 0.262
Onchocerca volvulus 0.0113 0.147 0.3867
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0061 0.0545 0.0779
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0316 0.0712
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0186 0.276 0.3943
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0096 0.1177 0.2652
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0075 0.0795 0.1136
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0207 0.3138 0.7071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0316 0.0712
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0139 0.0314
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0113 0.147 0.3313
Onchocerca volvulus 0.0113 0.147 0.3867
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0559 0.0559
Trichomonas vaginalis esterase, putative 0.0038 0.0139 0.0314
Echinococcus granulosus cathepsin l cysteine peptidase 0.0113 0.147 0.147
Schistosoma mansoni bromodomain containing protein 0.0064 0.0604 0.0863
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0113 0.147 0.3313
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0139 0.0199
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.016 0.2311 0.5208
Brugia malayi Papain family cysteine protease containing protein 0.0061 0.0545 0.1229
Loa Loa (eye worm) hypothetical protein 0.0042 0.0215 0.0347
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0113 0.147 0.3313
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.1177 0.1177
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0075 0.0795 0.1791
Echinococcus multilocularis cathepsin b 0.0186 0.276 0.276
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0139 0.0314
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0113 0.147 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0316 0.0712
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0113 0.147 0.2372
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0316 0.0712
Trypanosoma cruzi cysteine peptidase, putative 0.0113 0.147 0.4152
Brugia malayi Bromodomain containing protein 0.0076 0.0814 0.1833
Loa Loa (eye worm) hypothetical protein 0.0038 0.0139 0.0225
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0048 0.0316 0.215
Leishmania major cathepsin L-like protease 0.0113 0.147 0.4143
Loa Loa (eye worm) cathepsin B 0.0075 0.0795 0.1282
Loa Loa (eye worm) hypothetical protein 0.0041 0.0202 0.0326
Entamoeba histolytica cysteine protease, putative 0.0061 0.0545 0.154
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0113 0.147 1
Leishmania major hypothetical protein, conserved 0.022 0.3371 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0113 0.147 0.3313
Trypanosoma cruzi cysteine proteinase, putative 0.0061 0.0545 0.154
Loa Loa (eye worm) hypothetical protein 0.0036 0.0105 0.017
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0336 0.0756
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.006 0.0533 0.1814
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0139 0.0314
Schistosoma mansoni hypothetical protein 0.0049 0.0336 0.048
Brugia malayi Cathepsin L-like precursor 0.0113 0.147 0.3313
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0042 0.0215 0.0215
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0048 0.0316 0.0587
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0042 0.0215 0.0215
Echinococcus granulosus geminin 0.0177 0.2603 0.2603
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0113 0.147 1
Onchocerca volvulus Bile acid receptor homolog 0.0042 0.0215 0.0527
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.0545 0.3709
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0316 0.0712
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.0545 0.3709
Entamoeba histolytica hypothetical protein 0.0073 0.077 0.2175
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0172 0.2524 0.2524
Brugia malayi Papain family cysteine protease containing protein 0.0113 0.147 0.3313
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0113 0.147 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0113 0.147 0.3313
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0082 0.0928 0.262
Echinococcus multilocularis cysteine protease 0.0113 0.147 0.147
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0374 0.0842
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0196 0.2934 0.661
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0042 0.0215 0.0215
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.0215 0.0484
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0139 0.0139
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0042 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.0036 0.0105 0.017
Entamoeba histolytica cysteine proteinase, putative 0.0061 0.0545 0.154
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0559 0.0559
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0042 0.0215 0.0347
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0042 0.0215 0.0347
Onchocerca volvulus 0.0038 0.0139 0.0326
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0139 0.0394
Loa Loa (eye worm) hypothetical protein 0.0071 0.0737 0.1189
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0042 0.0215 0.0307
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0113 0.147 1
Schistosoma mansoni hypothetical protein 0.0035 0.0089 0.0127
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0113 0.147 0.3313
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0113 0.147 0.3313
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0042 0.0215 0.0484
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0017 0.0114
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0037 0.0126 0.0284
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0595 1 1
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.0354 0.1
Entamoeba histolytica cysteine proteinase 2 0.0061 0.0545 0.154
Trypanosoma cruzi hypothetical protein, conserved 0.0206 0.3115 0.8797
Brugia malayi Cathepsin L-like cysteine proteinase 0.0077 0.084 0.1892
Loa Loa (eye worm) hypothetical protein 0.0038 0.0139 0.0225
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.1177 0.1177
Echinococcus granulosus cathepsin L 0.0061 0.0545 0.0545
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0559 0.3799
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.0354 0.0354
Trypanosoma brucei cysteine peptidase C (CPC) 0.0075 0.0795 0.5406
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.023 0.3541 1
Giardia lamblia Cathepsin B precursor 0.0075 0.0795 0.4012
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0048 0.0316 0.0893
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0316 0.0712
Trypanosoma cruzi cysteine peptidase, putative 0.0036 0.0105 0.0298
Loa Loa (eye worm) hypothetical protein 0.0038 0.0139 0.0225
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0215 0.0215
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0185 0.2739 0.7735
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.0215 0.0484
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0048 0.0316 0.0893
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0042 0.0215 0.0347
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0075 0.0795 0.2245
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0037 0.0126 0.0284
Plasmodium vivax vivapain-3 0.0061 0.0545 0.3637
Brugia malayi Steroid receptor seven-up type 2 0.0042 0.0215 0.0484
Loa Loa (eye worm) hypothetical protein 0.0239 0.3696 0.5963
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.077 0.11
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0113 0.148 0.3743
Plasmodium falciparum cysteine proteinase falcipain 1 0.0061 0.0545 0.3121
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0113 0.147 0.3313
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0139 0.0314
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.1177 0.1177
Loa Loa (eye worm) hypothetical protein 0.0042 0.0215 0.0347
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0048 0.0316 0.0452
Schistosoma mansoni coup transcription factor 0.0042 0.0215 0.0307
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0113 0.147 1
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0037 0.0126 0.075
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0061 0.0545 0.0779
Mycobacterium ulcerans glutaminase 0.0281 0.4438 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0316 0.0712
Trypanosoma cruzi cysteine peptidase, putative 0.0113 0.147 0.4152
Toxoplasma gondii ABC1 family protein 0.0038 0.0139 0.0949
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0077 0.084 0.1892
Echinococcus granulosus ecdysone induced protein 78C 0.0042 0.0215 0.0215
Toxoplasma gondii cathepsin B 0.0075 0.0795 0.5406
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0316 0.0712
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0113 0.147 0.3313
Entamoeba histolytica cysteine proteinase, putative 0.0077 0.084 0.2371
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0042 0.0215 0.0527
Entamoeba histolytica cysteine protease, putative 0.0061 0.0545 0.154
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0113 0.147 0.3313
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0042 0.0215 0.0215
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0048 0.0316 0.0893
Echinococcus granulosus cathepsin b 0.0186 0.276 0.276
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0077 0.084 0.2371
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0316 0.0712
Loa Loa (eye worm) phosphatidylinositol 3 0.0068 0.0672 0.1084
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0048 0.0321 0.0321
Brugia malayi Cathepsin L-like precursor 0.0113 0.147 0.3313
Loa Loa (eye worm) hypothetical protein 0.0186 0.276 0.4454
Entamoeba histolytica cysteine protease, putative 0.0061 0.0545 0.154
Leishmania major trypanothione reductase 0.005 0.0354 0.0703
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.1177 0.1682
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0082 0.0928 0.2091
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0559 0.0975
Brugia malayi photoreceptor-specific nuclear receptor 0.0042 0.0215 0.0484
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0316 0.0712
Onchocerca volvulus 0.0113 0.147 0.3867
Onchocerca volvulus Cathepsin L homolog 0.0113 0.147 0.3867
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0048 0.0316 0.0587
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0113 0.147 0.3313
Schistosoma mansoni thyroid hormone receptor 0.0042 0.0215 0.0307
Entamoeba histolytica cysteine protease, putative 0.0061 0.0545 0.154
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0113 0.147 0.3313
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0215 0.3285 0.9278
Giardia lamblia Cathepsin B precursor 0.0075 0.0795 0.4012
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0113 0.147 0.147
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.054 0.054
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0559 0.1334
Plasmodium vivax vivapain-2 0.0113 0.147 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0042 0.0215 0.0215
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.023 0.3541 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0316 0.0712
Brugia malayi nuclear receptor NHR-88 0.0042 0.0215 0.0484
Loa Loa (eye worm) glutaminase 0.0281 0.4438 0.7161
Echinococcus multilocularis cathepsin L cysteine protease 0.0113 0.147 0.147
Brugia malayi Cathepsin L-like precursor 0.0113 0.147 0.3313
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0172 0.2524 0.2524
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0139 0.0844
Trypanosoma brucei trypanothione reductase 0.005 0.0354 0.2408
Toxoplasma gondii cathepsin CPL 0.0113 0.147 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0215 0.0215
Echinococcus granulosus survival motor neuron protein 1 0.0239 0.3696 0.3696
Schistosoma mansoni hypothetical protein 0.0177 0.2603 0.3719
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.077 0.077
Echinococcus multilocularis cathepsin L 0.0061 0.0545 0.0545
Entamoeba histolytica hypothetical protein 0.0073 0.077 0.2175
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0316 0.0712
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.023 0.3541 0.7979
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0425 0.7 0.7
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0126 0.1704 0.4368
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0316 0.0712
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0374 0.0603
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0048 0.0316 0.0712
Entamoeba histolytica cysteine proteinase, putative 0.0113 0.147 0.4152
Entamoeba histolytica hypothetical protein 0.0073 0.077 0.2175
Brugia malayi Nuclear hormone receptor-like 1 0.0042 0.0215 0.0484
Leishmania major cathepsin L-like protease 0.0113 0.147 0.4143
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0042 0.0215 0.0347
Echinococcus multilocularis cysteine protease 0.0113 0.147 0.147
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0048 0.0316 0.0587
Onchocerca volvulus 0.0113 0.147 0.3867
Onchocerca volvulus 0.0077 0.084 0.2189
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0017 0.0017
Entamoeba histolytica cysteine proteinase, putative 0.0061 0.0545 0.154
Loa Loa (eye worm) hypothetical protein 0.0048 0.0321 0.0518
Loa Loa (eye worm) hypothetical protein 0.0042 0.0215 0.0347
Entamoeba histolytica cysteine proteinase, putative 0.0113 0.147 0.4152
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.0545 0.1229
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0042 0.0215 0.0215
Echinococcus multilocularis survival motor neuron protein 1 0.0239 0.3696 0.3696
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0032 0.0047 0.0318
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0042 0.0215 0.0215
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0113 0.147 0.3313
Loa Loa (eye worm) hypothetical protein 0.0036 0.0105 0.017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0316 0.0712
Schistosoma mansoni thyroid hormone receptor 0.0042 0.0215 0.0307
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0042 0.0215 0.0484
Entamoeba histolytica cysteine proteinase, putative 0.0061 0.0545 0.154
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0042 0.0215 0.0307
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0048 0.0316 0.215
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0139 0.0394
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0048 0.0316 0.0587
Echinococcus granulosus cathepsin l1 0.0113 0.147 0.147
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0037 0.0126 0.018
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0215 0.0215
Schistosoma mansoni retinoic acid receptor RXR 0.0042 0.0215 0.0307
Plasmodium vivax unspecified product 0.0061 0.0545 0.3637
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.0545 0.1229
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0113 0.147 0.3313
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0082 0.0928 0.262
Leishmania major cathepsin L-like protease 0.0113 0.147 0.4143
Plasmodium vivax thioredoxin reductase, putative 0.005 0.0354 0.232
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0152 0.2158 0.2158
Onchocerca volvulus 0.0113 0.147 0.3867
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0316 0.0712
Loa Loa (eye worm) hypothetical protein 0.0039 0.016 0.0258
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0113 0.147 0.3313
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0113 0.147 0.3313
Onchocerca volvulus 0.0049 0.0336 0.0848
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0113 0.147 0.3313
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0316 0.0712
Brugia malayi steroid hormone receptor 0.0042 0.0215 0.0484
Loa Loa (eye worm) glutaminase 2 0.0281 0.4438 0.7161
Loa Loa (eye worm) hypothetical protein 0.0032 0.0047 0.0075
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0037 0.0126 0.0203
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0559 0.0975
Brugia malayi Cathepsin L-like precursor 0.0113 0.147 0.3313
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0316 0.0712
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0048 0.0316 0.0712
Echinococcus granulosus cathepsin L cysteine proteinase 0.0113 0.147 0.147
Entamoeba histolytica cysteine protease, putative 0.0061 0.0545 0.154

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 5.4 Inhibition of cathepsin B ChEMBL. 19515558
IC50 (binding) = 5.4 Inhibition of human liver cathepsin B assessed as inhibition of fluorogenic substrate cleavage ChEMBL. 19616430
IC50 (binding) = 5.6 Inhibition of cathepsin K ChEMBL. 19515558
IC50 (binding) = 5.6 Inhibition of cathepsin K assessed as inhibition of fluorogenic substrate cleavage ChEMBL. 19616430
IC50 (binding) = 6.1 Inhibition of cathepsin S ChEMBL. 19515558
IC50 (binding) = 6.1 Inhibition of cathepsin S assessed as inhibition of fluorogenic substrate cleavage ChEMBL. 19616430
IC50 (binding) = 6.4 Inhibition of cathepsin L2 ChEMBL. 19515558
IC50 (binding) = 6.4 Inhibition of cathepsin L2 assessed as inhibition of fluorogenic substrate cleavage ChEMBL. 19616430
IC50 (binding) = 7.9 Inhibition of cathepsin L ChEMBL. 19515558
IC50 (binding) = 7.9 Inhibition of cathepsin L assessed as inhibition of fluorogenic substrate cleavage ChEMBL. 19616430

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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