Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0021 | 0.0212 | 0.0212 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0038 | 0.1323 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0067 | 0.3208 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0018 | 0 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0062 | 0.283 | 0.8824 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0067 | 0.3208 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0038 | 0.1323 | 0.1328 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.1224 | 0.1224 |
Plasmodium vivax | vivapain-2 | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.3024 | 0.3024 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0038 | 0.1323 | 0.1323 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0021 | 0.0212 | 0.0212 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0021 | 0.0212 | 0.0212 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0038 | 0.1323 | 0.1323 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0067 | 0.3208 | 1 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0065 | 0.3033 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0021 | 0.0212 | 0.0212 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0035 | 0.1123 | 0.1127 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0065 | 0.3033 | 0.3043 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0021 | 0.0212 | 0.0213 |
Echinococcus granulosus | FTZ F1 alpha | 0.0021 | 0.0212 | 0.0212 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0212 | 0.0213 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0038 | 0.1323 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.9469 | 0.9502 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0021 | 0.0212 | 0.0212 |
Echinococcus granulosus | tar DNA binding protein | 0.0064 | 0.3024 | 0.3024 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0021 | 0.0212 | 0.0213 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0172 | 0.9966 | 0.9966 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0065 | 0.3033 | 0.9455 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0064 | 0.3024 | 0.3034 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0021 | 0.0212 | 0.0401 |
Echinococcus multilocularis | tar DNA binding protein | 0.0064 | 0.3024 | 0.3024 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0065 | 0.3033 | 0.3033 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.3024 | 0.3024 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0021 | 0.0212 | 0.0212 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0021 | 0.0212 | 0.0213 |
Schistosoma mansoni | alpha-glucosidase | 0.0148 | 0.8419 | 0.8419 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.1323 | 0.4125 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0021 | 0.0212 | 0.0213 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0021 | 0.0212 | 0.0401 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0021 | 0.0212 | 0.0213 |
Echinococcus multilocularis | muscleblind protein | 0.0164 | 0.9469 | 0.9469 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0164 | 0.9469 | 0.9469 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.1224 | 0.469 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0067 | 0.3208 | 1 |
Echinococcus multilocularis | geminin | 0.0173 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0021 | 0.0212 | 0.0213 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.9469 | 0.9502 |
Entamoeba histolytica | Acid sphingomyelinase-like phosphodiesterase, putative | 0.0058 | 0.261 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0067 | 0.3208 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.1224 | 0.469 |
Leishmania major | cathepsin L-like protease | 0.0067 | 0.3208 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0021 | 0.0212 | 0.0212 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0038 | 0.1323 | 0.4125 |
Brugia malayi | nuclear receptor NHR-88 | 0.0021 | 0.0212 | 0.0213 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0021 | 0.0212 | 0.0213 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0065 | 0.3033 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0067 | 0.3208 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0212 | 0.0213 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0021 | 0.0212 | 0.0213 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0038 | 0.1323 | 0.5069 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0212 | 0.0213 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0067 | 0.3208 | 1 |
Brugia malayi | steroid hormone receptor | 0.0021 | 0.0212 | 0.0213 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0021 | 0.0212 | 0.0212 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0067 | 0.3208 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0038 | 0.1323 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0021 | 0.0212 | 0.0213 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0021 | 0.0212 | 0.0212 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0038 | 0.1323 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0212 | 0.0213 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0035 | 0.1123 | 0.1127 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0067 | 0.3208 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0021 | 0.0212 | 0.0212 |
Plasmodium vivax | vivapain-2 | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0212 | 0.0213 |
Onchocerca volvulus | 0.0021 | 0.0212 | 0.0401 | |
Echinococcus granulosus | muscleblind protein | 0.0164 | 0.9469 | 0.9469 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0172 | 0.9966 | 0.9966 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0172 | 0.9966 | 1 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0172 | 0.9966 | 0.9966 |
Brugia malayi | hypothetical protein | 0.0037 | 0.1224 | 0.1228 |
Schistosoma mansoni | thyroid hormone receptor | 0.0021 | 0.0212 | 0.0212 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0038 | 0.1323 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0021 | 0.0212 | 0.0212 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0038 | 0.1323 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0038 | 0.1323 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0032 | 0.0936 | 0.0936 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0021 | 0.0212 | 0.0213 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0018 | 0 | 0.5 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0053 | 0.2277 | 0.7098 |
Brugia malayi | Muscleblind-like protein | 0.0164 | 0.9469 | 0.9502 |
Leishmania major | cathepsin L-like protease | 0.0067 | 0.3208 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.3024 | 0.3024 |
Entamoeba histolytica | Acid sphingomyelinase-like phosphodiesterase, putative | 0.0058 | 0.261 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0067 | 0.3208 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0212 | 0.0213 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0032 | 0.0936 | 0.094 |
Schistosoma mansoni | alpha-glucosidase | 0.0148 | 0.8419 | 0.8419 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0021 | 0.0212 | 0.0213 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.261 | 0.2619 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.1224 | 0.1224 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0212 | 0.0213 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0021 | 0.0212 | 0.0212 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0021 | 0.0212 | 0.0212 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0021 | 0.0212 | 0.0213 |
Loa Loa (eye worm) | RNA binding protein | 0.0064 | 0.3024 | 0.3034 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0021 | 0.0212 | 0.0212 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0021 | 0.0212 | 0.0213 |
Leishmania major | cathepsin L-like protease | 0.0067 | 0.3208 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0067 | 0.3208 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0021 | 0.0212 | 0.0213 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0021 | 0.0212 | 0.0213 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0021 | 0.0212 | 0.0212 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0067 | 0.3208 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0021 | 0.0212 | 0.0213 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.1224 | 0.469 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0038 | 0.1323 | 0.1328 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.0407 | 0.0407 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0021 | 0.0212 | 0.0212 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0021 | 0.0212 | 0.0212 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0407 | 0.0408 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0021 | 0.0212 | 0.0401 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.3024 | 0.3024 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0056 | 0.2506 | 0.2515 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0032 | 0.0936 | 0.0936 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0021 | 0.0212 | 0.0212 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0038 | 0.1323 | 1 |
Brugia malayi | ecdysteroid receptor | 0.0021 | 0.0212 | 0.0213 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0038 | 0.1323 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0067 | 0.3208 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0032 | 0.0936 | 0.0936 |
Brugia malayi | TAR-binding protein | 0.0064 | 0.3024 | 0.3034 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0032 | 0.0936 | 0.0936 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0065 | 0.3033 | 0.3033 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0067 | 0.3208 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.1323 | 0.4125 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0021 | 0.0212 | 0.0213 |
Onchocerca volvulus | 0.0099 | 0.5283 | 1 | |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0038 | 0.1323 | 0.5069 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0021 | 0.0212 | 0.0212 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0021 | 0.0212 | 0.0212 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0038 | 0.1323 | 1 |
Schistosoma mansoni | alpha glucosidase | 0.0038 | 0.1323 | 0.1323 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0021 | 0.0212 | 0.0213 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0065 | 0.3033 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0064 | 0.3024 | 0.3034 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0021 | 0.0212 | 0.0212 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0021 | 0.0212 | 0.0212 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0032 | 0.0936 | 0.0936 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0021 | 0.0212 | 0.0213 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0032 | 0.0936 | 0.0936 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0021 | 0.0212 | 0.0212 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0032 | 0.0936 | 0.094 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.1224 | 0.1224 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0035 | 0.1123 | 0.1127 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0212 | 0.0213 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1123 | 0.1127 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0021 | 0.0212 | 0.0212 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0021 | 0.0212 | 0.0213 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0021 | 0.0212 | 0.0212 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0065 | 0.3033 | 0.3033 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0021 | 0.0212 | 0.0213 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0172 | 0.9966 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0021 | 0.0212 | 0.0212 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0021 | 0.0212 | 0.0213 |
Brugia malayi | RNA binding protein | 0.0064 | 0.3024 | 0.3034 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0021 | 0.0212 | 0.0212 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0021 | 0.0212 | 0.0213 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.1224 | 0.1224 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0021 | 0.0212 | 0.0213 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0067 | 0.3208 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0024 | 0.0407 | 0.0408 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0021 | 0.0212 | 0.0212 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0021 | 0.0212 | 0.0213 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0032 | 0.0936 | 0.0936 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.1224 | 0.469 |
Schistosoma mansoni | nuclear hormone receptor | 0.0021 | 0.0212 | 0.0212 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0064 | 0.3024 | 0.3034 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.3024 | 0.3024 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 100 mg kg-1 | Anticonvulsant activity in ip dosed albino CF1 mouse seizure model assessed as protection against hind limb extension by MES test | ChEMBL. | 20041718 |
TD50 (ADMET) | > 300 mg kg-1 | Neurological toxicity in ip dosed albino CF1 mouse assessed as neurological impairment by rotarod test | ChEMBL. | 20041718 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.