Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0008 | 0.0045 | 0.0009 |
Brugia malayi | Carboxylesterase family protein | 0.0067 | 0.0759 | 0.1592 |
Echinococcus granulosus | Alpha N acetylgalactosaminidase | 0.0105 | 0.1214 | 0.2088 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.007 | 0.0791 | 0.1597 |
Echinococcus multilocularis | Glycoside hydrolase, family 27 | 0.0105 | 0.1214 | 0.1182 |
Echinococcus granulosus | geminin | 0.0173 | 0.2046 | 0.3561 |
Brugia malayi | hypothetical protein | 0.0027 | 0.0269 | 0.0565 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0759 | 0.1592 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0759 | 0.1592 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0067 | 0.0759 | 0.128 |
Onchocerca volvulus | 0.0067 | 0.0759 | 1 | |
Onchocerca volvulus | 0.0067 | 0.0759 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0759 | 0.1592 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0067 | 0.0759 | 0.9571 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0016 | 0.014 | 0.0148 |
Onchocerca volvulus | 0.0067 | 0.0759 | 1 | |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0033 | 0.0343 | 0.0308 |
Brugia malayi | MH1 domain containing protein | 0.0008 | 0.0045 | 0.0095 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0008 | 0.0045 | 0.0095 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.007 | 0.0791 | 0.1597 |
Echinococcus granulosus | Smad4 | 0.0008 | 0.0045 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.0398 | 0.4763 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0071 | 0.0806 | 0.1693 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0067 | 0.0759 | 0.128 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0759 | 0.1592 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0008 | 0.0045 | 0.0016 |
Loa Loa (eye worm) | carboxylesterase | 0.0398 | 0.4763 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0067 | 0.0759 | 0.1528 |
Brugia malayi | isocitrate dehydrogenase | 0.0016 | 0.014 | 0.0294 |
Trichomonas vaginalis | alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative | 0.007 | 0.0791 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0398 | 0.4763 | 1 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0105 | 0.1214 | 0.2492 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0058 | 0.0646 | 0.4787 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0473 | 0.5679 | 1 |
Schistosoma mansoni | smad | 0.0008 | 0.0045 | 0.0019 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0065 | 0.073 | 0.1467 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0067 | 0.0759 | 0.1528 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.1205 | 0.253 |
Brugia malayi | Carboxylesterase family protein | 0.0067 | 0.0759 | 0.1592 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0016 | 0.014 | 0.0104 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0398 | 0.4763 | 1 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0045 | 0.0019 |
Echinococcus granulosus | acetylcholinesterase | 0.0398 | 0.4763 | 0.8378 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.014 | 0.0104 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0269 | 0.0565 |
Loa Loa (eye worm) | hypothetical protein | 0.0398 | 0.4763 | 1 |
Echinococcus multilocularis | geminin | 0.0173 | 0.2046 | 0.2017 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.014 | 0.0104 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.0806 | 0.1629 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0016 | 0.014 | 0.0148 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0122 | 0.1425 | 0.2991 |
Brugia malayi | MH2 domain containing protein | 0.0008 | 0.0045 | 0.0095 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0008 | 0.0045 | 0.0009 |
Leishmania major | hypothetical protein, conserved | 0.0027 | 0.0269 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0067 | 0.0759 | 0.1592 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0067 | 0.0759 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0027 | 0.0269 | 1 |
Echinococcus multilocularis | smad | 0.0008 | 0.0045 | 0.0009 |
Onchocerca volvulus | 0.0067 | 0.0759 | 1 | |
Toxoplasma gondii | melibiase subfamily protein | 0.0105 | 0.1214 | 1 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0009 | 0.0057 | 0.012 |
Brugia malayi | MH2 domain containing protein | 0.0122 | 0.1425 | 0.2991 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0398 | 0.4763 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0398 | 0.4763 | 1 |
Echinococcus granulosus | neuropeptide s receptor | 0.0473 | 0.5679 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0398 | 0.4763 | 0.4744 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0343 | 0.0649 |
Brugia malayi | Carboxylesterase family protein | 0.0067 | 0.0759 | 0.1592 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0027 | 0.0269 | 0.1333 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.2046 | 0.425 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0027 | 0.0269 | 1 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0016 | 0.014 | 0.022 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0012 | 0.009 | 0.0095 |
Echinococcus granulosus | cpg binding protein | 0.0032 | 0.0336 | 0.0531 |
Loa Loa (eye worm) | carboxylesterase | 0.0067 | 0.0759 | 0.1592 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0067 | 0.0759 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0398 | 0.4763 | 0.4744 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0045 | 0.0019 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0067 | 0.0759 | 0.0725 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0033 | 0.0343 | 0.0308 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0067 | 0.0759 | 0.1528 |
Brugia malayi | MH2 domain containing protein | 0.0008 | 0.0045 | 0.0095 |
Echinococcus granulosus | carboxylesterase 5A | 0.0398 | 0.4763 | 0.8378 |
Echinococcus granulosus | GPCR family 2 | 0.0033 | 0.0343 | 0.0544 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0015 | 0.0124 | 0.0186 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0008 | 0.0045 | 0.0016 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0059 | 0.004 |
Brugia malayi | hypothetical protein | 0.0017 | 0.0154 | 0.0323 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0059 | 0.0023 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0067 | 0.0759 | 0.0725 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0067 | 0.0759 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0104 | 0.1205 | 0.253 |
Echinococcus granulosus | neuroligin | 0.0067 | 0.0759 | 0.128 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0105 | 0.1214 | 0.2492 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0033 | 0.0343 | 0.0721 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.014 | 0.0104 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0016 | 0.014 | 0.0104 |
Echinococcus granulosus | smad | 0.0008 | 0.0045 | 0.0016 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0122 | 0.1425 | 0.2991 |
Loa Loa (eye worm) | carboxylesterase | 0.0067 | 0.0759 | 0.1592 |
Schistosoma mansoni | Smad4 | 0.0008 | 0.0045 | 0.0019 |
Echinococcus multilocularis | Alpha N acetylgalactosaminidase | 0.0105 | 0.1214 | 0.1182 |
Brugia malayi | MH1 domain containing protein | 0.0008 | 0.0045 | 0.0095 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0104 | 0.1205 | 0.253 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0473 | 0.5679 | 0.5663 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0033 | 0.0343 | 0.0544 |
Brugia malayi | CXXC zinc finger family protein | 0.0031 | 0.0315 | 0.066 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.014 | 0.0184 |
Brugia malayi | hypothetical protein | 0.0067 | 0.0759 | 0.1592 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0759 | 0.1592 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0067 | 0.0759 | 0.0725 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0067 | 0.0759 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.0315 | 0.0589 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0033 | 0.0343 | 0.0544 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0791 | 0.1661 |
Brugia malayi | Melibiase family protein | 0.007 | 0.0791 | 0.1661 |
Echinococcus multilocularis | cpg binding protein | 0.0032 | 0.0336 | 0.0301 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0067 | 0.0759 | 0.1528 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0759 | 0.1592 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0012 | 0.009 | 0.0054 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0105 | 0.1214 | 0.2492 |
Schistosoma mansoni | gliotactin | 0.0067 | 0.0759 | 0.1528 |
Brugia malayi | Isocitrate dehydrogenase | 0.0016 | 0.014 | 0.0294 |
Schistosoma mansoni | acetylcholinesterase | 0.0067 | 0.0759 | 0.1528 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0473 | 0.5679 | 0.5663 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0067 | 0.0759 | 0.128 |
Schistosoma mansoni | hypothetical protein | 0.0012 | 0.009 | 0.0114 |
Loa Loa (eye worm) | Smad1 | 0.0008 | 0.0045 | 0.0095 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0104 | 0.1205 | 0.253 |
Echinococcus multilocularis | neuroligin | 0.0067 | 0.0759 | 0.0725 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.2046 | 0.425 |
Onchocerca volvulus | 0.0067 | 0.0759 | 1 | |
Echinococcus granulosus | acetylcholinesterase | 0.0398 | 0.4763 | 0.8378 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0343 | 0.0649 |
Schistosoma mansoni | cpg binding protein | 0.0032 | 0.0336 | 0.0634 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.0269 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0033 | 0.0343 | 0.0308 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0343 | 0.0649 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.0269 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0343 | 0.0649 |
Brugia malayi | Smad1 | 0.0008 | 0.0045 | 0.0095 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0008 | 0.0045 | 0.0019 |
Schistosoma mansoni | cpg binding protein | 0.0032 | 0.0336 | 0.0634 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.0269 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0398 | 0.4763 | 0.4744 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0016 | 0.014 | 0.0294 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0759 | 0.1592 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0806 | 0.1693 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0008 | 0.0045 | 0.0095 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0033 | 0.0343 | 0.0721 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0033 | 0.0343 | 0.0721 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0067 | 0.0759 | 0.9571 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0045 | 0.0019 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0067 | 0.0759 | 0.1528 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0031 | 0.0315 | 0.066 |
Loa Loa (eye worm) | histone methyltransferase | 0.0009 | 0.0059 | 0.0123 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0343 | 0.0721 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.0269 | 1 |
Echinococcus multilocularis | Smad4 | 0.0008 | 0.0045 | 0.0009 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0105 | 0.1214 | 0.2492 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.