Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 1 | 1 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0019 | 0.3639 | 0.5 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0019 | 0.3639 | 0.5 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.0019 | 0.3639 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 1 | 1 |
Plasmodium falciparum | ATP-dependent DNA helicase Q1 | 0.0019 | 0.3639 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 1 | 1 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.001 | 0.0139 | 0.0139 |
Loa Loa (eye worm) | RecQ helicase | 0.0019 | 0.3639 | 1 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.0019 | 0.3639 | 1 |
Entamoeba histolytica | recQ family helicase, putative | 0.0019 | 0.3639 | 0.3639 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.3639 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 1 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 1 | 1 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0019 | 0.3639 | 0.5 |
Entamoeba histolytica | recQ family DNA helicase | 0.001 | 0.0139 | 0.0139 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 1 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0019 | 0.3639 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 1 | 1 |
Schistosoma mansoni | DNA helicase recq1 | 0.0019 | 0.3639 | 0.3639 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0019 | 0.3639 | 0.5 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0019 | 0.3639 | 1 |
Treponema pallidum | ATP-dependent DNA helicase | 0.001 | 0.0139 | 0.5 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0019 | 0.3639 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0139 | 0.00000000841 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 1 | 1 |
Schistosoma mansoni | DNA helicase recq5 | 0.0019 | 0.3639 | 0.3639 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.001 | 0.0139 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0019 | 0.3639 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.0139 | 0.0381 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0019 | 0.3639 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 25.1189 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.