Detailed information for compound 1063966

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 442.415 | Formula: C23H22O9
  • H donors: 0 H acceptors: 3 LogP: 2.56 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)C(=O)O[C@@H]1CO[C@H]2[C@@H]1OC[C@@H]2OC(=O)c1ccccc1OC(=O)C
  • InChi: 1S/C23H22O9/c1-13(24)30-17-9-4-3-8-16(17)23(26)32-19-12-29-20-18(11-28-21(19)20)31-22(25)14-6-5-7-15(10-14)27-2/h3-10,18-21H,11-12H2,1-2H3/t18-,19+,20-,21-/m1/s1
  • InChiKey: PMAKABJLYQONLX-PLACYPQZSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0017 0.0062
Schistosoma mansoni hypothetical protein 0.005 0.019 0.046
Loa Loa (eye worm) hypothetical protein 0.0031 0.0085 0.0314
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0 0.0001
Brugia malayi Carboxylesterase family protein 0.0083 0.038 0.1405
Brugia malayi hypothetical protein 0.0026 0.0055 0.0205
Brugia malayi nuclear receptor RXR 0.0017 0.0001 0.0005
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0188 0.0694
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0026 0.0052 0.0126
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0085 0.0031
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.1381 0.7734 0.7734
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0258 0.0625
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0077 0.0284
Brugia malayi Bromodomain containing protein 0.003 0.0077 0.0284
Trichomonas vaginalis set domain proteins, putative 0.0491 0.2691 1
Chlamydia trachomatis replicative DNA helicase 0.04 0.2174 0.5
Schistosoma mansoni survival motor neuron protein 0.005 0.019 0.046
Schistosoma mansoni jumonji domain containing protein 0.0078 0.0348 0.0842
Brugia malayi Pre-SET motif family protein 0.0062 0.0258 0.0955
Onchocerca volvulus 0.0491 0.2691 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0085 0.0314
Brugia malayi hypothetical protein 0.0017 0.0001 0.0005
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0085 0.0205
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0077 0.2963
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0017 0.0097
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0055 0.0327
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0062 0.0258 0.0625
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0017 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0031 0.0085 0.0314
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0188 0.0454
Echinococcus granulosus neuroligin 0.0083 0.038 0.0919
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0112 0.0539 0.1304
Brugia malayi hypothetical protein 0.0017 0.0001 0.0005
Brugia malayi MH2 domain containing protein 0.0026 0.0052 0.0193
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0085 0.0205
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0 0.0001
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.04 0.2174 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0085 0.0205
Loa Loa (eye worm) Smad1 0.0026 0.0052 0.0193
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0085 0.0205
Loa Loa (eye worm) hypothetical protein 0.0062 0.0258 0.0955
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0085 0.0314
Brugia malayi MH2 domain containing protein 0.0375 0.2033 0.7518
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0085 0.0314
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0085 0.0314
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0085 0.0314
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0017 0.0041
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0085 0.0314
Loa Loa (eye worm) hypothetical protein 0.0083 0.038 0.1405
Schistosoma mansoni microtubule-associated protein tau 0.0746 0.4135 1
Toxoplasma gondii hypothetical protein 0.005 0.0193 0.7475
Brugia malayi nuclear hormone receptor 0.0031 0.0085 0.0314
Brugia malayi nuclear receptor NHR-88 0.0031 0.0085 0.0314
Loa Loa (eye worm) hypothetical protein 0.0031 0.0085 0.0314
Schistosoma mansoni gliotactin 0.0083 0.038 0.0919
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0077 0.0186
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0085 0.0205
Echinococcus granulosus histone lysine methyltransferase setb 0.0062 0.0258 0.0625
Loa Loa (eye worm) hypothetical protein 0.0052 0.02 0.0739
Loa Loa (eye worm) MH2 domain-containing protein 0.0375 0.2033 0.7518
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0313 0.1679 1
Schistosoma mansoni smad1 5 8 and 0.0026 0.0052 0.0126
Mycobacterium tuberculosis Carboxylesterase LipT 0.0083 0.038 0.038
Brugia malayi Carboxylesterase family protein 0.0083 0.038 0.1405
Loa Loa (eye worm) hypothetical protein 0.0026 0.0055 0.0205
Entamoeba histolytica hypothetical protein 0.0112 0.0539 1
Schistosoma mansoni acetylcholinesterase 0.0083 0.038 0.0919
Brugia malayi MH1 domain containing protein 0.0026 0.0052 0.0193
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.02 0.0739
Plasmodium vivax SET domain protein, putative 0.0062 0.0258 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.019 0.0704
Schistosoma mansoni Replicative DNA helicase 0.04 0.2174 0.5257
Loa Loa (eye worm) hypothetical protein 0.0017 0.0001 0.0005
Onchocerca volvulus 0.0062 0.0258 0.0694
Loa Loa (eye worm) hypothetical protein 0.0083 0.038 0.1405
Loa Loa (eye worm) hypothetical protein 0.0083 0.038 0.1405
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0017 0.0631
Echinococcus granulosus Smad4 0.0026 0.0052 0.0126
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0113 0.0416
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0085 0.0314
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0085 0.0205
Echinococcus granulosus neuropeptide s receptor 0.048 0.2629 0.6358
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0085 0.0314
Loa Loa (eye worm) hypothetical protein 0.0494 0.2704 1
Mycobacterium ulcerans replicative DNA helicase DnaB 0.04 0.2174 1
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0083 0.038 0.0919
Brugia malayi ecdysteroid receptor 0.0031 0.0085 0.0314
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0085 0.0314
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0085 0.0314
Loa Loa (eye worm) hypothetical protein 0.0494 0.2704 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0 0.0001
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0085 0.0205
Mycobacterium tuberculosis Conserved hypothetical protein 0.0165 0.084 0.084
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0188 0.0454
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0085 0.0205
Echinococcus multilocularis carboxylesterase 5A 0.0494 0.2704 0.6538
Echinococcus multilocularis BC026374 protein (S09 family) 0.0083 0.038 0.0919
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0085 0.0205
Echinococcus granulosus survival motor neuron protein 1 0.0245 0.1294 0.313
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0188 0.0454
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0055 0.0327
Onchocerca volvulus 0.0031 0.0085 0.0031
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0313 0.1679 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0001 0.0003
Brugia malayi hypothetical protein 0.0083 0.038 0.1405
Loa Loa (eye worm) hypothetical protein 0.0083 0.038 0.1405
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0083 0.038 0.0919
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0113 0.0272
Leishmania major hypothetical protein, conserved 0.0026 0.0055 0.0327
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0085 0.0205
Brugia malayi steroid hormone receptor 0.0031 0.0085 0.0314
Onchocerca volvulus 0.0083 0.038 0.116
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0157 0.093
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0055 0.7178
Loa Loa (eye worm) hypothetical protein 0.0031 0.0085 0.0314
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0017 0.0097
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0085 0.0314
Entamoeba histolytica hypothetical protein 0.0112 0.0539 1
Treponema pallidum replicative DNA helicase (dnaB) 0.04 0.2174 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.02 0.0739
Mycobacterium ulcerans hypothetical protein 0.0165 0.084 0.3819
Toxoplasma gondii exonuclease III APE 0.0019 0.0017 0.0631
Echinococcus granulosus TGF beta signal transducer SmadC 0.0026 0.0052 0.0126
Schistosoma mansoni neuroligin 3 (S09 family) 0.0083 0.038 0.0919
Brugia malayi MH2 domain containing protein 0.0026 0.0052 0.0193
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0098 0.0462 0.1118
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0185 0.0956 0.3364
Brugia malayi MH1 domain containing protein 0.0026 0.0052 0.0193
Onchocerca volvulus 0.0083 0.038 0.116
Loa Loa (eye worm) carboxylesterase 0.0083 0.038 0.1405
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0 0.0001
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0077 0.0186
Echinococcus granulosus microtubule associated protein 2 0.0746 0.4135 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0085 0.0205
Echinococcus multilocularis Smad4 0.0026 0.0052 0.0126
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0083 0.038 0.0919
Loa Loa (eye worm) hypothetical protein 0.0035 0.0107 0.0397
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0085 0.0205
Brugia malayi hypothetical protein 0.0112 0.0539 0.1994
Brugia malayi Carboxylesterase family protein 0.0494 0.2704 1
Onchocerca volvulus 0.0083 0.038 0.116
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0085 0.0314
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0085 0.0314
Echinococcus granulosus mothers against decapentaplegic 5 0.0026 0.0052 0.0126
Brugia malayi Pre-SET motif family protein 0.0432 0.2353 0.8703
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0085 0.0205
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0148 0.0746 0.4441
Schistosoma mansoni coup transcription factor 0.0031 0.0085 0.0205
Echinococcus granulosus geminin 0.0174 0.0892 0.2157
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0258 0.0625
Schistosoma mansoni smad1 5 8 and 0.0026 0.0052 0.0126
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0077 0.2963
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0157 0.093
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0188 0.0454
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0085 0.0314
Echinococcus granulosus acetylcholinesterase 0.0494 0.2704 0.6538
Loa Loa (eye worm) carboxylesterase 0.0083 0.038 0.1405
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0085 0.0314
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0085 0.0205
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0026 0.0052 0.0126
Mycobacterium ulcerans carboxylesterase, LipT 0.0083 0.038 0.1684
Loa Loa (eye worm) twinkle helicase 0.0114 0.0555 0.2053
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0055 0.2127
Echinococcus multilocularis acetylcholinesterase 0.0494 0.2704 0.6538
Echinococcus multilocularis neuropeptide s receptor 0.048 0.2629 0.6358
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0085 0.0205
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0017 0.0097
Loa Loa (eye worm) hypothetical protein 0.0031 0.0085 0.0314
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0143 0.0346
Schistosoma mansoni hypothetical protein 0.0174 0.0892 0.2157
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0062 0.0258 1
Plasmodium falciparum phd finger protein, putative 0.003 0.0077 1
Schistosoma mansoni hypothetical protein 0.0174 0.0892 0.2157
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0062 0.0258 0.0625
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0001 0.0005
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0054 0.0211 0.1255
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0313 0.1679 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0077 0.0186
Brugia malayi hypothetical protein 0.0245 0.1294 0.4787
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0085 0.0314
Schistosoma mansoni hypothetical protein 0.0035 0.0107 0.026
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0085 0.0205
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0 0.0001
Schistosoma mansoni Smad4 0.0026 0.0052 0.0126
Echinococcus multilocularis peregrin 0.003 0.0077 0.0186
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0 0.0001
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0143 0.0346
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0258 0.0625
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0085 0.0314
Onchocerca volvulus 0.005 0.019 0.0434
Plasmodium vivax hypothetical protein, conserved 0.003 0.0077 0.2963
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0188 0.0454
Entamoeba histolytica hypothetical protein 0.0112 0.0539 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0085 0.0205
Onchocerca volvulus 0.0083 0.038 0.116
Brugia malayi isocitrate dehydrogenase 0.0016 0 0.0002
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0083 0.038 0.038
Schistosoma mansoni ap endonuclease 0.0019 0.0017 0.0041
Loa Loa (eye worm) hypothetical protein 0.003 0.0077 0.0284
Trichomonas vaginalis spcc417.12 protein, putative 0.0083 0.038 0.1358
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0001 0.0005
Echinococcus multilocularis survival motor neuron protein 1 0.0245 0.1294 0.313
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0017 0.0097
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0085 0.0314
Echinococcus granulosus carboxylesterase 5A 0.0494 0.2704 0.6538
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0017 0.0041
Entamoeba histolytica hypothetical protein 0.0112 0.0539 1
Echinococcus granulosus para nitrobenzyl esterase 0.0083 0.038 0.0919
Echinococcus granulosus BC026374 protein S09 family 0.0083 0.038 0.0919
Echinococcus granulosus peregrin 0.003 0.0077 0.0186
Loa Loa (eye worm) hypothetical protein 0.0017 0.0001 0.0005
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0107 0.0397
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0085 0.0205
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0085 0.0314
Loa Loa (eye worm) acetylcholinesterase 1 0.0494 0.2704 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0085 0.0031
Loa Loa (eye worm) hypothetical protein 0.0245 0.1294 0.4787
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0494 0.2704 0.6538
Mycobacterium leprae Conserved hypothetical protein 0.0524 0.2877 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0085 0.0205
Loa Loa (eye worm) hypothetical protein 0.0017 0.0001 0.0005
Schistosoma mansoni hypothetical protein 0.0112 0.0539 0.1304
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0055 0.7178
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0157 0.093
Loa Loa (eye worm) hypothetical protein 0.0051 0.0198 0.0732
Brugia malayi Smad1 0.0026 0.0052 0.0193
Loa Loa (eye worm) MH1 domain-containing protein 0.0026 0.0052 0.0193
Echinococcus granulosus smad 0.0026 0.0052 0.0126
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0085 0.0314
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0085 0.0205
Loa Loa (eye worm) hypothetical protein 0.0031 0.0085 0.0314
Loa Loa (eye worm) transcription factor SMAD2 0.0375 0.2033 0.7518
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0085 0.0205
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0432 0.2353 0.8703
Loa Loa (eye worm) hypothetical protein 0.0083 0.038 0.1405
Giardia lamblia PHD finger protein 15 0.003 0.0077 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0017 0.0001 0.0005
Brugia malayi jmjC domain containing protein 0.0036 0.0113 0.0416
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0148 0.0746 0.4441
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0085 0.0031
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0055 0.0327
Echinococcus multilocularis neuroligin 0.0083 0.038 0.0919
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0083 0.038 0.0919
Schistosoma mansoni ap endonuclease 0.0019 0.0017 0.0041
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.02 0.0739
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0085 0.0314
Schistosoma mansoni transcription factor LCR-F1 0.0112 0.0539 0.1304
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0148 0.0746 0.4441
Brugia malayi Carboxylesterase family protein 0.0083 0.038 0.1405
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0085 0.0205
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.0245 0.0593
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0085 0.0314
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0083 0.038 0.1358
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0188 0.0694
Echinococcus multilocularis smad 0.0026 0.0052 0.0126
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0257 0.0951
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0083 0.038 0.038
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0017 0.213
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0113 0.0272
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0113 0.0272
Echinococcus multilocularis acetylcholinesterase 0.0494 0.2704 0.6538
Loa Loa (eye worm) hypothetical protein 0.0083 0.038 0.1405
Brugia malayi Isocitrate dehydrogenase 0.0016 0 0.0002
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0085 0.0205
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0017 0.0062
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0 0.0002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0085 0.0314
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0017 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0085 0.0314
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.0157 0.093
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0085 0.0205
Brugia malayi jmjC domain containing protein 0.0098 0.0462 0.171
Brugia malayi N-terminal motif family protein 0.0185 0.0956 0.3537
Echinococcus multilocularis para nitrobenzyl esterase 0.0083 0.038 0.0919
Onchocerca volvulus 0.0083 0.038 0.116
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0085 0.0205
Echinococcus multilocularis mothers against decapentaplegic 5 0.0026 0.0052 0.0126
Schistosoma mansoni smad 0.0026 0.0052 0.0126
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0055 0.2127
Loa Loa (eye worm) hypothetical protein 0.0185 0.0956 0.3537
Brugia malayi Carboxylesterase family protein 0.0494 0.2704 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.038 0.1405
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0062 0.0258 0.0625
Loa Loa (eye worm) hypothetical protein 0.0017 0.0001 0.0005
Echinococcus multilocularis neuropeptide receptor A26 0.048 0.2629 0.6358
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0188 0.0454
Loa Loa (eye worm) carboxylesterase 0.0494 0.2704 1
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0085 0.0205
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0083 0.038 0.0919
Leishmania major mitochondrial DNA polymerase beta 0.0313 0.1679 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0017 0.0001 0.0003
Brugia malayi hypothetical protein 0.0017 0.0003 0.0011
Echinococcus granulosus neuropeptide receptor A26 0.048 0.2629 0.6358
Schistosoma mansoni hypothetical protein 0.003 0.0077 0.0186
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0085 0.0205
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0113 0.0272
Loa Loa (eye worm) MH2 domain-containing protein 0.0026 0.0052 0.0193
Schistosoma mansoni smad1 5 8 and 0.0026 0.0052 0.0126
Loa Loa (eye worm) hypothetical protein 0.0017 0.0001 0.0005
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0085 0.0205
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0085 0.0205
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0188 0.0454
Loa Loa (eye worm) hypothetical protein 0.0031 0.0085 0.0314
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0098 0.0462 0.1118
Echinococcus multilocularis geminin 0.0174 0.0892 0.2157
Echinococcus granulosus acetylcholinesterase 0.0494 0.2704 0.6538
Brugia malayi PHD-finger family protein 0.003 0.0077 0.0284
Schistosoma mansoni BC026374 protein (S09 family) 0.0083 0.038 0.0919
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0017 0.0001 0.0003
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0112 0.0539 0.1304
Echinococcus multilocularis microtubule associated protein 2 0.0746 0.4135 1
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0085 0.0314
Brugia malayi Carboxylesterase family protein 0.0083 0.038 0.1405
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0085 0.0205

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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