Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | carboxylesterase 5A | 0.0627 | 0.9296 | 0.9296 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0106 | 0.0981 | 0.0981 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0106 | 0.0981 | 0.0981 |
Brugia malayi | Carboxylesterase family protein | 0.0627 | 0.9296 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0106 | 0.0981 | 0.1055 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.1143 | 0.123 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0106 | 0.0981 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.0981 | 0.1055 |
Echinococcus granulosus | neuroligin | 0.0106 | 0.0981 | 0.0981 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0106 | 0.0981 | 0.0981 |
Brugia malayi | Carboxylesterase family protein | 0.0106 | 0.0981 | 0.1055 |
Loa Loa (eye worm) | hypothetical protein | 0.0627 | 0.9296 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.0981 | 0.1055 |
Loa Loa (eye worm) | hypothetical protein | 0.0627 | 0.9296 | 1 |
Onchocerca volvulus | 0.0106 | 0.0981 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.0106 | 0.0981 | 0.1055 |
Onchocerca volvulus | 0.0106 | 0.0981 | 0.5 | |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0671 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0106 | 0.0981 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0627 | 0.9296 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0627 | 0.9296 | 0.9296 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0106 | 0.0981 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0627 | 0.9296 | 0.9296 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.0981 | 0.1055 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0627 | 0.9296 | 1 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0106 | 0.0981 | 0.0981 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0106 | 0.0981 | 0.5 |
Onchocerca volvulus | 0.0106 | 0.0981 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.0981 | 0.1055 |
Brugia malayi | Carboxylesterase family protein | 0.0106 | 0.0981 | 0.1055 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.0981 | 0.1055 |
Brugia malayi | hypothetical protein | 0.0106 | 0.0981 | 0.1055 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0627 | 0.9296 | 0.9296 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.0981 | 0.1055 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.1143 | 0.123 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0671 | 1 | 1 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0106 | 0.0981 | 0.0981 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0106 | 0.0981 | 0.0981 |
Loa Loa (eye worm) | carboxylesterase | 0.0106 | 0.0981 | 0.1055 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0106 | 0.0981 | 0.0981 |
Loa Loa (eye worm) | carboxylesterase | 0.0627 | 0.9296 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0627 | 0.9296 | 0.9296 |
Schistosoma mansoni | gliotactin | 0.0106 | 0.0981 | 0.0981 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0106 | 0.0981 | 0.0981 |
Brugia malayi | Carboxylesterase family protein | 0.0106 | 0.0981 | 0.1055 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0106 | 0.0981 | 0.0981 |
Echinococcus multilocularis | acetylcholinesterase | 0.0627 | 0.9296 | 0.9296 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0106 | 0.0981 | 0.0981 |
Echinococcus multilocularis | acetylcholinesterase | 0.0627 | 0.9296 | 0.9296 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.1143 | 0.123 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0106 | 0.0981 | 0.0981 |
Echinococcus multilocularis | neuroligin | 0.0106 | 0.0981 | 0.0981 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.0981 | 0.1055 |
Onchocerca volvulus | 0.0106 | 0.0981 | 0.5 | |
Onchocerca volvulus | 0.0106 | 0.0981 | 0.5 | |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0106 | 0.0981 | 0.5 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0106 | 0.0981 | 0.5 |
Schistosoma mansoni | acetylcholinesterase | 0.0106 | 0.0981 | 0.0981 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 63.0957 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.