Detailed information for compound 1064080

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 290.311 | Formula: C16H18O5
  • H donors: 1 H acceptors: 2 LogP: 1.71 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCO[C@H]1c2c(ccc3c2oc(=O)cc3)OC([C@H]1O)(C)C
  • InChi: 1S/C16H18O5/c1-4-19-14-12-10(21-16(2,3)15(14)18)7-5-9-6-8-11(17)20-13(9)12/h5-8,14-15,18H,4H2,1-3H3/t14-,15-/m0/s1
  • InChiKey: UCLKQWHJVUDTFJ-GJZGRUSLSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus multilocularis thyroid hormone receptor alpha 0.0162 0.0269 0.0261
Schistosoma mansoni hypothetical protein 0.0047 0.0033 0.0033
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0068 0.0075 0.129
Echinococcus granulosus cytoplasmic intermediate filament protein 0.008 0.0099 0.0096
Trichomonas vaginalis D-aminoacylase, putative 0.0221 0.039 0.3385
Schistosoma mansoni hypothetical protein 0.0231 0.041 0.041
Loa Loa (eye worm) hypothetical protein 0.0221 0.039 0.0379
Toxoplasma gondii histone lysine methyltransferase SET1 0.0237 0.0424 0.9001
Brugia malayi hypothetical protein 0.0147 0.0238 0.0499
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0068 0.0075 0.129
Leishmania major cathepsin L-like protease 0.0063 0.0065 0.1117
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0131 0.0205 0.0203
Loa Loa (eye worm) transcription factor SMAD2 0.2024 0.4103 0.4096
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0314 0.0582 1
Brugia malayi jmjC domain containing protein 0.0038 0.0014 0.0008
Echinococcus granulosus lamin 0.0165 0.0275 0.0272
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0797 0.1577 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0014 0.0002
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0068 0.0075 0.0304
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0056 0.0051 0.0812
Loa Loa (eye worm) hypothetical protein 0.0147 0.0238 0.0226
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0231 0.041 0.0403
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.026 0.047 0.8073
Echinococcus multilocularis thioredoxin glutathione reductase 0.0196 0.0339 0.0332
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0044 0.0025 0.0248
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0068 0.0075 0.129
Plasmodium falciparum glutathione reductase 0.0196 0.0339 0.7133
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0172 0.029 0.2488
Entamoeba histolytica hypothetical protein 0.0421 0.0803 1
Echinococcus multilocularis zinc finger protein 0.0058 0.0055 0.0048
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0065 0.1117
Schistosoma mansoni aminopeptidase A (M01 family) 0.026 0.047 0.047
Echinococcus multilocularis expressed protein 0.0045 0.0028 0.0021
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0056 0.0051 0.0331
Mycobacterium leprae Probable lipase LipE 0.0221 0.039 0.2339
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0231 0.041 0.0403
Mycobacterium tuberculosis Probable reductase 0.0447 0.0857 0.2943
Echinococcus multilocularis dnaJ subfamily B 0.1252 0.2515 0.2509
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0038 0.0014 0.0241
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0497 0.096 0.3308
Toxoplasma gondii PHD-finger domain-containing protein 0.0119 0.018 0.3683
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0056 0.0051 0.0877
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0068 0.0075 0.1409
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0119 0.018 0.018
Brugia malayi MH1 domain containing protein 0.0076 0.0092 0.018
Schistosoma mansoni jumonji domain containing protein 0.0038 0.0014 0.0014
Trichomonas vaginalis set domain proteins, putative 0.0273 0.0496 0.4333
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0065 0.1117
Loa Loa (eye worm) hypothetical protein 0.0231 0.041 0.0399
Brugia malayi beta-lactamase family protein 0.0221 0.039 0.0835
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0172 0.029 0.3406
Leishmania major GTP-binding protein, putative 0.0044 0.0025 0.0435
Brugia malayi jmjC domain containing protein 0.0038 0.0014 0.0008
Echinococcus multilocularis JmjC domain containing protein 4 0.0038 0.0014 0.0007
Schistosoma mansoni ferritin light chain 0.0045 0.0028 0.0028
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.026 0.047 0.0463
Echinococcus multilocularis lysine specific demethylase 6a 0.0038 0.0014 0.0007
Treponema pallidum fructose-bisphosphate aldolase 0.0172 0.029 1
Loa Loa (eye worm) hypothetical protein 0.0221 0.039 0.0379
Trypanosoma cruzi PAB1-binding protein , putative 0.0106 0.0152 0.2619
Schistosoma mansoni ets-related 0.0225 0.0398 0.0398
Loa Loa (eye worm) hypothetical protein 0.0221 0.039 0.0379
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0065 0.1117
Toxoplasma gondii aminopeptidase N, putative 0.026 0.047 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0376 0.071 0.0708
Trypanosoma cruzi trypanothione reductase, putative 0.0068 0.0075 0.129
Mycobacterium tuberculosis Conserved protein 0.0221 0.039 0.1287
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.0026 0.0447
Brugia malayi PHD-finger family protein 0.0119 0.018 0.0372
Echinococcus granulosus mothers against decapentaplegic 6 0.0062 0.0062 0.0059
Brugia malayi hypothetical protein 0.2247 0.4562 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0154 0.0253 0.0253
Echinococcus multilocularis mothers against decapentaplegic 2 0.0062 0.0062 0.0055
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0039 0.0015 0.0258
Onchocerca volvulus 0.0221 0.039 0.5576
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0138 0.0219 0.0219
Brugia malayi RNA, U transporter 1 0.0169 0.0284 0.0601
Schistosoma mansoni hypothetical protein 0.0231 0.041 0.041
Echinococcus granulosus histone lysine methyltransferase setb 0.0072 0.0083 0.008
Schistosoma mansoni microtubule-associated protein tau 0.2239 0.4547 0.4547
Mycobacterium tuberculosis Conserved protein 0.0221 0.039 0.1287
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0044 0.0025 0.0435
Schistosoma mansoni hypothetical protein 0.0231 0.041 0.041
Trypanosoma brucei hypothetical protein, conserved 0.0221 0.039 0.6709
Echinococcus granulosus lysine specific demethylase 5A 0.0154 0.0253 0.025
Schistosoma mansoni tar DNA-binding protein 0.0266 0.0484 0.0484
Brugia malayi beta-lactamase family protein 0.0221 0.039 0.0835
Trichomonas vaginalis glutaminase, putative 0.058 0.113 1
Onchocerca volvulus 0.0147 0.0238 0.3316
Echinococcus granulosus TGF beta signal transducer SmadC 0.0138 0.0219 0.0217
Echinococcus granulosus mothers against decapentaplegic 2 0.0062 0.0062 0.0059
Plasmodium falciparum M1-family alanyl aminopeptidase 0.026 0.047 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0014 0.0002
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0221 0.039 0.039
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0068 0.0075 0.5
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1412 0.2844 1
Echinococcus multilocularis muscleblind protein 0.015 0.0244 0.0237
Brugia malayi MH2 domain containing protein 0.2024 0.4103 0.8991
Plasmodium falciparum thioredoxin reductase 0.0196 0.0339 0.7133
Loa Loa (eye worm) MH1 domain-containing protein 0.0062 0.0062 0.005
Schistosoma mansoni tar DNA-binding protein 0.0266 0.0484 0.0484
Onchocerca volvulus 0.0165 0.0275 0.3863
Echinococcus granulosus beta LACTamase domain containing family member 0.0221 0.039 0.0388
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.3412 0.6962 0.696
Schistosoma mansoni smad 0.0138 0.0219 0.0219
Brugia malayi MH1 domain containing protein 0.0138 0.0219 0.0458
Schistosoma mansoni smad1 5 8 and 0.0138 0.0219 0.0219
Brugia malayi hypothetical protein 0.0068 0.0075 0.0143
Loa Loa (eye worm) hypothetical protein 0.015 0.0244 0.0233
Brugia malayi jmjC domain containing protein 0.0038 0.0014 0.0008
Schistosoma mansoni ap endonuclease 0.0056 0.0051 0.0051
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.026 0.047 0.8073
Echinococcus multilocularis GPCR, family 2 0.0231 0.041 0.0403
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0056 0.0051 0.0971
Schistosoma mansoni hypothetical protein 0.069 0.1357 0.1357
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.005 0.0038 0.0061
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0065 0.1117
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0053 0.0044 0.0037
Schistosoma mansoni tar DNA-binding protein 0.0266 0.0484 0.0484
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.026 0.047 0.8073
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0074 0.0088 0.0085
Echinococcus granulosus microtubule associated protein 2 0.2239 0.4547 0.4545
Mycobacterium ulcerans hypothetical protein 0.0165 0.0276 0.1599
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.024 0.0429 0.0418
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0389 0.0736 0.0734
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0065 0.1117
Schistosoma mansoni hypothetical protein 0.0131 0.0205 0.0205
Echinococcus granulosus GPCR family 2 0.0231 0.041 0.0408
Echinococcus granulosus histone acetyltransferase KAT2B 0.0142 0.0227 0.0225
Trypanosoma brucei importin beta-1 subunit, putative 0.006 0.0058 0.0992
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0014 0.0002
Brugia malayi mothers against decapentaplegic homolog 3 0.0062 0.0062 0.0113
Loa Loa (eye worm) hypothetical protein 0.0079 0.0098 0.0086
Schistosoma mansoni ferritin 0.0045 0.0028 0.0028
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0231 0.041 0.0408
Trichomonas vaginalis D-aminoacylase, putative 0.0221 0.039 0.3385
Brugia malayi Heterochromatin protein 1 0.0068 0.0075 0.0142
Loa Loa (eye worm) hypothetical protein 0.0062 0.0062 0.005
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0729 0.1436 0.1426
Echinococcus multilocularis jumonji domain containing protein 0.0165 0.0275 0.0268
Schistosoma mansoni thyroid hormone receptor 0.0162 0.0269 0.0269
Toxoplasma gondii aminopeptidase n, putative 0.026 0.047 1
Schistosoma mansoni smad1 5 8 and 0.0138 0.0219 0.0219
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0068 0.0075 0.129
Mycobacterium ulcerans aminopeptidase N PepN 0.026 0.047 0.2851
Loa Loa (eye worm) hypothetical protein 0.0038 0.0014 0.0002
Trichomonas vaginalis importin beta-1, putative 0.0048 0.0035 0.02
Echinococcus granulosus importin subunit beta 1 0.006 0.0058 0.0055
Mycobacterium tuberculosis Conserved protein 0.0221 0.039 0.1287
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0068 0.0075 0.129
Loa Loa (eye worm) hypothetical protein 0.0106 0.0153 0.0142
Brugia malayi RNA recognition motif domain containing protein 0.0266 0.0484 0.104
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0026 0.0447
Echinococcus multilocularis jumonji domain containing 1A 0.0038 0.0014 0.0007
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0007 0.0007
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.026 0.047 1
Brugia malayi Peptidase family M1 containing protein 0.026 0.047 0.1009
Plasmodium vivax ataxin-2 like protein, putative 0.0106 0.0152 0.3091
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0056 0.0051 0.0877
Brugia malayi latrophilin 2 splice variant baaae 0.0498 0.0961 0.2089
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0044 0.0025 0.0325
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0047 0.0033 0.0025
Onchocerca volvulus 0.026 0.047 0.6751
Brugia malayi hypothetical protein 0.0421 0.0803 0.1741
Schistosoma mansoni smad1 5 8 and 0.0138 0.0219 0.0219
Loa Loa (eye worm) hypothetical protein 0.0072 0.0083 0.0071
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0074 0.0088 0.008
Echinococcus multilocularis aminopeptidase N 0.026 0.047 0.0463
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0142 0.0227 0.4721
Plasmodium falciparum phd finger protein, putative 0.0119 0.018 0.3633
Loa Loa (eye worm) MH2 domain-containing protein 0.2024 0.4103 0.4096
Onchocerca volvulus 0.026 0.047 0.6751
Loa Loa (eye worm) thioredoxin reductase 0.0196 0.0339 0.0328
Loa Loa (eye worm) hypothetical protein 0.006 0.0058 0.0046
Giardia lamblia PHD finger protein 15 0.0119 0.018 0.5824
Echinococcus multilocularis muscleblind protein 1 0.015 0.0244 0.0237
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.0035 0.02
Echinococcus granulosus cpg binding protein 0.0127 0.0196 0.0193
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0221 0.039 0.0835
Loa Loa (eye worm) hypothetical protein 0.0319 0.0592 0.0581
Echinococcus granulosus GTP binding nuclear protein Ran 0.0044 0.0025 0.0023
Schistosoma mansoni jumonji/arid domain-containing protein 0.0154 0.0253 0.0253
Mycobacterium leprae conserved hypothetical protein 0.0221 0.039 0.2339
Plasmodium falciparum glutathione reductase 0.0068 0.0075 0.134
Echinococcus multilocularis beta LACTamase domain containing family member 0.0221 0.039 0.0383
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0729 0.1436 0.3132
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0068 0.0075 0.0167
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0149 0.0241 0.4145
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0038 0.0014 0.0241
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.026 0.047 0.4095
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0221 0.039 0.1287
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.008 0.0099 0.0092
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0221 0.039 0.039
Onchocerca volvulus 0.0221 0.039 0.5576
Trypanosoma cruzi aminopeptidase, putative 0.026 0.047 0.8073
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0039 0.0015 0.0101
Onchocerca volvulus 0.0116 0.0174 0.2374
Loa Loa (eye worm) peptidase family M1 containing protein 0.026 0.047 0.0459
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0065 0.1117
Trichomonas vaginalis D-aminoacylase, putative 0.0221 0.039 0.3385
Echinococcus multilocularis chromobox protein 1 0.0068 0.0075 0.0068
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0068 0.0075 0.129
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0046 0.003 0.0341
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0636 0.1244 0.1234
Echinococcus granulosus dnaJ subfamily B 0.1252 0.2515 0.2513
Loa Loa (eye worm) hypothetical protein 0.0221 0.039 0.0379
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0141 0.0226 0.0223
Brugia malayi Bromodomain containing protein 0.0135 0.0213 0.0445
Echinococcus granulosus puromycin sensitive aminopeptidase 0.026 0.047 0.0467
Echinococcus granulosus peregrin 0.0135 0.0213 0.0211
Schistosoma mansoni smad 0.0062 0.0062 0.0062
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0056 0.0051 0.4895
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0014 0.0002
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0047 0.0033 0.003
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0172 0.029 0.2488
Schistosoma mansoni thyroid hormone receptor 0.0162 0.0269 0.0269
Brugia malayi Calcitonin receptor-like protein seb-1 0.0729 0.1436 0.3132
Giardia lamblia Fructose-bisphosphate aldolase 0.0172 0.029 1
Loa Loa (eye worm) nuclear factor I 0.0076 0.0092 0.0081
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0068 0.0075 0.129
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.026 0.047 0.047
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0447 0.0857 0.2943
Trichomonas vaginalis penicillin-binding protein, putative 0.0221 0.039 0.3385
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0026 0.0447
Echinococcus granulosus JmjC domain containing protein 4 0.0038 0.0014 0.0011
Entamoeba histolytica aminopeptidase, putative 0.026 0.047 0.5715
Schistosoma mansoni ferritin 0.0045 0.0028 0.0028
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0056 0.0051 0.0885
Trypanosoma cruzi aminopeptidase, putative 0.026 0.047 0.8073
Brugia malayi Smad1 0.0138 0.0219 0.0458
Schistosoma mansoni ran 0.0044 0.0025 0.0025
Brugia malayi hypothetical protein 0.026 0.047 0.1009
Leishmania major trypanothione reductase 0.0196 0.0339 0.5828
Mycobacterium ulcerans esterase/lipase LipP 0.0221 0.039 0.2339
Schistosoma mansoni hypothetical protein 0.0039 0.0015 0.0015
Schistosoma mansoni ran 0.0044 0.0025 0.0025
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0141 0.0226 0.0218
Brugia malayi glutathione reductase 0.0196 0.0339 0.0722
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0068 0.0075 0.129
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0072 0.0083 0.0083
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.026 0.047 0.4095
Echinococcus multilocularis microtubule associated protein 2 0.2239 0.4547 0.4543
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0172 0.029 0.2488
Loa Loa (eye worm) aminopeptidase N 0.026 0.047 0.0459
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0026 0.0447
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0376 0.071 0.1537
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0068 0.0075 0.129
Brugia malayi MH2 domain containing protein 0.0138 0.0219 0.0458
Echinococcus multilocularis lysine specific demethylase 5A 0.0144 0.0231 0.0224
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0056 0.0051 0.0082
Echinococcus granulosus tar DNA binding protein 0.0266 0.0484 0.0481
Brugia malayi hypothetical protein 0.026 0.047 0.1009
Loa Loa (eye worm) jmjC domain-containing protein 0.0245 0.044 0.0429
Trichomonas vaginalis ran, putative 0.0044 0.0025 0.0118
Plasmodium vivax JmjC domain containing protein 0.0038 0.0014 0.0079
Brugia malayi jmjC domain containing protein 0.0154 0.0253 0.0532
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0056 0.0051 0.0048
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.4887 1 1
Brugia malayi Peptidase family M1 containing protein 0.026 0.047 0.1009
Entamoeba histolytica hypothetical protein 0.0421 0.0803 1
Schistosoma mansoni ap endonuclease 0.0056 0.0051 0.0051
Schistosoma mansoni protein phosphatase 2C 0.0038 0.0014 0.0014
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0038 0.0014 0.0079
Echinococcus granulosus puromycin sensitive aminopeptidase 0.026 0.047 0.0467
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.026 0.047 1
Mycobacterium tuberculosis Probable lipase LipE 0.0221 0.039 0.1287
Schistosoma mansoni Smad4 0.0138 0.0219 0.0219
Brugia malayi exodeoxyribonuclease III family protein 0.0056 0.0051 0.0089
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0072 0.0083 0.0075
Onchocerca volvulus 0.0165 0.0275 0.3863
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0068 0.0075 0.1409
Giardia lamblia NADH oxidase lateral transfer candidate 0.0068 0.0075 0.1879
Echinococcus granulosus mothers against decapentaplegic 5 0.0138 0.0219 0.0217
Loa Loa (eye worm) MH2 domain-containing protein 0.0062 0.0062 0.005
Echinococcus multilocularis musashi 0.0165 0.0275 0.0267
Mycobacterium tuberculosis Conserved hypothetical protein 0.0165 0.0276 0.088
Schistosoma mansoni cpg binding protein 0.0127 0.0196 0.0196
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0068 0.0075 0.0073
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0172 0.029 0.2488
Brugia malayi PHD-finger family protein 0.0069 0.0078 0.0148
Loa Loa (eye worm) RNA binding protein 0.0266 0.0484 0.0473
Echinococcus multilocularis cpg binding protein 0.0127 0.0196 0.0188
Brugia malayi CXXC zinc finger family protein 0.0116 0.0174 0.0359
Brugia malayi Pre-SET motif family protein 0.024 0.0429 0.0919
Trichomonas vaginalis mercuric reductase, putative 0.0068 0.0075 0.0563
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0065 0.1117
Loa Loa (eye worm) leukotriene A4 hydrolase 0.4887 1 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0231 0.041 0.0399
Echinococcus granulosus jumonji domain containing protein 0.0165 0.0275 0.0273
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.026 0.047 0.0463
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0068 0.0075 0.0304
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0068 0.0075 0.134
Plasmodium vivax thioredoxin reductase, putative 0.0196 0.0339 0.7156
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0231 0.041 0.0408
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0068 0.0075 0.129
Schistosoma mansoni glutaminase 0.058 0.113 0.113
Echinococcus multilocularis smad 0.0138 0.0219 0.0212
Treponema pallidum exodeoxyribonuclease (exoA) 0.0056 0.0051 0.088
Plasmodium vivax glutathione reductase, putative 0.0196 0.0339 0.7156
Schistosoma mansoni gabp alpha 0.0074 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0162 0.0268 0.0257
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0068 0.0075 0.0142
Schistosoma mansoni hypothetical protein 0.0636 0.1244 0.1244
Loa Loa (eye worm) hypothetical protein 0.0038 0.0014 0.0002
Toxoplasma gondii exonuclease III APE 0.0056 0.0051 0.0885
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0065 0.1117
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.0037 0.0639
Brugia malayi beta-lactamase 0.0221 0.039 0.0835
Plasmodium falciparum ataxin-2 like protein, putative 0.0106 0.0152 0.3036
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0088 0.0117 0.0106
Toxoplasma gondii HEAT repeat-containing protein 0.006 0.0058 0.103
Brugia malayi Importin beta-1 subunit 0.006 0.0058 0.0104
Loa Loa (eye worm) hypothetical protein 0.0063 0.0066 0.0054
Plasmodium falciparum histone acetyltransferase GCN5 0.0126 0.0194 0.3943
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0172 0.029 0.2488
Echinococcus granulosus thioredoxin glutathione reductase 0.0196 0.0339 0.0337
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0797 0.1577 1
Mycobacterium ulcerans beta-lactamase 0.0221 0.039 0.2339
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0471 0.0905 0.0905
Loa Loa (eye worm) hypothetical protein 0.026 0.047 0.0459
Toxoplasma gondii ABC1 family protein 0.0221 0.039 0.8272
Loa Loa (eye worm) glutaminase 2 0.058 0.113 0.1119
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0037 0.0012 0.0004
Leishmania major hypothetical protein, conserved 0.0038 0.0014 0.0241
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0447 0.0857 0.2943
Loa Loa (eye worm) TAR-binding protein 0.0266 0.0484 0.0473
Schistosoma mansoni hypothetical protein 0.069 0.1357 0.1357
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0165 0.0275 0.0263
Plasmodium vivax hypothetical protein, conserved 0.0046 0.003 0.0418
Loa Loa (eye worm) hypothetical protein 0.026 0.047 0.0459
Onchocerca volvulus 0.0221 0.039 0.5576
Loa Loa (eye worm) hypothetical protein 0.0077 0.0093 0.0081
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0221 0.039 0.1287
Loa Loa (eye worm) glutaminase 0.058 0.113 0.1119
Brugia malayi Latrophilin receptor protein 2 0.0231 0.041 0.0878
Entamoeba histolytica hypothetical protein 0.0421 0.0803 1
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0038 0.0014 0.0014
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0025 0.0435
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0068 0.0075 0.129
Echinococcus granulosus lamin dm0 0.0165 0.0275 0.0272
Toxoplasma gondii thioredoxin reductase 0.0196 0.0339 0.7156
Mycobacterium tuberculosis Probable oxidoreductase 0.0497 0.096 0.3308
Brugia malayi Peptidase family M1 containing protein 0.026 0.047 0.1009
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0075 0.0564
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.026 0.047 0.4095
Echinococcus granulosus lysine specific demethylase 6a 0.0038 0.0014 0.0011
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.026 0.047 0.047
Mycobacterium tuberculosis Probable hydrolase 0.0221 0.039 0.1287
Schistosoma mansoni hypothetical protein 0.0231 0.041 0.041
Loa Loa (eye worm) hypothetical protein 0.0729 0.1436 0.1426
Mycobacterium ulcerans lipase LipD 0.0221 0.039 0.2339
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0062 0.0062 0.0716
Schistosoma mansoni Smad4 0.0062 0.0062 0.0062
Echinococcus granulosus snurportin 1 0.0636 0.1244 0.1242
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0221 0.039 0.1287
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0366 0.0689 1
Schistosoma mansoni intermediate filament proteins 0.0165 0.0275 0.0275
Echinococcus granulosus GA binding protein alpha chain 0.0074 0.0088 0.0085
Trypanosoma brucei PAB1-binding protein , putative 0.0106 0.0152 0.2619
Plasmodium vivax hypothetical protein, conserved 0.0119 0.018 0.3683
Brugia malayi hypothetical protein 0.0106 0.0152 0.0312
Leishmania major cathepsin L-like protease 0.0063 0.0065 0.1117
Echinococcus multilocularis Smad4 0.0138 0.0219 0.0212
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.026 0.047 0.8073
Onchocerca volvulus Alhambra homolog 0.0119 0.018 0.2456
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0376 0.071 0.071
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0044 0.0025 0.0018
Schistosoma mansoni apoferritin-2 0.0045 0.0028 0.0028
Echinococcus multilocularis mothers against decapentaplegic 5 0.0138 0.0219 0.0212
Trypanosoma cruzi trypanothione reductase, putative 0.0196 0.0339 0.5828
Trichomonas vaginalis esterase, putative 0.0221 0.039 0.3385
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0138 0.0219 0.0212
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0038 0.0014 0.0079
Loa Loa (eye worm) hypothetical protein 0.0119 0.018 0.0168
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.026 0.047 0.8073
Trypanosoma brucei importin beta-1 subunit, putative 0.006 0.0058 0.0992
Treponema pallidum NADH oxidase 0.0068 0.0075 0.1797
Brugia malayi Muscleblind-like protein 0.015 0.0244 0.0514
Leishmania major cathepsin L-like protease 0.0063 0.0065 0.1117
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.002 0.0088
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0056 0.0051 0.0039
Echinococcus granulosus expressed protein 0.0045 0.0028 0.0025
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.026 0.047 0.0463
Brugia malayi N-terminal motif family protein 0.0366 0.0689 0.1492
Loa Loa (eye worm) hypothetical protein 0.0146 0.0235 0.0224
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0142 0.0227 0.1925
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0065 0.1117
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0314 0.0582 1
Trypanosoma cruzi hypothetical protein, conserved 0.0221 0.039 0.6709
Echinococcus granulosus puromycin sensitive aminopeptidase 0.026 0.047 0.0467
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.026 0.047 0.047
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0266 0.0484 0.0473
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0376 0.071 0.0703
Echinococcus granulosus zinc finger protein 0.0058 0.0055 0.0053
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0068 0.0075 0.129
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0131 0.0205 0.0198
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0376 0.071 0.071
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.026 0.047 0.8073
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0068 0.0075 0.129
Schistosoma mansoni hypothetical protein 0.1252 0.2515 0.2515
Brugia malayi jmjC domain containing protein 0.0038 0.0014 0.0008
Echinococcus multilocularis peregrin 0.0135 0.0213 0.0206
Plasmodium vivax importin-beta 2, putative 0.006 0.0058 0.103
Echinococcus multilocularis leukotriene A 4 hydrolase 0.4887 1 1
Loa Loa (eye worm) hypothetical protein 0.0106 0.0152 0.0141
Schistosoma mansoni importin beta-1 0.006 0.0058 0.0058
Brugia malayi cytoplasmic intermediate filament protein 0.0088 0.0117 0.0234
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0149 0.0241 0.4145
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0065 0.1117
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0068 0.0075 0.0075
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0471 0.0905 0.0898
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0247 0.0444 0.0444
Schistosoma mansoni ferritin 0.0045 0.0028 0.0028
Echinococcus granulosus phd:f box containing protein 0.0038 0.0014 0.0011
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0421 0.0803 0.0801
Echinococcus granulosus smad 0.0138 0.0219 0.0217
Trypanosoma cruzi PAB1-binding protein , putative 0.0106 0.0152 0.2619
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0025 0.0435
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0142 0.0227 0.4721
Echinococcus multilocularis GA binding protein alpha chain 0.0074 0.0088 0.008
Schistosoma mansoni cpg binding protein 0.0127 0.0196 0.0196
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0376 0.071 0.0699
Toxoplasma gondii LsmAD domain-containing protein 0.0106 0.0152 0.3091
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0376 0.071 0.0703
Trypanosoma cruzi hypothetical protein, conserved 0.0221 0.039 0.6709
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0053 0.0044 0.0044
Loa Loa (eye worm) intermediate filament protein 0.0165 0.0275 0.0263
Echinococcus granulosus chromobox protein 1 0.0068 0.0075 0.0073
Brugia malayi Ets-domain containing protein 0.0074 0.0088 0.017
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0065 0.1117
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0142 0.0227 0.4721
Loa Loa (eye worm) jmjC domain-containing protein 0.0154 0.0253 0.0241
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0075 0.0564
Brugia malayi Intermediate filament tail domain containing protein 0.0165 0.0275 0.0581
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0797 0.1577 0.5502
Plasmodium falciparum importin beta, putative 0.006 0.0058 0.0959
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0044 0.0025 0.0033
Plasmodium vivax hypothetical protein, conserved 0.0221 0.039 0.8272
Echinococcus granulosus puromycin sensitive aminopeptidase 0.026 0.047 0.0467
Loa Loa (eye worm) hypothetical protein 0.0165 0.0275 0.0263
Loa Loa (eye worm) glutathione reductase 0.0196 0.0339 0.0328
Brugia malayi Thioredoxin reductase 0.0196 0.0339 0.0722
Brugia malayi jmjC domain containing protein 0.0389 0.0736 0.1594
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0038 0.0014 0.0241
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0044 0.0025 0.0325
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0056 0.0051 0.0044
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0065 0.1117
Schistosoma mansoni zinc finger protein 0.0058 0.0055 0.0055
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0065 0.1117
Trypanosoma brucei trypanothione reductase 0.0196 0.0339 0.5828
Mycobacterium tuberculosis Probable lipase LipD 0.0221 0.039 0.1287
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0068 0.0075 0.0068
Trichomonas vaginalis ap endonuclease, putative 0.0056 0.0051 0.0348
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0497 0.096 0.6012
Trichomonas vaginalis chromobox protein, putative 0.0041 0.002 0.0067
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0221 0.039 0.2339
Echinococcus granulosus Smad4 0.0138 0.0219 0.0217
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0056 0.0051 0.0877
Schistosoma mansoni phd/f-box containing protein 0.0038 0.0014 0.0014
Brugia malayi PHD-finger family protein 0.0049 0.0037 0.0058
Loa Loa (eye worm) TATA binding protein associated factor 0.026 0.047 0.0459
Echinococcus multilocularis snurportin 1 0.0636 0.1244 0.1238
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0172 0.029 0.2488
Schistosoma mansoni tar DNA-binding protein 0.0266 0.0484 0.0484
Echinococcus multilocularis importin subunit beta 1 0.006 0.0058 0.005
Loa Loa (eye worm) hypothetical protein 0.008 0.0099 0.0087
Schistosoma mansoni phosphatidylserine receptor 0.0038 0.0014 0.0014
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0044 0.0025 0.0014
Toxoplasma gondii PHD-finger domain-containing protein 0.0039 0.0015 0.0101
Loa Loa (eye worm) hypothetical protein 0.0366 0.0689 0.0679
Loa Loa (eye worm) hypothetical protein 0.0498 0.0961 0.0951
Trypanosoma brucei Aminopeptidase M1, putative 0.026 0.047 0.8073
Trypanosoma brucei Aminopeptidase M1, putative 0.026 0.047 0.8073
Schistosoma mansoni hypothetical protein 0.0421 0.0803 0.0803
Loa Loa (eye worm) beta-lactamase 0.0221 0.039 0.0379
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.026 0.047 0.0463
Mycobacterium ulcerans glutaminase 0.058 0.113 0.711
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0421 0.0803 0.0796
Schistosoma mansoni lamin 0.0165 0.0275 0.0275
Leishmania major hypothetical protein, conserved 0.0221 0.039 0.6709
Mycobacterium ulcerans hypothetical protein 0.0221 0.039 0.2339
Toxoplasma gondii NADPH-glutathione reductase 0.0068 0.0075 0.1409
Trichomonas vaginalis ap endonuclease, putative 0.0056 0.0051 0.0348
Entamoeba histolytica hypothetical protein 0.0421 0.0803 1
Loa Loa (eye worm) hypothetical protein 0.015 0.0244 0.0233
Echinococcus granulosus puromycin sensitive aminopeptidase 0.026 0.047 0.0467
Echinococcus multilocularis geminin 0.069 0.1357 0.135
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0069 0.0077 0.0077
Echinococcus multilocularis mothers against decapentaplegic 6 0.0062 0.0062 0.0055
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0056 0.0051 0.0877
Trypanosoma cruzi cruzipain precursor, putative 0.0063 0.0065 0.1117
Echinococcus granulosus aminopeptidase N 0.026 0.047 0.0467
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.026 0.047 0.8073
Echinococcus multilocularis tumor protein p63 0.218 0.4426 0.4422
Brugia malayi TAR-binding protein 0.0266 0.0484 0.104
Toxoplasma gondii hypothetical protein 0.0051 0.0039 0.0632
Entamoeba histolytica acetyltransferase, GNAT family 0.0126 0.0194 0.2165
Echinococcus multilocularis lamin 0.0165 0.0275 0.0267
Echinococcus granulosus jumonji domain containing 1A 0.0038 0.0014 0.0011
Schistosoma mansoni apoferritin-2 0.0045 0.0028 0.0028
Echinococcus granulosus fetal alzheimer antigen falz 0.0053 0.0044 0.0042
Brugia malayi MH1 domain containing protein 0.0138 0.0219 0.0458
Leishmania major hypothetical protein, conserved 0.0106 0.0152 0.2619
Brugia malayi glutaminase DH11.1 0.058 0.113 0.2459
Loa Loa (eye worm) MH2 domain-containing protein 0.0138 0.0219 0.0208
Onchocerca volvulus 0.0273 0.0496 0.7144
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.0035 0.02
Loa Loa (eye worm) acetyltransferase 0.0471 0.0905 0.0894
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0068 0.0075 0.129
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.026 0.047 0.8073
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0068 0.0075 0.129
Echinococcus granulosus ferritin 0.0045 0.0028 0.0025
Trypanosoma cruzi importin beta-1 subunit, putative 0.0048 0.0035 0.0593
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0054 0.0046 0.0789
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0196 0.0339 0.1105
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0149 0.0241 0.4145
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0068 0.0075 0.134
Brugia malayi Ets-domain containing protein 0.0074 0.0088 0.017
Brugia malayi Bromodomain containing protein 0.009 0.0121 0.0243
Brugia malayi MH1 domain containing protein 0.0076 0.0092 0.018
Schistosoma mansoni jumonji domain containing protein 0.0309 0.0571 0.0571
Schistosoma mansoni cellular tumor antigen P53 0.0319 0.0592 0.0592
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0068 0.0075 1
Brugia malayi MH2 domain containing protein 0.0138 0.0219 0.0458
Loa Loa (eye worm) hypothetical protein 0.0049 0.0037 0.0025
Leishmania major importin beta-1 subunit, putative 0.0048 0.0035 0.0593
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.026 0.047 0.8073
Echinococcus granulosus tumor protein p63 0.218 0.4426 0.4425
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.026 0.047 1
Trypanosoma brucei aminopeptidase, putative 0.026 0.047 0.8073
Schistosoma mansoni ferritin light chain 0.0045 0.0028 0.0028
Schistosoma mansoni hypothetical protein 0.0498 0.0961 0.0961
Echinococcus granulosus geminin 0.069 0.1357 0.1355
Echinococcus multilocularis PHD finger protein rhinoceros 0.0119 0.018 0.0172
Trichomonas vaginalis bromodomain-containing protein, putative 0.0142 0.0227 0.1925
Loa Loa (eye worm) hypothetical protein 0.0095 0.0131 0.012
Loa Loa (eye worm) PHD-finger family protein 0.0119 0.018 0.0168
Brugia malayi MH2 domain containing protein 0.0062 0.0062 0.0113
Toxoplasma gondii aminopeptidase N protein 0.026 0.047 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0092 0.0081
Loa Loa (eye worm) bromodomain containing protein 0.0048 0.0034 0.0022
Schistosoma mansoni lamin 0.0165 0.0275 0.0275
Toxoplasma gondii PHD-finger domain-containing protein 0.0119 0.018 0.3683
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0072 0.0083 0.0083
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0172 0.029 0.2488
Echinococcus multilocularis phd:f box containing protein 0.0038 0.0014 0.0007
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0068 0.0075 0.0304
Echinococcus granulosus muscleblind protein 0.015 0.0244 0.0242
Brugia malayi F/Y-rich N-terminus family protein 0.0079 0.0099 0.0194
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0049 0.0036 0.0028
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0048 0.0033 0.0033
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0376 0.071 0.0708
Echinococcus granulosus PHD finger protein rhinoceros 0.0119 0.018 0.0177
Echinococcus multilocularis ferritin 0.0045 0.0028 0.0021
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.026 0.047 0.0463
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0497 0.096 0.3308
Echinococcus granulosus intermediate filament protein 0.0165 0.0275 0.0272
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0314 0.0582 1
Schistosoma mansoni Smad4 0.0062 0.0062 0.0062
Echinococcus granulosus chromobox protein 1 0.0068 0.0075 0.0073
Schistosoma mansoni hypothetical protein 0.0043 0.0023 0.0023
Mycobacterium tuberculosis Probable esterase LipL 0.0221 0.039 0.1287
Loa Loa (eye worm) hypothetical protein 0.0221 0.039 0.0379
Plasmodium falciparum thioredoxin reductase 0.0068 0.0075 0.134
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.0075 0.0064
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0039 0.0015 0.0258
Echinococcus multilocularis chromobox protein 1 0.0068 0.0075 0.0068
Loa Loa (eye worm) hypothetical protein 0.026 0.047 0.0459
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0074 0.0088 0.0076
Brugia malayi TATA binding protein associated factor 0.026 0.047 0.1009
Entamoeba histolytica hypothetical protein 0.0048 0.0035 0.0118
Schistosoma mansoni bromodomain containing protein 0.0148 0.0241 0.0241
Loa Loa (eye worm) hypothetical protein 0.0204 0.0354 0.0343
Trichomonas vaginalis penicillin-binding protein, putative 0.0221 0.039 0.3385
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.001 0.001
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.026 0.047 0.0463
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0447 0.0857 0.5349
Brugia malayi acetyltransferase, GNAT family protein 0.0471 0.0905 0.1964
Loa Loa (eye worm) Smad1 0.0138 0.0219 0.0208
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0065 0.1117
Schistosoma mansoni chromobox protein 0.0068 0.0075 0.0075
Brugia malayi RNA binding protein 0.0266 0.0484 0.104
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.005 0.0038 0.0061
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0172 0.029 0.2488
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0014 0.0013
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0058 0.0054 0.0923
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.026 0.047 0.8073
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0231 0.041 0.0878
Brugia malayi intermediate filament protein 0.0165 0.0275 0.0581
Trypanosoma cruzi Aminopeptidase M1, putative 0.026 0.047 0.8073
Echinococcus multilocularis lamin dm0 0.0165 0.0275 0.0267
Schistosoma mansoni transcription factor LCR-F1 0.0421 0.0803 0.0803
Schistosoma mansoni hypothetical protein 0.0119 0.018 0.018
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0068 0.0075 0.1409
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0068 0.0075 1
Schistosoma mansoni chromobox protein 0.0068 0.0075 0.0075
Echinococcus granulosus methyl CpG binding domain protein 2 0.0035 0.0007 0.0005
Loa Loa (eye worm) MH1 domain-containing protein 0.0138 0.0219 0.0208
Loa Loa (eye worm) PHD-finger family protein 0.0043 0.0023 0.0011
Giardia lamblia Histone acetyltransferase GCN5 0.0126 0.0194 0.6358
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0447 0.0857 0.2943
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0056 0.0051 0.0149
Onchocerca volvulus 0.0048 0.0033 0.0291
Brugia malayi chromobox protein homolog 3 0.0038 0.0014 0.0007
Onchocerca volvulus 0.026 0.047 0.6751
Schistosoma mansoni ferritin 0.0045 0.0028 0.0028
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0447 0.0857 0.2943
Mycobacterium ulcerans aminopeptidase N PepN 0.026 0.047 0.2851
Schistosoma mansoni cpg binding protein 0.0116 0.0174 0.0174
Echinococcus multilocularis tar DNA binding protein 0.0266 0.0484 0.0476
Loa Loa (eye worm) CXXC zinc finger family protein 0.0116 0.0174 0.0163
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0049 0.0036 0.0033
Schistosoma mansoni tar DNA-binding protein 0.0266 0.0484 0.0484
Trichomonas vaginalis chromobox protein, putative 0.0041 0.002 0.0067
Trichomonas vaginalis glutathione reductase, putative 0.0068 0.0075 0.0563
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0389 0.0736 0.0729
Leishmania major mitochondrial DNA polymerase beta 0.0314 0.0582 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0221 0.039 0.0379
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0007 0.0007
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0172 0.029 0.3406
Echinococcus granulosus histone acetyltransferase KAT2B 0.0453 0.0868 0.0865
Brugia malayi AF-10 protein 0.0039 0.0015 0.001
Loa Loa (eye worm) hypothetical protein 0.0077 0.0093 0.0081
Onchocerca volvulus 0.0319 0.0592 0.8566
Loa Loa (eye worm) fli-1 protein 0.0225 0.0398 0.0387
Echinococcus granulosus puromycin sensitive aminopeptidase 0.026 0.047 0.0467
Mycobacterium tuberculosis Probable dehydrogenase 0.0447 0.0857 0.2943
Trichomonas vaginalis ferritin, putative 0.0045 0.0028 0.0141
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0376 0.071 0.071
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.001 0.0003
Plasmodium falciparum ataxin-2 like protein, putative 0.0106 0.0152 0.3036
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0014 0.0013
Brugia malayi Bromodomain containing protein 0.0173 0.029 0.0615
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0068 0.0075 0.129
Brugia malayi Fli-1 protein 0.0225 0.0398 0.0853
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0037 0.0012 0.0009
Loa Loa (eye worm) hypothetical protein 0.0221 0.039 0.0379

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 8.1995 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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