Detailed information for compound 1064308

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 277.792 | Formula: C15H20ClN3
  • H donors: 0 H acceptors: 1 LogP: 3.52 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCN(c1ccc(c(c1)Cl)C#N)[C@H]1CCN(C1)C
  • InChi: 1S/C15H20ClN3/c1-3-7-19(14-6-8-18(2)11-14)13-5-4-12(10-17)15(16)9-13/h4-5,9,14H,3,6-8,11H2,1-2H3/t14-/m0/s1
  • InChiKey: UUAAKAQBPJEPBW-AWEZNQCLSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens progesterone receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0047 0.0104 0.0119
Schistosoma mansoni sulfide quinone reductase 0.0078 0.0218 0.0218
Echinococcus granulosus lamin 0.0139 0.0448 0.1444
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0032 0.0093
Schistosoma mansoni hypothetical protein 0.0041 0.008 0.008
Trypanosoma cruzi NADH dehydrogenase, putative 0.0078 0.0218 0.0497
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0078 0.0218 0.1955
Echinococcus multilocularis glutamate synthase 0.0078 0.0218 0.0703
Brugia malayi glutathione reductase 0.0844 0.308 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0139 0.0448 0.1453
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0047 0.0104 0.0335
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0078 0.0218 0.0703
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0022 0.0011 0.0033
Trichomonas vaginalis mercuric reductase, putative 0.0293 0.102 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0078 0.0218 0.1955
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0293 0.102 0.3205
Loa Loa (eye worm) hypothetical protein 0.0032 0.0049 0.0159
Plasmodium falciparum glutathione reductase 0.0844 0.308 1
Mycobacterium tuberculosis Probable reductase 0.1926 0.7118 0.8958
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0047 0.0104 0.0104
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0293 0.102 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0293 0.102 0.331
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.1926 0.7118 0.8958
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0078 0.0218 0.0497
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0068 0.0453
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0293 0.102 0.3161
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0078 0.0218 0.1955
Loa Loa (eye worm) MH1 domain-containing protein 0.0043 0.0089 0.0289
Toxoplasma gondii NADPH-glutathione reductase 0.0293 0.102 0.3205
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0047 0.0104 0.0336
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0049 0.0049
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0078 0.0218 0.1242
Plasmodium falciparum thioredoxin reductase 0.0293 0.102 0.2803
Trypanosoma brucei NADH dehydrogenase 0.0078 0.0218 0.0704
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0844 0.308 0.3716
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0032 0.0093
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0059 0.0361
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0078 0.0218 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0633 0.2291 0.7438
Giardia lamblia NADH oxidase lateral transfer candidate 0.0293 0.102 1
Brugia malayi MH1 domain containing protein 0.0024 0.0017 0.0055
Brugia malayi Smad1 0.0043 0.0089 0.0289
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0215 0.073 0.2371
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0047 0.0104 0.0119
Mycobacterium tuberculosis Probable oxidoreductase 0.2141 0.792 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0049 0.0158
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0293 0.102 0.3161
Brugia malayi RNA binding protein 0.047 0.1683 0.5464
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0293 0.102 1
Echinococcus granulosus lamin dm0 0.0139 0.0448 0.1444
Onchocerca volvulus 0.0032 0.0049 0.0551
Trichomonas vaginalis set domain proteins, putative 0.0257 0.0887 0.8666
Echinococcus multilocularis lamin 0.0139 0.0448 0.1444
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0078 0.0218 0.0497
Loa Loa (eye worm) hypothetical protein 0.0065 0.0169 0.0549
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0059 0.0361
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0078 0.0218 0.0708
Schistosoma mansoni tar DNA-binding protein 0.047 0.1683 0.1683
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0038 0.0068 0.0218
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.047 0.1683 0.5464
Loa Loa (eye worm) MH2 domain-containing protein 0.0043 0.0089 0.0289
Onchocerca volvulus 0.0139 0.0448 0.5044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0059 0.0361
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0023 0.0001
Schistosoma mansoni glutamate synthase 0.0078 0.0218 0.0218
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0078 0.0218 0.0704
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0293 0.102 0.3161
Schistosoma mansoni hypothetical protein 0.0078 0.0218 0.0218
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0293 0.102 0.3161
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0078 0.0218 0.1955
Toxoplasma gondii selenide, water dikinase 0.0078 0.0218 0.0558
Loa Loa (eye worm) programmed cell death 8 0.0078 0.0218 0.0708
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0049 0.0049
Schistosoma mansoni lamin 0.0139 0.0448 0.0448
Loa Loa (eye worm) intermediate filament protein 0.0139 0.0448 0.1453
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0078 0.0218 0.1955
Loa Loa (eye worm) hypothetical protein 0.0024 0.0017 0.0055
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0078 0.0218 0.0703
Leishmania major trypanothione reductase 0.0844 0.308 1
Treponema pallidum NADH oxidase 0.0293 0.102 1
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0047 0.0104 0.0119
Schistosoma mansoni smad1 5 8 and 0.0043 0.0089 0.0089
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0293 0.102 0.331
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.1926 0.7118 0.8958
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0078 0.0218 0.0703
Brugia malayi glutamate synthase 0.0078 0.0218 0.0708
Plasmodium falciparum thioredoxin reductase 0.0844 0.308 1
Schistosoma mansoni smad1 5 8 and 0.0043 0.0089 0.0089
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0078 0.0218 0.0704
Echinococcus granulosus tumor protein p63 0.0704 0.2558 0.8251
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.1926 0.7118 0.8958
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0078 0.0218 0.0558
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0293 0.102 0.3161
Brugia malayi cytoplasmic intermediate filament protein 0.0075 0.0206 0.067
Onchocerca volvulus 0.0139 0.0448 0.5044
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0078 0.0218 0.0558
Entamoeba histolytica thioredoxin reductase, putative 0.0078 0.0218 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.2141 0.792 1
Onchocerca volvulus 0.0078 0.0218 0.2457
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0293 0.102 0.3161
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0078 0.0218 0.0558
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0078 0.0218 0.0703
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0078 0.0218 0.0704
Schistosoma mansoni glutamate synthase 0.0078 0.0218 0.0218
Schistosoma mansoni sulfide quinone reductase 0.0078 0.0218 0.0218
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0044 0.0143
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0293 0.102 0.1042
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0293 0.102 0.3161
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0293 0.102 0.3161
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0033 0.0103
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0078 0.0218 1
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0078 0.0218 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0078 0.0218 0.0708
Loa Loa (eye worm) transcription factor SMAD2 0.0633 0.2291 0.7438
Echinococcus multilocularis Smad4 0.0043 0.0089 0.0287
Loa Loa (eye worm) hypothetical protein 0.0103 0.0313 0.1016
Schistosoma mansoni smad1 5 8 and 0.0043 0.0089 0.0089
Schistosoma mansoni tar DNA-binding protein 0.047 0.1683 0.1683
Loa Loa (eye worm) RNA binding protein 0.047 0.1683 0.5464
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0078 0.0218 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0033 0.0103
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0293 0.102 1
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0078 0.0218 0.0708
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0293 0.102 0.331
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0293 0.102 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0059 0.0361
Schistosoma mansoni cellular tumor antigen P53 0.0103 0.0313 0.0313
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0078 0.0218 0.0558
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0078 0.0218 0.0497
Loa Loa (eye worm) TAR-binding protein 0.047 0.1683 0.5464
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0078 0.0218 0.0558
Echinococcus granulosus Smad4 0.0043 0.0089 0.0287
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0046 0.0233
Leishmania major hypothetical protein, conserved 0.0078 0.0218 0.0497
Echinococcus multilocularis tumor protein p63 0.0704 0.2558 0.8251
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0059 0.0361
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0078 0.0218 0.0703
Brugia malayi hypothetical protein 0.0041 0.008 0.0258
Giardia lamblia Glutamate synthase 0.0078 0.0218 0.1242
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0059 0.0361
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0047 0.0104 0.1779
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.2141 0.792 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0078 0.0556
Loa Loa (eye worm) glutathione reductase 0.0844 0.308 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0078 0.0218 0.1955
Loa Loa (eye worm) hypothetical protein 0.0137 0.0438 0.1422
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0078 0.0218 0.0703
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0068 0.0453
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0078 0.0218 0.0497
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.008 0.0257
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0104 0.0814
Brugia malayi MH1 domain containing protein 0.0024 0.0017 0.0055
Brugia malayi MH2 domain containing protein 0.0633 0.2291 0.7438
Trichomonas vaginalis glutamate synthase, putative 0.0078 0.0218 0.1955
Giardia lamblia Thioredoxin reductase 0.0078 0.0218 0.1242
Onchocerca volvulus 0.0103 0.0313 0.3527
Plasmodium vivax glutathione reductase, putative 0.0844 0.308 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0075 0.0206 0.067
Trypanosoma cruzi trypanothione reductase, putative 0.0844 0.308 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0043 0.0089 0.0287
Trypanosoma cruzi trypanothione reductase, putative 0.0293 0.102 0.3161
Leishmania major NADH dehydrogenase, putative 0.0078 0.0218 0.0497
Trichomonas vaginalis glutamate synthase, putative 0.0078 0.0218 0.1955
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0104 0.0814
Plasmodium falciparum glutathione reductase 0.0293 0.102 0.2803
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0293 0.102 0.3161
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0293 0.102 0.3292
Loa Loa (eye worm) Smad1 0.0043 0.0089 0.0289
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.2141 0.792 1
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0215 0.073 0.2371
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0047 0.0104 0.0336
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0293 0.102 0.2803
Echinococcus granulosus tar DNA binding protein 0.047 0.1683 0.543
Brugia malayi intermediate filament protein 0.0139 0.0448 0.1453
Plasmodium vivax thioredoxin reductase, putative 0.0844 0.308 1
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0078 0.0218 0.0703
Loa Loa (eye worm) hypothetical protein 0.0065 0.0169 0.0549
Echinococcus multilocularis thioredoxin glutathione reductase 0.085 0.31 1
Trypanosoma cruzi NADH dehydrogenase, putative 0.0078 0.0218 0.0497
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0042 0.0194
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0059 0.0361
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0078 0.0218 0.0497
Schistosoma mansoni smad 0.0043 0.0089 0.0089
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0047 0.0104 0.0338
Toxoplasma gondii thioredoxin reductase 0.0844 0.308 1
Echinococcus granulosus smad 0.0043 0.0089 0.0287
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0078 0.0218 0.0703
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0078 0.0218 0.0497
Loa Loa (eye worm) nuclear factor I 0.0024 0.0017 0.0055
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0078 0.0218 0.0703
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0078 0.0218 0.1955
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0078 0.0218 0.1955
Echinococcus granulosus intermediate filament protein 0.0139 0.0448 0.1444
Mycobacterium tuberculosis Putative ferredoxin reductase 0.1926 0.7118 0.8958
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0104 0.0814
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0033 0.0103
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0049 0.0049
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.1926 0.7118 0.8958
Trichomonas vaginalis glutathione reductase, putative 0.0293 0.102 1
Brugia malayi TAR-binding protein 0.047 0.1683 0.5464
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0293 0.102 0.3161
Echinococcus multilocularis mothers against decapentaplegic 5 0.0043 0.0089 0.0287
Loa Loa (eye worm) hypothetical protein 0.0139 0.0448 0.1453
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0293 0.102 0.3161
Brugia malayi MH1 domain containing protein 0.0043 0.0089 0.0289
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0068 0.0453
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0293 0.102 0.3205
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0078 0.0218 0.0704
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0293 0.102 0.3205
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0293 0.102 0.3161
Entamoeba histolytica disulphide oxidoreductase, putative 0.0078 0.0218 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0068 0.0453
Leishmania major hypothetical protein, conserved 0.0078 0.0218 0.0497
Brugia malayi Pre-SET motif family protein 0.0226 0.0771 0.2503
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0023 0.0001
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0047 0.0104 0.0335
Echinococcus multilocularis lamin dm0 0.0139 0.0448 0.1444
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0078 0.0218 0.0703
Echinococcus multilocularis smad 0.0043 0.0089 0.0287
Schistosoma mansoni lamin 0.0139 0.0448 0.0448
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.0218 0.0497
Schistosoma mansoni disulfide oxidoreductase 0.0078 0.0218 0.0218
Echinococcus granulosus glutamate synthase 0.0078 0.0218 0.0703
Brugia malayi RNA recognition motif domain containing protein 0.047 0.1683 0.5464
Toxoplasma gondii target of rapamycin (TOR), putative 0.0035 0.0059 0.0033
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0049 0.0049
Brugia malayi Pre-SET motif family protein 0.0032 0.0049 0.0159
Schistosoma mansoni glutamate synthase 0.0078 0.0218 0.0218
Trichomonas vaginalis apoptosis inducing factor, putative 0.0078 0.0218 0.1955
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0047 0.0104 0.1779
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0293 0.102 0.2803
Onchocerca volvulus 0.0257 0.0887 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0068 0.0453
Trypanosoma brucei trypanothione reductase 0.0844 0.308 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.0179 0.058
Schistosoma mansoni Smad4 0.0043 0.0089 0.0089
Brugia malayi Intermediate filament tail domain containing protein 0.0139 0.0448 0.1453
Echinococcus multilocularis musashi 0.0139 0.0448 0.1444
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0293 0.102 0.102
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0293 0.102 0.3292
Plasmodium vivax ferrodoxin reductase, putative 0.0078 0.0218 0.0558
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.008 0.0257
Schistosoma mansoni tar DNA-binding protein 0.047 0.1683 0.1683
Brugia malayi Thioredoxin reductase 0.0844 0.308 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0023 0.0001
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0078 0.0218 0.0558
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0023 0.0001
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0293 0.102 0.3313
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0049 0.0158
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0078 0.0218 0.1955
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0078 0.0218 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0047 0.0104 0.0338
Mycobacterium tuberculosis Probable dehydrogenase 0.1926 0.7118 0.8958
Loa Loa (eye worm) thioredoxin reductase 0.0844 0.308 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0067 0.0179 0.0577
Echinococcus granulosus thioredoxin glutathione reductase 0.085 0.31 1
Echinococcus multilocularis tar DNA binding protein 0.047 0.1683 0.543
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0078 0.0218 0.0558
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0043 0.0089 0.0287
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0078 0.0218 0.0497
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.008 0.008
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.0218 0.0497
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0293 0.102 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0047 0.0104 0.0119
Echinococcus granulosus mothers against decapentaplegic 5 0.0043 0.0089 0.0287
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0078 0.0218 0.0703
Loa Loa (eye worm) hypothetical protein 0.0078 0.0218 0.0708
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0067 0.0179 0.0577
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0293 0.102 0.331
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0226 0.0771 0.2503
Schistosoma mansoni intermediate filament proteins 0.0139 0.0448 0.0448
Brugia malayi MH2 domain containing protein 0.0043 0.0089 0.0289
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0078 0.0218 0.0708
Schistosoma mansoni tar DNA-binding protein 0.047 0.1683 0.1683
Brugia malayi MH2 domain containing protein 0.0043 0.0089 0.0289
Leishmania major hypothetical protein, conserved 0.0078 0.0218 0.0497
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0293 0.102 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0043 0.0089 0.0089
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0078 0.0218 0.1955
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0049 0.0158
Trypanosoma brucei hypothetical protein, conserved 0.0078 0.0218 0.0704
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0078 0.0218 0.0703
Schistosoma mansoni tar DNA-binding protein 0.047 0.1683 0.1683
Brugia malayi MH1 domain containing protein 0.0043 0.0089 0.0289

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) > 10000 nM Agonist activity at PR expressed in african green monkey CV-1 cells by luciferase reporter assay ChEMBL. 19595590
IC50 (binding) = 400 nM Binding affinity to PR by fluorescence polarization based competition binding assay ChEMBL. 19595590

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.