Detailed information for compound 1064322

Basic information

Technical information
  • TDR Targets ID: 1064322
  • Name: N-[2-(cyclopentylamino)-2-oxoethyl]-N-(3,4-di methoxyphenyl)-N'-(5-methyl-1,2-oxazol-3-yl)b utanediamide
  • MW: 458.508 | Formula: C23H30N4O6
  • H donors: 2 H acceptors: 4 LogP: 1.76 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1OC)N(C(=O)CCC(=O)Nc1noc(c1)C)CC(=O)NC1CCCC1
  • InChi: 1S/C23H30N4O6/c1-15-12-20(26-33-15)25-21(28)10-11-23(30)27(14-22(29)24-16-6-4-5-7-16)17-8-9-18(31-2)19(13-17)32-3/h8-9,12-13,16H,4-7,10-11,14H2,1-3H3,(H,24,29)(H,25,26,28)
  • InChiKey: RSKWJHVNTAWCRB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[2-(cyclopentylamino)-2-oxo-ethyl]-N-(3,4-dimethoxyphenyl)-N'-(5-methylisoxazol-3-yl)butanediamide
  • N-[2-(cyclopentylamino)-2-oxoethyl]-N-(3,4-dimethoxyphenyl)-N'-(5-methyl-3-isoxazolyl)butanediamide
  • N-[2-(cyclopentylamino)-2-keto-ethyl]-N-(3,4-dimethoxyphenyl)-N'-(5-methylisoxazol-3-yl)succinamide
  • N-[2-(cyclopentylamino)-2-oxo-ethyl]-N-(3,4-dimethoxyphenyl)-N'-(5-methyl-1,2-oxazol-3-yl)butanediamide
  • ASN 05570366

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni protein kinase C mu 0.0068 0.0651 0.172
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.007 0.5
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0075 0.0739 0.183
Schistosoma mansoni serine/threonine protein kinase 0.0311 0.3786 1
Loa Loa (eye worm) AGC/PKN protein kinase 0.0075 0.0739 0.1691
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.007 0.5
Trichomonas vaginalis AGC family protein kinase 0.0079 0.0793 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.1282 0.2935
Loa Loa (eye worm) hypothetical protein 0.0068 0.0651 0.1491
Onchocerca volvulus 0.0281 0.3407 1
Schistosoma mansoni lamin 0.0026 0.0117 0.0309
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.007 0.5
Entamoeba histolytica protein kinase, putative 0.0075 0.0739 0.4173
Schistosoma mansoni hypothetical protein 0.0051 0.0429 0.1133
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0073 0.0712 0.8884
Schistosoma mansoni serine/threonine protein kinase 0.0291 0.3527 0.9315
Brugia malayi C1-like domain containing protein 0.0194 0.2279 0.6462
Onchocerca volvulus 0.0196 0.2307 0.677
Schistosoma mansoni diacylglycerol kinase theta 0.0068 0.0651 0.172
Schistosoma mansoni protein kinase C mu 0.0194 0.2279 0.6019
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.007 0.5
Schistosoma mansoni hypothetical protein 0.0166 0.1913 0.5053
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.007 0.0173
Onchocerca volvulus 0.0048 0.0401 0.1176
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0068 0.0651 0.1491
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.007 0.5
Entamoeba histolytica hypothetical protein 0.0035 0.0231 0.1003
Toxoplasma gondii AGC kinase 0.0075 0.0739 1
Brugia malayi protein kinase C3,putative 0.007 0.0678 0.1922
Schistosoma mansoni protein kinase C 0.0075 0.075 0.1982
Onchocerca volvulus 0.0192 0.2253 0.6611
Loa Loa (eye worm) hypothetical protein 0.0068 0.0651 0.1491
Echinococcus multilocularis Rac GTPase activating protein 1 0.0068 0.0651 0.0651
Toxoplasma gondii diacylglycerol kinase, putative 0.0068 0.0651 0.8695
Echinococcus multilocularis raf serine:threonine protein kinase 0.0068 0.0651 0.0651
Loa Loa (eye worm) hypothetical protein 0.0068 0.0651 0.1491
Entamoeba histolytica protein kinase, putative 0.0079 0.0793 0.4509
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0075 0.0739 0.0739
Trichomonas vaginalis AGC family protein kinase 0.0079 0.0793 1
Brugia malayi Protein kinase domain containing protein 0.0075 0.0739 0.2094
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0075 0.0739 0.1691
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.007 0.007
Echinococcus multilocularis protein kinase c iota type 0.0142 0.1613 0.1613
Loa Loa (eye worm) hypothetical protein 0.0068 0.0651 0.1491
Schistosoma mansoni hypothetical protein 0.0166 0.1913 0.5053
Echinococcus multilocularis protein kinase c epsilon type 0.0291 0.3527 0.3527
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0068 0.0651 0.172
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0161 0.1851 0.1851
Echinococcus granulosus Protein kinase C brain isozyme 0.0311 0.3786 0.938
Echinococcus granulosus protein kinase C gamma type 0.0243 0.2912 0.7214
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.007 0.5
Echinococcus granulosus myotubularin protein 13 0.0072 0.0705 0.1747
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0231 0.0571
Echinococcus multilocularis unc 13 (munc13) 0.0075 0.075 0.075
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0117 0.0268
Brugia malayi diacylglycerol kinase 0.0068 0.0651 0.1847
Echinococcus granulosus tumor protein p63 0.033 0.4037 1
Loa Loa (eye worm) raf kinase 0.0068 0.0651 0.1491
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0231 0.0609
Brugia malayi p70 ribosomal S6 kinase beta 0.0075 0.0739 0.2094
Trichomonas vaginalis AGC family protein kinase 0.0079 0.0793 1
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0075 0.0739 0.0739
Schistosoma mansoni serine/threonine protein kinase 0.0075 0.0739 0.1951
Loa Loa (eye worm) hypothetical protein 0.0026 0.0111 0.0254
Schistosoma mansoni hypothetical protein 0.0035 0.0231 0.0609
Onchocerca volvulus 0.0026 0.0117 0.0343
Brugia malayi hypothetical protein 0.0035 0.0231 0.0654
Loa Loa (eye worm) hypothetical protein 0.0281 0.3407 0.7799
Echinococcus granulosus intermediate filament protein 0.0026 0.0117 0.029
Echinococcus granulosus serine:threonine protein kinase N2 0.0143 0.1619 0.401
Echinococcus multilocularis lamin dm0 0.0026 0.0117 0.0117
Echinococcus granulosus geminin 0.0166 0.1913 0.474
Brugia malayi Protein kinase domain containing protein 0.007 0.0678 0.1922
Schistosoma mansoni intermediate filament proteins 0.0026 0.0117 0.0309
Echinococcus granulosus serine:threonine protein kinase N2 0.0075 0.0739 0.183
Echinococcus granulosus lamin 0.0026 0.0117 0.029
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0194 0.2279 0.5217
Schistosoma mansoni serine/threonine protein kinase 0.0075 0.0739 0.1951
Onchocerca volvulus 0.0075 0.075 0.2203
Trichomonas vaginalis AGC family protein kinase 0.0079 0.0793 1
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0075 0.0739 0.183
Trichomonas vaginalis AGC family protein kinase 0.0079 0.0793 1
Schistosoma mansoni hypothetical protein 0.0068 0.0651 0.172
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0068 0.0651 0.172
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0068 0.0651 0.1614
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.007 0.5
Brugia malayi diacylglycerol kinase 0.0068 0.0651 0.1847
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.007 0.0678 0.168
Entamoeba histolytica hypothetical protein 0.0035 0.0231 0.1003
Brugia malayi Pleckstrin Homology Domain 0.0072 0.0705 0.2
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.007 0.5
Brugia malayi Protein kinase c protein 2 0.0238 0.2851 0.8084
Loa Loa (eye worm) hypothetical protein 0.0072 0.0705 0.1615
Echinococcus multilocularis N chimaerin 0.0068 0.0651 0.0651
Echinococcus granulosus RNA directed DNA polymerase 0.0161 0.1851 0.4586
Echinococcus multilocularis lamin 0.0026 0.0117 0.0117
Loa Loa (eye worm) RasGEF domain-containing protein 0.0068 0.0651 0.1491
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0171 0.1977 0.4526
Brugia malayi Variant SH3 domain containing protein 0.0068 0.0651 0.1847
Echinococcus multilocularis serine threonine protein kinase 0.0243 0.2912 0.2912
Echinococcus multilocularis RNA directed DNA polymerase 0.0161 0.1851 0.1851
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.007 0.0678 0.0678
Loa Loa (eye worm) hypothetical protein 0.0068 0.0651 0.1491
Schistosoma mansoni ap endonuclease 0.0023 0.007 0.0185
Loa Loa (eye worm) hypothetical protein 0.0356 0.4369 1
Echinococcus granulosus Rac GTPase activating protein 1 0.0068 0.0651 0.1614
Schistosoma mansoni serine/threonine protein kinase 0.007 0.0678 0.1791
Loa Loa (eye worm) hypothetical protein 0.0026 0.0117 0.0268
Echinococcus multilocularis myotubularin protein 13 0.0072 0.0705 0.0705
Onchocerca volvulus 0.0124 0.1378 0.4045
Entamoeba histolytica hypothetical protein 0.0068 0.0651 0.3628
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0068 0.0651 0.1491
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0068 0.0651 0.1491
Brugia malayi MH2 domain containing protein 0.0117 0.1282 0.3635
Schistosoma mansoni serine/threonine protein kinase 0.0075 0.0739 0.1951
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.007 0.016
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0401 0.1058
Loa Loa (eye worm) hypothetical protein 0.0349 0.4281 0.98
Entamoeba histolytica protein kinase, putative 0.0079 0.0793 0.4509
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0311 0.3786 0.3786
Loa Loa (eye worm) hypothetical protein 0.0229 0.2726 0.6239
Trichomonas vaginalis AGC family protein kinase 0.0079 0.0793 1
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0075 0.0739 0.1691
Echinococcus multilocularis serine:threonine protein kinase N2 0.0075 0.0739 0.0739
Loa Loa (eye worm) hypothetical protein 0.0281 0.3407 0.7799
Entamoeba histolytica hypothetical protein 0.0035 0.0231 0.1003
Echinococcus multilocularis musashi 0.0026 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.0281 0.3407 0.7799
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0075 0.075 0.1859
Schistosoma mansoni serine/threonine protein kinase 0.0068 0.0651 0.172
Entamoeba histolytica diacylglycerol kinase, putative 0.0068 0.0651 0.3628
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0075 0.0739 0.1691
Loa Loa (eye worm) hypothetical protein 0.0124 0.1378 0.3155
Echinococcus granulosus N chimaerin 0.0068 0.0651 0.1614
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.007 0.0198
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0117 0.0268
Schistosoma mansoni serine/threonine protein kinase 0.007 0.0678 0.1791
Loa Loa (eye worm) hypothetical protein 0.0124 0.1378 0.3155
Trypanosoma brucei rac serine-threonine kinase, putative 0.0079 0.0793 1
Brugia malayi RhoGAP domain containing protein 0.0068 0.0651 0.1847
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0194 0.2279 0.6462
Loa Loa (eye worm) hypothetical protein 0.0196 0.2307 0.528
Entamoeba histolytica hypothetical protein 0.0035 0.0231 0.1003
Echinococcus granulosus lamin dm0 0.0026 0.0117 0.029
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0291 0.3527 0.8074
Brugia malayi Hr1 repeat family protein 0.0075 0.0739 0.2094
Brugia malayi Protein kinase domain containing protein 0.0079 0.0793 0.2247
Loa Loa (eye worm) hypothetical protein 0.0161 0.1851 0.4238
Echinococcus granulosus NDR protein kinase 0.0075 0.0739 0.183
Echinococcus granulosus Diacylglycerol kinase theta 0.0068 0.0651 0.1614
Echinococcus granulosus protein kinase c epsilon type 0.0291 0.3527 0.8737
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.007 0.5
Entamoeba histolytica diacylglycerol kinase, putative 0.0068 0.0651 0.3628
Brugia malayi Protein kinase domain containing protein 0.0075 0.0739 0.2094
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0068 0.0651 0.0651
Echinococcus multilocularis serine:threonine protein kinase N2 0.0215 0.2554 0.2554
Schistosoma mansoni vav2 0.0072 0.0705 0.1863
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0126 0.1405 0.3216
Echinococcus multilocularis tumor protein p63 0.033 0.4037 0.4037
Brugia malayi protein kinase C II. 0.0291 0.3527 1
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0075 0.0739 0.0739
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0075 0.0739 0.1691
Trichomonas vaginalis AGC family protein kinase 0.0075 0.0739 0.9253
Echinococcus granulosus protein kinase c iota type 0.0142 0.1613 0.3996
Echinococcus multilocularis serine:threonine protein kinase 38 0.0075 0.0739 0.0739
Trichomonas vaginalis AGC family protein kinase 0.0075 0.0739 0.9253
Schistosoma mansoni unc-13 (munc13) 0.0075 0.075 0.1982
Schistosoma mansoni atypical protein kinase C 0.0142 0.1613 0.426
Entamoeba histolytica protein kinase, putative 0.0075 0.0739 0.4173
Schistosoma mansoni lamin 0.0026 0.0117 0.0309
Schistosoma mansoni rac gtpase activating protein 0.0068 0.0651 0.172
Brugia malayi intermediate filament protein 0.0026 0.0117 0.0332
Schistosoma mansoni ap endonuclease 0.0023 0.007 0.0185
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.1282 0.2935
Schistosoma mansoni serine/threonine protein kinase 0.0311 0.3786 1
Schistosoma mansoni unc-13 (munc13) 0.0075 0.075 0.1982
Loa Loa (eye worm) hypothetical protein 0.0192 0.2253 0.5156
Echinococcus multilocularis protein kinase c eta type 0.0068 0.0651 0.0651
Brugia malayi RhoGEF domain containing protein 0.0068 0.0651 0.1847
Brugia malayi RhoGAP domain containing protein 0.0068 0.0651 0.1847
Trichomonas vaginalis AGC family protein kinase 0.0079 0.0793 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0231 0.0231
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0075 0.0739 0.183
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.007 0.0678 0.1552
Loa Loa (eye worm) hypothetical protein 0.0048 0.0401 0.0917
Schistosoma mansoni diacylglycerol kinase theta 0.0068 0.0651 0.172
Echinococcus granulosus raf serine:threonine protein kinase 0.0068 0.0651 0.1614
Schistosoma mansoni serine/threonine kinase 0.0075 0.0739 0.1951
Trichomonas vaginalis AGC family protein kinase 0.0075 0.0739 0.9253
Loa Loa (eye worm) hypothetical protein 0.0068 0.0651 0.1491
Onchocerca volvulus 0.0026 0.0117 0.0343
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0075 0.075 0.075
Trichomonas vaginalis AGC family protein kinase 0.0079 0.0793 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.007 0.5
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0117 0.0332
Loa Loa (eye worm) AGC/AKT protein kinase 0.0079 0.0793 0.1814
Brugia malayi Ras association domain family 1 isoform A 0.0068 0.0651 0.1847
Echinococcus granulosus unc 13 munc13 0.0075 0.075 0.1859
Loa Loa (eye worm) hypothetical protein 0.0075 0.075 0.1718
Schistosoma mansoni serine/threonine protein kinase 0.0075 0.0739 0.1951
Echinococcus multilocularis geminin 0.0166 0.1913 0.1913
Echinococcus granulosus protein kinase c eta type 0.0068 0.0651 0.1614
Entamoeba histolytica PH domain containing protein kinase, putative 0.0147 0.1673 1
Echinococcus multilocularis Diacylglycerol kinase theta 0.0068 0.0651 0.0651
Loa Loa (eye worm) AGC/NDR protein kinase 0.0075 0.0739 0.1691

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0024 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

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