Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Human immunodeficiency virus 1 | Integrase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | hypothetical protein | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Plasmodium yoelii | integrase-related | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Trypanosoma congolense | RNA helicase, putative | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Trypanosoma brucei | RNA helicase, putative | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | acetyl coenzyme A C acetyltransferase | 0.0055 | 0.1697 | 0.1783 |
Mycobacterium ulcerans | beta-lactamase | 0.0035 | 0.0721 | 0.5 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0035 | 0.0721 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0721 | 0.5 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0092 | 0.3512 | 1 |
Onchocerca volvulus | 0.0035 | 0.0721 | 1 | |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.003 | 0.0482 | 0.0661 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0035 | 0.0742 | 0.0381 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0721 | 0.5 |
Onchocerca volvulus | 0.0035 | 0.0721 | 1 | |
Echinococcus granulosus | Tolloid protein 1 | 0.003 | 0.0482 | 0.0541 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0721 | 0.5 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0035 | 0.0721 | 0.0873 |
Echinococcus multilocularis | geminin | 0.0169 | 0.7293 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0.0721 | 0.5 |
Trypanosoma brucei | RNA helicase, putative | 0.0125 | 0.5143 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0721 | 0.0989 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.1904 | 0.4694 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.7293 | 1 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.0093 | 0.0127 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0721 | 0.0789 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0721 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0721 | 0.0789 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0035 | 0.0721 | 0.5 |
Brugia malayi | PHD-finger family protein | 0.0079 | 0.2905 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0721 | 0.5 |
Trichomonas vaginalis | esterase, putative | 0.0035 | 0.0721 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0721 | 0.0789 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0721 | 0.0789 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0035 | 0.0721 | 0.0351 |
Mycobacterium ulcerans | hypothetical protein | 0.0035 | 0.0721 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0721 | 0.0987 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.0721 | 0.0789 |
Brugia malayi | beta-lactamase | 0.0035 | 0.0721 | 0.0987 |
Echinococcus granulosus | acetyl coenzyme A C acetyltransferase | 0.0055 | 0.1697 | 0.2228 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0721 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0721 | 0.0789 |
Toxoplasma gondii | ABC1 family protein | 0.0035 | 0.0721 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0125 | 0.5143 | 0.7051 |
Mycobacterium ulcerans | lipase LipD | 0.0035 | 0.0721 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0721 | 0.0989 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0035 | 0.0742 | 0.0902 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0721 | 0.0789 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0.0721 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.0038 | 0.0857 | 0.1545 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0721 | 0.0987 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.0721 | 0.0987 |
Onchocerca volvulus | 0.0035 | 0.0721 | 1 | |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0721 | 0.5 |
Echinococcus granulosus | geminin | 0.0169 | 0.7293 | 1 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0077 | 0.279 | 0.3388 |
Mycobacterium leprae | Probable lipase LipE | 0.0035 | 0.0721 | 0.5 |
Schistosoma mansoni | bromodomain containing protein | 0.0025 | 0.0207 | 0.0284 |
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.0721 | 0.0789 |
Echinococcus granulosus | laminin | 0.003 | 0.0482 | 0.0541 |
Schistosoma mansoni | egf-like domain protein | 0.003 | 0.0482 | 0.0661 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.7293 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0035 | 0.0721 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 69 nM | Inhibition of HIV1 recombinant integrase strand transfer activity treated after enzyme assembly and washing | ChEMBL. | 19523819 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.