Detailed information for compound 1064438

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 525.59 | Formula: C29H35NO8
  • H donors: 2 H acceptors: 6 LogP: 4.65 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC[C@]1(C)[C@H](O)CC[C@@]2([C@@H]1CCC(=C)[C@H]2C/C=C/1\[C@@H](COC1=O)OC(=O)/C=C/c1ccc(cc1)[N+](=O)[O-])C
  • InChi: 1S/C29H35NO8/c1-18-4-12-24-28(2,15-14-25(32)29(24,3)17-31)22(18)11-10-21-23(16-37-27(21)34)38-26(33)13-7-19-5-8-20(9-6-19)30(35)36/h5-10,13,22-25,31-32H,1,4,11-12,14-17H2,2-3H3/b13-7+,21-10+/t22-,23-,24+,25-,28+,29+/m1/s1
  • InChiKey: BZQGYSXBDCQLKA-YZNRELOPSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0386 0.029
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0386 0.029
Loa Loa (eye worm) hypothetical protein 0.016 0.3565 0.6593
Loa Loa (eye worm) hypothetical protein 0.0022 0.0316 0.0537
Schistosoma mansoni transcription factor LCR-F1 0.0021 0.0287 0.0287
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.0238 0.5393 0.5393
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0056 0.0056
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0289 0.0289
Loa Loa (eye worm) hypothetical protein 0.0025 0.0386 0.0668
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0289 0.0289
Loa Loa (eye worm) agrin synaptic family protein 0.0022 0.0316 0.0537
Loa Loa (eye worm) hypothetical protein 0.0022 0.0316 0.0537
Echinococcus granulosus nuclear receptor nhr 48 0.001 0.0028 0.0028
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0044 0.003
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0289 0.0487
Schistosoma mansoni hypothetical protein 0.0434 1 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0386 0.029
Schistosoma mansoni nuclear hormone receptor 0.001 0.0028 0.0028
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.0238 0.5393 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0044 0.0044
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0237 0.5
Schistosoma mansoni zinc finger protein 0.001 0.0028 0.0028
Schistosoma mansoni hypothetical protein 0.0021 0.0287 0.0287
Brugia malayi Pre-SET motif family protein 0.0222 0.5003 0.9273
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0289 0.0487
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0028 0.0028
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0386 0.029
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0152 0.3357 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0289 0.0289
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0386 0.0668
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0028 0.0028
Schistosoma mansoni coup transcription factor 0.0021 0.0289 0.0289
Schistosoma mansoni follistatin 0.0022 0.0316 0.0316
Loa Loa (eye worm) hypothetical protein 0.0033 0.0559 0.0989
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0033 0.0559 0.0559
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0112 0.2421 0.0645
Brugia malayi secreted modular calcium-binding protein 1 0.0022 0.0316 0.0537
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0152 0.3357 0.6052
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0237 0.0077
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0386 0.0668
Loa Loa (eye worm) hypothetical protein 0.0011 0.0056 0.0052
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0033 0.0559 0.0559
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0022 0.0316 0.0537
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0555 0.0555
Brugia malayi sodium-independent organic anion transporter family protein 0.0033 0.0559 0.0989
Schistosoma mansoni cpg binding protein 0.0032 0.0552 0.0552
Brugia malayi hypothetical protein 0.016 0.3565 0.6593
Brugia malayi SPARC precursor 0.0022 0.0316 0.0537
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0386 0.0552
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0289 0.0487
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0289 0.0487
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0289 0.0289
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0289 0.0289
Schistosoma mansoni cpg binding protein 0.0032 0.0552 0.0552
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0289 0.0487
Loa Loa (eye worm) hypothetical protein 0.0033 0.0559 0.0989
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0289 0.0289
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0289 0.0289
Echinococcus granulosus follistatin 0.0022 0.0316 0.0316
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 0.7087 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0289 0.0487
Loa Loa (eye worm) hypothetical protein 0.0019 0.0237 0.0389
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.0238 0.5393 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0021 0.0287 0.0287
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0289 0.0487
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0033 0.0559 0.0559
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0222 0.5003 0.9273
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 0.7087 1
Treponema pallidum fructose-bisphosphate aldolase 0.031 0.7087 0.5
Brugia malayi steroid hormone receptor 0.0021 0.0289 0.0487
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 0.7087 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0237 0.0389
Brugia malayi sodium-independent organic anion transporter family protein 0.0033 0.0559 0.0989
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0289 0.0289
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0022 0.0316 0.0537
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.118 1
Brugia malayi nuclear receptor NHR-88 0.0021 0.0289 0.0487
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0512 0.0512
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0555 0.0555
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0386 0.0668
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0289 0.0487
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0289 0.0289
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0041 0.0024
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0289 0.0289
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0289 0.0487
Brugia malayi hypothetical protein 0.0033 0.0559 0.0989
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0289 0.0487
Schistosoma mansoni nuclear receptor 0.001 0.0028 0.0028
Onchocerca volvulus Putative organic anion transporter 0.0033 0.0559 0.0932
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0021 0.0287 0.0287
Echinococcus multilocularis agrin 0.0022 0.0316 0.0316
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.001 0.0028 0.0028
Echinococcus granulosus Protein patched homolog 1 0.0098 0.2099 0.2099
Echinococcus granulosus cpg binding protein 0.0032 0.0552 0.0552
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0112 0.2421 0.0645
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0237 0.5
Loa Loa (eye worm) hypothetical protein 0.0021 0.0289 0.0487
Onchocerca volvulus 0.0032 0.0555 0.0926
Loa Loa (eye worm) hypothetical protein 0.0025 0.0386 0.0668
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0289 0.0487
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.001 0.0028 0.0028
Echinococcus multilocularis nuclear receptor nhr 48 0.001 0.0028 0.0028
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0555 0.0555
Plasmodium vivax SET domain protein, putative 0.0032 0.0555 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.001 0.0028 0.0028
Brugia malayi CHE-14 protein 0.0098 0.2099 0.3861
Loa Loa (eye worm) hypothetical protein 0.0033 0.0559 0.0989
Loa Loa (eye worm) hypothetical protein 0.0021 0.0289 0.0487
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 0.7087 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0056 0.0052
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0555 0.2767
Echinococcus granulosus agrin 0.0022 0.0316 0.0316
Onchocerca volvulus 0.016 0.3565 0.6213
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.1342 0.1342
Schistosoma mansoni nuclear receptor 0.001 0.0028 0.0028
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0289 0.0289
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.0238 0.5393 1
Echinococcus granulosus Solute carrier organic anion transporter family 0.0033 0.0559 0.0559
Brugia malayi hypothetical protein 0.0021 0.0287 0.0484
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.001 0.0028 0.0028
Echinococcus multilocularis sterol regulatory element binding protein 0.0098 0.2099 0.2099
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0386 0.029
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0289 0.0289
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0555 0.0555
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0021 0.0289 0.0487
Onchocerca volvulus 0.0033 0.0559 0.0932
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0289 0.0289
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0289 0.0487
Brugia malayi prostaglandin transporter 0.0033 0.0559 0.0989
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 0.7087 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0559 0.0989
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0238 0.5393 0.5
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 0.7087 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0289 0.0487
Echinococcus multilocularis protein patched 0.0098 0.2099 0.2099
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0289 0.0459
Onchocerca volvulus 0.0021 0.0289 0.0459
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0289 0.0289
Loa Loa (eye worm) hypothetical protein 0.0011 0.0056 0.0052
Trichomonas vaginalis set domain proteins, putative 0.0252 0.572 0.726
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0289 0.0289
Schistosoma mansoni cpg binding protein 0.003 0.0511 0.0511
Schistosoma mansoni agrin 0.0022 0.0316 0.0316
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0289 0.0487
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0289 0.0289
Brugia malayi Pre-SET motif family protein 0.0032 0.0555 0.0983
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0056 0.0052
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0289 0.0459
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0289 0.0487
Echinococcus granulosus sterol regulatory element binding protein 0.0098 0.2099 0.2099
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.2099 0.2099
Brugia malayi hypothetical protein 0.0011 0.0056 0.0052
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0386 0.029
Onchocerca volvulus 0.0025 0.0386 0.0629
Onchocerca volvulus 0.0022 0.0316 0.0507
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0056 0.0052
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0112 0.2421 0.0645
Onchocerca volvulus 0.0033 0.0559 0.0932
Echinococcus multilocularis cpg binding protein 0.0032 0.0552 0.0552
Onchocerca volvulus 0.003 0.0511 0.0849
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0056 0.0056
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0056 0.0056
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0289 0.0289
Mycobacterium ulcerans hypothetical protein 0.0025 0.0386 0.029
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0289 0.0487
Loa Loa (eye worm) hypothetical protein 0.0022 0.0316 0.0537
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0022 0.0316 0.0537
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0056 0.0052
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0289 0.0487
Onchocerca volvulus Putative organic anion transporter 0.0033 0.0559 0.0932
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 0.7087 1
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.0238 0.5393 0.5393
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0289 0.0289
Giardia lamblia Fructose-bisphosphate aldolase 0.031 0.7087 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0289 0.0487
Echinococcus multilocularis Niemann Pick C1 protein 0.0098 0.2099 0.2099
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0289 0.0289
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0289 0.0487
Schistosoma mansoni organic anion transporter 0.0033 0.0559 0.0559
Schistosoma mansoni nuclear hormone receptor 0.001 0.0028 0.0028
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0022 0.0316 0.0537
Loa Loa (eye worm) hypothetical protein 0.0021 0.0289 0.0487
Echinococcus multilocularis protein dispatched 1 0.0098 0.2099 0.2099
Onchocerca volvulus 0.0252 0.572 1
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0289 0.0289
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0386 0.0145
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0033 0.0559 0.0989
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0289 0.0289
Loa Loa (eye worm) hypothetical protein 0.0011 0.0056 0.0052
Onchocerca volvulus 0.0033 0.0559 0.0932
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0238 0.5393 1
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0289 0.0487
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0386 0.0145
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0044 0.0044
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0289 0.0289
Echinococcus granulosus thyroid hormone receptor alpha 0.001 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0032 0.0555 0.0983
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0289 0.0487
Onchocerca volvulus Putative organic anion transporter 0.0033 0.0559 0.0932
Schistosoma mansoni nuclear receptor nhr-48 0.001 0.0028 0.0028
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0289 0.0289
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.001 0.0028 0.0028
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0289 0.0289
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0289 0.0487
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0152 0.3357 1
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0022 0.0316 0.0537
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0289 0.0487
Loa Loa (eye worm) hypothetical protein 0.0025 0.0386 0.0668
Echinococcus multilocularis expressed protein 0.0022 0.0316 0.0316
Loa Loa (eye worm) hypothetical protein 0.0019 0.0237 0.0389
Brugia malayi CXXC zinc finger family protein 0.003 0.0511 0.0901
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0386 0.029
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0028 0.0028
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0555 0.0555
Loa Loa (eye worm) hypothetical protein 0.0022 0.0316 0.0537
Brugia malayi sodium-independent organic anion transporter family protein 0.0033 0.0559 0.0989
Loa Loa (eye worm) hypothetical protein 0.0033 0.0559 0.0989
Schistosoma mansoni organic anion transporter 0.0033 0.0559 0.0559
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0289 0.0289
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0511 0.0901
Loa Loa (eye worm) hypothetical protein 0.0033 0.0559 0.0989
Onchocerca volvulus 0.0033 0.0559 0.0932
Loa Loa (eye worm) hypothetical protein 0.0019 0.0237 0.0389
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0098 0.2099 0.3861
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0028 0.0028
Brugia malayi hypothetical protein 0.0011 0.0056 0.0052
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 0.7087 1
Schistosoma mansoni patched 1 0.0098 0.2099 0.2099
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0555 0.0555
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.031 0.7087 1
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0289 0.0289
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0289 0.0289
Brugia malayi ecdysteroid receptor 0.0021 0.0289 0.0487
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0289 0.0289
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0289 0.0459
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0289 0.0289
Loa Loa (eye worm) hypothetical protein 0.0011 0.0056 0.0052
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.0238 0.5393 0.5393
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0289 0.0289
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0028 0.0028
Brugia malayi nuclear receptor RXR 0.0011 0.0056 0.0052
Brugia malayi nuclear hormone receptor 0.0021 0.0289 0.0487
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.0238 0.5393 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0386 0.0552
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0386 0.0145
Loa Loa (eye worm) hypothetical protein 0.0021 0.0289 0.0487
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.031 0.7087 1
Echinococcus multilocularis follistatin 0.0022 0.0316 0.0316
Loa Loa (eye worm) hypothetical protein 0.0098 0.2099 0.3861
Brugia malayi hypothetical protein 0.0033 0.0559 0.0989
Loa Loa (eye worm) hypothetical protein 0.0019 0.0237 0.0389
Loa Loa (eye worm) hypothetical protein 0.0033 0.0559 0.0989
Echinococcus multilocularis dnaJ subfamily B 0.0434 1 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0289 0.0487
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0555 0.0555
Echinococcus granulosus Niemann Pick C1 protein 0.0098 0.2099 0.2099
Onchocerca volvulus 0.0033 0.0559 0.0932
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0289 0.0487
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0289 0.0487
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0289 0.0487
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0238 0.5393 1
Toxoplasma gondii transporter, major facilitator family protein 0.0033 0.0559 0.2807

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) Antifungal activity against Candida albicans at 0.05 mg/disk after 25 hrs ChEMBL. 19152987
IZ (functional) < 4 mm Antibacterial activity against Escherichia coli at 0.05 mg/disk after 25 hrs ChEMBL. 19152987

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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