Detailed information for compound 1064547

Basic information

Technical information
  • TDR Targets ID: 1064547
  • Name: 1-[5-(4-methoxyphenyl)-2-phenyl-2H-1,3,4-oxad iazol-3-yl]ethanone
  • MW: 296.321 | Formula: C17H16N2O3
  • H donors: 0 H acceptors: 1 LogP: 2.91 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)C1=NN(C(O1)c1ccccc1)C(=O)C
  • InChi: 1S/C17H16N2O3/c1-12(20)19-17(14-6-4-3-5-7-14)22-16(18-19)13-8-10-15(21-2)11-9-13/h3-11,17H,1-2H3
  • InChiKey: INSKKHXYAABQID-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.016 0.016
Echinococcus multilocularis tar DNA binding protein 0.0145 0.6945 0.6945
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0145 0.6945 0.6955
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0 0.5
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0 0.5
Echinococcus multilocularis geminin 0.019 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.016 0.016
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0 0.5
Schistosoma mansoni alpha-glucosidase 0.0163 0.8199 0.8199
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.019 0.9986 1
Echinococcus granulosus lysosomal alpha glucosidase 0.019 0.9986 0.9986
Trichomonas vaginalis sucrase-isomaltase, putative 0.0042 0 0.5
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0 0.5
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.016 0.016
Loa Loa (eye worm) TAR-binding protein 0.0145 0.6945 0.6955
Schistosoma mansoni hypothetical protein 0.019 1 1
Schistosoma mansoni tar DNA-binding protein 0.0145 0.6945 0.6945
Echinococcus multilocularis lysosomal alpha glucosidase 0.019 0.9986 0.9986
Onchocerca volvulus Huntingtin homolog 0.0137 0.6441 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0 0.5
Onchocerca volvulus Huntingtin homolog 0.0137 0.6441 1
Schistosoma mansoni tar DNA-binding protein 0.0145 0.6945 0.6945
Brugia malayi RNA binding protein 0.0145 0.6945 0.6955
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0137 0.6441 0.645
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0 0.5
Schistosoma mansoni tar DNA-binding protein 0.0145 0.6945 0.6945
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.016 0.016
Brugia malayi Glycosyl hydrolases family 31 protein 0.019 0.9986 1
Schistosoma mansoni alpha-glucosidase 0.0163 0.8199 0.8199
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0 0.5
Schistosoma mansoni hypothetical protein 0.019 1 1
Brugia malayi RNA recognition motif domain containing protein 0.0145 0.6945 0.6955
Loa Loa (eye worm) RNA binding protein 0.0145 0.6945 0.6955
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.016 0.016
Leishmania major alpha glucosidase II subunit, putative 0.0042 0 0.5
Schistosoma mansoni tar DNA-binding protein 0.0145 0.6945 0.6945
Trichomonas vaginalis maltase-glucoamylase, putative 0.0042 0 0.5
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0 0.5
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.016 0.016
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0042 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0137 0.6441 0.645
Brugia malayi hypothetical protein 0.0137 0.6441 0.645
Brugia malayi TAR-binding protein 0.0145 0.6945 0.6955
Echinococcus multilocularis lysosomal alpha glucosidase 0.019 0.9986 0.9986
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.016 0.016
Schistosoma mansoni tar DNA-binding protein 0.0145 0.6945 0.6945
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.016 0.016
Echinococcus granulosus tar DNA binding protein 0.0145 0.6945 0.6945
Trypanosoma brucei glucosidase, putative 0.0042 0 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.016 0.016
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0 0.5

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 100 uM Antiproliferative activity against mouse L1210 cells after 72 hrs by MTT assay ChEMBL. 19894742

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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