Detailed information for compound 1064833

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 417.543 | Formula: C26H31N3O2
  • H donors: 1 H acceptors: 2 LogP: 4.72 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N(O)C)CCCCCC(c1cn(c2c1cccc2)C)c1cn(c2c1cccc2)C
  • InChi: 1S/C26H31N3O2/c1-27-17-22(20-12-7-9-14-24(20)27)19(11-5-4-6-16-26(30)29(3)31)23-18-28(2)25-15-10-8-13-21(23)25/h7-10,12-15,17-19,31H,4-6,11,16H2,1-3H3
  • InChiKey: OODBDCJTXSJPJY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) steroid hormone receptor 0.0018 0.0133 0.0235
Schistosoma mansoni hypothetical protein 0.0025 0.0203 0.0336
Loa Loa (eye worm) hypothetical protein 0.0007 0.0013 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0035 0.0062
Mycobacterium ulcerans aminopeptidase N PepN 0.0045 0.0422 0.3091
Loa Loa (eye worm) hypothetical protein 0.0047 0.0437 0.0773
Loa Loa (eye worm) hypothetical protein 0.0045 0.0422 0.0746
Trypanosoma brucei DNA polymerase kappa, putative 0.0009 0.0039 0.0069
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0013 0.0076 0.0203
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0035 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0213 0.0376
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0128 0.1311 0.1299
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0133 0.0212
Echinococcus multilocularis zinc finger protein 0.001 0.0052 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0035 0.0062
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0018 0.0131 0.0232
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0008 0.0023 0.001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0133 0.0235
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0149 0.1528 0.2701
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.001 0.0042 0.0051
Loa Loa (eye worm) Notch2 0.0007 0.0013 0.0023
Toxoplasma gondii isocitrate dehydrogenase 0.0008 0.0023 0.0041
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0535 0.5655 1
Echinococcus granulosus fetal alzheimer antigen falz 0.0012 0.0067 0.0096
Loa Loa (eye worm) hypothetical protein 0.0047 0.0437 0.0773
Echinococcus granulosus short transient receptor potential channel 6 0.0062 0.0606 0.1051
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.001 0.0043 0.0142
Trypanosoma brucei DNA polymerase IV, putative 0.0009 0.0039 0.0069
Onchocerca volvulus 0.0018 0.0133 0.0923
Loa Loa (eye worm) hypothetical protein 0.0009 0.0031 0.0055
Loa Loa (eye worm) hypothetical protein 0.0009 0.0031 0.0055
Schistosoma mansoni bromodomain containing protein 0.0032 0.0281 0.0476
Onchocerca volvulus 0.0021 0.0162 0.1148
Entamoeba histolytica hypothetical protein 0.0022 0.0172 0.0244
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0047 0.0437 0.0752
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0133 0.0212
Trichomonas vaginalis conserved hypothetical protein 0.0294 0.3076 0.5439
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0009 0.0031 0.0139
Schistosoma mansoni hypothetical protein 0.0025 0.0203 0.0336
Brugia malayi nuclear hormone receptor 0.0018 0.0133 0.0212
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0015 0.0096 0.017
Mycobacterium tuberculosis Conserved protein 0.0047 0.0437 0.1368
Loa Loa (eye worm) hypothetical protein 0.0045 0.0422 0.0746
Loa Loa (eye worm) hypothetical protein 0.0018 0.0133 0.0235
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0012 0.0064 0.0165
Loa Loa (eye worm) hypothetical protein 0.0018 0.0131 0.0232
Echinococcus granulosus zinc finger protein 0.001 0.0052 0.0069
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0031 0.0018
Mycobacterium ulcerans lipase LipD 0.0047 0.0437 0.321
Trypanosoma cruzi hypothetical protein, conserved 0.0047 0.0437 0.074
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0018 0.0133 0.0235
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0008 0.0023 0.0018
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0083 0.0829 0.0817
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0018 0.0133 0.0212
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0535 0.5655 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0009 0.0039 0.0069
Trypanosoma brucei ISWI complex protein 0.0008 0.0021 0.0037
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0128 0.1311 0.1299
Loa Loa (eye worm) hypothetical protein 0.002 0.0154 0.0273
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0021 0.0163 0.0253
Schistosoma mansoni ap endonuclease 0.0025 0.0206 0.0343
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0025 0.0206 0.1414
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0128 0.1311 0.23
Echinococcus granulosus sterol regulatory element binding protein 0.0026 0.0213 0.0354
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0018 0.0131 0.038
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.007 0.0692 0.1223
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0126 0.1288 0.226
Trypanosoma cruzi Aminopeptidase M1, putative 0.0128 0.1311 0.229
Mycobacterium ulcerans polyketide synthase 0.0012 0.0068 0.0336
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0009 0.0035 0.0026
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0009 0.0036 0.0026
Trypanosoma brucei DNA polymerase kappa, putative 0.0009 0.0039 0.0069
Loa Loa (eye worm) hypothetical protein 0.0007 0.0013 0.0023
Echinococcus multilocularis serine protein kinase ATM 0.0012 0.0071 0.0058
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0035 0.0062
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0133 0.0212
Trichomonas vaginalis ap endonuclease, putative 0.0025 0.0206 0.0365
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0012 0.0068 0.0336
Loa Loa (eye worm) hypothetical protein 0.0018 0.0131 0.0232
Echinococcus granulosus short transient receptor potential channel 6 0.0062 0.0606 0.1051
Brugia malayi tailless protein 0.0009 0.0031 0.0032
Leishmania major hypothetical protein, conserved 0.0047 0.0437 0.074
Loa Loa (eye worm) hypothetical protein 0.0009 0.0031 0.0055
Schistosoma mansoni cpg binding protein 0.0016 0.011 0.0171
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.026 0.2714 0.4779
Brugia malayi nuclear receptor RXR 0.0009 0.0031 0.0032
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0045 0.0422 0.0712
Brugia malayi hypothetical protein 0.0009 0.0031 0.0032
Schistosoma mansoni aminopeptidase A (M01 family) 0.0045 0.0422 0.0725
Entamoeba histolytica hypothetical protein 0.0022 0.0172 0.0244
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.001 0.0043 0.0142
Trichomonas vaginalis D-aminoacylase, putative 0.0047 0.0437 0.0773
Brugia malayi nuclear receptor NHR-88 0.0018 0.0133 0.0212
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.003 0.0263 0.0442
Brugia malayi Nuclear hormone receptor E75 0.0009 0.0031 0.0032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0035 0.0062
Loa Loa (eye worm) notch protein 0.0007 0.0013 0.0023
Mycobacterium ulcerans aminopeptidase N PepN 0.0128 0.1311 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0133 0.0212
Schistosoma mansoni zinc finger protein 0.0008 0.0021 0.0013
Toxoplasma gondii ABC1 family protein 0.0047 0.0437 0.0773
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0018 0.0133 0.0212
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0009 0.0039 0.0026
Echinococcus multilocularis short transient receptor potential channel 6 0.0062 0.0606 0.0594
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0045 0.0422 0.0712
Trypanosoma brucei Enriched in surface-labeled proteome protein 12 0.026 0.2714 0.4798
Toxoplasma gondii FATC domain-containing protein 0.0012 0.0071 0.0125
Echinococcus granulosus nuclear receptor nhr 48 0.0009 0.0031 0.0032
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0018 0.0133 0.0212
Entamoeba histolytica aminopeptidase, putative 0.0128 0.1311 0.227
Brugia malayi Calcium binding EGF domain containing protein 0.0018 0.0131 0.0209
Loa Loa (eye worm) hypothetical protein 0.0007 0.0013 0.0023
Giardia lamblia DINP protein human, muc B family 0.0009 0.0039 0.1342
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0133 0.012
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0009 0.0031 0.0032
Echinococcus granulosus histone lysine methyltransferase setb 0.0009 0.0033 0.0036
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0018 0.0133 0.0212
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0009 0.0031 0.0018
Loa Loa (eye worm) hypothetical protein 0.0007 0.0013 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0035 0.0062
Mycobacterium leprae Probable lipase LipE 0.0047 0.0437 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0009 0.0035 0.0062
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0035 0.0062
Brugia malayi hypothetical protein 0.0022 0.0172 0.0282
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0128 0.1311 0.2318
Giardia lamblia TCP-1 chaperonin subunit beta 0.0015 0.0096 0.4306
Echinococcus multilocularis protein dispatched 1 0.0029 0.0251 0.0238
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0018 0.0133 0.0235
Trypanosoma brucei DNA polymerase kappa, putative 0.0009 0.0039 0.0069
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0009 0.0035 0.0062
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0535 0.5655 1
Mycobacterium ulcerans hypothetical protein 0.0047 0.0437 0.321
Brugia malayi hypothetical protein 0.0128 0.1311 0.23
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0045 0.0422 0.0712
Loa Loa (eye worm) hypothetical protein 0.0009 0.0031 0.0055
Brugia malayi conserved hypotetical protein 0.0009 0.0031 0.0032
Loa Loa (eye worm) hypothetical protein 0.0047 0.0437 0.0773
Loa Loa (eye worm) hypothetical protein 0.0047 0.0437 0.0773
Entamoeba histolytica hypothetical protein 0.0012 0.0071 0.0063
Echinococcus granulosus methyl CpG binding domain protein 2 0.0008 0.003 0.003
Schistosoma mansoni egf-like domain protein 0.0018 0.0131 0.0209
Schistosoma mansoni cpg binding protein 0.0016 0.011 0.0171
Schistosoma mansoni ap endonuclease 0.0025 0.0206 0.0343
Echinococcus multilocularis ecdysone induced protein 78C 0.0018 0.0133 0.012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0035 0.0062
Brugia malayi photoreceptor-specific nuclear receptor 0.0018 0.0133 0.0212
Onchocerca volvulus Arrow homolog 0.0018 0.0131 0.091
Brugia malayi orphan nuclear receptor NR2E1 0.0009 0.0031 0.0032
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.007 0.0692 0.1191
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0025 0.0206 0.0343
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0018 0.0133 0.0235
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0025 0.0206 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0437 0.0773
Loa Loa (eye worm) hypothetical protein 0.006 0.058 0.1025
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0013 0.0076 0.0203
Brugia malayi hypothetical protein 0.0009 0.0031 0.0032
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0128 0.1311 0.229
Treponema pallidum exodeoxyribonuclease (exoA) 0.0025 0.0206 0.5
Leishmania major DNA polymerase eta, putative 0.0009 0.0039 0.0033
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0021 0.0163 0.0253
Schistosoma mansoni terminal deoxycytidyl transferase 0.0009 0.0039 0.0046
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0031 0.0032
Loa Loa (eye worm) hypothetical protein 0.0009 0.0033 0.0059
Mycobacterium ulcerans beta-lactamase 0.0047 0.0437 0.321
Loa Loa (eye worm) hypothetical protein 0.0007 0.0013 0.0023
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0018 0.0129 0.0116
Onchocerca volvulus 0.0009 0.0031 0.0139
Mycobacterium ulcerans DNA polymerase IV 0.0009 0.0039 0.0113
Brugia malayi T-complex protein 1, beta subunit 0.0015 0.0096 0.0148
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0047 0.0437 0.1368
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0009 0.0035 0.0039
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0021
Schistosoma mansoni methyl-cpg binding protein mbd 0.0008 0.003 0.003
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0009 0.0033 0.0036
Brugia malayi nuclear hormone receptor family member nhr-6 0.0009 0.0031 0.0032
Onchocerca volvulus 0.0045 0.0422 0.3152
Schistosoma mansoni thyroid hormone receptor 0.0018 0.0133 0.0212
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0025 0.0212 0.034
Trichomonas vaginalis D-aminoacylase, putative 0.0047 0.0437 0.0773
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0018 0.0133 0.0212
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0015 0.0096 0.0148
Brugia malayi nuclear hormone receptor family member odr-7 0.0009 0.0031 0.0032
Schistosoma mansoni hypothetical protein 0.0359 0.3775 0.6668
Trypanosoma brucei DNA polymerase eta, putative 0.0009 0.0039 0.0069
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0128 0.1311 0.1299
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0035 0.0062
Brugia malayi nuclear receptor NHR-88 0.0009 0.0031 0.0032
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.001 0.0042 0.0029
Mycobacterium tuberculosis Conserved hypothetical protein 0.0009 0.0039 0.0085
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0535 0.5655 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0013 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0071 0.0125
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0128 0.1311 0.2318
Loa Loa (eye worm) hypothetical protein 0.0009 0.0031 0.0055
Onchocerca volvulus 0.0014 0.0091 0.0602
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0025 0.0206 0.033
Loa Loa (eye worm) hypothetical protein 0.0007 0.0013 0.0023
Trypanosoma brucei DNA polymerase kappa, putative 0.0006 0.0008 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0035 0.0062
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0018 0.0133 0.0212
Brugia malayi Fibulin-1 precursor 0.0018 0.0131 0.0209
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0035 0.0062
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0128 0.1311 0.1299
Loa Loa (eye worm) hypothetical protein 0.0007 0.0013 0.0023
Loa Loa (eye worm) hypothetical protein 0.002 0.0154 0.0273
Toxoplasma gondii calcium binding egf domain-containing protein 0.0018 0.0131 0.0232
Trypanosoma brucei DNA polymerase kappa, putative 0.0009 0.0039 0.0069
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0009 0.0035 0.0039
Brugia malayi beta-lactamase family protein 0.0047 0.0437 0.0752
Trypanosoma cruzi DNA polymerase kappa, putative 0.0009 0.0039 0.0033
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0009 0.0039 0.0046
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0008 0.0023 0.0005
Loa Loa (eye worm) hypothetical protein 0.0007 0.0013 0.0023
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0042 0.0051
Echinococcus multilocularis aminopeptidase N 0.0128 0.1311 0.1299
Echinococcus multilocularis Tolloid protein 1 0.0018 0.0131 0.0118
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0015 0.0096 0.0148
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.026 0.2714 0.4779
Trypanosoma cruzi target of rapamycin kinase 3 0.0009 0.0035 0.0026
Echinococcus granulosus cpg binding protein 0.0016 0.011 0.0171
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0535 0.5655 1
Echinococcus granulosus dna polymerase kappa 0.0009 0.0039 0.0046
Trypanosoma brucei DNA polymerase kappa, putative 0.0006 0.0008 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0035 0.0062
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0009 0.0035 0.0026
Loa Loa (eye worm) DR-78 0.0009 0.0031 0.0055
Mycobacterium ulcerans Type I modular polyketide synthase 0.0012 0.0068 0.0336
Brugia malayi exodeoxyribonuclease III family protein 0.0025 0.0206 0.0343
Toxoplasma gondii calcium binding egf domain-containing protein 0.0018 0.0131 0.0232
Echinococcus multilocularis short transient receptor potential channel 6 0.0062 0.0606 0.0594
Loa Loa (eye worm) hypothetical protein 0.0009 0.0031 0.0055
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0008 0.0023 0.0005
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0012 0.0068 0.0177
Schistosoma mansoni hypothetical protein 0.0201 0.209 0.3681
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0018 0.0133 0.0212
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0132 0.1346 0.2362
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0025 0.0206 0.0325
Trypanosoma brucei hypothetical protein, conserved 0.0047 0.0437 0.0773
Schistosoma mansoni hypothetical protein 0.001 0.0049 0.0063
Brugia malayi hypothetical protein 0.001 0.0042 0.0051
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0045 0.0422 0.0708
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0023 0.0182 0.0299
Loa Loa (eye worm) T-complex protein 1 0.0015 0.0096 0.017
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0008 0.0023 0.0041
Plasmodium vivax hypothetical protein, conserved 0.0047 0.0437 0.0735
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.001 0.0042 0.0051
Loa Loa (eye worm) isocitrate dehydrogenase 0.0008 0.0023 0.0041
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0009 0.0035 0.0062
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0009 0.0031 0.0032
Mycobacterium tuberculosis Probable lipase LipD 0.0047 0.0437 0.1368
Loa Loa (eye worm) TATA binding protein associated factor 0.0045 0.0422 0.0746
Onchocerca volvulus 0.0047 0.0437 0.327
Entamoeba histolytica hypothetical protein 0.0022 0.0172 0.0244
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0018 0.0133 0.012
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0012 0.0068 0.0177
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0009 0.0035 0.0039
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.001 0.0042 0.0074
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0018 0.0133 0.0212
Onchocerca volvulus Heat shock factor protein 2 homolog 0.006 0.058 0.4365
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0083 0.0829 0.1434
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0045 0.0422 0.0708
Loa Loa (eye worm) hypothetical protein 0.0026 0.0213 0.0376
Mycobacterium tuberculosis Probable esterase LipL 0.0047 0.0437 0.1368
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0018 0.0133 0.0235
Plasmodium falciparum T-complex protein 1 subunit beta 0.0015 0.0096 0.013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0018 0.0133 0.0235
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0035 0.0062
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.026 0.2714 0.4779
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0035 0.0062
Loa Loa (eye worm) hypothetical protein 0.0009 0.0031 0.0055
Trypanosoma cruzi aminopeptidase, putative 0.0045 0.0422 0.0712
Toxoplasma gondii t-complex protein beta subunit 0.0015 0.0096 0.017
Echinococcus granulosus Protein patched homolog 1 0.0026 0.0213 0.0354
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0012 0.0068 0.1045
Mycobacterium tuberculosis Probable hydrolase 0.0047 0.0437 0.1368
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0128 0.1311 0.2318
Loa Loa (eye worm) peptidase family M1 containing protein 0.0045 0.0422 0.0746
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0018 0.0133 0.0212
Loa Loa (eye worm) hypothetical protein 0.0011 0.0053 0.0093
Loa Loa (eye worm) hypothetical protein 0.0007 0.0013 0.0023
Loa Loa (eye worm) PHD-finger family protein 0.001 0.0049 0.0086
Toxoplasma gondii aminopeptidase n, putative 0.0045 0.0422 0.0746
Echinococcus granulosus beta LACTamase domain containing family member 0.0047 0.0437 0.0752
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0045 0.0422 0.0725
Trichomonas vaginalis penicillin-binding protein, putative 0.0047 0.0437 0.0773
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0008 0.0023 0.0018
Echinococcus granulosus expressed conserved protein 0.0056 0.0537 0.0928
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0035 0.0062
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0133 0.0212
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0018 0.0133 0.0235
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.026 0.2714 0.4779
Echinococcus multilocularis FTZ F1 alpha 0.0018 0.0133 0.012
Loa Loa (eye worm) hypothetical protein 0.0019 0.0142 0.0251
Brugia malayi steroid hormone receptor 0.0018 0.0133 0.0212
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0126 0.1288 0.1277
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0018 0.0131 0.0209
Entamoeba histolytica heat shock transcription factor, putative 0.006 0.058 0.0968
Schistosoma mansoni hypothetical protein 0.0025 0.0203 0.0336
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0149 0.1528 0.2674
Echinococcus multilocularis dnaJ subfamily B 0.0201 0.209 0.208
Brugia malayi beta-lactamase family protein 0.0047 0.0437 0.0752
Toxoplasma gondii isocitrate dehydrogenase 0.0008 0.0023 0.0041
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0018 0.0133 0.012
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0128 0.1311 0.1299
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0009 0.0035 0.0062
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0009 0.0035 0.0026
Loa Loa (eye worm) hypothetical protein 0.0007 0.0013 0.0023
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0045 0.0422 0.0746
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0009 0.0035 0.0022
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0018 0.0131 0.0232
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0011 0.0059 0.015
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0025 0.0206 0.033
Onchocerca volvulus 0.0011 0.0059 0.0356
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0045 0.0422 0.041
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.001 0.0046 0.0531
Trypanosoma brucei DNA polymerase kappa, putative 0.0009 0.0039 0.0069
Loa Loa (eye worm) hypothetical protein 0.0018 0.0131 0.0232
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0009 0.0035 0.0039
Loa Loa (eye worm) hypothetical protein 0.0007 0.0013 0.0023
Echinococcus granulosus geminin 0.0359 0.3775 0.6668
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0018 0.0133 0.0212
Toxoplasma gondii exonuclease III APE 0.0025 0.0206 0.0365
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0035 0.0062
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.0074
Trypanosoma brucei DNA polymerase kappa, putative 0.0009 0.0039 0.0069
Onchocerca volvulus 0.0047 0.0437 0.327
Mycobacterium ulcerans thioesterase 0.001 0.0046 0.017
Entamoeba histolytica heat shock transcription factor, putative 0.006 0.058 0.0968
Echinococcus granulosus ecdysone induced protein 78C 0.0018 0.0133 0.0212
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.003 0.0263 0.025
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0008 0.0023 0.0005
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0009 0.0031 0.0032
Echinococcus multilocularis geminin 0.0359 0.3775 0.3767
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0045 0.0422 0.0712
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0035 0.0062
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.0074
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.001 0.0044 0.0102
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0013 0.0076 0.0397
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0015 0.0096 0.0148
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0047 0.0437 0.0773
Trichomonas vaginalis DNA polymerase eta, putative 0.0009 0.0039 0.0069
Trypanosoma cruzi DNA polymerase eta, putative 0.0009 0.0039 0.0033
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0009 0.0039 0.0085
Trypanosoma brucei DNA polymerase kappa, putative 0.0006 0.0008 0.0015
Brugia malayi ecdysteroid receptor 0.0018 0.0133 0.0212
Schistosoma mansoni methyl-cpg binding protein mbd 0.0008 0.003 0.003
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0126 0.1288 0.226
Schistosoma mansoni coup transcription factor 0.0018 0.0133 0.0212
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0535 0.5655 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0009 0.0033 0.0036
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0008 0.0023 0.0034
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0128 0.1311 0.229
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0018 0.0133 0.0212
Onchocerca volvulus 0.0128 0.1311 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.0829 0.1466
Echinococcus granulosus TRP transient receptor potential channel 0.0035 0.0315 0.0535
Trypanosoma brucei DNA polymerase IV, putative 0.0009 0.0039 0.0069
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0535 0.5655 1
Loa Loa (eye worm) fatty acid synthase 0.0012 0.0066 0.0117
Mycobacterium ulcerans Type I modular polyketide synthase 0.0012 0.0068 0.0336
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0009 0.0035 0.0026
Leishmania major T-complex protein 1, beta subunit, putative 0.0015 0.0096 0.0134
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0035 0.0062
Mycobacterium ulcerans thioesterase TesA 0.001 0.0046 0.017
Schistosoma mansoni retinoic acid receptor RXR 0.0018 0.0133 0.0212
Echinococcus multilocularis dna polymerase kappa 0.0009 0.0039 0.0026
Mycobacterium ulcerans polyketide synthase 0.0013 0.0076 0.0397
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0133 0.012
Trypanosoma cruzi aminopeptidase, putative 0.0128 0.1311 0.229
Echinococcus granulosus leukotriene A 4 hydrolase 0.0045 0.0422 0.0725
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0009 0.0031 0.0018
Loa Loa (eye worm) hypothetical protein 0.0007 0.0013 0.0023
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0297 0.3117 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0013 0.0023
Echinococcus multilocularis expressed conserved protein 0.0056 0.0537 0.0524
Loa Loa (eye worm) hypothetical protein 0.0018 0.0131 0.0232
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0035 0.0062
Trypanosoma brucei unspecified product 0.0006 0.0008 0.0015
Echinococcus multilocularis dna polymerase eta 0.0009 0.0039 0.0026
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0008 0.003 0.0017
Brugia malayi CXXC zinc finger family protein 0.0014 0.0091 0.0138
Toxoplasma gondii type I fatty acid synthase, putative 0.0013 0.0076 0.0134
Schistosoma mansoni hypothetical protein 0.0025 0.0203 0.0336
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0015 0.0096 0.013
Schistosoma mansoni nuclear receptor nhr-48 0.0009 0.0031 0.0032
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0009 0.0033 0.002
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0018 0.0133 0.0212
Loa Loa (eye worm) nuclear receptor NHR-67 0.0009 0.0031 0.0055
Brugia malayi TATA binding protein associated factor 0.0045 0.0422 0.0725
Echinococcus granulosus Tolloid protein 1 0.0018 0.0131 0.0209
Echinococcus multilocularis thyroid hormone receptor alpha 0.0018 0.0133 0.012
Brugia malayi isocitrate dehydrogenase 0.0008 0.0023 0.0018
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0012 0.0068 0.1045
Brugia malayi hypothetical protein 0.001 0.0042 0.0051
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0045 0.0422 0.0725
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0009 0.0035 0.0039
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0009 0.0035 0.0026
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0535 0.5655 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0013 0.0076 0.1237
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0015 0.0096 0.0148
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0128 0.1311 0.23
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0018 0.0131 0.038
Echinococcus granulosus Nuclear hormone receptor HR96 0.0009 0.0031 0.0032
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0045 0.0422 0.0708
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0008 0.0023 0.0041
Echinococcus granulosus aminopeptidase N 0.0128 0.1311 0.23
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0126 0.1288 0.226
Onchocerca volvulus Protein ultraspiracle homolog 0.0018 0.0133 0.0923
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0009 0.0035 0.0022
Echinococcus granulosus serine protein kinase ATM 0.0012 0.0071 0.0102
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0009 0.0035 0.0026
Mycobacterium tuberculosis Conserved protein 0.0047 0.0437 0.1368
Echinococcus granulosus transient receptor potential ion channel A 0.0091 0.0914 0.1596
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0012 0.0067 0.0054
Schistosoma mansoni hypothetical protein 0.0008 0.0021 0.0013
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0018 0.0129 0.0206
Loa Loa (eye worm) hypothetical protein 0.0007 0.0013 0.0023
Brugia malayi HSF-type DNA-binding domain containing protein 0.006 0.058 0.1004
Echinococcus multilocularis protein patched 0.0026 0.0213 0.02
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0035 0.0062
Loa Loa (eye worm) hypothetical protein 0.0031 0.0274 0.0484
Schistosoma mansoni transient receptor potential channel 0.0062 0.0606 0.1051
Entamoeba histolytica deoxycytidyl transferase, putative 0.0009 0.0039 0.0007
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0047 0.0437 0.0752
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0009 0.0039 0.0046
Echinococcus multilocularis nuclear receptor nhr 48 0.0009 0.0031 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0035 0.0062
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0133 0.0212
Schistosoma mansoni transcription factor LCR-F1 0.0022 0.0172 0.0282
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0035 0.0062
Loa Loa (eye worm) hypothetical protein 0.0007 0.0013 0.0023
Toxoplasma gondii hypothetical protein 0.0024 0.0196 0.0347
Echinococcus multilocularis transient receptor potential ion channel A 0.0091 0.0914 0.0902
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0031 0.0032
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0025 0.0206 0.033
Brugia malayi PHD-finger family protein 0.0013 0.008 0.0118
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0009 0.0039 0.0069
Loa Loa (eye worm) hypothetical protein 0.0018 0.0133 0.0235
Toxoplasma gondii EGF family domain-containing protein 0.0007 0.0013 0.0023
Brugia malayi Steroid receptor seven-up type 2 0.0018 0.0133 0.0212
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0008 0.0023 0.0041
Trichomonas vaginalis ap endonuclease, putative 0.0025 0.0206 0.0365
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0133 0.0212
Brugia malayi Peptidase family M1 containing protein 0.0128 0.1311 0.23
Mycobacterium leprae conserved hypothetical protein 0.0047 0.0437 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0025 0.0206 0.0624
Echinococcus granulosus dna polymerase eta 0.0009 0.0039 0.0046
Schistosoma mansoni transient receptor potential channel 0.0062 0.0606 0.1051
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0012 0.0071 0.0102
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0035 0.0062
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0009 0.0031 0.0055
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0008 0.0023 0.001
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0535 0.5655 1
Brugia malayi beta-lactamase 0.0047 0.0437 0.0752
Loa Loa (eye worm) hypothetical protein 0.0009 0.0031 0.0055
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0128 0.1311 0.23
Schistosoma mansoni cpg binding protein 0.0014 0.0091 0.0138
Schistosoma mansoni nuclear receptor 0.0009 0.0031 0.0032
Loa Loa (eye worm) hypothetical protein 0.0009 0.0031 0.0055
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0047 0.0437 0.1368
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0011 0.0059 0.0105
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0012 0.0068 0.0177
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0133 0.0212
Brugia malayi Bromodomain containing protein 0.0038 0.0343 0.0585
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0009 0.0031 0.0018
Schistosoma mansoni hypothetical protein 0.0359 0.3775 0.6668
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0535 0.5655 1
Onchocerca volvulus 0.0128 0.1311 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0009 0.0035 0.0026
Trypanosoma brucei unspecified product 0.0009 0.0039 0.0069
Loa Loa (eye worm) hypothetical protein 0.0035 0.0315 0.0557
Brugia malayi Isocitrate dehydrogenase 0.0008 0.0023 0.0018
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.0074
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0025 0.0206 0.0365
Echinococcus multilocularis cpg binding protein 0.0016 0.011 0.0097
Loa Loa (eye worm) hypothetical protein 0.0059 0.0573 0.1013
Trichomonas vaginalis D-aminoacylase, putative 0.0047 0.0437 0.0773
Loa Loa (eye worm) hypothetical protein 0.0045 0.0422 0.0746
Mycobacterium ulcerans DNA polymerase IV 0.0009 0.0039 0.0113
Loa Loa (eye worm) hypothetical protein 0.0007 0.0013 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0018 0.0133 0.0212
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0042 0.0051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0018 0.0133 0.0235
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0009 0.0035 0.0062
Trypanosoma cruzi DNA polymerase kappa, putative 0.0009 0.0039 0.0033
Loa Loa (eye worm) aminopeptidase N 0.0128 0.1311 0.2318
Echinococcus granulosus Niemann Pick C1 protein 0.0085 0.0848 0.1479
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0018 0.0131 0.0209
Leishmania major mitochondrial DNA polymerase beta 0.0149 0.1528 0.2674
Mycobacterium leprae Polyketide synthase Pks13 0.0018 0.0131 0.2572
Brugia malayi nuclear receptor NHR-67 0.0009 0.0031 0.0032
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0133 0.0212
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0018 0.0131 0.0232
Brugia malayi T-complex protein 1, beta subunit 0.0015 0.0096 0.0148
Schistosoma mansoni steroid hormone receptor ad4bp 0.0018 0.0133 0.0212
Echinococcus granulosus Niemann Pick C1 protein 0.0059 0.0575 0.0996
Toxoplasma gondii target of rapamycin (TOR), putative 0.0009 0.0035 0.0062
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0006 0.0005 0.0008
Loa Loa (eye worm) hypothetical protein 0.0009 0.0031 0.0055
Loa Loa (eye worm) hypothetical protein 0.0009 0.0031 0.0055
Schistosoma mansoni zinc finger protein 0.001 0.0052 0.0069
Echinococcus multilocularis fibrillin 1 0.0018 0.0131 0.0118
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0045 0.0422 0.0708
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0149 0.1528 0.2674
Schistosoma mansoni patched 1 0.0026 0.0213 0.0354
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0035 0.0062
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0083 0.0829 0.1446
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0013 0.0076 0.1237
Brugia malayi Bromodomain containing protein 0.0019 0.0142 0.0228
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0011 0.0053 0.0057
Brugia malayi Transient-receptor-potential like protein 0.0035 0.0315 0.0535
Loa Loa (eye worm) nuclear hormone receptor 0.0009 0.0031 0.0055
Loa Loa (eye worm) phosphatidylinositol 3 0.0009 0.0035 0.0062
Mycobacterium tuberculosis Conserved protein 0.0047 0.0437 0.1368
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.0074
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0535 0.5655 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.007 0.0692 0.1191
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0018 0.0133 0.0212
Trypanosoma brucei DNA polymerase kappa, putative 0.0009 0.0039 0.0069
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0047 0.0437 0.1368
Onchocerca volvulus Bile acid receptor homolog 0.0018 0.0133 0.0923
Brugia malayi Peptidase family M1 containing protein 0.0128 0.1311 0.23
Mycobacterium ulcerans esterase/lipase LipP 0.0047 0.0437 0.321
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0035 0.0315 0.0302
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0031 0.0032
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0535 0.5655 0.565
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0012 0.0071 0.0089
Brugia malayi Nuclear hormone receptor E75 0.0009 0.0031 0.0032
Brugia malayi ImpB/MucB/SamB family protein 0.0009 0.0039 0.0046
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0021 0.0163 0.0253
Trypanosoma cruzi DNA polymerase kappa, putative 0.0009 0.0039 0.0033
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0126 0.1288 0.226
Trypanosoma brucei aminopeptidase, putative 0.0045 0.0422 0.0746
Leishmania major phosphatidylinositol kinase related protein, putative 0.0009 0.0036 0.0026
Loa Loa (eye worm) hypothetical protein 0.0032 0.0281 0.0497
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0015 0.0096 0.0083
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0035 0.0062
Trypanosoma brucei DNA polymerase IV, putative 0.0009 0.0039 0.0069
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0047 0.0437 0.321
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0018 0.0133 0.0212
Schistosoma mansoni DNA polymerase eta 0.0009 0.0039 0.0046
Schistosoma mansoni transient receptor potential channel 4 0.0094 0.0947 0.1656
Loa Loa (eye worm) hypothetical protein 0.0035 0.0312 0.0552
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.001 0.0043 0.0442
Onchocerca volvulus Fatty acid synthase homolog 0.0022 0.017 0.1209
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0128 0.1311 0.23
Brugia malayi Niemann-Pick C1 protein precursor 0.0059 0.0575 0.0996
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0035 0.0062
Toxoplasma gondii histone lysine methyltransferase SET1 0.0028 0.0239 0.0422
Loa Loa (eye worm) hypothetical protein 0.0007 0.0013 0.0023
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0008 0.0023 0.001
Trypanosoma brucei hypothetical protein, conserved 0.026 0.2714 0.4798
Loa Loa (eye worm) hypothetical protein 0.0007 0.0013 0.0023
Schistosoma mansoni thyroid hormone receptor 0.0018 0.0133 0.0212
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0012 0.0067 0.0096
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0035 0.0062
Entamoeba histolytica hypothetical protein 0.0022 0.0172 0.0244
Trypanosoma cruzi DNA polymerase kappa, putative 0.0009 0.0039 0.0033
Mycobacterium ulcerans polyketide synthase Pks13 0.0018 0.0131 0.0826
Mycobacterium leprae Probable polyketide synthase Pks1 0.0013 0.0076 0.1237
Loa Loa (eye worm) beta-lactamase 0.0047 0.0437 0.0773
Echinococcus granulosus Nuclear hormone receptor HR96 0.0009 0.0031 0.0032
Brugia malayi nuclear hormone receptor 0.0009 0.0031 0.0032
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0133 0.0212
Loa Loa (eye worm) hypothetical protein 0.0018 0.0131 0.0232
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0025 0.0206 0.0304
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0009 0.0035 0.0039
Echinococcus multilocularis Niemann Pick C1 protein 0.0085 0.0848 0.0836
Loa Loa (eye worm) hypothetical protein 0.0018 0.0133 0.0235
Schistosoma mansoni mixed-lineage leukemia protein mll 0.003 0.026 0.0438
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0012 0.0064 0.0165
Mycobacterium ulcerans Type I modular polyketide synthase 0.0012 0.0068 0.0336
Trypanosoma brucei Aminopeptidase M1, putative 0.0128 0.1311 0.2318
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0018 0.0133 0.0212
Trypanosoma brucei Aminopeptidase M1, putative 0.0128 0.1311 0.2318
Mycobacterium ulcerans hypothetical protein 0.0078 0.0776 0.5845
Loa Loa (eye worm) hypothetical protein 0.0022 0.0173 0.0306
Loa Loa (eye worm) hypothetical protein 0.0007 0.0013 0.0023
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0022 0.0172 0.0282
Schistosoma mansoni transient receptor potential channel 0.0094 0.0947 0.1656
Brugia malayi hypothetical protein 0.0045 0.0422 0.0725
Loa Loa (eye worm) hypothetical protein 0.0094 0.0947 0.1675
Loa Loa (eye worm) hypothetical protein 0.0047 0.0437 0.0773
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0009 0.0035 0.0062
Echinococcus multilocularis sterol regulatory element binding protein 0.0026 0.0213 0.02
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0013 0.0076 0.0203
Loa Loa (eye worm) hypothetical protein 0.0083 0.0829 0.1466
Echinococcus multilocularis laminin 0.0018 0.0131 0.0118
Brugia malayi ecdysone receptor 0.0009 0.0031 0.0032
Schistosoma mansoni zinc finger protein 0.0009 0.0031 0.0032
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0009 0.0031 0.0139
Loa Loa (eye worm) hypothetical protein 0.0018 0.0133 0.0235
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0128 0.1311 0.1299
Echinococcus granulosus FTZ F1 alpha 0.0018 0.0133 0.0212
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0126 0.1288 0.226
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0015 0.0096 0.0109
Leishmania major DNA polymerase kappa, putative 0.0009 0.0039 0.0033
Toxoplasma gondii type I fatty acid synthase, putative 0.0008 0.0031 0.0055
Schistosoma mansoni nuclear receptor 0.0009 0.0031 0.0032
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.0074
Trichomonas vaginalis penicillin-binding protein, putative 0.0047 0.0437 0.0773
Trypanosoma brucei unspecified product 0.0006 0.0008 0.0015
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0012 0.0068 0.0097
Loa Loa (eye worm) hypothetical protein 0.0009 0.0031 0.0055
Mycobacterium tuberculosis Conserved hypothetical protein 0.0078 0.0776 0.246
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0128 0.1311 0.229
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0126 0.1288 0.1277
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0535 0.5655 1
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0045 0.0422 0.0746
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0045 0.0422 0.0712
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0535 0.5655 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0013 0.0023
Brugia malayi nuclear receptor RXR 0.001 0.0042 0.0051
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0535 0.5655 1
Trypanosoma cruzi hypothetical protein, conserved 0.0047 0.0437 0.074
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0126 0.1288 0.226
Loa Loa (eye worm) hypothetical protein 0.0009 0.0031 0.0055
Trichomonas vaginalis Sialidase-1 precursor, putative 0.0294 0.3076 0.5439
Onchocerca volvulus 0.0009 0.0031 0.0139
Mycobacterium tuberculosis Probable lipase LipE 0.0047 0.0437 0.1368
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0009 0.0032 0.0062
Loa Loa (eye worm) hypothetical protein 0.0018 0.0133 0.0235
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0535 0.5655 1
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0045 0.0422 0.0725
Trypanosoma brucei DNA polymerase kappa, putative 0.0009 0.0039 0.0069
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0009 0.0031 0.0018
Trichomonas vaginalis esterase, putative 0.0047 0.0437 0.0773
Loa Loa (eye worm) hypothetical protein 0.0083 0.0829 0.1466
Brugia malayi ImpB/MucB/SamB family protein 0.0009 0.0039 0.0046
Loa Loa (eye worm) CXXC zinc finger family protein 0.0014 0.0091 0.0161
Trichomonas vaginalis chaperonin, putative 0.0015 0.0096 0.017
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0045 0.0422 0.0725
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0133 0.0212
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0009 0.0039 0.0033
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0021 0.0163 0.0289
Echinococcus granulosus transient receptor potential gamma protein 0.0094 0.0947 0.1656
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0128 0.1311 0.23
Echinococcus multilocularis transient receptor potential gamma protein 0.0094 0.0947 0.0935
Loa Loa (eye worm) hypothetical protein 0.0007 0.0013 0.0023
Onchocerca volvulus 0.0047 0.0437 0.327
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0035 0.0062
Brugia malayi CHE-14 protein 0.0026 0.0213 0.0354
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0012 0.0071 0.0102
Leishmania major phosphatidylinositol 3-kinase, putative 0.0009 0.0035 0.0026
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0015 0.0096 0.0134
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0126 0.1288 0.2277
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0018 0.0133 0.0212
Echinococcus multilocularis beta LACTamase domain containing family member 0.0047 0.0437 0.0425
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0008 0.0023 0.001
Brugia malayi AMP-binding enzyme family protein 0.0011 0.0059 0.0082
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0009 0.0039 0.0069
Schistosoma mansoni niemann-pick C1 (NPC1) 0.006 0.0585 0.1013
Mycobacterium tuberculosis Probable thioesterase TesA 0.001 0.0046 0.0109
Echinococcus granulosus dnaJ subfamily B 0.0201 0.209 0.3681
Toxoplasma gondii aminopeptidase N, putative 0.0045 0.0422 0.0746
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0009 0.0035 0.0026
Echinococcus multilocularis isocitrate dehydrogenase 0.0008 0.0023 0.001
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0059 0.0575 0.096
Trypanosoma brucei DNA polymerase kappa, putative 0.0009 0.0039 0.0069
Loa Loa (eye worm) hypothetical protein 0.0009 0.0039 0.0069
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0022 0.0172 0.0159
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0015 0.0096 0.017
Trypanosoma brucei hypothetical protein, conserved 0.026 0.2714 0.4798
Toxoplasma gondii aminopeptidase N protein 0.0045 0.0422 0.0746
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0026 0.0213 0.0376
Schistosoma mansoni hypothetical protein 0.0022 0.0172 0.0282
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0025 0.0206 0.0194
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0018 0.0133 0.012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0035 0.0062
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0013 0.0076 0.0397
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0025 0.0206 0.0365
Loa Loa (eye worm) hypothetical protein 0.0018 0.0133 0.0235
Giardia lamblia GTOR 0.0009 0.0035 0.1149
Loa Loa (eye worm) hypothetical protein 0.0059 0.0575 0.1017
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0535 0.5655 1
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0045 0.0422 0.0712
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0018 0.0133 0.0923
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0025 0.0206 0.5
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0047 0.0437 0.0752
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0018 0.0133 0.012
Loa Loa (eye worm) hypothetical protein 0.0018 0.0133 0.0235
Brugia malayi Peptidase family M1 containing protein 0.0045 0.0422 0.0725
Schistosoma mansoni RAR-like nuclear receptor 0.0018 0.0133 0.0212
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0025 0.0206 0.0325
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0009 0.0031 0.0032
Echinococcus granulosus thyroid hormone receptor alpha 0.0009 0.0031 0.0032
Echinococcus granulosus laminin 0.0018 0.0131 0.0209
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.026 0.2714 0.4779
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0012 0.0071 0.0125
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0042 0.0051
Echinococcus multilocularis Niemann Pick C1 protein 0.0059 0.0575 0.0563
Loa Loa (eye worm) bromodomain containing protein 0.0009 0.0033 0.0059
Entamoeba histolytica heat shock transcription factor, putative 0.006 0.058 0.0968

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 20 uM Cytotoxicity against human H460 cells after 24 hrs by sulforhodamine B assay ChEMBL. 19359173
IC50 (functional) > 20 uM Cytotoxicity against human HCT116 cells after 24 hrs by sulforhodamine B assay ChEMBL. 19359173

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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