Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0111 | 0.6107 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.2196 | 0.3485 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.016 | 0.0094 |
Giardia lamblia | Kinase, PLK | 0.0111 | 0.6107 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0327 | 0.0372 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0036 | 0.1702 | 0.2787 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0141 | 0.7865 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0032 | 0.1485 | 0.1485 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0019 | 0.0711 | 0.0926 |
Echinococcus multilocularis | musashi | 0.0026 | 0.1129 | 0.1849 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0018 | 0.0623 | 0.1021 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0061 | 0.3179 | 0.3179 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0055 | 0.2846 | 0.4517 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0019 | 0.0711 | 0.0926 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0019 | 0.0711 | 0.0926 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.0798 | 0.0798 |
Schistosoma mansoni | zinc finger protein | 0.0015 | 0.0483 | 0.0483 |
Echinococcus granulosus | zinc finger protein | 0.0021 | 0.0832 | 0.1363 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.016 | 0.0094 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0024 | 0.1007 | 0.165 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0019 | 0.0711 | 0.205 |
Schistosoma mansoni | lamin | 0.0026 | 0.1129 | 0.1129 |
Schistosoma mansoni | lamin | 0.0026 | 0.1129 | 0.1129 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0026 | 0.1129 | 0.1629 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0019 | 0.0711 | 0.0926 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0017 | 0.0586 | 0.0586 |
Schistosoma mansoni | DNA ligase IV | 0.001 | 0.016 | 0.016 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0057 | 0.2934 | 1 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0019 | 0.0711 | 0.0406 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0126 | 0.7033 | 0.8837 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0013 | 0.0327 | 0.0535 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0019 | 0.0711 | 0.0406 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0054 | 0.274 | 0.274 |
Echinococcus granulosus | nibrin | 0.001 | 0.016 | 0.0262 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0019 | 0.0711 | 0.0926 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0019 | 0.0711 | 0.205 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.1101 | 0.1661 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.3758 | 0.6088 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.016 | 0.0094 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0019 | 0.0711 | 0.0926 |
Plasmodium falciparum | glutathione reductase | 0.0019 | 0.0711 | 0.205 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0024 | 0.1007 | 0.1007 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.1129 | 0.1708 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0019 | 0.0711 | 0.0711 |
Plasmodium falciparum | thioredoxin reductase | 0.0055 | 0.2846 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0055 | 0.2846 | 0.4661 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0062 | 0.3204 | 0.5246 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0055 | 0.2846 | 0.2985 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0054 | 0.274 | 0.4486 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0111 | 0.6107 | 1 |
Brugia malayi | intermediate filament protein | 0.0026 | 0.1129 | 0.1629 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0019 | 0.0711 | 0.0926 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0111 | 0.6107 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0054 | 0.274 | 0.4486 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0019 | 0.0711 | 0.1164 |
Plasmodium falciparum | thioredoxin reductase | 0.0019 | 0.0711 | 0.205 |
Schistosoma mansoni | intermediate filament proteins | 0.0026 | 0.1129 | 0.1129 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0019 | 0.0711 | 0.0926 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0019 | 0.0711 | 0.1164 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0483 | 0.0483 |
Trypanosoma brucei | trypanothione reductase | 0.0055 | 0.2846 | 0.4517 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0011 | 0.021 | 0.0083 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0018 | 0.0622 | 0.0864 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0062 | 0.3204 | 0.5246 |
Brugia malayi | Bromodomain containing protein | 0.0077 | 0.4108 | 0.6639 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0019 | 0.0711 | 0.205 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0019 | 0.0711 | 1 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0014 | 0.0409 | 0.0418 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0111 | 0.6107 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0018 | 0.0623 | 0.0623 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0103 | 0.0169 |
Echinococcus granulosus | intermediate filament protein | 0.0026 | 0.1129 | 0.1849 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1986 | 0.3136 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0019 | 0.0711 | 0.0406 |
Schistosoma mansoni | chromosome transmission fidelity factor | 0.001 | 0.016 | 0.016 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.016 | 0.0094 |
Schistosoma mansoni | topbp1 | 0.001 | 0.016 | 0.016 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0019 | 0.0711 | 0.0926 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0019 | 0.0711 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0055 | 0.2846 | 0.9684 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0054 | 0.274 | 0.4391 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0141 | 0.7865 | 1 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0024 | 0.1007 | 0.165 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.016 | 0.0094 |
Brugia malayi | PHD-finger family protein | 0.0027 | 0.1147 | 0.166 |
Brugia malayi | CXXC zinc finger family protein | 0.0029 | 0.1276 | 0.1876 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0019 | 0.0711 | 0.0926 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0111 | 0.6107 | 1 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0021 | 0.0798 | 0.1157 |
Brugia malayi | Thioredoxin reductase | 0.0055 | 0.2846 | 0.4517 |
Schistosoma mansoni | zinc finger protein | 0.0021 | 0.0832 | 0.0832 |
Brugia malayi | glutathione reductase | 0.0055 | 0.2846 | 0.4517 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0111 | 0.6107 | 1 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0019 | 0.0711 | 0.205 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0054 | 0.274 | 0.4338 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.0017 | 0.0586 | 0.096 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0019 | 0.0711 | 0.0926 |
Loa Loa (eye worm) | glutathione reductase | 0.0055 | 0.2846 | 0.4569 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0111 | 0.6107 | 1 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0019 | 0.0711 | 0.0926 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0019 | 0.0711 | 0.0926 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1846 | 0.2903 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0298 | 0.0325 |
Treponema pallidum | NADH oxidase | 0.0019 | 0.0711 | 1 |
Trypanosoma brucei | polo-like protein kinase | 0.0111 | 0.6107 | 1 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0014 | 0.041 | 0.042 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0111 | 0.6107 | 0.6107 |
Onchocerca volvulus | 0.0026 | 0.1129 | 0.1629 | |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0017 | 0.0586 | 0.0586 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0019 | 0.0711 | 0.1985 |
Echinococcus multilocularis | cpg binding protein | 0.0032 | 0.1485 | 0.2432 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0019 | 0.0711 | 0.0406 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0026 | 0.1129 | 0.1708 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0019 | 0.0711 | 0.1985 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0111 | 0.6107 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0019 | 0.0711 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0019 | 0.0711 | 0.0926 |
Echinococcus multilocularis | nibrin | 0.001 | 0.016 | 0.0262 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0126 | 0.7033 | 0.8837 |
Mycobacterium tuberculosis | Probable reductase | 0.0126 | 0.7033 | 0.8837 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0126 | 0.7033 | 0.8837 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0141 | 0.7865 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0026 | 0.1129 | 0.1708 |
Echinococcus multilocularis | lamin | 0.0026 | 0.1129 | 0.1849 |
Echinococcus granulosus | replication factor c subunit 1 | 0.001 | 0.016 | 0.0262 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0014 | 0.041 | 0.042 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.1276 | 0.1276 |
Echinococcus granulosus | cpg binding protein | 0.0032 | 0.1485 | 0.2432 |
Echinococcus multilocularis | zinc finger protein | 0.0021 | 0.0832 | 0.1363 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0623 | 0.0866 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0103 | 0.0169 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0054 | 0.274 | 0.4486 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0126 | 0.7033 | 0.8837 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0054 | 0.274 | 0.274 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.016 | 0.0094 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0111 | 0.6107 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0019 | 0.0711 | 1 |
Onchocerca volvulus | 0.0029 | 0.1276 | 0.1876 | |
Trichomonas vaginalis | CAMK family protein kinase | 0.0111 | 0.6107 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0036 | 0.1702 | 0.2787 |
Echinococcus granulosus | lamin | 0.0026 | 0.1129 | 0.1849 |
Echinococcus multilocularis | replication factor c subunit 1 | 0.001 | 0.016 | 0.0262 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0055 | 0.2846 | 0.4661 |
Schistosoma mansoni | cpg binding protein | 0.0032 | 0.1485 | 0.1485 |
Schistosoma mansoni | topbp1 | 0.001 | 0.016 | 0.016 |
Trypanosoma brucei | ISWI complex protein | 0.0015 | 0.0483 | 0.0542 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0054 | 0.274 | 0.274 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0111 | 0.6107 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0055 | 0.281 | 0.4456 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0013 | 0.0327 | 0.0535 |
Onchocerca volvulus | 0.0026 | 0.1129 | 0.1629 | |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0018 | 0.0623 | 0.0623 |
Plasmodium vivax | glutathione reductase, putative | 0.0055 | 0.2846 | 1 |
Trypanosoma cruzi | ISWI complex protein | 0.0015 | 0.0483 | 0.0542 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0019 | 0.0711 | 1 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0029 | 0.1276 | 0.1953 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0111 | 0.6107 | 1 |
Trypanosoma cruzi | ISWI complex protein | 0.0015 | 0.0483 | 0.0542 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0055 | 0.2846 | 0.4569 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0298 | 0.0325 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0126 | 0.7033 | 0.892 |
Leishmania major | trypanothione reductase | 0.0055 | 0.2846 | 0.4203 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0055 | 0.281 | 0.4456 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0019 | 0.0711 | 0.0926 |
Plasmodium falciparum | glutathione reductase | 0.0055 | 0.2846 | 1 |
Schistosoma mansoni | kinase | 0.0056 | 0.2896 | 0.2896 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.0409 | 0.0509 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0055 | 0.2846 | 1 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0018 | 0.0623 | 0.1021 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0111 | 0.6107 | 1 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0019 | 0.0711 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0038 | 0.1842 | 0.2828 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0019 | 0.0711 | 0.0926 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0019 | 0.0711 | 0.0926 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0111 | 0.6107 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0111 | 0.6107 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0026 | 0.1129 | 0.1849 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0111 | 0.6107 | 1 |
Echinococcus granulosus | methyl CpG binding domain protein 2 | 0.0017 | 0.0586 | 0.096 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0141 | 0.7865 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0126 | 0.7033 | 0.8837 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0054 | 0.274 | 0.4486 |
Schistosoma mansoni | bromodomain containing protein | 0.0065 | 0.3415 | 0.3415 |
Echinococcus granulosus | lamin dm0 | 0.0026 | 0.1129 | 0.1849 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 3.16 % | Antimalarial activity against Plasmodium falciparum W2mef at 10 uM after 48 hrs by hoechst 33342-thiazole orange stain based flow cytometry assay | ChEMBL. | 19666223 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.