Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.1201 | 1 | 1 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.1201 | 1 | 1 |
Leishmania major | 0.1201 | 1 | 0.5 | |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.1201 | 1 | 1 |
Toxoplasma gondii | fructose-bisphospatase II | 0.1201 | 1 | 1 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.1201 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0627 | 0.375 | 0.2893 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.1201 | 1 | 1 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0397 | 0.1237 | 0.1237 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.1201 | 1 | 1 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.1201 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0397 | 0.1237 | 0.0035 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0627 | 0.375 | 0.2868 |
Schistosoma mansoni | tyrosine kinase | 0.0397 | 0.1237 | 0.0035 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0627 | 0.375 | 0.375 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | NA 0 uM | In vitro inhibition of rat Metabotropic glutamate receptor 1 in CHO cells using the CDP-DAG accumulation method: Not active microM | ChEMBL. | 12798316 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.