Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.0809 | 0.5 |
Brugia malayi | RNA binding protein | 0.0067 | 0.4614 | 0.4614 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.1558 | 0.0815 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0033 | 0.1558 | 0.1558 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0809 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0067 | 0.4614 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0809 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.4614 | 0.8686 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0106 | 0.8108 | 0.8108 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.8108 | 0.7942 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0072 | 0.5077 | 0.5077 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.4614 | 0.8686 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0126 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0067 | 0.4614 | 0.414 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0809 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0067 | 0.4614 | 1 |
Brugia malayi | TAR-binding protein | 0.0067 | 0.4614 | 0.4614 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0809 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0106 | 0.8108 | 0.7942 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0106 | 0.8108 | 0.8108 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.4614 | 0.8686 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0126 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0067 | 0.4614 | 0.414 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.4614 | 0.8686 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.0809 | 0.5 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0809 | 0.0809 |
Schistosoma mansoni | hypothetical protein | 0.0072 | 0.5077 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0067 | 0.4614 | 0.4614 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0033 | 0.1558 | 0.0815 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0033 | 0.1558 | 0.1558 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0809 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.4614 | 0.8686 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0067 | 0.4614 | 0.414 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0809 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.5077 | 0.4643 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IZ (functional) | = 21 mm | Antibacterial activity against Escherichia coli ATCC 8739 at 100 ug/ml after 24 hrs by agar cup plate method | ChEMBL. | 19640616 |
MIC (functional) | = 29.6 ug ml-1 | Antibacterial activity against Escherichia coli ATCC 8739 after 24 hrs by microtitration method | ChEMBL. | 19640616 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.