Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0019 | 0.0235 | 0.0097 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0235 | 0.0189 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0041 | 0.2001 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0061 | 0.3659 | 0.3531 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0136 | 0.9684 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0067 | 0.415 | 1 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0067 | 0.415 | 0.4033 |
Schistosoma mansoni | chromobox protein | 0.0067 | 0.415 | 0.4033 |
Echinococcus granulosus | chromobox protein 1 | 0.0067 | 0.415 | 0.4167 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.003 | 0.1181 | 0.5314 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.0197 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.2215 | 0.2059 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0235 | 0.0189 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0235 | 0.0189 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0019 | 0.0235 | 0.0039 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0019 | 0.0235 | 0.0097 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0235 | 0.0189 |
Trypanosoma brucei | unspecified product | 0.0019 | 0.0235 | 0.0189 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0235 | 0.0189 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.0235 | 1 |
Echinococcus granulosus | chromobox protein 1 | 0.0067 | 0.415 | 0.4167 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1771 | 0.1605 |
Leishmania major | DNA polymerase eta, putative | 0.003 | 0.1181 | 0.4874 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0694 | 0.0507 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0024 | 0.0694 | 0.2465 |
Loa Loa (eye worm) | RNA binding protein | 0.0061 | 0.3659 | 0.3531 |
Brugia malayi | TAR-binding protein | 0.0061 | 0.3659 | 0.3659 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0235 | 0.0189 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0024 | 0.0694 | 0.2465 |
Brugia malayi | RNA binding protein | 0.0061 | 0.3659 | 0.3659 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0235 | 0.0189 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0235 | 0.0189 |
Loa Loa (eye worm) | acetyltransferase | 0.014 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.3659 | 0.3531 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0041 | 0.2048 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0038 | 0.1771 | 0.3981 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0041 | 0.2048 | 1 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0019 | 0.0235 | 0.0243 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0024 | 0.0694 | 0.2687 |
Schistosoma mansoni | DNA polymerase eta | 0.0043 | 0.2215 | 0.2059 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.3659 | 0.3531 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0235 | 0.0189 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0019 | 0.0235 | 0.0189 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0235 | 0.0189 |
Echinococcus granulosus | dna polymerase kappa | 0.0019 | 0.0235 | 0.004 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0019 | 0.0235 | 0.004 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0235 | 0.0189 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0024 | 0.0694 | 0.2687 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0235 | 0.0189 |
Trichomonas vaginalis | chromobox protein, putative | 0.0067 | 0.415 | 1 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0038 | 0.1772 | 1 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0041 | 0.2048 | 0.4682 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.0197 | 0.0197 |
Trichomonas vaginalis | chromobox protein, putative | 0.0041 | 0.2001 | 0.4564 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.1115 | 0.0936 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.0235 | 0.0235 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.014 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0.0694 | 0.3158 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0038 | 0.1772 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0.0197 | 0.5 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.003 | 0.1181 | 0.4874 |
Echinococcus multilocularis | dna polymerase kappa | 0.0019 | 0.0235 | 0.0039 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0694 | 0.0694 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.3659 | 0.3531 |
Echinococcus multilocularis | chromobox protein 1 | 0.0067 | 0.415 | 0.4033 |
Brugia malayi | Heterochromatin protein 1 | 0.0067 | 0.415 | 0.415 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.3659 | 0.3531 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.0235 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0235 | 0.0189 |
Echinococcus multilocularis | chromobox protein 1 | 0.0067 | 0.415 | 0.4033 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.014 | 1 | 1 |
Echinococcus granulosus | dna polymerase eta | 0.0043 | 0.2215 | 0.2127 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0019 | 0.0235 | 0.0039 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0041 | 0.2048 | 0.4682 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0019 | 0.0235 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0043 | 0.2215 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0235 | 0.0189 |
Trichomonas vaginalis | chromobox protein, putative | 0.0041 | 0.2001 | 0.4564 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0.0694 | 0.3158 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0043 | 0.2215 | 0.2215 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0027 | 0.0884 | 0.1739 |
Brugia malayi | chromobox protein homolog 3 | 0.0038 | 0.1771 | 0.1771 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0027 | 0.0884 | 0.1739 |
Echinococcus multilocularis | dna polymerase eta | 0.0043 | 0.2215 | 0.2059 |
Loa Loa (eye worm) | TAR-binding protein | 0.0061 | 0.3659 | 0.3531 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0019 | 0.0235 | 0.0039 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0235 | 0.0189 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0038 | 0.1771 | 0.3981 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0019 | 0.0235 | 1 |
Leishmania major | DNA polymerase kappa, putative | 0.0019 | 0.0235 | 0.0189 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0235 | 0.0189 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0061 | 0.3659 | 0.3531 |
Leishmania major | hypothetical protein, conserved | 0.0024 | 0.0694 | 0.2465 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0061 | 0.3659 | 0.3659 |
Giardia lamblia | DINP protein human, muc B family | 0.0019 | 0.0235 | 0.0243 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.3659 | 0.3531 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0041 | 0.2048 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0024 | 0.0694 | 0.2465 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0019 | 0.0235 | 0.0039 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0041 | 0.2048 | 0.1951 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0235 | 0.0189 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0038 | 0.1772 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0043 | 0.2215 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0043 | 0.2215 | 1 |
Schistosoma mansoni | chromobox protein | 0.0067 | 0.415 | 0.4033 |
Echinococcus granulosus | tar DNA binding protein | 0.0061 | 0.3659 | 0.3649 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0038 | 0.1771 | 0.7399 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.