Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ubiquitin specific peptidase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0793 | 0.0793 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0842 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0793 | 0.0793 |
Loa Loa (eye worm) | beta-lactamase | 0.0036 | 0.0793 | 0.3122 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0793 | 0.3122 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0036 | 0.0793 | 0.3963 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.0842 | 0.3869 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0793 | 0.3122 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0037 | 0.0839 | 0.4196 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0036 | 0.0793 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.1074 | 0.4231 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0793 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.0793 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0793 | 0.3122 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.2539 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0036 | 0.0793 | 0.5 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0023 | 0.0185 | 0.0927 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0036 | 0.0793 | 0.0793 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0793 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0793 | 0.3122 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0793 | 0.3122 |
Brugia malayi | Bromodomain containing protein | 0.0078 | 0.2748 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.1168 | 0.4598 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0036 | 0.0793 | 0.0793 |
Schistosoma mansoni | bromodomain containing protein | 0.0066 | 0.2175 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0793 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0793 | 0.3122 |
Mycobacterium ulcerans | beta-lactamase | 0.0036 | 0.0793 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0959 | 0.3775 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.0842 | 0.4207 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0842 | 1 |
Onchocerca volvulus | 0.0036 | 0.0793 | 0.5 | |
Mycobacterium ulcerans | lipase LipD | 0.0036 | 0.0793 | 1 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0036 | 0.0793 | 0.0793 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0793 | 0.3644 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0036 | 0.0793 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0062 | 0.2001 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0036 | 0.0793 | 0.3122 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0036 | 0.0793 | 0.2885 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.0793 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0036 | 0.0793 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0036 | 0.0793 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0036 | 0.0793 | 1 |
Trichomonas vaginalis | esterase, putative | 0.0036 | 0.0793 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0842 | 1 |
Echinococcus multilocularis | zinc finger protein | 0.002 | 0.004 | 0.0202 |
Mycobacterium leprae | Probable lipase LipE | 0.0036 | 0.0793 | 0.5 |
Onchocerca volvulus | 0.0036 | 0.0793 | 0.5 | |
Brugia malayi | beta-lactamase | 0.0036 | 0.0793 | 0.2885 |
Brugia malayi | hypothetical protein | 0.0037 | 0.0842 | 0.3063 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0793 | 0.0793 |
Brugia malayi | Bromodomain containing protein | 0.004 | 0.0955 | 0.3476 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0021 | 0.0092 | 0.0363 |
Echinococcus granulosus | zinc finger protein | 0.002 | 0.004 | 0.0202 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0062 | 0.2001 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0842 | 1 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0036 | 0.0793 | 0.0793 |
Schistosoma mansoni | zinc finger protein | 0.002 | 0.004 | 0.0186 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0793 | 1 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0036 | 0.0793 | 0.0793 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.0092 | 0.0423 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0023 | 0.0185 | 0.0852 |
Mycobacterium ulcerans | hypothetical protein | 0.0036 | 0.0793 | 1 |
Giardia lamblia | DINP protein human, muc B family | 0.002 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0036 | 0.0793 | 0.0793 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0036 | 0.0793 | 0.3963 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0793 | 0.2885 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0793 | 0.3644 |
Brugia malayi | PHD-finger family protein | 0.0026 | 0.0301 | 0.1096 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0842 | 0.3869 |
Onchocerca volvulus | 0.0036 | 0.0793 | 0.5 | |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0036 | 0.0793 | 0.0793 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.0842 | 0.4207 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0793 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0.0793 | 0.5 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0023 | 0.0185 | 0.0927 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0793 | 0.2885 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0037 | 0.0839 | 0.4196 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.631 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.