Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.3491 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.2186 | 0.2186 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0663 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0.0188 | 0.5 |
Onchocerca volvulus | 0.0155 | 1 | 0.5 | |
Brugia malayi | TAR-binding protein | 0.0065 | 0.3491 | 0.3491 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.3491 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.2186 | 0.6048 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.3491 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.2186 | 0.6048 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.2186 | 0.6048 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0019 | 0.0188 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0065 | 0.3491 | 0.3491 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0188 | 0.5 |
Brugia malayi | RNA binding protein | 0.0065 | 0.3491 | 0.3491 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.0188 | 0.5 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.0188 | 0.0188 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0065 | 0.3491 | 0.3366 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0663 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.3491 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0663 | 0.0484 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0026 | 0.0663 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0026 | 0.0663 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.2186 | 0.6048 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0188 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.2186 | 0.6048 |
Loa Loa (eye worm) | RNA binding protein | 0.0065 | 0.3491 | 0.3366 |
Echinococcus multilocularis | tar DNA binding protein | 0.0065 | 0.3491 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0663 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.3491 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.2186 | 0.6048 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.0188 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.2186 | 0.2036 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0026 | 0.0663 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0065 | 0.3491 | 0.3366 |
Brugia malayi | hypothetical protein | 0.0026 | 0.0663 | 0.0663 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0.0188 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0065 | 0.3491 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.2186 | 0.6048 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0.0188 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.0663 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0663 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.