Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0019 | 0.3333 | 0.3333 |
Echinococcus granulosus | nicotinic acetylcholine receptor beta 1 subunit | 0.0019 | 0.3398 | 0.3398 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 1 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0019 | 0.3398 | 0.3398 |
Loa Loa (eye worm) | ACC-1 protein | 0.0019 | 0.3398 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.3398 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.3333 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.3398 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.3398 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.3333 | 0.5 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0019 | 0.3398 | 0.3398 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0019 | 0.3398 | 0.3398 |
Echinococcus multilocularis | neuronal acetylcholine receptor subunit alpha 4 | 0.0019 | 0.3398 | 0.3398 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.3398 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.3398 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.3398 | 1 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0019 | 0.3398 | 0.3398 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 1 | 1 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0019 | 0.3398 | 0.3398 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.3398 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0019 | 0.3398 | 0.3398 |
Onchocerca volvulus | 0.0019 | 0.3398 | 1 | |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0019 | 0.3398 | 0.3398 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0019 | 0.3398 | 0.3398 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0019 | 0.3398 | 0.3398 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0019 | 0.3398 | 0.3398 |
Brugia malayi | acetylcholine receptor alpha subunit precursor, putative | 0.0019 | 0.3398 | 0.3398 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.3398 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.3398 | 1 |
Loa Loa (eye worm) | LGC-31 protein | 0.0019 | 0.3398 | 1 |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | 0.0019 | 0.3398 | 0.3398 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.3333 | 0.5 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0019 | 0.3398 | 0.3398 |
Loa Loa (eye worm) | excitatory GABA receptor EXP-1A | 0.0019 | 0.3398 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.3398 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.3398 | 1 |
Onchocerca volvulus | 0.0019 | 0.3398 | 1 | |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0019 | 0.3398 | 0.3398 |
Loa Loa (eye worm) | acetylcholine receptor alpha subunit | 0.0019 | 0.3398 | 1 |
Onchocerca volvulus | 0.0019 | 0.3398 | 1 | |
Schistosoma mansoni | nAChR subunit | 0.0019 | 0.3398 | 0.3398 |
Schistosoma mansoni | nAChR subunit | 0.0019 | 0.3398 | 0.3398 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0019 | 0.3398 | 1 |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.0019 | 0.3398 | 0.3398 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0.3333 | 0.5 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0019 | 0.3398 | 0.3398 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.3333 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.3398 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.3398 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0.3333 | 0.5 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0019 | 0.3398 | 0.3398 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0019 | 0.3333 | 0.5 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0019 | 0.3398 | 0.3398 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0019 | 0.3398 | 0.3398 |
Brugia malayi | acetylcholine receptor protein, alpha-like chain, putative | 0.0019 | 0.3398 | 0.3398 |
Brugia malayi | Cation transporter family protein | 0.0019 | 0.3398 | 0.3398 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.0019 | 0.3398 | 0.3398 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 1 | 1 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor non-alpha subunit | 0.0019 | 0.3398 | 1 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0019 | 0.3398 | 0.3398 |
Echinococcus multilocularis | nicotinic acetylcholine receptor beta 1 subunit | 0.0019 | 0.3398 | 0.3398 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0019 | 0.3398 | 0.3398 |
Brugia malayi | acetylcholine receptor, alpha-type subunit unc-38 precursor | 0.0019 | 0.3398 | 0.3398 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.3333 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.3398 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.3333 | 0.3333 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0019 | 0.3398 | 0.3398 |
Onchocerca volvulus | 0.0019 | 0.3398 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.3398 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.3333 | 0.5 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0019 | 0.3398 | 0.3398 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.3333 | 0.5 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0019 | 0.3398 | 0.3398 |
Brugia malayi | Cation transporter family protein | 0.0019 | 0.3398 | 0.3398 |
Brugia malayi | nicotinic acetylcholine receptor beta-1 chain precursor | 0.0019 | 0.3398 | 0.3398 |
Onchocerca volvulus | Putative nachr subunit | 0.0019 | 0.3398 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0019 | 0.3398 | 0.3398 |
Loa Loa (eye worm) | ACC-1 protein | 0.0019 | 0.3398 | 1 |
Onchocerca volvulus | 0.0019 | 0.3398 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0037 | 1 | 1 |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0019 | 0.3398 | 1 |
Brugia malayi | Cation transporter family protein | 0.0019 | 0.3398 | 0.3398 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta2-like) | 0.0019 | 0.3398 | 0.3398 |
Schistosoma mansoni | nAChR subunit | 0.0019 | 0.3398 | 0.3398 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.3398 | 1 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0019 | 0.3398 | 0.3398 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.3333 | 0.3333 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 1 | 1 |
Echinococcus granulosus | acetylcholine receptor subunit beta 1 | 0.0019 | 0.3398 | 0.3398 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.3398 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.3333 | 0.5 |
Echinococcus multilocularis | acetylcholine receptor subunit beta 1 | 0.0019 | 0.3398 | 0.3398 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0019 | 0.3398 | 0.3398 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.3333 | 0.3333 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit type | 0.0019 | 0.3398 | 0.3398 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.3333 | 0.9808 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0019 | 0.3398 | 0.3398 |
Schistosoma mansoni | nAChR subunit | 0.0019 | 0.3398 | 0.3398 |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.0019 | 0.3398 | 0.3398 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.3398 | 1 |
Echinococcus granulosus | nAChR subunit | 0.0019 | 0.3398 | 0.3398 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.3333 | 0.3333 |
Onchocerca volvulus | 0.0019 | 0.3398 | 1 | |
Brugia malayi | excitatory GABA receptor EXP-1A | 0.0019 | 0.3398 | 0.3398 |
Schistosoma mansoni | nAChR subunit | 0.0019 | 0.3398 | 0.3398 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.3333 | 0.3333 |
Schistosoma mansoni | nAChR subunit | 0.0019 | 0.3398 | 0.3398 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0019 | 0.3398 | 0.3398 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0019 | 0.3398 | 0.3398 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0019 | 0.3398 | 0.3398 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0019 | 0.3398 | 0.3398 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0.3333 | 0.5 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0019 | 0.3398 | 0.3398 |
Loa Loa (eye worm) | ligand-Gated ion Channel family member | 0.0019 | 0.3398 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.3398 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0.3333 | 0.5 |
Echinococcus multilocularis | nAChR subunit | 0.0019 | 0.3398 | 0.3398 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0019 | 0.3398 | 0.3398 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 1 | 1 |
Schistosoma mansoni | nAChR subunit | 0.0019 | 0.3398 | 0.3398 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0.3333 | 0.5 |
Echinococcus granulosus | neuronal acetylcholine receptor subunit alpha 4 | 0.0019 | 0.3398 | 0.3398 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.916 mM | Inhibition of GLUT2-mediated [14C]D-glucose uptake in human MCF7 cells by liquid scintillation counting | ChEMBL. | 19586773 |
Ki (binding) | = 6.21 mM | Inhibition of GLUT2-mediated [14C]D-glucose uptake in human MDA-MB-231 cells by liquid scintillation counting | ChEMBL. | 19586773 |
Ki (binding) | = 154 uM | Inhibition of GLUT5-mediated [14C]D-fructose uptake in human MCF7 cells by liquid scintillation counting | ChEMBL. | 19586773 |
Ki (binding) | = 330 uM | Inhibition of GLUT5-mediated [14C]D-fructose uptake in human MDA-MB-231 cells by liquid scintillation counting | ChEMBL. | 19586773 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.