Detailed information for compound 106595

Basic information

Technical information
  • TDR Targets ID: 106595
  • Name: N-(2-methylanilino)-2-oxo-N'-phenylpropanimid amide
  • MW: 267.326 | Formula: C16H17N3O
  • H donors: 2 H acceptors: 1 LogP: 4.05 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)/C(=N\c1ccccc1)/NNc1ccccc1C
  • InChi: 1S/C16H17N3O/c1-12-8-6-7-11-15(12)18-19-16(13(2)20)17-14-9-4-3-5-10-14/h3-11,18H,1-2H3,(H,17,19)
  • InChiKey: AHRZKBRUOKXHGT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-methylanilino)-2-oxo-N'-phenyl-propanamidine
  • N-(2-methylanilino)-2-oxo-N'-phenylpropanamidine
  • N-[(2-methylphenyl)amino]-2-oxo-N'-phenyl-propanimidamide
  • 2-keto-N-(o-toluidino)-N'-phenyl-propionamidine
  • N-[(2-methylphenyl)amino]-2-oxo-N'-phenylpropanimidamide
  • N-[(2-methylphenyl)amino]-2-oxo-N'-phenyl-propanamidine
  • N-[(2-methylphenyl)amino]-2-oxo-N'-phenylpropanamidine
  • 2-keto-N-[(2-methylphenyl)amino]-N'-phenyl-propionamidine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens corticotropin releasing hormone receptor 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130760 All targets in OG5_130760
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 Get druggable targets OG5_130760 All targets in OG5_130760
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 Get druggable targets OG5_130760 All targets in OG5_130760
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative Get druggable targets OG5_130760 All targets in OG5_130760
Schistosoma japonicum IPR001879,Hormone receptor, extracellular,domain-containing Get druggable targets OG5_130760 All targets in OG5_130760
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c corticotropin releasing hormone receptor 1 444 aa 445 aa 25.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis ecdysone induced protein 78C 0.0046 0.0214 0.0213
Echinococcus granulosus fetal alzheimer antigen falz 0.002 0.0039 0.0038
Brugia malayi conserved hypotetical protein 0.0022 0.0048 0.004
Loa Loa (eye worm) nuclear receptor NHR-67 0.0022 0.0048 0.0048
Onchocerca volvulus 0.0174 0.1092 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0174 0.1092 0.1091
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0046 0.0214 0.0206
Loa Loa (eye worm) G-protein coupled receptor 0.0174 0.1092 0.1092
Echinococcus multilocularis neuropeptide Y receptor 0.0174 0.1092 0.1091
Schistosoma mansoni hypothetical protein 0.005 0.0238 0.0237
Echinococcus granulosus lysosomal alpha glucosidase 0.0121 0.0728 0.0727
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0072 0.0391 0.0391
Onchocerca volvulus 0.0174 0.1092 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0174 0.1092 0.1085
Echinococcus multilocularis G protein coupled receptor 139 0.0174 0.1092 0.1091
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0174 0.1092 0.1091
Brugia malayi hypothetical protein 0.0024 0.0066 0.0058
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0046 0.0214 0.0213
Loa Loa (eye worm) hypothetical protein 0.0174 0.1092 0.1092
Loa Loa (eye worm) hypothetical protein 0.0174 0.1092 0.1092
Echinococcus granulosus sterol regulatory element binding protein 0.0609 0.4058 0.4058
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0046 0.0214 0.1901
Schistosoma mansoni zinc finger protein 0.0018 0.0022 0.0021
Schistosoma mansoni hypothetical protein 0.0174 0.1092 0.1091
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0141 0.0141
Echinococcus granulosus peptide allatostatin:somatostatin 0.0174 0.1092 0.1091
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0051 0.0249 0.0248
Entamoeba histolytica hypothetical protein 0.0037 0.0152 1
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.0694 0.4638 0.5
Echinococcus granulosus Protein patched homolog 1 0.0609 0.4058 0.4058
Loa Loa (eye worm) hypothetical protein 0.0022 0.0048 0.0048
Brugia malayi GnHR receptor homolog 0.0174 0.1092 0.1085
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0018 0.0023 0.167
Brugia malayi Tachykinin-like peptides receptor 99D 0.0174 0.1092 0.1085
Loa Loa (eye worm) hypothetical protein 0.0022 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0174 0.1092 0.1092
Brugia malayi hypothetical protein 0.0174 0.1092 0.1085
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0046 0.0214 0.0213
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0102 0.0102
Brugia malayi hypothetical protein 0.0174 0.1092 0.1085
Echinococcus granulosus rhodopsin orphan GPCR 0.0174 0.1092 0.1091
Echinococcus granulosus G protein coupled receptor 139 0.0174 0.1092 0.1091
Schistosoma mansoni zinc finger protein 0.0022 0.0048 0.0047
Brugia malayi MH2 domain containing protein 0.0123 0.0737 0.073
Loa Loa (eye worm) hypothetical protein 0.0046 0.0214 0.0214
Loa Loa (eye worm) glutathione reductase 0.0029 0.0099 0.0099
Schistosoma mansoni nuclear receptor nhr-48 0.0022 0.0048 0.0047
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0064 0.0336 0.0336
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0174 0.1092 0.1091
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0174 0.1092 0.1091
Brugia malayi Nuclear hormone receptor E75 0.0022 0.0048 0.004
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0024 0.0066 0.0065
Schistosoma mansoni survival motor neuron protein 0.005 0.0238 0.0237
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0046 0.0214 0.0213
Brugia malayi hypothetical protein 0.0243 0.1558 0.1551
Brugia malayi Calcitonin receptor-like protein seb-1 0.0111 0.0661 0.0653
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0066 0.0353 0.8672
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0046 0.0214 0.0206
Loa Loa (eye worm) hypothetical protein 0.0022 0.0048 0.0048
Echinococcus multilocularis rhodopsin orphan GPCR 0.0174 0.1092 0.1091
Echinococcus granulosus thioredoxin glutathione reductase 0.0029 0.0101 0.01
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0024 0.0066 0.0065
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0074 0.0403 1
Schistosoma mansoni polycystin 1-related 0.0016 0.0008 0.0007
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0174 0.1092 0.1091
Brugia malayi larval opioid receptor 0.0174 0.1092 0.1085
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.022 0.1405 0.1405
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0174 0.1092 0.1091
Onchocerca volvulus 0.005 0.0238 0.2127
Loa Loa (eye worm) steroid hormone receptor 0.0046 0.0214 0.0214
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0609 0.4058 0.4058
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0018 0.0023 0.5
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0174 0.1092 0.1091
Schistosoma mansoni RAR-like nuclear receptor 0.0046 0.0214 0.0213
Echinococcus granulosus rhodopsin orphan GPCR 0.0174 0.1092 0.1091
Trypanosoma brucei glucosidase, putative 0.0027 0.0084 0.0061
Schistosoma mansoni opsin-like receptor 0.0174 0.1092 0.1091
Brugia malayi Dopamine receptor 0.0174 0.1092 0.1085
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.1479 1 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0152 0.0152
Schistosoma mansoni lipoxygenase 0.0044 0.0201 0.02
Brugia malayi nuclear receptor RXR 0.0022 0.0048 0.004
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.003 0.0103 0.0102
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0046 0.0214 0.0214
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0022 0.0048 0.004
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0046 0.0214 0.0206
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.0737 0.0737
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0046 0.0214 0.0214
Schistosoma mansoni amine GPCR 0.0174 0.1092 0.1091
Brugia malayi AKH receptor 0.0174 0.1092 0.1085
Loa Loa (eye worm) hypothetical protein 0.0174 0.1092 0.1092
Trichomonas vaginalis conserved hypothetical protein 0.0609 0.4058 0.8726
Onchocerca volvulus 0.0022 0.0048 0.0373
Schistosoma mansoni lipoxygenase 0.0016 0.0008 0.0007
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0111 0.0661 0.0661
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0174 0.1092 0.1091
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0046 0.0214 0.0214
Onchocerca volvulus 0.0046 0.0214 0.1901
Brugia malayi nuclear hormone receptor family member nhr-6 0.0022 0.0048 0.004
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0238 0.0231
Brugia malayi nuclear hormone receptor family member odr-7 0.0022 0.0048 0.004
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0046 0.0214 0.0206
Loa Loa (eye worm) hypothetical protein 0.0022 0.0048 0.0048
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0048 0.0047
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0174 0.1092 0.1085
Schistosoma mansoni neuropeptide F-like receptor 0.0174 0.1092 0.1091
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0141 0.014
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0174 0.1092 0.1091
Brugia malayi G protein-coupled receptor 0.0174 0.1092 0.1085
Schistosoma mansoni cpg binding protein 0.0033 0.0124 0.0123
Loa Loa (eye worm) follicle stimulating hormone receptor 0.07 0.4682 0.4682
Loa Loa (eye worm) hypothetical protein 0.0022 0.0048 0.0048
Echinococcus granulosus FTZ F1 alpha 0.0046 0.0214 0.0213
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0046 0.0214 0.0213
Echinococcus multilocularis fetal alzheimer antigen, falz 0.002 0.0039 0.0038
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0046 0.0214 0.0214
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0174 0.1092 0.1091
Echinococcus granulosus 7tm_1 domain containing protein 0.0174 0.1092 0.1091
Echinococcus granulosus somatostatin receptor 0.0174 0.1092 0.1091
Brugia malayi tailless protein 0.0022 0.0048 0.004
Loa Loa (eye worm) hypothetical protein 0.0174 0.1092 0.1092
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0141 0.0133
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0048 0.0047
Loa Loa (eye worm) hypothetical protein 0.0174 0.1092 0.1092
Schistosoma mansoni biogenic amine receptor 0.0174 0.1092 0.1091
Brugia malayi hypothetical protein 0.0174 0.1092 0.1085
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0152 0.0152
Echinococcus multilocularis rhodopsin orphan GPCR 0.0174 0.1092 0.1091
Echinococcus multilocularis serotonin receptor 0.0174 0.1092 0.1091
Echinococcus granulosus lipoxygenase domain containing protein 0.0016 0.0008 0.0007
Onchocerca volvulus 0.0174 0.1092 1
Loa Loa (eye worm) hypothetical protein 0.0174 0.1092 0.1092
Echinococcus multilocularis somatostatin receptor 0.0174 0.1092 0.1091
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0018 0.0023 0.5
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0174 0.1092 0.1092
Echinococcus granulosus GPCR family 2 0.0035 0.0141 0.014
Echinococcus multilocularis neuropeptides capa receptor 0.0174 0.1092 0.1091
Brugia malayi hypothetical protein 0.0037 0.0152 0.0145
Schistosoma mansoni amine GPCR 0.0174 0.1092 0.1091
Onchocerca volvulus 0.0174 0.1092 1
Echinococcus multilocularis neuropeptide receptor A26 0.0174 0.1092 0.1091
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.1479 1 1
Loa Loa (eye worm) hypothetical protein 0.0174 0.1092 0.1092
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0694 0.4638 1
Loa Loa (eye worm) hypothetical protein 0.0174 0.1092 0.1092
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0174 0.1092 0.1091
Echinococcus granulosus hypothetical protein 0.0174 0.1092 0.1091
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0141 0.014
Brugia malayi follicle stimulating hormone receptor 0.07 0.4682 0.4678
Echinococcus multilocularis protein dispatched 1 0.0609 0.4058 0.4058
Loa Loa (eye worm) hypothetical protein 0.0024 0.0066 0.0066
Echinococcus granulosus biogenic amine 5HT receptor 0.0174 0.1092 0.1091
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0027 0.0084 0.224
Echinococcus granulosus neuropeptides capa receptor 0.0174 0.1092 0.1091
Echinococcus multilocularis neutral alpha glucosidase AB 0.0027 0.0084 0.0083
Brugia malayi Glycosyl hydrolases family 31 protein 0.0027 0.0084 0.0076
Echinococcus multilocularis g-protein coupled receptor 0.0174 0.1092 0.1091
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.1479 1 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0024 0.0066 0.0066
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0066 0.0353 0.8672
Onchocerca volvulus Protein ultraspiracle homolog 0.0046 0.0214 0.1901
Loa Loa (eye worm) hypothetical protein 0.0174 0.1092 0.1092
Brugia malayi Nuclear hormone receptor E75 0.0022 0.0048 0.004
Brugia malayi Serotonin receptor 0.0174 0.1092 0.1085
Brugia malayi neuropeptide F receptor 0.0174 0.1092 0.1085
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0046 0.0214 0.0206
Echinococcus multilocularis G-protein coupled receptor, putative 0.0174 0.1092 0.1091
Schistosoma mansoni neuropeptide receptor 0.0174 0.1092 0.1091
Schistosoma mansoni neuropeptide receptor 0.0174 0.1092 0.1091
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0174 0.1092 0.1091
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0174 0.1092 0.1091
Loa Loa (eye worm) hypothetical protein 0.0022 0.0048 0.0048
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0046 0.0214 0.0213
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0174 0.1092 0.1085
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0046 0.0214 0.0206
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0174 0.1092 0.1091
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0046 0.0214 0.0206
Loa Loa (eye worm) hypothetical protein 0.0174 0.1092 0.1092
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0141 0.0133
Loa Loa (eye worm) hypothetical protein 0.0174 0.1092 0.1092
Loa Loa (eye worm) doublecortin family protein 0.0016 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0174 0.1092 0.1092
Trypanosoma cruzi trypanothione reductase, putative 0.0029 0.0099 0.0015
Echinococcus multilocularis survival motor neuron protein 1 0.0243 0.1558 0.1557
Loa Loa (eye worm) nuclear hormone receptor 0.0022 0.0048 0.0048
Echinococcus granulosus rhodopsin orphan GPCR 0.0174 0.1092 0.1091
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0174 0.1092 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0609 0.4058 0.4058
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0174 0.1092 0.1091
Brugia malayi steroid hormone receptor 0.0046 0.0214 0.0206
Schistosoma mansoni alpha glucosidase 0.0027 0.0084 0.0083
Loa Loa (eye worm) thioredoxin reductase 0.0029 0.0099 0.0099
Schistosoma mansoni neuropeptide f receptor 76f 0.0174 0.1092 0.1091
Brugia malayi hypothetical protein 0.0174 0.1092 0.1085
Echinococcus granulosus lipoxygenase domain containing protein 0.0016 0.0008 0.0007
Echinococcus multilocularis rhodopsin orphan GPCR 0.0174 0.1092 0.1091
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0072 0.0391 0.039
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.1479 1 1
Onchocerca volvulus 0.0174 0.1092 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0174 0.1092 0.1091
Mycobacterium tuberculosis Probable dehydrogenase 0.0066 0.0353 0.8672
Brugia malayi hypothetical protein 0.0174 0.1092 0.1085
Loa Loa (eye worm) hypothetical protein 0.0022 0.0048 0.0048
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0046 0.0214 0.0213
Echinococcus granulosus neuropeptide receptor A26 0.0174 0.1092 0.1091
Echinococcus multilocularis allatostatin A receptor 0.0174 0.1092 0.1091
Loa Loa (eye worm) hypothetical protein 0.0174 0.1092 0.1092
Onchocerca volvulus 0.0174 0.1092 1
Brugia malayi latrophilin 2 splice variant baaae 0.0076 0.042 0.0413
Schistosoma mansoni amine GPCR 0.0174 0.1092 0.1091
Echinococcus granulosus L aminoadipate semialdehyde 0.0064 0.0336 0.0336
Brugia malayi neuropeptide F receptor 0.0174 0.1092 0.1085
Echinococcus granulosus geminin 0.0126 0.0761 0.076
Loa Loa (eye worm) hypothetical protein 0.0174 0.1092 0.1092
Echinococcus granulosus neuropeptide Y receptor 0.0174 0.1092 0.1091
Entamoeba histolytica hypothetical protein 0.0037 0.0152 1
Brugia malayi glutathione reductase 0.0029 0.0099 0.0091
Schistosoma mansoni hypothetical protein 0.042 0.2767 0.2766
Echinococcus multilocularis GPCR, family 2 0.0035 0.0141 0.014
Loa Loa (eye worm) TYRA-2 protein 0.0174 0.1092 0.1092
Loa Loa (eye worm) hypothetical protein 0.0046 0.0214 0.0214
Loa Loa (eye worm) hypothetical protein 0.0174 0.1092 0.1092
Loa Loa (eye worm) hypothetical protein 0.0174 0.1092 0.1092
Echinococcus multilocularis rhodopsin orphan GPCR 0.0174 0.1092 0.1091
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0694 0.4638 1
Plasmodium falciparum thioredoxin reductase 0.0029 0.0099 1
Loa Loa (eye worm) hypothetical protein 0.0174 0.1092 0.1092
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0027 0.0084 0.4706
Schistosoma mansoni steroid hormone receptor ad4bp 0.0046 0.0214 0.0213
Echinococcus granulosus serotonin receptor 0.0174 0.1092 0.1091
Echinococcus granulosus neuropeptide receptor 0.0174 0.1092 0.1091
Loa Loa (eye worm) hypothetical protein 0.0174 0.1092 0.1092
Echinococcus granulosus rhodopsin orphan GPCR 0.0174 0.1092 0.1091
Echinococcus multilocularis neuropeptide s receptor 0.0174 0.1092 0.1091
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.1479 1 1
Entamoeba histolytica hypothetical protein 0.0037 0.0152 1
Echinococcus multilocularis g protein coupled receptor 0.0174 0.1092 0.1091
Loa Loa (eye worm) hypothetical protein 0.0022 0.0048 0.0048
Brugia malayi hypothetical protein 0.0174 0.1092 0.1085
Schistosoma mansoni biogenic amine (5HT) receptor 0.0174 0.1092 0.1091
Brugia malayi nuclear hormone receptor 0.0022 0.0048 0.004
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0046 0.0214 0.0206
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0001
Onchocerca volvulus 0.0174 0.1092 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0174 0.1092 0.1091
Echinococcus granulosus thyroid hormone receptor alpha 0.0022 0.0048 0.0047
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0174 0.1092 0.1091
Loa Loa (eye worm) hypothetical protein 0.0064 0.0336 0.0336
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0174 0.1092 0.1091
Echinococcus granulosus rhodopsin orphan GPCR 0.0174 0.1092 0.1091
Schistosoma mansoni hypothetical protein 0.0174 0.1092 0.1091
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0029 0.0099 0.1991
Onchocerca volvulus 0.0174 0.1092 1
Loa Loa (eye worm) PHD-finger family protein 0.0017 0.0017 0.0017
Brugia malayi ORL1-like opioid receptor 0.0174 0.1092 0.1085
Echinococcus multilocularis protein patched 0.0609 0.4058 0.4058
Echinococcus multilocularis L aminoadipate semialdehyde 0.0064 0.0336 0.0336
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0022 0.0048 0.0047
Schistosoma mansoni neuropeptide receptor 0.0174 0.1092 0.1091
Loa Loa (eye worm) hypothetical protein 0.0016 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0035 0.0141 0.0141
Echinococcus multilocularis thyroid hormone receptor alpha 0.0046 0.0214 0.0213
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0072 0.0391 0.039
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0046 0.0214 0.0214
Onchocerca volvulus 0.007 0.0379 0.3423
Loa Loa (eye worm) hypothetical protein 0.0174 0.1092 0.1092
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0174 0.1092 0.1091
Schistosoma mansoni alpha-glucosidase 0.0104 0.0613 0.0612
Schistosoma mansoni amine GPCR 0.0174 0.1092 0.1091
Brugia malayi RE15519p 0.0174 0.1092 0.1085
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0046 0.0214 0.0213
Loa Loa (eye worm) hypothetical protein 0.0046 0.0214 0.0214
Onchocerca volvulus 0.0174 0.1092 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0174 0.1092 0.1091
Schistosoma mansoni hypothetical protein 0.0174 0.1092 0.1091
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0046 0.0214 0.0213
Echinococcus granulosus 7TM GPCR rhodopsin 0.0174 0.1092 0.1091
Echinococcus multilocularis g protein coupled receptor 0.0174 0.1092 0.1091
Echinococcus multilocularis neuropeptides capa receptor 0.0174 0.1092 0.1091
Brugia malayi Melatonin receptor type 1A 0.0174 0.1092 0.1085
Echinococcus multilocularis rhodopsin orphan GPCR 0.0174 0.1092 0.1091
Echinococcus multilocularis orexin receptor type 2 0.0174 0.1092 0.1091
Schistosoma mansoni hypothetical protein 0.0126 0.0761 0.076
Schistosoma mansoni adenoreceptor 0.0174 0.1092 0.1091
Loa Loa (eye worm) hypothetical protein 0.0024 0.0066 0.0066
Echinococcus multilocularis neuropeptide Y receptor 0.0174 0.1092 0.1091
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0046 0.0214 0.0213
Brugia malayi hypothetical protein 0.0022 0.0048 0.004
Schistosoma mansoni histamine h1 receptor 0.0174 0.1092 0.1091
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0072 0.0391 0.039
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0066 0.0058
Schistosoma mansoni growth hormone secretagogue receptor 0.0174 0.1092 0.1091
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0022 0.0048 0.0047
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0046 0.0214 0.0213
Loa Loa (eye worm) hypothetical protein 0.0174 0.1092 0.1092
Loa Loa (eye worm) hypothetical protein 0.0297 0.1925 0.1925
Brugia malayi sulfakinin receptor protein 0.0174 0.1092 0.1085
Echinococcus multilocularis dro:myosuppressin receptor 0.0174 0.1092 0.1091
Echinococcus granulosus tm gpcr rhodopsin 0.0174 0.1092 0.1091
Trypanosoma brucei trypanothione reductase 0.0029 0.0099 0.0076
Echinococcus multilocularis neuropeptide receptor 0.0174 0.1092 0.1091
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0327 0.0326
Loa Loa (eye worm) hypothetical protein 0.0046 0.0214 0.0214
Echinococcus granulosus g protein coupled receptor 0.0174 0.1092 0.1091
Echinococcus granulosus nuclear receptor nhr 48 0.0022 0.0048 0.0047
Loa Loa (eye worm) hypothetical protein 0.0022 0.0048 0.0048
Brugia malayi G-protein coupled receptor 0.0174 0.1092 0.1085
Echinococcus multilocularis rhodopsin orphan GPCR 0.0174 0.1092 0.1091
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0174 0.1092 0.1092
Echinococcus multilocularis nuclear receptor nhr 48 0.0022 0.0048 0.0047
Loa Loa (eye worm) hypothetical protein 0.0046 0.0214 0.0214
Schistosoma mansoni hypothetical protein 0.0037 0.0152 0.0152
Echinococcus granulosus Niemann Pick C1 protein 0.0609 0.4058 0.4058
Onchocerca volvulus 0.0174 0.1092 1
Echinococcus multilocularis geminin 0.0126 0.0761 0.076
Echinococcus granulosus neuropeptides capa receptor 0.0174 0.1092 0.1091
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0046 0.0214 0.0214
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0174 0.1092 0.1091
Loa Loa (eye worm) hypothetical protein 0.0022 0.0048 0.0048
Echinococcus granulosus RUN 0.0016 0.0008 0.0007
Loa Loa (eye worm) hypothetical protein 0.0174 0.1092 0.1092
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0022 0.0048 0.0048
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0018 0.0023 0.5
Echinococcus multilocularis RUN 0.0016 0.0008 0.0007
Brugia malayi nuclear receptor RXR 0.0024 0.0066 0.0058
Loa Loa (eye worm) melatonin receptor type 1A 0.0174 0.1092 0.1092
Loa Loa (eye worm) hypothetical protein 0.0174 0.1092 0.1092
Loa Loa (eye worm) hypothetical protein 0.0174 0.1092 0.1092
Loa Loa (eye worm) hypothetical protein 0.0022 0.0048 0.0048
Echinococcus multilocularis lysosomal alpha glucosidase 0.0121 0.0728 0.0727
Echinococcus multilocularis serotonin receptor 0.0174 0.1092 0.1091
Brugia malayi Nuclear hormone receptor-like 1 0.0046 0.0214 0.0206
Brugia malayi hypothetical protein 0.0174 0.1092 0.1085
Echinococcus granulosus allatostatin A receptor 0.0174 0.1092 0.1091
Echinococcus multilocularis sex peptide receptor 0.0174 0.1092 0.1091
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.1479 1 1
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0048 0.0047
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0174 0.1092 0.1091
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0152 0.0152
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0174 0.1092 0.1092
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0072 0.0391 0.039
Echinococcus multilocularis lipoxygenase domain containing protein 0.0016 0.0008 0.0007
Brugia malayi G protein-coupled receptor F59B2.13 0.0174 0.1092 0.1085
Schistosoma mansoni retinoic acid receptor RXR 0.0046 0.0214 0.0213
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0046 0.0214 0.0214
Brugia malayi Bromodomain containing protein 0.0064 0.0335 0.0327
Loa Loa (eye worm) hypothetical protein 0.0174 0.1092 0.1092
Schistosoma mansoni opsin-like receptor 0.0174 0.1092 0.1091
Onchocerca volvulus 0.0174 0.1092 1
Schistosoma mansoni hypothetical protein 0.0076 0.042 0.0419
Onchocerca volvulus 0.0174 0.1092 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0174 0.1092 0.1091
Loa Loa (eye worm) hypothetical protein 0.0046 0.0214 0.0214
Loa Loa (eye worm) hypothetical protein 0.0174 0.1092 0.1092
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0174 0.1092 0.1085
Loa Loa (eye worm) G-protein coupled receptor 0.0174 0.1092 0.1092
Loa Loa (eye worm) hypothetical protein 0.0022 0.0048 0.0048
Schistosoma mansoni neuropeptide F-like receptor 0.0174 0.1092 0.1091
Schistosoma mansoni loxhd1 0.0016 0.0008 0.0007
Schistosoma mansoni rab6-interacting 0.0016 0.0008 0.0007
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0072 0.0391 0.0383
Echinococcus granulosus neuropeptide Y receptor 0.0174 0.1092 0.1091
Brugia malayi Glycosyl hydrolases family 31 protein 0.0121 0.0728 0.072
Brugia malayi putative neuropeptide receptor 0.0174 0.1092 0.1085
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0046 0.0214 0.0213
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0024 0.0066 0.0065
Brugia malayi Dopamine receptor protein 1 0.0174 0.1092 0.1085
Echinococcus granulosus biogenic amine 5HT receptor 0.0174 0.1092 0.1091
Loa Loa (eye worm) DR-78 0.0022 0.0048 0.0048
Onchocerca volvulus 0.0174 0.1092 1
Schistosoma mansoni hypothetical protein 0.0017 0.0017 0.0016
Loa Loa (eye worm) hypothetical protein 0.0174 0.1092 0.1092
Brugia malayi G-protein coupled receptor 0.0174 0.1092 0.1085
Brugia malayi CXXC zinc finger family protein 0.0029 0.0102 0.0094
Brugia malayi ecdysteroid receptor 0.0046 0.0214 0.0206
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.0737 0.0737
Echinococcus multilocularis lipoxygenase domain containing protein 0.0016 0.0008 0.0007
Leishmania major trypanothione reductase 0.0029 0.0099 0.0076
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.022 0.1405 0.1405
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0072 0.0391 0.039
Loa Loa (eye worm) hypothetical protein 0.0174 0.1092 0.1092
Schistosoma mansoni coup transcription factor 0.0046 0.0214 0.0213
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0694 0.4638 1
Echinococcus multilocularis zinc finger protein 0.0018 0.0022 0.0021
Onchocerca volvulus 0.0174 0.1092 1
Schistosoma mansoni cpg binding protein 0.0029 0.0102 0.0101
Loa Loa (eye worm) hypothetical protein 0.0034 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0174 0.1092 0.1092
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0174 0.1092 0.1085
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0066 0.0353 0.8672
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0174 0.1092 0.1091
Loa Loa (eye worm) hypothetical protein 0.0174 0.1092 0.1092
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0174 0.1092 0.1091
Onchocerca volvulus 0.0174 0.1092 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0066 0.0066
Brugia malayi CHE-14 protein 0.0609 0.4058 0.4054
Echinococcus multilocularis FTZ F1 alpha 0.0046 0.0214 0.0213
Onchocerca volvulus 0.0064 0.0336 0.3032
Echinococcus granulosus orexin receptor type 2 0.0174 0.1092 0.1091
Echinococcus granulosus ecdysone induced protein 78C 0.0046 0.0214 0.0213
Schistosoma mansoni alpha-glucosidase 0.0104 0.0613 0.0612
Loa Loa (eye worm) hypothetical protein 0.0174 0.1092 0.1092
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0022 0.0048 0.0047
Plasmodium vivax glutathione reductase, putative 0.0029 0.0099 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0074 0.0403 1
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.1479 1 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0022 0.0048 0.0047
Schistosoma mansoni bromodomain containing protein 0.0054 0.0269 0.0268
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0174 0.1092 0.1091
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0066 0.0353 0.8672
Echinococcus granulosus tachykinin peptides receptor 99D 0.0174 0.1092 0.1091
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0174 0.1092 0.1092
Echinococcus granulosus rhodopsin orphan GPCR 0.0174 0.1092 0.1091
Schistosoma mansoni biogenic amine receptor 0.0174 0.1092 0.1091
Schistosoma mansoni biogenic amine receptor 0.0174 0.1092 0.1091
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0174 0.1092 0.1091
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0174 0.1092 0.1091
Loa Loa (eye worm) hypothetical protein 0.0174 0.1092 0.1092
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0174 0.1092 0.1091
Loa Loa (eye worm) hypothetical protein 0.0046 0.0214 0.0214
Loa Loa (eye worm) neuropeptide F receptor 0.0174 0.1092 0.1092
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0174 0.1092 0.1091
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0044 0.0201 0.02
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0174 0.1092 0.1091
Brugia malayi hypothetical protein 0.0022 0.0048 0.004
Brugia malayi Thioredoxin reductase 0.0029 0.0099 0.0091
Schistosoma mansoni nuclear receptor 0.0022 0.0048 0.0047
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0046 0.0214 0.0213
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0046 0.0214 0.0213
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0044 0.0201 0.02
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0174 0.1092 0.1091
Loa Loa (eye worm) hypothetical protein 0.0174 0.1092 0.1092
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0174 0.1092 0.1091
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0072 0.0391 0.039
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0046 0.0214 0.0213
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.002 0.0039 0.0038
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0174 0.1092 0.1091
Echinococcus granulosus tm gpcr rhodopsin 0.0174 0.1092 0.1091
Brugia malayi Bromodomain containing protein 0.0032 0.0116 0.0109
Brugia malayi Serotonin receptor 0.0174 0.1092 0.1085
Entamoeba histolytica hypothetical protein 0.0037 0.0152 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0174 0.1092 0.1091
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0174 0.1092 0.1091
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0072 0.0391 0.039
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0174 0.1092 0.1091
Onchocerca volvulus 0.0174 0.1092 1
Brugia malayi hypothetical protein 0.0174 0.1092 0.1085
Schistosoma mansoni rab6-interacting 0.0016 0.0008 0.0007
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0074 0.0403 1
Brugia malayi nuclear receptor NHR-88 0.0046 0.0214 0.0206
Mycobacterium tuberculosis Probable oxidoreductase 0.0074 0.0403 1
Brugia malayi Dopamine receptor protein 2 0.0174 0.1092 0.1085
Loa Loa (eye worm) hypothetical protein 0.0016 0.0008 0.0008
Schistosoma mansoni patched 1 0.0609 0.4058 0.4058
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0046 0.0214 0.0213
Echinococcus multilocularis fmrfamide receptor 0.0174 0.1092 0.1091
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0046 0.0214 0.0206
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0046 0.0214 0.0206
Echinococcus multilocularis neuropeptide FF receptor 2 0.0174 0.1092 0.1091
Echinococcus granulosus fmrfamide receptor 0.0174 0.1092 0.1091
Loa Loa (eye worm) hypothetical protein 0.0174 0.1092 0.1092
Loa Loa (eye worm) hypothetical protein 0.0032 0.0117 0.0117
Schistosoma mansoni hypothetical protein 0.0035 0.0141 0.014
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0174 0.1092 0.1091
Brugia malayi putative neuropeptide receptor NPR1 0.0174 0.1092 0.1085
Onchocerca volvulus 0.0174 0.1092 1
Echinococcus granulosus dnaJ subfamily B 0.042 0.2767 0.2766
Echinococcus multilocularis lysosomal alpha glucosidase 0.0121 0.0728 0.0727
Loa Loa (eye worm) hypothetical protein 0.0058 0.0299 0.0299
Echinococcus multilocularis g protein coupled receptor 0.0174 0.1092 0.1091
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0018 0.0023 0.167
Loa Loa (eye worm) hypothetical protein 0.0174 0.1092 0.1092
Schistosoma mansoni myosin xvIII 0.0174 0.1092 0.1091
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0064 0.0336 0.0329
Schistosoma mansoni neuropeptide receptor 0.0174 0.1092 0.1091
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0051 0.0249 0.0248
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0174 0.1092 0.1091
Loa Loa (eye worm) hypothetical protein 0.0174 0.1092 0.1092
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0297 0.1925 0.1919
Loa Loa (eye worm) hypothetical protein 0.0243 0.1558 0.1558
Loa Loa (eye worm) neuropeptide F receptor 0.0174 0.1092 0.1092
Loa Loa (eye worm) hypothetical protein 0.0174 0.1092 0.1092
Echinococcus multilocularis rhodopsin orphan GPCR 0.0174 0.1092 0.1091
Schistosoma mansoni hypothetical protein 0.0126 0.0761 0.076
Brugia malayi orphan nuclear receptor NR2E1 0.0022 0.0048 0.004
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0022 0.0048 0.0373
Schistosoma mansoni hypothetical protein 0.0035 0.0141 0.014
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0121 0.0728 0.0728
Echinococcus granulosus neuropeptide receptor 0.0174 0.1092 0.1091
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0022 0.0048 0.0047
Schistosoma mansoni hypothetical protein 0.0035 0.0141 0.014
Schistosoma mansoni amine GPCR 0.0174 0.1092 0.1091
Schistosoma mansoni cpg binding protein 0.0033 0.0124 0.0123
Echinococcus multilocularis neuropeptide receptor 0.0174 0.1092 0.1091
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0024 0.0066 0.0065
Loa Loa (eye worm) hypothetical protein 0.0076 0.042 0.042
Loa Loa (eye worm) hypothetical protein 0.0609 0.4058 0.4058
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0022 0.0048 0.0047
Schistosoma mansoni alpha-1 adrenergic receptor 0.0174 0.1092 0.1091
Schistosoma mansoni nuclear hormone receptor 0.0046 0.0214 0.0213
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0027 0.0084 0.4706
Echinococcus multilocularis cpg binding protein 0.0033 0.0124 0.0123
Loa Loa (eye worm) hypothetical protein 0.0174 0.1092 0.1092
Loa Loa (eye worm) hypothetical protein 0.0174 0.1092 0.1092
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.003 0.0103 0.0102
Schistosoma mansoni opsin-like receptor 0.0174 0.1092 0.1091
Loa Loa (eye worm) hypothetical protein 0.0174 0.1092 0.1092
Brugia malayi nuclear hormone receptor 0.0046 0.0214 0.0206
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0046 0.0214 0.0213
Schistosoma mansoni hypothetical protein 0.0035 0.0141 0.014
Echinococcus granulosus Polycystic kidney disease protein 0.0016 0.0008 0.0007
Plasmodium vivax thioredoxin reductase, putative 0.0029 0.0099 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0609 0.4058 0.4058
Loa Loa (eye worm) hypothetical protein 0.0174 0.1092 0.1092
Loa Loa (eye worm) hypothetical protein 0.0024 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0022 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0174 0.1092 0.1092
Echinococcus granulosus Nuclear hormone receptor HR96 0.0022 0.0048 0.0047
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0022 0.0048 0.0047
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0022 0.0048 0.0047
Echinococcus granulosus zinc finger protein 0.0018 0.0022 0.0021
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0174 0.1092 0.1091
Brugia malayi photoreceptor-specific nuclear receptor 0.0046 0.0214 0.0206
Brugia malayi hypothetical protein 0.0174 0.1092 0.1085
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0174 0.1092 0.1091
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0046 0.0214 0.0213
Echinococcus multilocularis fmrfamide receptor 0.0174 0.1092 0.1091
Mycobacterium tuberculosis Probable reductase 0.0066 0.0353 0.8672
Leishmania major alpha glucosidase II subunit, putative 0.0027 0.0084 0.0061
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0609 0.4058 0.4058
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0046 0.0214 0.0206
Onchocerca volvulus 0.0022 0.0048 0.0373
Schistosoma mansoni nuclear receptor 0.0022 0.0048 0.0047
Echinococcus multilocularis thioredoxin glutathione reductase 0.0029 0.0101 0.01
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0174 0.1092 0.1091
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0048 0.0047
Echinococcus granulosus neutral alpha glucosidase AB 0.0027 0.0084 0.0083
Loa Loa (eye worm) hypothetical protein 0.1479 1 1
Loa Loa (eye worm) hypothetical protein 0.0174 0.1092 0.1092
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0046 0.0214 0.0213
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0046 0.0214 0.0206
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0066 0.0058
Brugia malayi hypothetical protein 0.0174 0.1092 0.1085
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0295 1
Echinococcus multilocularis Polycystic kidney disease protein 0.0016 0.0008 0.0007
Echinococcus granulosus g-protein coupled receptor 0.0174 0.1092 0.1091
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0046 0.0214 0.0213
Schistosoma mansoni hypothetical protein 0.0016 0.0008 0.0007
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0046 0.0214 0.0206
Loa Loa (eye worm) hypothetical protein 0.0174 0.1092 0.1092
Loa Loa (eye worm) hypothetical protein 0.0174 0.1092 0.1092
Brugia malayi ecdysone receptor 0.0022 0.0048 0.004
Brugia malayi nuclear receptor NHR-88 0.0022 0.0048 0.004
Brugia malayi nuclear receptor NHR-67 0.0022 0.0048 0.004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0174 0.1092 0.1091
Echinococcus granulosus neuropeptide s receptor 0.0174 0.1092 0.1091
Onchocerca volvulus 0.0029 0.0102 0.0865
Echinococcus multilocularis dnaJ subfamily B 0.042 0.2767 0.2766
Onchocerca volvulus Bile acid receptor homolog 0.0046 0.0214 0.1901
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.1479 1 1
Schistosoma mansoni thyroid hormone receptor 0.0046 0.0214 0.0213
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0022 0.0048 0.0373
Brugia malayi PHD-finger family protein 0.0022 0.0052 0.0045
Schistosoma mansoni hypothetical protein 0.0174 0.1092 0.1091
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0152 0.0152
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0027 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0046 0.0214 0.0214
Loa Loa (eye worm) hypothetical protein 0.0024 0.0066 0.0066
Echinococcus granulosus g protein coupled receptor 0.0174 0.1092 0.1091
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0066 0.0353 0.8672
Echinococcus granulosus survival motor neuron protein 1 0.0243 0.1558 0.1557
Echinococcus granulosus dro:myosuppressin receptor 0.0174 0.1092 0.1091
Onchocerca volvulus Neuropeptide F receptor homolog 0.0174 0.1092 1
Echinococcus granulosus sex peptide receptor 0.0174 0.1092 0.1091
Brugia malayi Steroid receptor seven-up type 2 0.0046 0.0214 0.0206
Echinococcus granulosus neuropeptide FF receptor 2 0.0174 0.1092 0.1091
Echinococcus granulosus cpg binding protein 0.0033 0.0124 0.0123
Toxoplasma gondii thioredoxin reductase 0.0029 0.0099 0.2785
Echinococcus granulosus g protein coupled receptor 0.0174 0.1092 0.1091
Plasmodium falciparum glutathione reductase 0.0029 0.0099 1
Schistosoma mansoni thyroid hormone receptor 0.0046 0.0214 0.0213
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0174 0.1092 0.1091
Echinococcus granulosus tm gpcr rhodopsin 0.0174 0.1092 0.1091
Brugia malayi hypothetical protein 0.0024 0.0066 0.0058
Echinococcus granulosus rhodopsin orphan GPCR 0.0174 0.1092 0.1091

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 526 nM Binding affinity against human Corticotropin releasing factor receptor 1 ChEMBL. 12014949
Ki (binding) = 526 nM Binding affinity against human Corticotropin releasing factor receptor 1 ChEMBL. 12014949

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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