Detailed information for compound 1066357

Basic information

Technical information
  • TDR Targets ID: 1066357
  • Name: 4-ethylamino-6-(phenylamino)-1,3,5-triazine-2 -carbonitrile
  • MW: 240.264 | Formula: C12H12N6
  • H donors: 2 H acceptors: 4 LogP: 2.59 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCNc1nc(Nc2ccccc2)nc(n1)C#N
  • InChi: 1S/C12H12N6/c1-2-14-11-16-10(8-13)17-12(18-11)15-9-6-4-3-5-7-9/h3-7H,2H2,1H3,(H2,14,15,16,17,18)
  • InChiKey: FHCGJKYYSNANOR-UHFFFAOYSA-N  

Network

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Synonyms

  • 4-ethylamino-6-(phenylamino)-s-triazine-2-carbonitrile
  • Oprea1_052655
  • ZINC00270639
  • Oprea1_856463
  • STOCK1S-45588
  • NCGC00166357-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL References
Carica papaya Papain Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium vivax vivapain-3 Papain   345 aa 340 aa 33.2 %
Plasmodium falciparum cysteine proteinase falcipain 1 Papain   345 aa 376 aa 30.6 %
Entamoeba histolytica cysteine protease, putative Papain   345 aa 291 aa 24.1 %
Schistosoma japonicum ko:K01275 cathepsin C [EC3.4.14.1], putative Papain   345 aa 313 aa 29.7 %
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) Papain   345 aa 324 aa 35.2 %
Echinococcus granulosus cathepsin b Papain   345 aa 321 aa 25.9 %
Echinococcus multilocularis cathepsin L Papain   345 aa 352 aa 36.4 %
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Papain   345 aa 328 aa 33.5 %
Onchocerca volvulus Papain   345 aa 344 aa 23.3 %
Echinococcus multilocularis cathepsin L Papain   345 aa 355 aa 27.3 %
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Papain   345 aa 323 aa 26.3 %
Babesia bovis papain family cysteine protease containing protein Papain   345 aa 342 aa 31.0 %
Schistosoma japonicum Disco-interacting protein 2 homolog B, putative Papain   345 aa 342 aa 30.7 %
Entamoeba histolytica cysteine protease, putative Papain   345 aa 361 aa 24.9 %
Entamoeba histolytica cysteine protease, putative Papain   345 aa 373 aa 27.3 %
Onchocerca volvulus Protein MCM10 homolog Papain   345 aa 294 aa 34.7 %
Onchocerca volvulus Papain   345 aa 324 aa 32.1 %
Echinococcus granulosus cathepsin L Papain   345 aa 356 aa 36.0 %
Onchocerca volvulus Cathepsin L homolog Papain   345 aa 317 aa 33.8 %
Brugia malayi Papain family cysteine protease containing protein Papain   345 aa 308 aa 27.6 %
Trypanosoma cruzi cysteine proteinase, putative Papain   345 aa 299 aa 30.1 %
Brugia malayi cathepsin B-like cysteine proteinase Papain   345 aa 306 aa 26.1 %
Onchocerca volvulus Papain   345 aa 307 aa 35.5 %
Entamoeba histolytica cysteine protease, putative Papain   345 aa 392 aa 23.0 %
Plasmodium yoelii cysteine proteinase precursor Papain   345 aa 346 aa 30.6 %
Neospora caninum hypothetical protein Papain   345 aa 297 aa 23.2 %
Giardia lamblia Dipeptidyl-peptidase I precursor Papain   345 aa 281 aa 26.0 %
Trypanosoma cruzi cysteine proteinase, putative Papain   345 aa 298 aa 29.2 %
Theileria parva cysteine proteinase, putative Papain   345 aa 307 aa 29.0 %
Entamoeba histolytica cysteine protease, putative Papain   345 aa 351 aa 25.1 %
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Papain   345 aa 328 aa 33.5 %
Entamoeba histolytica cysteine protease, putative Papain   345 aa 321 aa 29.3 %
Plasmodium berghei berghepain-1 Papain   345 aa 345 aa 29.9 %
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) Papain   345 aa 320 aa 28.4 %
Onchocerca volvulus Papain   345 aa 312 aa 35.6 %
Entamoeba histolytica cysteine protease, putative Papain   345 aa 351 aa 25.1 %
Theileria parva cysteine proteinase, putative Papain   345 aa 350 aa 29.4 %
Plasmodium knowlesi knowpain-1 Papain   345 aa 396 aa 29.8 %
Echinococcus granulosus cathepsin L Papain   345 aa 316 aa 29.1 %
Entamoeba histolytica cysteine protease, putative Papain   345 aa 351 aa 25.1 %
Dictyostelium discoideum cathepsin L-like proteinase Papain   345 aa 330 aa 37.3 %
Giardia lamblia Dipeptidyl-peptidase I precursor Papain   345 aa 280 aa 29.6 %
Onchocerca volvulus Papain   345 aa 326 aa 31.9 %
Drosophila melanogaster CG6347 gene product from transcript CG6347-RA Papain   345 aa 355 aa 30.4 %
Entamoeba histolytica cysteine protease, putative Papain   345 aa 318 aa 22.3 %
Plasmodium vivax vivapain-1 Papain   345 aa 360 aa 30.0 %
Entamoeba histolytica cysteine protease, putative Papain   345 aa 357 aa 26.9 %
Plasmodium vivax unspecified product Papain   345 aa 358 aa 30.2 %
Entamoeba histolytica cysteine protease, putative Papain   345 aa 351 aa 25.1 %
Entamoeba histolytica cysteine protease, putative Papain   345 aa 302 aa 24.8 %
Trypanosoma cruzi cysteine protease, putative Papain   345 aa 344 aa 30.8 %
Entamoeba histolytica cysteine protease, putative Papain   345 aa 343 aa 25.4 %
Theileria parva cysteine proteinase, putative Papain   345 aa 324 aa 32.1 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Plasmodium falciparum endoplasmin, putative 0.0038 0.0513 0.0921
Entamoeba histolytica recQ family helicase, putative 0.0022 0.0205 0.1091
Trichomonas vaginalis endoplasmin, putative 0.0038 0.0513 0.0553
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0035 0.0451 0.0434
Trichomonas vaginalis CAMK family protein kinase 0.011 0.1882 0.2988
Loa Loa (eye worm) transcription factor SMAD2 0.0138 0.2423 0.4142
Schistosoma mansoni heat shock protein 0.0052 0.0787 0.1324
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0202 0.065
Echinococcus multilocularis survival motor neuron protein 1 0.0245 0.4477 0.4467
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0733 0.0716
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0053 0.0804 0.3585
Echinococcus multilocularis mitogen activated protein kinase 3 0.0053 0.0804 0.0787
Schistosoma mansoni hypothetical protein 0.0042 0.0581 0.0969
Schistosoma mansoni tar DNA-binding protein 0.0211 0.3819 0.6547
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0056 0.0038
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0036 0.0468 0.0775
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0689 0.0867
Schistosoma mansoni DNA helicase recq5 0.0022 0.0205 0.0322
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0689 0.0867
Loa Loa (eye worm) hypothetical protein 0.0032 0.0391 0.0641
Echinococcus granulosus cathepsin l cysteine peptidase 0.0047 0.0689 0.0672
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0202 0.0316
Leishmania major heat shock protein 83-1 0.0052 0.0787 0.2681
Echinococcus granulosus cathepsin L cysteine proteinase 0.0047 0.0689 0.0672
Brugia malayi TAR-binding protein 0.0211 0.3819 0.6547
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0024 0.0251 0.0296
Echinococcus multilocularis cysteine protease 0.0047 0.0689 0.0672
Echinococcus granulosus intermediate filament protein 0.0029 0.0345 0.0327
Entamoeba histolytica cysteine protease, putative 0.0024 0.0251 0.1336
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0391 0.0336
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0104 0.1776 0.937
Echinococcus granulosus lamin 0.0029 0.0345 0.0327
Schistosoma mansoni hypothetical protein 0.0036 0.0468 0.0775
Echinococcus granulosus cathepsin L 0.0024 0.0251 0.0233
Brugia malayi RNA recognition motif domain containing protein 0.0211 0.3819 0.6547
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0047 0.0689 0.0867
Trypanosoma brucei heat shock protein, putative 0.0052 0.0787 0.3483
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0049 0.0725 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0733 0.0716
Trypanosoma cruzi cysteine proteinase, putative 0.0024 0.0251 0.0927
Schistosoma mansoni serine/threonine protein kinase 0.011 0.1882 0.321
Trypanosoma cruzi heat shock protein 90, putative 0.0022 0.0205 0.067
Toxoplasma gondii aldehyde dehydrogenase 0.0136 0.2384 0.6664
Leishmania major cathepsin L-like protease 0.0104 0.1776 0.7213
Onchocerca volvulus Cathepsin F homolog 0.0047 0.0689 0.2241
Echinococcus multilocularis neuropeptide s receptor 0.0534 1 1
Trichomonas vaginalis CAMK family protein kinase 0.011 0.1882 0.2988
Onchocerca volvulus 0.0047 0.0689 0.2241
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0205 0.0322
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0205 0.0574
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0024 0.0251 0.0296
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0024 0.0251 0.0401
Entamoeba histolytica cysteine proteinase, putative 0.0024 0.0251 0.1336
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0205 0.0007
Brugia malayi Endoplasmin precursor 0.0052 0.0787 0.1324
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.011 0.1882 0.7699
Brugia malayi Calcitonin receptor-like protein seb-1 0.0113 0.1941 0.3311
Brugia malayi Cathepsin L-like precursor 0.0016 0.0085 0.0115
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0104 0.1776 0.937
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0045 0.0642 0.0625
Echinococcus multilocularis mitogen activated protein kinase 0.0053 0.0804 0.0787
Giardia lamblia Sgs1 DNA helicase, putative 0.0022 0.0205 0.0022
Entamoeba histolytica cysteine protease, putative 0.0024 0.0251 0.1336
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0104 0.1776 0.937
Echinococcus granulosus cathepsin l1 0.0047 0.0689 0.0672
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0022 0.0205 0.0187
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0205 0.0322
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0689 0.0867
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0053 0.0804 0.2247
Onchocerca volvulus 0.0047 0.0689 0.2241
Loa Loa (eye worm) hypothetical protein 0.0071 0.1153 0.1955
Loa Loa (eye worm) heat shock protein 75 0.0035 0.0451 0.0745
Trypanosoma brucei heat shock protein, putative 0.0052 0.0787 0.3483
Entamoeba histolytica cysteine protease, putative 0.0024 0.0251 0.1336
Schistosoma mansoni kinase 0.0056 0.0856 0.1443
Onchocerca volvulus 0.0047 0.0689 0.2241
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0804 0.1071
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0733 0.1231
Echinococcus granulosus heat shock protein 90 0.0045 0.0642 0.0625
Trypanosoma brucei heat shock protein, putative 0.0052 0.0787 0.3483
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0581 0.0563
Loa Loa (eye worm) RecQ helicase 0.0022 0.0205 0.0322
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0205 0.0007
Onchocerca volvulus 0.005 0.0743 0.2593
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0036 0.0468 0.0451
Loa Loa (eye worm) hypothetical protein 0.0014 0.0046 0.0047
Echinococcus multilocularis GPCR, family 2 0.0036 0.0468 0.0451
Treponema pallidum heat shock protein 90 0.0049 0.0725 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0032 0.0391 0.0641
Leishmania major heat shock protein 83-1 0.0052 0.0787 0.2681
Trypanosoma cruzi heat shock protein 90, putative 0.0052 0.0787 0.3906
Schistosoma mansoni glutaminase 0.0316 0.5824 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0345 0.0562
Brugia malayi Ets-domain containing protein 0.0084 0.1385 0.2354
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0136 0.2384 1
Brugia malayi Fli-1 protein 0.0254 0.464 0.796
Plasmodium falciparum cysteine proteinase falcipain 3 0.0047 0.0689 0.1444
Schistosoma mansoni cathepsin F (C01 family) 0.0047 0.0689 0.1155
Schistosoma mansoni ap endonuclease 0.0022 0.0202 0.0316
Trypanosoma cruzi cysteine peptidase, putative 0.0024 0.0251 0.0927
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0689 0.0867
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0689 0.0867
Plasmodium falciparum cysteine proteinase falcipain 1 0.0024 0.0251 0.0147
Entamoeba histolytica cysteine protease, putative 0.0024 0.0251 0.1336
Trichomonas vaginalis CAMK family protein kinase 0.011 0.1882 0.2988
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0689 0.0867
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0136 0.2384 1
Trypanosoma cruzi cysteine peptidase, putative 0.0104 0.1776 0.9411
Loa Loa (eye worm) hypothetical protein 0.0077 0.1259 0.2137
Trypanosoma brucei polo-like protein kinase 0.011 0.1882 1
Entamoeba histolytica hypothetical protein 0.0042 0.0581 0.3086
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0689 0.0867
Trypanosoma cruzi heat shock protein 85, putative 0.0052 0.0787 0.3906
Entamoeba histolytica cysteine proteinase 2 0.0024 0.0251 0.1336
Entamoeba histolytica serine/threonine protein kinase, putative 0.011 0.1882 1
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0205 0.0187
Trichomonas vaginalis CAMK family protein kinase 0.0054 0.0828 0.1115
Brugia malayi Cathepsin L-like precursor 0.0047 0.0689 0.1155
Leishmania major heat shock protein 83-1 0.0052 0.0787 0.2681
Echinococcus granulosus survival motor neuron protein 1 0.0245 0.4477 0.4467
Leishmania major cathepsin L-like protease 0.0047 0.0689 0.2233
Schistosoma mansoni aldehyde dehydrogenase 0.0136 0.2384 0.4075
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0202 0.0184
Schistosoma mansoni heat shock protein 0.0052 0.0787 0.1324
Echinococcus granulosus heat shock protein 90 0.0052 0.0787 0.077
Loa Loa (eye worm) hypothetical protein 0.0016 0.0085 0.0115
Trypanosoma cruzi cysteine peptidase, putative 0.0047 0.0689 0.3362
Trypanosoma cruzi polo-like protein kinase, putative 0.011 0.1882 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0205 0.0322
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0689 0.0867
Entamoeba histolytica cysteine protease, putative 0.0024 0.0251 0.1336
Echinococcus multilocularis lamin dm0 0.0029 0.0345 0.0327
Schistosoma mansoni hypothetical protein 0.0036 0.0468 0.0775
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0733 0.1231
Trypanosoma cruzi heat shock protein 85, putative 0.0052 0.0787 0.3906
Mycobacterium ulcerans aldehyde dehydrogenase 0.0136 0.2384 0.3882
Loa Loa (eye worm) fli-1 protein 0.0254 0.464 0.796
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0733 0.0716
Mycobacterium ulcerans glutaminase 0.0316 0.5824 1
Echinococcus granulosus tar DNA binding protein 0.0211 0.3819 0.3808
Plasmodium falciparum heat shock protein 90, putative 0.0198 0.3578 1
Echinococcus granulosus endoplasmin 0.0049 0.0725 0.0708
Trichomonas vaginalis heat shock protein, putative 0.0049 0.0725 0.0932
Schistosoma mansoni lamin 0.0029 0.0345 0.0562
Brugia malayi Cathepsin L-like precursor 0.0047 0.0689 0.1155
Toxoplasma gondii cathepsin CPL 0.0047 0.0689 0.1926
Leishmania major heat shock protein 83-1 0.0052 0.0787 0.2681
Loa Loa (eye worm) ctsf protein 0.0047 0.0689 0.1155
Trichomonas vaginalis heat shock protein, putative 0.003 0.0368 0.0296
Trichomonas vaginalis CAMK family protein kinase 0.011 0.1882 0.2988
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.0689 0.3662
Schistosoma mansoni lamin 0.0029 0.0345 0.0562
Leishmania major cathepsin L-like protease 0.0104 0.1776 0.7213
Echinococcus multilocularis cathepsin L cysteine protease 0.0047 0.0689 0.0672
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0205 0.0574
Loa Loa (eye worm) latrophilin receptor protein 2 0.0036 0.0468 0.0775
Leishmania major heat shock protein 83-1 0.0052 0.0787 0.2681
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0345 0.0562
Echinococcus multilocularis lamin 0.0029 0.0345 0.0327
Schistosoma mansoni heat shock protein 0.0035 0.0451 0.0745
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0047 0.0689 0.0672
Trichomonas vaginalis CAMK family protein kinase 0.0054 0.0828 0.1115
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0205 0.0671
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0049 0.0725 0.24
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0211 0.3819 0.6547
Brugia malayi MH2 domain containing protein 0.0138 0.2423 0.4142
Entamoeba histolytica cysteine protease, putative 0.0024 0.0251 0.1336
Brugia malayi intermediate filament protein 0.0029 0.0345 0.0562
Onchocerca volvulus 0.0047 0.0689 0.2241
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0036 0.0468 0.0451
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0053 0.0804 0.276
Trypanosoma cruzi cysteine protease, putative 0.0024 0.0251 0.0927
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0053 0.0804 0.276
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0202 0.0564
Brugia malayi Cathepsin L-like precursor 0.0032 0.0391 0.0641
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0804 0.4002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0689 0.0867
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0136 0.2384 0.237
Leishmania major cysteine peptidase A (CPA) 0.0047 0.0689 0.2233
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0035 0.0451 0.0434
Loa Loa (eye worm) MH2 domain-containing protein 0.0138 0.2423 0.4142
Toxoplasma gondii heat shock protein HSP90 0.0052 0.0787 0.2199
Trypanosoma cruzi heat shock protein 85, putative 0.0052 0.0787 0.3906
Plasmodium vivax heat shock protein 90, putative 0.0035 0.0451 0.1261
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0689 0.0867
Giardia lamblia Kinase, PLK 0.011 0.1882 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0689 0.0867
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0689 0.0867
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0022 0.0205 0.0187
Trypanosoma cruzi cysteine proteinase, putative 0.0024 0.0251 0.0927
Entamoeba histolytica heat shock protein 90, putative 0.0052 0.0787 0.4181
Trypanosoma brucei heat shock protein, putative 0.0052 0.0787 0.3483
Plasmodium vivax heat shock protein 86, putative 0.0052 0.0787 0.2199
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0804 0.1071
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0733 0.0716
Entamoeba histolytica cysteine proteinase, putative 0.0024 0.0251 0.1336
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0689 0.0867
Schistosoma mansoni intermediate filament proteins 0.0029 0.0345 0.0562
Trypanosoma brucei heat shock protein 84, putative 0.0035 0.0451 0.1484
Echinococcus multilocularis musashi 0.0029 0.0345 0.0327
Loa Loa (eye worm) hypothetical protein 0.0032 0.0391 0.0641
Trichomonas vaginalis heat shock protein, putative 0.0038 0.0513 0.0553
Entamoeba histolytica hypothetical protein 0.0042 0.0581 0.3086
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0689 0.0867
Schistosoma mansoni hypothetical protein 0.0077 0.1259 0.2137
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0104 0.1776 0.937
Echinococcus granulosus GPCR family 2 0.0036 0.0468 0.0451
Trichomonas vaginalis CAMK family protein kinase 0.011 0.1882 0.2988
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0391 0.0336
Brugia malayi glutaminase DH11.1 0.0316 0.5824 1
Trypanosoma cruzi cruzipain precursor, putative 0.0104 0.1776 0.9411
Schistosoma mansoni survival motor neuron protein 0.005 0.0743 0.1248
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.0689 0.3662
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0205 0.0022
Onchocerca volvulus Serine\/threonine kinase homolog 0.011 0.1882 1
Plasmodium vivax unspecified product 0.0024 0.0251 0.0703
Trypanosoma cruzi Heat shock protein 83, putative 0.0052 0.0787 0.3906
Schistosoma mansoni DNA helicase recq1 0.0022 0.0205 0.0322
Loa Loa (eye worm) hypothetical protein 0.0047 0.0689 0.1155
Entamoeba histolytica cysteine proteinase, putative 0.0032 0.0391 0.2076
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0104 0.1776 0.937
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0047 0.0689 0.1155
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0804 0.4002
Schistosoma mansoni aldehyde dehydrogenase 0.0136 0.2384 0.4075
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0345 0.0562
Leishmania major cathepsin L-like protease 0.0047 0.0689 0.2233
Entamoeba histolytica cysteine protease, putative 0.0024 0.0251 0.1336
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0113 0.1941 0.3311
Entamoeba histolytica cysteine protease, putative 0.0047 0.0689 0.3662
Echinococcus granulosus lamin dm0 0.0029 0.0345 0.0327
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0047 0.0689 0.1444
Schistosoma mansoni tar DNA-binding protein 0.0211 0.3819 0.6547
Leishmania major heat shock protein 83-1 0.0052 0.0787 0.2681
Plasmodium falciparum heat shock protein 90, putative 0.003 0.0368 0.0493
Plasmodium vivax vivapain-2 0.0047 0.0689 0.1926
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0085 0.0116
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0088 0.1478 0.775
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0022 0.0205 0.0187
Onchocerca volvulus Cathepsin L homolog 0.0047 0.0689 0.2241
Leishmania major heat shock protein 83-1 0.0052 0.0787 0.2681
Brugia malayi Papain family cysteine protease containing protein 0.0024 0.0251 0.0401
Plasmodium vivax endoplasmin, putative 0.0052 0.0787 0.2199
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0743 0.1248
Brugia malayi latrophilin 2 splice variant baaae 0.0077 0.1259 0.2137
Brugia malayi hypothetical protein 0.0245 0.4477 0.768
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0689 0.0867
Entamoeba histolytica cysteine protease, putative 0.0024 0.0251 0.1336
Trypanosoma brucei heat shock protein, putative 0.0052 0.0787 0.3483
Entamoeba histolytica cysteine proteinase 1, putative 0.0024 0.0251 0.1336
Trichomonas vaginalis heat shock protein, putative 0.0045 0.0642 0.0784
Leishmania major heat shock protein 83-1 0.0052 0.0787 0.2681
Trypanosoma brucei Heat shock protein 83, putative 0.0052 0.0787 0.3483
Mycobacterium ulcerans aldehyde dehydrogenase 0.0136 0.2384 0.3882
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0689 0.0867
Brugia malayi Cathepsin L-like precursor 0.0032 0.0391 0.0641
Brugia malayi Papain family cysteine protease containing protein 0.0024 0.0251 0.0401
Loa Loa (eye worm) glutaminase 0.0316 0.5824 1
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0205 0.0322
Schistosoma mansoni tar DNA-binding protein 0.0211 0.3819 0.6547
Trypanosoma cruzi polo-like protein kinase, putative 0.011 0.1882 1
Leishmania major cathepsin L-like protease 0.0047 0.0689 0.2233
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0047 0.0689 0.0672
Echinococcus multilocularis endoplasmin 0.0049 0.0725 0.0708
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0022 0.0205 0.0322
Trypanosoma cruzi major cysteine proteinase, putative 0.0066 0.104 0.5315
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0104 0.1776 0.937
Brugia malayi cathepsin L-like precursor 0.0032 0.0391 0.0641
Plasmodium falciparum heat shock protein 90 0.0052 0.0787 0.1733
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0022 0.0205 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0689 0.0867
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0022 0.0202 0.1072
Echinococcus granulosus geminin 0.0193 0.3486 0.3474
Entamoeba histolytica hypothetical protein 0.0042 0.0581 0.3086
Echinococcus multilocularis GA binding protein alpha chain 0.0084 0.1385 0.1369
Entamoeba histolytica cysteine protease, putative 0.0024 0.0251 0.1336
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0136 0.2384 0.237
Trypanosoma brucei heat shock protein 90, putative 0.0052 0.0787 0.3483
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0689 0.0867
Leishmania major heat shock protein 83-1 0.0052 0.0787 0.2681
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0056 0.0038
Trichomonas vaginalis CAMK family protein kinase 0.011 0.1882 0.2988
Brugia malayi Hsp90 protein 0.0035 0.0451 0.0745
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0689 0.0867
Leishmania major heat shock protein 83-1 0.0052 0.0787 0.2681
Echinococcus multilocularis cathepsin L 0.0024 0.0251 0.0233
Brugia malayi Cathepsin L-like precursor 0.0047 0.0689 0.1155
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0104 0.1776 0.937
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0024 0.0251 0.0927
Trypanosoma brucei heat shock protein, putative 0.0052 0.0787 0.3483
Toxoplasma gondii heat shock protein 90, putative 0.0052 0.0787 0.2199
Leishmania major cathepsin L-like protease 0.0047 0.0689 0.2233
Plasmodium vivax unspecified product 0.0016 0.0085 0.0237
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0113 0.1941 0.3311
Toxoplasma gondii heat shock protein 75, putative 0.0035 0.0451 0.1261
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.0642 0.3102
Schistosoma mansoni ap endonuclease 0.0022 0.0202 0.0316
Toxoplasma gondii Hsp90 domain-containing protein 0.0198 0.3578 1
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0804 0.1071
Plasmodium vivax vivapain-1 0.0024 0.0251 0.0703
Leishmania major heat shock protein, putative 0.0035 0.0451 0.1143
Entamoeba histolytica cysteine proteinase, putative 0.0024 0.0251 0.1336
Leishmania major cathepsin L-like protease 0.0104 0.1776 0.7213
Entamoeba histolytica cysteine protease, putative 0.0024 0.0251 0.1336
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0036 0.0468 0.0451
Echinococcus multilocularis cysteine protease 0.0047 0.0689 0.0672
Trichomonas vaginalis glutaminase, putative 0.0316 0.5824 1
Onchocerca volvulus Cathepsin L homolog 0.0047 0.0689 0.2241
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0205 0.0011
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0202 0.0316
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.011 0.1882 0.321
Mycobacterium ulcerans aldehyde dehydrogenase 0.0136 0.2384 0.3882
Entamoeba histolytica cysteine protease, putative 0.0024 0.0251 0.1336
Brugia malayi Cathepsin L-like precursor 0.0047 0.0689 0.1155
Echinococcus granulosus GA binding protein alpha chain 0.0084 0.1385 0.1369
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0104 0.1776 0.937
Brugia malayi Cathepsin L-like precursor 0.0047 0.0689 0.1155
Echinococcus granulosus neuropeptide receptor A26 0.0534 1 1
Leishmania major heat shock protein 83-1 0.0052 0.0787 0.2681
Schistosoma mansoni endoplasmin 0.0052 0.0787 0.1324
Loa Loa (eye worm) hypothetical protein 0.0032 0.0391 0.0641
Leishmania major heat shock protein 83-1 0.0052 0.0787 0.2681
Entamoeba histolytica cysteine protease, putative 0.0024 0.0251 0.1336
Echinococcus granulosus serine:threonine protein kinase PLK1 0.011 0.1882 0.1867
Brugia malayi heat shock protein 90 0.0052 0.0787 0.1324
Brugia malayi cathepsin F-like cysteine proteinase 0.0016 0.0085 0.0115
Schistosoma mansoni gabp alpha 0.0084 0.1385 0.2354
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0024 0.0251 0.0401
Leishmania major heat shock protein 83-1 0.0052 0.0787 0.2681
Echinococcus granulosus cysteine protease 0.0024 0.0251 0.0233
Trypanosoma brucei heat shock protein 90, putative 0.0052 0.0787 0.3483
Echinococcus multilocularis heat shock protein 90 0.0045 0.0642 0.0625
Loa Loa (eye worm) endoplasmin 0.0052 0.0787 0.1324
Giardia lamblia Grp94/Hsp90 0.0049 0.0725 0.3117
Brugia malayi MAP kinase sur-1 0.0053 0.0804 0.1353
Giardia lamblia Heat shock protein HSP 90-alpha 0.0052 0.0787 0.3483
Schistosoma mansoni hypothetical protein 0.0036 0.0468 0.0775
Echinococcus multilocularis tar DNA binding protein 0.0211 0.3819 0.3808
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0345 0.0562
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0104 0.1776 0.937
Brugia malayi Papain family cysteine protease containing protein 0.0047 0.0689 0.1155
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0104 0.1776 0.937
Brugia malayi serine/threonine-protein kinase plk-2 0.011 0.1882 0.321
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0047 0.0689 0.1444
Schistosoma mansoni endoplasmin 0.0052 0.0787 0.1324
Loa Loa (eye worm) hypothetical protein 0.0029 0.0334 0.0544
Brugia malayi Cathepsin L-like precursor 0.0047 0.0689 0.1155
Schistosoma mansoni cathepsin F (C01 family) 0.0032 0.0391 0.0641
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0104 0.1776 0.937
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0205 0.0007
Echinococcus multilocularis cathepsin L cysteine protease 0.0047 0.0689 0.0672
Onchocerca volvulus 0.0047 0.0689 0.2241
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0053 0.0804 0.1353
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0804 0.1353
Schistosoma mansoni hypothetical protein 0.0193 0.3486 0.5973
Schistosoma mansoni hypothetical protein 0.0193 0.3486 0.5973
Plasmodium vivax vivapain-2 0.0047 0.0689 0.1926
Leishmania major heat shock protein 83-1 0.0052 0.0787 0.2681
Leishmania major heat shock protein 83-1 0.0052 0.0787 0.2681
Loa Loa (eye worm) hypothetical protein 0.0016 0.0085 0.0115
Echinococcus granulosus bloom syndrome protein 0.0022 0.0205 0.0187
Giardia lamblia Heat shock protein HSP 90-alpha 0.0045 0.0642 0.2623
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0022 0.0205 0.0187
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0035 0.0451 0.0693
Brugia malayi Ets-domain containing protein 0.0084 0.1385 0.2354
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0804 0.1071
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0084 0.1385 0.2354
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0733 0.1231
Loa Loa (eye worm) hypothetical protein 0.0113 0.1941 0.3311
Trypanosoma brucei heat shock protein, putative 0.0052 0.0787 0.3483
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0049 0.0725 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0689 0.0867
Loa Loa (eye worm) glutaminase 2 0.0316 0.5824 1
Trypanosoma cruzi cysteine peptidase, putative 0.0104 0.1776 0.9411
Brugia malayi Latrophilin receptor protein 2 0.0036 0.0468 0.0775
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0024 0.0251 0.0401
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0733 0.1231
Loa Loa (eye worm) hypothetical protein 0.0245 0.4477 0.768
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0035 0.0451 0.2397
Schistosoma mansoni cathepsin s 0.0016 0.0085 0.0115
Schistosoma mansoni ets-related 0.0254 0.464 0.796
Brugia malayi RNA binding protein 0.0211 0.3819 0.6547
Trypanosoma cruzi cysteine peptidase, putative 0.0104 0.1776 0.9411
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0049 0.0725 0.24
Leishmania major heat shock protein 83-1 0.0052 0.0787 0.2681
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0251 0.0089
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0202 0.0184
Schistosoma mansoni tar DNA-binding protein 0.0211 0.3819 0.6547
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0047 0.0689 0.0867
Echinococcus multilocularis heat shock protein 0.0052 0.0787 0.077
Loa Loa (eye worm) cysteine protease 0.0047 0.0689 0.1155
Trypanosoma cruzi heat shock protein, putative 0.0035 0.0451 0.2038
Loa Loa (eye worm) RNA binding protein 0.0211 0.3819 0.6547
Entamoeba histolytica cysteine protease, putative 0.0024 0.0251 0.1336
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0205 0.0017
Loa Loa (eye worm) fibroinase 0.0047 0.0689 0.1155
Echinococcus multilocularis neuropeptide receptor A26 0.0534 1 1
Mycobacterium ulcerans heat shock protein 90 0.0049 0.0725 0.0932
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0053 0.0804 0.4002
Onchocerca volvulus 0.0032 0.0391 0.03
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0689 0.0867
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0047 0.0689 0.1155
Loa Loa (eye worm) hypothetical protein 0.0014 0.0056 0.0065
Brugia malayi hypothetical protein 0.0042 0.0581 0.0969
Trypanosoma brucei heat shock protein, putative 0.0052 0.0787 0.3483
Trichomonas vaginalis heat shock protein, putative 0.0052 0.0787 0.1041
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0581 0.0563
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0733 0.1231
Loa Loa (eye worm) hypothetical protein 0.0036 0.0468 0.0775
Echinococcus granulosus mitogen activated protein kinase 0.0053 0.0804 0.0787
Echinococcus granulosus cathepsin l1 0.0032 0.0391 0.0373
Trypanosoma cruzi heat shock protein 90, putative 0.0045 0.0642 0.3102
Onchocerca volvulus 0.0047 0.0689 0.2241
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0689 0.0867
Trichomonas vaginalis heat shock protein, putative 0.0049 0.0725 0.0932
Schistosoma mansoni tar DNA-binding protein 0.0211 0.3819 0.6547
Entamoeba histolytica hypothetical protein 0.0042 0.0581 0.3086
Toxoplasma gondii exonuclease III APE 0.0022 0.0202 0.0564
Plasmodium vivax vivapain-3 0.0024 0.0251 0.0703
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0085 0.0116
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0202 0.065
Entamoeba histolytica heat shock protein 90, putative 0.0052 0.0787 0.4181
Plasmodium vivax heat shock protein, putative 0.0198 0.3578 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0053 0.0804 0.0787
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0053 0.0804 0.4002
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.011 0.1882 0.1867
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0251 0.0089
Trichomonas vaginalis CAMK family protein kinase 0.011 0.1882 0.2988
Echinococcus granulosus cathepsin L cysteine protease 0.0024 0.0251 0.0233
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0581 0.0969
Echinococcus granulosus heat shock protein 0.0052 0.0787 0.077
Schistosoma mansoni hypothetical protein 0.0036 0.0468 0.0775
Leishmania major heat shock protein 83-1 0.0052 0.0787 0.2681
Loa Loa (eye worm) hypothetical protein 0.0016 0.0085 0.0115
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0016 0.0085 0.0115
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0689 0.0867
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0085 0.0115
Giardia lamblia Kinase, CMGC MAPK 0.0053 0.0804 0.3585
Echinococcus multilocularis heat shock protein 90 0.0052 0.0787 0.077
Echinococcus multilocularis geminin 0.0193 0.3486 0.3474
Trypanosoma brucei protein kinase, putative 0.0053 0.0804 0.3585
Loa Loa (eye worm) TAR-binding protein 0.0211 0.3819 0.6547
Entamoeba histolytica cysteine proteinase, putative 0.0024 0.0251 0.1336
Schistosoma mansoni hypothetical protein 0.005 0.0743 0.1248
Leishmania major cathepsin L-like protease 0.0047 0.0689 0.2233
Loa Loa (eye worm) heat shock protein 90 0.0052 0.0787 0.1324
Loa Loa (eye worm) hypothetical protein 0.0014 0.0046 0.0047
Schistosoma mansoni cathepsin F (C01 family) 0.0047 0.0689 0.1155
Onchocerca volvulus 0.0047 0.0689 0.2241
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0036 0.0468 0.0451

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.71 uM Inhibition of Trypanosoma cruzi cruzain after 15 mins ChEMBL. 19908842
Potency (functional) = 0.7079 um PUBCHEM_BIOASSAY: Confirmation qHTS Assay for Inhibitors of Cruzain. (Class of assay: confirmatory) [Related pubchem assays: 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1476 (cruzain qHTS without detergent), 1478 (cruzain qHTS with detergent)] ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay. (Class of assay: confirmatory) [Related pubchem assays: 1476 (Cruzain without detergent), 1478 (Cruzain with detergent)] ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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