Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | fructose-1,6-bisphosphatase 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | fructose-bisphospatase I | fructose-1,6-bisphosphatase 1 | 338 aa | 326 aa | 31.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | aurora B kinase, putative | 0.0246 | 1 | 1 |
Toxoplasma gondii | fructose-bisphospatase II | 0.0189 | 0.7618 | 0.6747 |
Echinococcus granulosus | Immunoglobulin | 0.001 | 0.0179 | 0.0179 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0246 | 1 | 0.5 |
Loa Loa (eye worm) | AUR protein kinase | 0.0246 | 1 | 1 |
Echinococcus granulosus | defective proboscis extension response | 0.001 | 0.0179 | 0.0179 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.0246 | 1 | 0.5 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0167 | 0.6698 | 0.6698 |
Schistosoma mansoni | tyrosine kinase | 0.0007 | 0.0039 | 0.0039 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0246 | 1 | 1 |
Schistosoma mansoni | vesicular amine transporter | 0.001 | 0.0179 | 0.0179 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0179 | 0.0179 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0014 | 0.0318 | 0.0318 |
Brugia malayi | serine/threonine kinase 12 | 0.0246 | 1 | 1 |
Loa Loa (eye worm) | AUR protein kinase | 0.0246 | 1 | 1 |
Schistosoma mansoni | protein kinase | 0.0246 | 1 | 1 |
Echinococcus granulosus | aurora kinase A | 0.0246 | 1 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.0246 | 1 | 1 |
Echinococcus multilocularis | roundabout 2 | 0.0016 | 0.0427 | 0.0427 |
Trichomonas vaginalis | AGC family protein kinase | 0.0246 | 1 | 0.5 |
Echinococcus granulosus | twitchin | 0.0015 | 0.0372 | 0.0372 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0156 | 0.624 | 1 |
Entamoeba histolytica | serine/threonine- protein kinase 6, putative | 0.0246 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0318 | 0.0318 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.0008 | 0.0084 | 0.0084 |
Onchocerca volvulus | 0.0152 | 0.6092 | 0.9763 | |
Entamoeba histolytica | serine/threonine protein kinase 6, putative | 0.0246 | 1 | 0.5 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.0246 | 1 | 1 |
Brugia malayi | fructose-1,6-bisphosphatase | 0.0189 | 0.7618 | 0.7618 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.0189 | 0.7618 | 0.6747 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0179 | 0.0179 |
Echinococcus granulosus | neuroglian | 0.0013 | 0.0288 | 0.0288 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.0189 | 0.7618 | 0.7618 |
Echinococcus multilocularis | Immunoglobulin | 0.001 | 0.0179 | 0.0179 |
Loa Loa (eye worm) | AUR protein kinase | 0.0246 | 1 | 1 |
Trypanosoma brucei | aurora B kinase | 0.0246 | 1 | 1 |
Echinococcus multilocularis | Immunoglobulin | 0.001 | 0.0179 | 0.0179 |
Entamoeba histolytica | protein kinase, putative | 0.0246 | 1 | 0.5 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.001 | 0.0179 | 0.0179 |
Brugia malayi | hypothetical protein | 0.001 | 0.0179 | 0.0179 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0179 | 0.0179 |
Echinococcus multilocularis | neuroglian | 0.0013 | 0.0288 | 0.0288 |
Entamoeba histolytica | protein kinase , putative | 0.0246 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0179 | 0.0179 |
Schistosoma mansoni | cell adhesion molecule | 0.0014 | 0.0318 | 0.0318 |
Schistosoma mansoni | nephrin | 0.0013 | 0.0288 | 0.0288 |
Echinococcus multilocularis | aurora kinase A | 0.0246 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0427 | 0.0427 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0189 | 0.7618 | 0.6747 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.0246 | 1 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0246 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0179 | 0.0179 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0167 | 0.6698 | 0.6698 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0179 | 0.0179 |
Giardia lamblia | Aurora kinase | 0.0246 | 1 | 0.5 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.0189 | 0.7618 | 0.7618 |
Toxoplasma gondii | aurora kinase | 0.0246 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0246 | 1 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0246 | 1 | 0.5 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0189 | 0.7618 | 0.6747 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0427 | 0.0427 |
Entamoeba histolytica | serine/threonine- protein kinase 6 , putative | 0.0246 | 1 | 0.5 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.0246 | 1 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.001 | 0.0179 | 0.0179 |
Echinococcus granulosus | roundabout 2 | 0.0016 | 0.0427 | 0.0427 |
Brugia malayi | Fibronectin type III domain containing protein | 0.001 | 0.0179 | 0.0179 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.001 | 0.0179 | 0.0179 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.0189 | 0.7618 | 0.7618 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.001 | 0.0179 | 0.0179 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.0189 | 0.7618 | 0.7618 |
Entamoeba histolytica | protein kinase, putative | 0.0246 | 1 | 0.5 |
Leishmania major | protein kinase, putative | 0.0246 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.