Detailed information for compound 106681

Basic information

Technical information
  • TDR Targets ID: 106681
  • Name: N-(3-chloro-4-fluorophenyl)-6,7-diethoxyquina zolin-4-amine
  • MW: 361.798 | Formula: C18H17ClFN3O2
  • H donors: 1 H acceptors: 2 LogP: 4.82 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1cc2c(ncnc2cc1OCC)Nc1ccc(c(c1)Cl)F
  • InChi: 1S/C18H17ClFN3O2/c1-3-24-16-8-12-15(9-17(16)25-4-2)21-10-22-18(12)23-11-5-6-14(20)13(19)7-11/h5-10H,3-4H2,1-2H3,(H,21,22,23)
  • InChiKey: ZTVIFZQDIJSFNH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3-chloro-4-fluoro-phenyl)-6,7-diethoxy-quinazolin-4-amine
  • N-(3-chloro-4-fluorophenyl)-6,7-diethoxy-4-quinazolinamine
  • (3-chloro-4-fluoro-phenyl)-(6,7-diethoxyquinazolin-4-yl)amine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens fructose-1,6-bisphosphatase 1 Starlite/ChEMBL References
Sus scrofa Fructose-1,6-bisphosphatase Starlite/ChEMBL References
Rattus norvegicus Fructose-1,6-bisphosphatase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans similar to S. cerevisiae FBP1 (YLR377C) Fructose-1,6-bisphosphatase Get druggable targets OG5_127400 All targets in OG5_127400
Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_127400 All targets in OG5_127400
Schistosoma japonicum ko:K03841 fructose-1,6-bisphosphatase I, putative Get druggable targets OG5_127400 All targets in OG5_127400
Neospora caninum Fructose-1 6-biphosphatase, related Get druggable targets OG5_127400 All targets in OG5_127400
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative Get druggable targets OG5_127400 All targets in OG5_127400
Leishmania infantum fructose-1,6-bisphosphatase, cytosolic, putative Get druggable targets OG5_127400 All targets in OG5_127400
Trypanosoma brucei gambiense fructose-1,6-bisphosphate, cytosolic, putative Get druggable targets OG5_127400 All targets in OG5_127400
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative Get druggable targets OG5_127400 All targets in OG5_127400
Leishmania donovani fructose-1,6-bisphosphatase, cytosolic, putative Get druggable targets OG5_127400 All targets in OG5_127400
Leishmania mexicana fructose-1,6-bisphosphatase, cytosolic, putative Get druggable targets OG5_127400 All targets in OG5_127400
Toxoplasma gondii fructose-bisphospatase II Get druggable targets OG5_127400 All targets in OG5_127400
Leishmania braziliensis fructose-1,6-bisphosphatase, cytosolic, putative Get druggable targets OG5_127400 All targets in OG5_127400
Trypanosoma brucei fructose-1,6-bisphosphatase Get druggable targets OG5_127400 All targets in OG5_127400
Trypanosoma congolense fructose-1,6-bisphosphate, cytosolic, putative Get druggable targets OG5_127400 All targets in OG5_127400
Leishmania major Get druggable targets OG5_127400 All targets in OG5_127400
Loa Loa (eye worm) fructose-1,6-bisphosphatase Get druggable targets OG5_127400 All targets in OG5_127400
Echinococcus multilocularis fructose 1,6 bisphosphatase 1 Get druggable targets OG5_127400 All targets in OG5_127400
Echinococcus granulosus fructose 16 bisphosphatase 1 Get druggable targets OG5_127400 All targets in OG5_127400
Schistosoma mansoni fructose-16-bisphosphatase-related Get druggable targets OG5_127400 All targets in OG5_127400
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus CES-1 homolog Fructose-1,6-bisphosphatase   338 aa 324 aa 58.6 %
Toxoplasma gondii fructose-bisphospatase I Fructose-1,6-bisphosphatase   338 aa 322 aa 31.1 %
Toxoplasma gondii fructose-bisphospatase I fructose-1,6-bisphosphatase 1 338 aa 326 aa 31.0 %
Neospora caninum fructose-1,6-bisphosphatase, putative Fructose-1,6-bisphosphatase   338 aa 302 aa 32.1 %
Trypanosoma congolense sedoheptulose-1,7-bisphosphatase, putative Fructose-1,6-bisphosphatase   338 aa 329 aa 27.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0093 0.1468 0.1468
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0093 0.1468 0.1468
Loa Loa (eye worm) hypothetical protein 0.0093 0.1468 0.1468
Loa Loa (eye worm) hypothetical protein 0.0093 0.1468 0.1468
Echinococcus granulosus g-protein coupled receptor 0.0093 0.1468 0.1468
Onchocerca volvulus 0.0093 0.1468 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0093 0.1468 0.1468
Brugia malayi neuropeptide F receptor 0.0093 0.1468 0.1468
Brugia malayi RE15519p 0.0093 0.1468 0.1468
Echinococcus granulosus fmrfamide receptor 0.0093 0.1468 0.1468
Schistosoma mansoni hypothetical protein 0.0093 0.1468 0.1468
Schistosoma mansoni neuropeptide receptor 0.0093 0.1468 0.1468
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0093 0.1468 0.1468
Onchocerca volvulus 0.0093 0.1468 0.5
Brugia malayi Serotonin receptor 0.0093 0.1468 0.1468
Schistosoma mansoni neuropeptide f receptor 76f 0.0093 0.1468 0.1468
Brugia malayi Dopamine receptor protein 1 0.0093 0.1468 0.1468
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0093 0.1468 0.1468
Loa Loa (eye worm) hypothetical protein 0.0093 0.1468 0.1468
Brugia malayi hypothetical protein 0.0093 0.1468 0.1468
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0093 0.1468 0.1468
Echinococcus granulosus g protein coupled receptor 0.0093 0.1468 0.1468
Loa Loa (eye worm) hypothetical protein 0.0093 0.1468 0.1468
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0093 0.1468 0.1468
Loa Loa (eye worm) fructose-1,6-bisphosphatase 0.0567 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0093 0.1468 0.1468
Echinococcus granulosus neuropeptide receptor 0.0093 0.1468 0.1468
Echinococcus granulosus neuropeptide receptor A26 0.0093 0.1468 0.1468
Echinococcus granulosus neuropeptides capa receptor 0.0093 0.1468 0.1468
Echinococcus multilocularis fructose 1,6 bisphosphatase 1 0.0567 1 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0093 0.1468 0.1468
Loa Loa (eye worm) hypothetical protein 0.0093 0.1468 0.1468
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0093 0.1468 0.1468
Schistosoma mansoni amine GPCR 0.0093 0.1468 0.1468
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0093 0.1468 0.5
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0093 0.1468 0.1468
Echinococcus granulosus g protein coupled receptor 0.0093 0.1468 0.1468
Echinococcus granulosus rhodopsin orphan GPCR 0.0093 0.1468 0.1468
Loa Loa (eye worm) hypothetical protein 0.0093 0.1468 0.1468
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0093 0.1468 0.1468
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0093 0.1468 0.1468
Echinococcus multilocularis orexin receptor type 2 0.0093 0.1468 0.1468
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0038 0.048 0.048
Loa Loa (eye worm) hypothetical protein 0.0093 0.1468 0.1468
Trypanosoma brucei fructose-1,6-bisphosphatase 0.0567 1 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0093 0.1468 0.1468
Echinococcus multilocularis rhodopsin orphan GPCR 0.0093 0.1468 0.1468
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0093 0.1468 0.1468
Brugia malayi Serotonin receptor 0.0093 0.1468 0.1468
Echinococcus multilocularis rhodopsin orphan GPCR 0.0093 0.1468 0.1468
Echinococcus multilocularis rhodopsin orphan GPCR 0.0093 0.1468 0.1468
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0093 0.1468 0.1468
Loa Loa (eye worm) hypothetical protein 0.0093 0.1468 0.1468
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0093 0.1468 0.1468
Brugia malayi G protein-coupled receptor F59B2.13 0.0093 0.1468 0.1468
Schistosoma mansoni adenoreceptor 0.0093 0.1468 0.1468
Schistosoma mansoni opsin-like receptor 0.0093 0.1468 0.1468
Schistosoma mansoni biogenic amine receptor 0.0093 0.1468 0.1468
Echinococcus granulosus tm gpcr rhodopsin 0.0093 0.1468 0.1468
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0093 0.1468 0.1468
Brugia malayi putative neuropeptide receptor 0.0093 0.1468 0.1468
Echinococcus multilocularis neuropeptide receptor 0.0093 0.1468 0.1468
Loa Loa (eye worm) hypothetical protein 0.0093 0.1468 0.1468
Brugia malayi sulfakinin receptor protein 0.0093 0.1468 0.1468
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0093 0.1468 0.1468
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.0542 0.0542
Onchocerca volvulus 0.0093 0.1468 0.5
Brugia malayi G-protein coupled receptor 0.0093 0.1468 0.1468
Brugia malayi ORL1-like opioid receptor 0.0093 0.1468 0.1468
Echinococcus granulosus rhodopsin orphan GPCR 0.0093 0.1468 0.1468
Schistosoma mansoni opsin-like receptor 0.0093 0.1468 0.1468
Echinococcus granulosus 7tm_1 domain containing protein 0.0093 0.1468 0.1468
Loa Loa (eye worm) hypothetical protein 0.0033 0.0391 0.0391
Echinococcus multilocularis g protein coupled receptor 0.0093 0.1468 0.1468
Brugia malayi GnHR receptor homolog 0.0093 0.1468 0.1468
Echinococcus multilocularis neuropeptide s receptor 0.0093 0.1468 0.1468
Echinococcus multilocularis neuropeptides capa receptor 0.0093 0.1468 0.1468
Loa Loa (eye worm) hypothetical protein 0.0093 0.1468 0.1468
Loa Loa (eye worm) hypothetical protein 0.0093 0.1468 0.1468
Loa Loa (eye worm) hypothetical protein 0.0093 0.1468 0.1468
Brugia malayi putative neuropeptide receptor NPR1 0.0093 0.1468 0.1468
Schistosoma mansoni hypothetical protein 0.0093 0.1468 0.1468
Echinococcus granulosus neuropeptide receptor 0.0093 0.1468 0.1468
Loa Loa (eye worm) hypothetical protein 0.0093 0.1468 0.1468
Loa Loa (eye worm) hypothetical protein 0.0093 0.1468 0.1468
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0093 0.1468 0.1468
Echinococcus granulosus rhodopsin orphan GPCR 0.0093 0.1468 0.1468
Echinococcus multilocularis G protein coupled receptor 139 0.0093 0.1468 0.1468
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0093 0.1468 0.1468
Loa Loa (eye worm) hypothetical protein 0.0093 0.1468 0.1468
Echinococcus multilocularis G-protein coupled receptor, putative 0.0093 0.1468 0.1468
Brugia malayi hypothetical protein 0.0093 0.1468 0.1468
Loa Loa (eye worm) hypothetical protein 0.0093 0.1468 0.1468
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0093 0.1468 0.1468
Schistosoma mansoni histamine h1 receptor 0.0093 0.1468 0.1468
Loa Loa (eye worm) neuropeptide F receptor 0.0093 0.1468 0.1468
Echinococcus granulosus 7TM GPCR rhodopsin 0.0093 0.1468 0.1468
Echinococcus granulosus orexin receptor type 2 0.0093 0.1468 0.1468
Echinococcus multilocularis neuropeptide receptor A26 0.0093 0.1468 0.1468
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0093 0.1468 0.1468
Echinococcus granulosus G protein coupled receptor 139 0.0093 0.1468 0.1468
Loa Loa (eye worm) hypothetical protein 0.0093 0.1468 0.1468
Echinococcus multilocularis rhodopsin orphan GPCR 0.0093 0.1468 0.1468
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.0542 0.0542
Onchocerca volvulus 0.0093 0.1468 0.5
Onchocerca volvulus 0.0093 0.1468 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0093 0.1468 0.1468
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0093 0.1468 0.1468
Onchocerca volvulus 0.0093 0.1468 0.5
Brugia malayi follicle stimulating hormone receptor 0.0093 0.1468 0.1468
Brugia malayi larval opioid receptor 0.0093 0.1468 0.1468
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0093 0.1468 0.1468
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0093 0.1468 0.1468
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.0435 0.5
Echinococcus multilocularis fmrfamide receptor 0.0093 0.1468 0.1468
Schistosoma mansoni growth hormone secretagogue receptor 0.0093 0.1468 0.1468
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0093 0.1468 0.1468
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0093 0.1468 0.1468
Onchocerca volvulus 0.0093 0.1468 0.5
Loa Loa (eye worm) hypothetical protein 0.0093 0.1468 0.1468
Echinococcus granulosus biogenic amine 5HT receptor 0.0093 0.1468 0.1468
Loa Loa (eye worm) hypothetical protein 0.0093 0.1468 0.1468
Echinococcus multilocularis sex peptide receptor 0.0093 0.1468 0.1468
Schistosoma mansoni amine GPCR 0.0093 0.1468 0.1468
Echinococcus multilocularis g protein coupled receptor 0.0093 0.1468 0.1468
Brugia malayi AKH receptor 0.0093 0.1468 0.1468
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0093 0.1468 0.1468
Onchocerca volvulus 0.0093 0.1468 0.5
Brugia malayi Dopamine receptor protein 2 0.0093 0.1468 0.1468
Echinococcus granulosus alpha 1A adrenergic receptor 0.0093 0.1468 0.1468
Loa Loa (eye worm) hypothetical protein 0.0093 0.1468 0.1468
Schistosoma mansoni biogenic amine (5HT) receptor 0.0093 0.1468 0.1468
Echinococcus granulosus dro:myosuppressin receptor 0.0093 0.1468 0.1468
Loa Loa (eye worm) hypothetical protein 0.0093 0.1468 0.1468
Loa Loa (eye worm) melatonin receptor type 1A 0.0093 0.1468 0.1468
Loa Loa (eye worm) G-protein coupled receptor 0.0093 0.1468 0.1468
Loa Loa (eye worm) hypothetical protein 0.0093 0.1468 0.1468
Echinococcus multilocularis neuropeptide FF receptor 2 0.0093 0.1468 0.1468
Schistosoma mansoni neuropeptide F-like receptor 0.0093 0.1468 0.1468
Echinococcus multilocularis rhodopsin orphan GPCR 0.0093 0.1468 0.1468
Toxoplasma gondii fructose-bisphospatase II 0.0567 1 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0093 0.1468 0.1468
Schistosoma mansoni amine GPCR 0.0093 0.1468 0.1468
Loa Loa (eye worm) hypothetical protein 0.0093 0.1468 0.1468
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0093 0.1468 0.1468
Schistosoma mansoni amine GPCR 0.0093 0.1468 0.1468
Echinococcus multilocularis neuropeptide Y receptor 0.0093 0.1468 0.1468
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0093 0.1468 0.1468
Schistosoma mansoni alpha-1 adrenergic receptor 0.0093 0.1468 0.1468
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0038 0.048 0.048
Onchocerca volvulus Neuropeptide F receptor homolog 0.0093 0.1468 0.5
Onchocerca volvulus 0.0093 0.1468 0.5
Schistosoma mansoni fructose-16-bisphosphatase-related 0.0567 1 1
Onchocerca volvulus 0.0093 0.1468 0.5
Echinococcus multilocularis g-protein coupled receptor 0.0093 0.1468 0.1468
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0093 0.1468 0.1468
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0567 1 1
Echinococcus granulosus g protein coupled receptor 0.0093 0.1468 0.1468
Loa Loa (eye worm) hypothetical protein 0.0093 0.1468 0.1468
Schistosoma mansoni biogenic amine receptor 0.0093 0.1468 0.1468
Echinococcus multilocularis neuropeptides capa receptor 0.0093 0.1468 0.1468
Echinococcus granulosus neuropeptide s receptor 0.0093 0.1468 0.1468
Onchocerca volvulus 0.0093 0.1468 0.5
Brugia malayi hypothetical protein 0.0093 0.1468 0.1468
Loa Loa (eye worm) hypothetical protein 0.0093 0.1468 0.1468
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0093 0.1468 0.1468
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0093 0.1468 0.1468
Brugia malayi hypothetical protein 0.0093 0.1468 0.1468
Echinococcus granulosus allatostatin A receptor 0.0093 0.1468 0.1468
Schistosoma mansoni biogenic amine (5HT) receptor 0.0093 0.1468 0.1468
Brugia malayi Tachykinin-like peptides receptor 99D 0.0093 0.1468 0.1468
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0093 0.1468 0.1468
Leishmania major 0.0567 1 0.5
Schistosoma mansoni neuropeptide receptor 0.0093 0.1468 0.1468
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0093 0.1468 0.1468
Loa Loa (eye worm) hypothetical protein 0.0093 0.1468 0.1468
Loa Loa (eye worm) hypothetical protein 0.0093 0.1468 0.1468
Brugia malayi hypothetical protein 0.0093 0.1468 0.1468
Echinococcus granulosus rhodopsin orphan GPCR 0.0093 0.1468 0.1468
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0093 0.1468 0.1468
Loa Loa (eye worm) neuropeptide F receptor 0.0093 0.1468 0.1468
Echinococcus multilocularis serotonin receptor 0.0093 0.1468 0.1468
Echinococcus granulosus sex peptide receptor 0.0093 0.1468 0.1468
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0038 0.048 0.048
Loa Loa (eye worm) hypothetical protein 0.0093 0.1468 0.1468
Echinococcus multilocularis rhodopsin orphan GPCR 0.0093 0.1468 0.1468
Schistosoma mansoni neuropeptide receptor 0.0093 0.1468 0.1468
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0093 0.1468 0.1468
Loa Loa (eye worm) hypothetical protein 0.0093 0.1468 0.1468
Brugia malayi Dopamine receptor 0.0093 0.1468 0.1468
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0093 0.1468 0.1468
Onchocerca volvulus 0.0093 0.1468 0.5
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.0435 0.5
Schistosoma mansoni neuropeptide receptor 0.0093 0.1468 0.1468
Echinococcus multilocularis neuropeptide Y receptor 0.0093 0.1468 0.1468
Brugia malayi G-protein coupled receptor 0.0093 0.1468 0.1468
Echinococcus granulosus hypothetical protein 0.0093 0.1468 0.1468
Loa Loa (eye worm) hypothetical protein 0.0093 0.1468 0.1468
Echinococcus granulosus neuropeptide Y receptor 0.0093 0.1468 0.1468
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0093 0.1468 0.1468
Brugia malayi hypothetical protein 0.0093 0.1468 0.1468
Brugia malayi Melatonin receptor type 1A 0.0093 0.1468 0.1468
Loa Loa (eye worm) hypothetical protein 0.0093 0.1468 0.1468
Echinococcus granulosus neuropeptide Y receptor 0.0093 0.1468 0.1468
Loa Loa (eye worm) hypothetical protein 0.0093 0.1468 0.1468
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0567 1 1
Echinococcus multilocularis serotonin receptor 0.0093 0.1468 0.1468
Echinococcus multilocularis allatostatin A receptor 0.0093 0.1468 0.1468
Loa Loa (eye worm) hypothetical protein 0.0093 0.1468 0.1468
Loa Loa (eye worm) hypothetical protein 0.0093 0.1468 0.1468
Echinococcus multilocularis g protein coupled receptor 0.0093 0.1468 0.1468
Brugia malayi hypothetical protein 0.0093 0.1468 0.1468
Loa Loa (eye worm) hypothetical protein 0.0093 0.1468 0.1468
Schistosoma mansoni opsin-like receptor 0.0093 0.1468 0.1468
Loa Loa (eye worm) hypothetical protein 0.0093 0.1468 0.1468
Onchocerca volvulus 0.0093 0.1468 0.5
Schistosoma mansoni biogenic amine receptor 0.0093 0.1468 0.1468
Onchocerca volvulus 0.0093 0.1468 0.5
Loa Loa (eye worm) hypothetical protein 0.0093 0.1468 0.1468
Loa Loa (eye worm) hypothetical protein 0.0093 0.1468 0.1468
Echinococcus granulosus rhodopsin orphan GPCR 0.0093 0.1468 0.1468
Echinococcus granulosus fructose 16 bisphosphatase 1 0.0567 1 1
Loa Loa (eye worm) TYRA-2 protein 0.0093 0.1468 0.1468
Echinococcus granulosus somatostatin receptor 0.0093 0.1468 0.1468
Schistosoma mansoni hypothetical protein 0.0093 0.1468 0.1468
Brugia malayi G protein-coupled receptor 0.0093 0.1468 0.1468
Brugia malayi hypothetical protein 0.0093 0.1468 0.1468
Loa Loa (eye worm) hypothetical protein 0.0093 0.1468 0.1468
Schistosoma mansoni myosin xvIII 0.0093 0.1468 0.1468
Echinococcus granulosus neuropeptide FF receptor 2 0.0093 0.1468 0.1468
Loa Loa (eye worm) hypothetical protein 0.0093 0.1468 0.1468
Brugia malayi neuropeptide F receptor 0.0093 0.1468 0.1468
Echinococcus granulosus neuropeptides capa receptor 0.0093 0.1468 0.1468
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0093 0.1468 0.1468
Loa Loa (eye worm) hypothetical protein 0.0093 0.1468 0.1468
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0093 0.1468 0.1468
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0093 0.1468 0.1468
Echinococcus granulosus tm gpcr rhodopsin 0.0093 0.1468 0.1468
Echinococcus granulosus rhodopsin orphan GPCR 0.0093 0.1468 0.1468
Loa Loa (eye worm) hypothetical protein 0.0093 0.1468 0.1468
Echinococcus granulosus serotonin receptor 0.0093 0.1468 0.1468
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0093 0.1468 0.1468
Loa Loa (eye worm) G-protein coupled receptor 0.0093 0.1468 0.1468
Echinococcus multilocularis rhodopsin orphan GPCR 0.0093 0.1468 0.1468
Schistosoma mansoni amine GPCR 0.0093 0.1468 0.1468
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0093 0.1468 0.1468
Echinococcus granulosus tachykinin peptides receptor 99D 0.0093 0.1468 0.1468
Loa Loa (eye worm) hypothetical protein 0.0093 0.1468 0.1468
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0093 0.1468 0.1468
Onchocerca volvulus 0.0093 0.1468 0.5
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0093 0.1468 0.1468
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0038 0.048 0.048
Echinococcus granulosus rhodopsin orphan GPCR 0.0093 0.1468 0.1468
Loa Loa (eye worm) hypothetical protein 0.0093 0.1468 0.1468
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0093 0.1468 0.1468
Echinococcus multilocularis dro:myosuppressin receptor 0.0093 0.1468 0.1468
Onchocerca volvulus 0.0093 0.1468 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0093 0.1468 0.1468
Schistosoma mansoni neuropeptide F-like receptor 0.0093 0.1468 0.1468
Echinococcus multilocularis somatostatin receptor 0.0093 0.1468 0.1468
Echinococcus multilocularis neuropeptide receptor 0.0093 0.1468 0.1468
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0093 0.1468 0.1468
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0093 0.1468 0.1468
Brugia malayi hypothetical protein 0.0093 0.1468 0.1468
Brugia malayi hypothetical protein 0.0093 0.1468 0.1468
Loa Loa (eye worm) hypothetical protein 0.0093 0.1468 0.1468
Echinococcus multilocularis fmrfamide receptor 0.0093 0.1468 0.1468
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0093 0.1468 0.1468
Echinococcus granulosus tm gpcr rhodopsin 0.0093 0.1468 0.1468
Onchocerca volvulus 0.0093 0.1468 0.5
Echinococcus granulosus biogenic amine 5HT receptor 0.0093 0.1468 0.1468
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0093 0.1468 0.1468

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.53 uM Concentration required to inhibit the human liver recombinant fructose-1,6-bisphosphatase. ChEMBL. 11140724
IC50 (binding) = 0.53 uM Concentration required to inhibit the human liver recombinant fructose-1,6-bisphosphatase. ChEMBL. 11140724
IC50 (binding) = 3.1 uM Compound was evaluated for its concentration required to inhibit the porcine kidney F16BPase ChEMBL. 11140724
IC50 (binding) = 3.1 uM Compound was evaluated for its concentration required to inhibit the porcine kidney F16BPase ChEMBL. 11140724
IC50 (functional) > 10 uM Compound was evaluated for its concentration required to inhibit the rabbit liver F16BPase ChEMBL. 11140724
IC50 (binding) > 10 uM Compound was evaluated for its concentration required to inhibit the rat liver F16BPase ChEMBL. 11140724
IC50 (binding) > 10 uM Compound was evaluated for its concentration required to inhibit the rat liver F16BPase ChEMBL. 11140724

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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