Detailed information for compound 1066851

Basic information

Technical information
  • TDR Targets ID: 1066851
  • Name: N-cyclopentyl-1-ethylpyrazole-3-carboxamide
  • MW: 207.272 | Formula: C11H17N3O
  • H donors: 1 H acceptors: 2 LogP: 1.41 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCn1ccc(n1)C(=O)NC1CCCC1
  • InChi: 1S/C11H17N3O/c1-2-14-8-7-10(13-14)11(15)12-9-5-3-4-6-9/h7-9H,2-6H2,1H3,(H,12,15)
  • InChiKey: RKEBYCQSMAJQGM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-cyclopentyl-1-ethyl-pyrazole-3-carboxamide
  • N-cyclopentyl-1-ethyl-3-pyrazolecarboxamide
  • IVK/0012064

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0182 0.4048
Echinococcus multilocularis smad 0.0009 0.005 0.0013
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0113 0.1184 0.3793
Brugia malayi MH1 domain containing protein 0.0009 0.005 0.0145
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0406 1
Schistosoma mansoni hypothetical protein 0.0036 0.034 0.0677
Loa Loa (eye worm) hypothetical protein 0.001 0.0061 0.0182
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0189 0.3329
Brugia malayi hypothetical protein 0.0041 0.0395 0.1254
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0187 0.03
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0061 0.0024
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0059 0.0022
Loa Loa (eye worm) transcription factor SMAD2 0.0135 0.1429 0.4582
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0042 0.0406 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0075 0.0149
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0187 0.0373
Schistosoma mansoni hypothetical protein 0.0077 0.0793 0.1582
Loa Loa (eye worm) hypothetical protein 0.0289 0.3113 1
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0187 0.0373
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0187 0.0586
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0037 0.0358 1
Schistosoma mansoni smad 0.0009 0.005 0.0099
Echinococcus granulosus Smad4 0.0009 0.005 0.0025
Loa Loa (eye worm) Smad1 0.0009 0.005 0.0145
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0182 0.0571
Brugia malayi nuclear hormone receptor 0.001 0.0061 0.0182
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0554 0.1768
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0075 0.0225
Brugia malayi hypothetical protein 0.0011 0.0075 0.0225
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0187 0.015
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.001 0.0061 0.0048
Brugia malayi Cytochrome P450 family protein 0.0055 0.0553 0.1764
Loa Loa (eye worm) hypothetical protein 0.0011 0.0075 0.0225
Entamoeba histolytica hypothetical protein 0.0041 0.0395 0.9471
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.001 0.0061 0.0024
Brugia malayi Nuclear hormone receptor E75 0.001 0.0061 0.0182
Brugia malayi nuclear receptor NHR-88 0.0022 0.0187 0.0586
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0187 0.0586
Loa Loa (eye worm) hypothetical protein 0.0022 0.0187 0.0586
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0187 0.03
Brugia malayi hypothetical protein 0.001 0.0061 0.0182
Echinococcus granulosus inositol monophosphatase 1 0.0042 0.0406 0.0742
Schistosoma mansoni inositol monophosphatase 0.0042 0.0406 0.081
Schistosoma mansoni nuclear hormone receptor 0.001 0.0061 0.0122
Loa Loa (eye worm) hypothetical protein 0.0022 0.0187 0.0586
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0182 0.5
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0042 0.0406 0.601
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0187 0.0373
Loa Loa (eye worm) nuclear receptor NHR-67 0.001 0.0061 0.0182
Schistosoma mansoni smad1 5 8 and 0.0009 0.005 0.0099
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0187 0.0586
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0187 0.03
Loa Loa (eye worm) hypothetical protein 0.0011 0.0075 0.0225
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0061 0.0048
Schistosoma mansoni hypothetical protein 0.0036 0.034 0.0677
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0061 0.0024
Brugia malayi ecdysteroid receptor 0.0022 0.0187 0.0586
Echinococcus granulosus nuclear receptor nhr 48 0.001 0.0061 0.0048
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0187 0.0373
Schistosoma mansoni nuclear receptor 0.001 0.0061 0.0122
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0187 0.015
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0187 0.015
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0036 0.034 0.1078
Brugia malayi nuclear hormone receptor 0.0022 0.0187 0.0586
Brugia malayi hypothetical protein 0.0011 0.0075 0.0225
Brugia malayi Calcitonin receptor-like protein seb-1 0.0113 0.1184 0.3793
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0189 0.0593
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0022 0.0189 0.3329
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0554 0.1105
Schistosoma mansoni hypothetical protein 0.0036 0.034 0.0677
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0042 0.0406 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0554 0.1768
Schistosoma mansoni nuclear hormone receptor 0.001 0.0061 0.0122
Loa Loa (eye worm) hypothetical protein 0.001 0.0061 0.0182
Brugia malayi tailless protein 0.001 0.0061 0.0182
Brugia malayi steroid hormone receptor 0.0022 0.0187 0.0586
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.005 0.0145
Brugia malayi orphan nuclear receptor NR2E1 0.001 0.0061 0.0182
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0187 0.0586
Loa Loa (eye worm) DR-78 0.001 0.0061 0.0182
Echinococcus granulosus cytochrome P450 2K1 0.0012 0.008 0.0087
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0036 0.034 0.0303
Trichomonas vaginalis inositol monophosphatase, putative 0.0042 0.0406 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0305 0.0965
Loa Loa (eye worm) hypothetical protein 0.0077 0.0793 0.2536
Schistosoma mansoni nuclear receptor 0.001 0.0061 0.0122
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0187 0.03
Brugia malayi conserved hypotetical protein 0.001 0.0061 0.0182
Loa Loa (eye worm) hypothetical protein 0.001 0.0061 0.0182
Schistosoma mansoni hypothetical protein 0.0041 0.0395 0.0787
Schistosoma mansoni hypothetical protein 0.0462 0.5014 1
Echinococcus multilocularis cpg binding protein 0.0034 0.0325 0.0289
Loa Loa (eye worm) hypothetical protein 0.0022 0.0187 0.0586
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0182 0.3118
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0395 0.0787
Entamoeba histolytica hypothetical protein 0.0041 0.0395 0.9471
Brugia malayi ecdysone receptor 0.001 0.0061 0.0182
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0187 0.0373
Brugia malayi Cytochrome P450 family protein 0.0022 0.0189 0.0593
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0187 0.015
Brugia malayi nuclear receptor NHR-88 0.001 0.0061 0.0182
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0187 0.0586
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0187 0.0373
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.005 0.0013
Loa Loa (eye worm) hypothetical protein 0.001 0.0061 0.0182
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0187 0.0586
Loa Loa (eye worm) hypothetical protein 0.0011 0.0075 0.0225
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0187 0.0586
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0187 0.0373
Echinococcus granulosus geminin 0.0192 0.2049 0.4042
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.0187 0.5162
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0075 0.0149
Echinococcus granulosus smad 0.0009 0.005 0.0025
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0187 0.0586
Brugia malayi Cytochrome P450 family protein 0.0012 0.008 0.0244
Loa Loa (eye worm) hypothetical protein 0.001 0.0061 0.0182
Loa Loa (eye worm) nuclear hormone receptor 0.001 0.0061 0.0182
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.0406 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.001 0.0061 0.0122
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0036 0.034 0.0607
Schistosoma mansoni cpg binding protein 0.0034 0.0325 0.0648
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0187 0.03
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0406 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0135 0.1429 0.4582
Brugia malayi MH2 domain containing protein 0.0009 0.005 0.0145
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.005 0.0099
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0182 0.3118
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0182 0.5
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0182 0.0291
Brugia malayi cytochrome P450 0.0012 0.008 0.0244
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0187 0.0586
Echinococcus granulosus dnaJ subfamily B 0.0462 0.5014 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0182 0.3118
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0182 0.3118
Loa Loa (eye worm) hypothetical protein 0.0036 0.034 0.1078
Schistosoma mansoni ap endonuclease 0.0021 0.0182 0.0363
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0187 0.015
Schistosoma mansoni Smad4 0.0009 0.005 0.0099
Brugia malayi CXXC zinc finger family protein 0.0032 0.0305 0.0965
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0059 0.0044
Echinococcus multilocularis nuclear receptor nhr 48 0.001 0.0061 0.0024
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0187 0.0586
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0406 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0187 0.03
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0042 0.0406 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0187 0.0586
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0189 0.3329
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0554 0.1039
Schistosoma mansoni cpg binding protein 0.0032 0.0305 0.0608
Schistosoma mansoni hypothetical protein 0.0036 0.034 0.0677
Brugia malayi MH1 domain containing protein 0.0009 0.005 0.0145
Onchocerca volvulus 0.0032 0.0305 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0187 0.0586
Schistosoma mansoni smad1 5 8 and 0.0009 0.005 0.0099
Loa Loa (eye worm) hypothetical protein 0.0022 0.0187 0.0586
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0187 0.0586
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0187 0.015
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.005 0.0013
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0187 0.0586
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0187 0.0373
Brugia malayi MH2 domain containing protein 0.0135 0.1429 0.4582
Loa Loa (eye worm) cytochrome P450 family protein 0.0055 0.0553 0.1764
Schistosoma mansoni cpg binding protein 0.0034 0.0325 0.0648
Loa Loa (eye worm) hypothetical protein 0.0011 0.0075 0.0225
Brugia malayi Cytochrome P450 family protein 0.0022 0.0189 0.0593
Leishmania major cytochrome p450-like protein 0.0022 0.0189 0.3329
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0554 0.0519
Loa Loa (eye worm) hypothetical protein 0.001 0.0061 0.0182
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0075 0.0037
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0395 0.0718
Loa Loa (eye worm) hypothetical protein 0.0011 0.0075 0.0225
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0187 0.0586
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0036 0.034 0.0607
Brugia malayi nuclear hormone receptor family member nhr-6 0.001 0.0061 0.0182
Echinococcus multilocularis geminin 0.0192 0.2049 0.202
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0075 0.0075
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0113 0.1184 0.3793
Loa Loa (eye worm) histone methyltransferase 0.001 0.0059 0.0175
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0187 0.0373
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0187 0.0586
Echinococcus multilocularis 0.0012 0.008 0.0043
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0187 0.0586
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.001 0.0061 0.0122
Brugia malayi latrophilin 2 splice variant baaae 0.0077 0.0793 0.2536
Loa Loa (eye worm) hypothetical protein 0.001 0.0061 0.0182
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0187 0.0586
Echinococcus multilocularis dnaJ subfamily B 0.0462 0.5014 0.4996
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0075 0.0225
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0061 0.0048
Brugia malayi nuclear receptor RXR 0.0011 0.0075 0.0225
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0069 0.0703 0.1403
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0187 0.0586
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0554 0.1105
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0187 0.0586
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0187 0.015
Brugia malayi MH2 domain containing protein 0.0009 0.005 0.0145
Loa Loa (eye worm) hypothetical protein 0.001 0.0061 0.0182
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0061 0.0048
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0182 0.0571
Loa Loa (eye worm) hypothetical protein 0.001 0.0057 0.017
Loa Loa (eye worm) hypothetical protein 0.0022 0.0187 0.0586
Loa Loa (eye worm) latrophilin receptor protein 2 0.0036 0.034 0.1078
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0036 0.034 0.0303
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0187 0.0586
Loa Loa (eye worm) hypothetical protein 0.001 0.0061 0.0182
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0554 0.1105
Schistosoma mansoni cytochrome P450 0.0012 0.008 0.016
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0182 0.3656
Schistosoma mansoni smad1 5 8 and 0.0009 0.005 0.0099
Brugia malayi Nuclear hormone receptor E75 0.001 0.0061 0.0182
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0182 0.3118
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0406 1
Loa Loa (eye worm) CYP4Cod1 0.0022 0.0189 0.0593
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0187 0.0373
Loa Loa (eye worm) hypothetical protein 0.001 0.0061 0.0182
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.0187 0.5162
Schistosoma mansoni hypothetical protein 0.0192 0.2049 0.4087
Echinococcus granulosus GPCR family 2 0.0036 0.034 0.0607
Loa Loa (eye worm) cytochrome P450 0.0012 0.008 0.0244
Brugia malayi nuclear receptor RXR 0.001 0.0061 0.0182
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0037 0.0358 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.005 0.0145
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0554 0.1039
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0182 0.5
Loa Loa (eye worm) hypothetical protein 0.001 0.0061 0.0182
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.0406 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0187 0.0586
Schistosoma mansoni zinc finger protein 0.001 0.0061 0.0122
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0395 0.0359
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.001 0.0061 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0187 0.0586
Schistosoma mansoni coup transcription factor 0.0022 0.0187 0.0373
Loa Loa (eye worm) hypothetical protein 0.0113 0.1184 0.3793
Schistosoma mansoni hypothetical protein 0.0012 0.008 0.016
Schistosoma mansoni nuclear receptor nhr-48 0.001 0.0061 0.0122
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0187 0.0586
Echinococcus multilocularis Smad4 0.0009 0.005 0.0013
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0187 0.015
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0061 0.0024
Toxoplasma gondii exonuclease III APE 0.0021 0.0182 0.1874
Schistosoma mansoni hypothetical protein 0.0192 0.2049 0.4087
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0623 1
Entamoeba histolytica hypothetical protein 0.0041 0.0395 0.9471
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.005 0.0025
Schistosoma mansoni ap endonuclease 0.0021 0.0182 0.0363
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0187 0.0586
Brugia malayi Inositol-1 0.0042 0.0406 0.1292
Brugia malayi nuclear receptor NHR-67 0.001 0.0061 0.0182
Brugia malayi nuclear hormone receptor family member odr-7 0.001 0.0061 0.0182
Echinococcus multilocularis inositol monophosphatase 1 0.0042 0.0406 0.037
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0187 0.03
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0187 0.0373
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.001 0.0061 0.0182
Schistosoma mansoni inositol monophosphatase 0.0042 0.0406 0.081
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0058 0.017
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0075 0.0225
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0187 0.03
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.0187 0.5162
Trypanosoma brucei cytochrome P450, putative 0.0022 0.0189 0.3329
Echinococcus granulosus cpg binding protein 0.0034 0.0325 0.0578
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0187 0.0373
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0182 0.0145
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0182 0.4048
Brugia malayi Latrophilin receptor protein 2 0.0036 0.034 0.1078
Brugia malayi hypothetical protein 0.001 0.0061 0.0182
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0182 0.5
Brugia malayi Smad1 0.0009 0.005 0.0145
Entamoeba histolytica hypothetical protein 0.0041 0.0395 0.9471
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0037 0.0074
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0554 0.0519
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0189 0.0593
Loa Loa (eye worm) hypothetical protein 0.001 0.0061 0.0182
Echinococcus multilocularis GPCR, family 2 0.0036 0.034 0.0303
Loa Loa (eye worm) inositol-1 0.0042 0.0406 0.1292
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.005 0.0025
Onchocerca volvulus 0.0022 0.0187 0.5162
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0187 0.03
Loa Loa (eye worm) hypothetical protein 0.001 0.0061 0.0182
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0187 0.015
Echinococcus granulosus thyroid hormone receptor alpha 0.001 0.0061 0.0048
Brugia malayi photoreceptor-specific nuclear receptor 0.0289 0.3113 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.001 0.0061 0.0182

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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