Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0702 | 0.2887 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0.1 | 0.7988 |
Echinococcus multilocularis | dna polymerase kappa | 0.002 | 0.0702 | 0.0595 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0024 | 0.1 | 0.4115 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0024 | 0.1 | 0.3197 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0702 | 0.2887 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.002 | 0.0702 | 0.1779 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.002 | 0.0702 | 0.0855 |
Echinococcus multilocularis | ATP dependent DNA helicase Q5 | 0.0011 | 0.0115 | 0.0002 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0018 | 0.0562 | 0.2961 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.1898 | 0.7812 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0039 | 0.198 | 0.1888 |
Schistosoma mansoni | DNA helicase recq1 | 0.0011 | 0.0115 | 0.0115 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0027 | 0.1143 | 0.5192 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.002 | 0.0702 | 0.1779 |
Plasmodium vivax | hypothetical protein, conserved | 0.0028 | 0.1252 | 1 |
Echinococcus granulosus | intestinal type alkaline phosphatase 1 | 0.0161 | 1 | 1 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0028 | 0.1252 | 0.1525 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.258 | 0.3144 |
Echinococcus granulosus | peregrin | 0.0028 | 0.1252 | 0.1151 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.2496 | 0.3042 |
Loa Loa (eye worm) | inositol-1 | 0.0038 | 0.1898 | 0.2313 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0034 | 0.1643 | 0.2002 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0011 | 0.0115 | 0.0606 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0021 | 0.0775 | 0.0775 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0024 | 0.1 | 0.7988 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0014 | 0.0295 | 0.1215 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0702 | 0.2887 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0046 | 0.243 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.002 | 0.0702 | 0.2887 |
Leishmania major | hypothetical protein, conserved | 0.0024 | 0.1 | 0.3197 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0014 | 0.0295 | 0.1215 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0034 | 0.1636 | 0.5 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.002 | 0.0702 | 0.2381 |
Echinococcus multilocularis | intestinal type alkaline phosphatase 1 | 0.0161 | 1 | 1 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.002 | 0.0702 | 0.0595 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0038 | 0.1898 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0011 | 0.0113 | 0.0113 |
Echinococcus granulosus | ATP dependent DNA helicase Q1 | 0.0011 | 0.0115 | 0.0002 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.2496 | 0.241 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.002 | 0.0702 | 0.2887 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0046 | 0.243 | 0.4433 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.0011 | 0.0115 | 0.014 |
Schistosoma mansoni | DNA polymerase eta | 0.0046 | 0.243 | 0.243 |
Plasmodium falciparum | ATP-dependent DNA helicase Q1 | 0.0011 | 0.0115 | 0.0919 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0038 | 0.1898 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0014 | 0.0295 | 0.1215 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.002 | 0.0702 | 0.1779 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.1 | 0.1218 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.0018 | 0.0576 | 0.4603 |
Trypanosoma brucei | unspecified product | 0.0014 | 0.0295 | 0.1215 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0034 | 0.1643 | 0.1643 |
Schistosoma mansoni | jumonji domain containing protein | 0.0073 | 0.4231 | 0.4231 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0024 | 0.1 | 0.5267 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.002 | 0.0702 | 0.2381 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.2496 | 0.2496 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0034 | 0.1643 | 0.1643 |
Echinococcus granulosus | jumonji domain containing protein | 0.0039 | 0.198 | 0.1888 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0038 | 0.1898 | 0.5 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0038 | 0.1898 | 0.1805 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.002 | 0.0702 | 0.1779 |
Schistosoma mansoni | inositol monophosphatase | 0.0038 | 0.1898 | 0.1898 |
Leishmania major | DNA polymerase kappa, putative | 0.002 | 0.0702 | 0.1779 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.2496 | 0.241 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0014 | 0.0328 | 0.1348 |
Brugia malayi | PHD-finger family protein | 0.0028 | 0.1252 | 0.2283 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0028 | 0.1252 | 0.6594 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0023 | 0.0931 | 0.7434 |
Echinococcus multilocularis | intestinal type alkaline phosphatase | 0.0161 | 1 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0038 | 0.1898 | 0.1898 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0034 | 0.1643 | 0.1547 |
Echinococcus granulosus | dna polymerase kappa | 0.002 | 0.0702 | 0.0595 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.002 | 0.0702 | 0.0702 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0702 | 0.2887 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0027 | 0.1143 | 0.5192 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.1252 | 0.1525 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0702 | 0.2887 |
Echinococcus multilocularis | ATP dependent DNA helicase Q1 | 0.0011 | 0.0115 | 0.0002 |
Echinococcus granulosus | bloom syndrome protein | 0.0027 | 0.1143 | 0.1042 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.243 | 0.2961 |
Trypanosoma brucei | unspecified product | 0.0014 | 0.0295 | 0.1215 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.2496 | 0.2496 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0028 | 0.1252 | 0.1151 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.002 | 0.0702 | 0.1779 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0038 | 0.1898 | 0.1805 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.2496 | 0.4553 |
Giardia lamblia | DINP protein human, muc B family | 0.002 | 0.0702 | 0.5161 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0011 | 0.0115 | 0.021 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0115 | 0.014 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0032 | 0.1527 | 0.5705 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0702 | 0.2887 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.2496 | 0.241 |
Brugia malayi | jmjC domain containing protein | 0.0092 | 0.5482 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0032 | 0.1527 | 0.5705 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0011 | 0.0115 | 0.0606 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.002 | 0.0702 | 0.0702 |
Schistosoma mansoni | hypothetical protein | 0.0028 | 0.1252 | 0.1252 |
Onchocerca volvulus | Alhambra homolog | 0.0028 | 0.1252 | 0.5 |
Plasmodium falciparum | phd finger protein, putative | 0.0028 | 0.1252 | 1 |
Brugia malayi | hypothetical protein | 0.0024 | 0.1 | 0.1824 |
Echinococcus granulosus | alkaline phosphatase intestinal gene 2 | 0.0161 | 1 | 1 |
Schistosoma mansoni | alkaline phosphatase | 0.0161 | 1 | 1 |
Echinococcus granulosus | alkaline phosphatase | 0.0161 | 1 | 1 |
Echinococcus multilocularis | alkaline phosphatase | 0.0161 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0016 | 0.043 | 0.0785 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.002 | 0.0702 | 0.0595 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.2496 | 0.2496 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0702 | 0.2887 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0024 | 0.1 | 0.3197 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0702 | 0.2887 |
Brugia malayi | Bromodomain containing protein | 0.0028 | 0.1252 | 0.2283 |
Brugia malayi | Inositol-1 | 0.0038 | 0.1898 | 0.3463 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0092 | 0.5482 | 0.5431 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0028 | 0.1252 | 0.6594 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0702 | 0.2887 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0038 | 0.1898 | 1 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0011 | 0.0115 | 0.021 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0.1 | 0.7988 |
Echinococcus granulosus | dna polymerase eta | 0.0046 | 0.243 | 0.2343 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0038 | 0.1898 | 1 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0032 | 0.1527 | 0.8044 |
Echinococcus multilocularis | peregrin | 0.0028 | 0.1252 | 0.1151 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.1898 | 0.7471 |
Loa Loa (eye worm) | RecQ helicase | 0.0027 | 0.1143 | 0.1393 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0028 | 0.1252 | 0.1151 |
Leishmania major | DNA polymerase eta, putative | 0.0046 | 0.243 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.002 | 0.0702 | 0.2887 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0034 | 0.1636 | 1 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0028 | 0.1252 | 0.1252 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.2496 | 0.241 |
Echinococcus multilocularis | bloom syndrome protein | 0.0027 | 0.1143 | 0.1042 |
Echinococcus multilocularis | dna polymerase eta | 0.0046 | 0.243 | 0.2343 |
Brugia malayi | jmjC domain containing protein | 0.0034 | 0.1643 | 0.2997 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.8206 | 1 |
Schistosoma mansoni | alkaline phosphatase | 0.0161 | 1 | 1 |
Schistosoma mansoni | DNA helicase recq5 | 0.0011 | 0.0115 | 0.0115 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0027 | 0.1143 | 0.2085 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0046 | 0.243 | 1 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0092 | 0.5482 | 0.5431 |
Schistosoma mansoni | hypothetical protein | 0.0083 | 0.4904 | 0.4904 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.002 | 0.0702 | 0.128 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0702 | 0.2887 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.002 | 0.0702 | 0.2381 |
Giardia lamblia | PHD finger protein 15 | 0.0028 | 0.1252 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0058 | 0.3232 | 0.3938 |
Echinococcus granulosus | ATP dependent DNA helicase Q5 | 0.0011 | 0.0115 | 0.0002 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0038 | 0.1898 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.1898 | 0.7471 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0034 | 0.1643 | 0.1547 |
Trypanosoma brucei | unspecified product | 0.002 | 0.0702 | 0.2887 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0038 | 0.1898 | 1 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.1898 | 0.7471 |
Echinococcus multilocularis | alkaline phosphatase, intestinal, gene 2 | 0.0161 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.