Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0577 | 0.169 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0065 | 0.0615 | 0.0615 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0057 | 0.0512 | 0.0512 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0057 | 0.0512 | 0.0512 |
Brugia malayi | TAR-binding protein | 0.0212 | 0.2511 | 0.7349 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0047 | 0.0378 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0019 | 0.0018 | 0.0051 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0258 | 0.0258 |
Schistosoma mansoni | ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related | 0.0017 | 0.0001 | 0.0001 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0283 | 0.3417 | 0.3417 |
Loa Loa (eye worm) | hypothetical protein | 0.0283 | 0.3417 | 1 |
Echinococcus granulosus | tumor protein p63 | 0.0404 | 0.4977 | 0.4977 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0283 | 0.3417 | 0.3417 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0017 | 0.0001 | 0.0003 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0017 | 0.0001 | 0.0003 |
Loa Loa (eye worm) | intermediate filament protein | 0.0063 | 0.0592 | 0.1733 |
Echinococcus granulosus | lamin dm0 | 0.0063 | 0.0592 | 0.0592 |
Schistosoma mansoni | smad1 5 8 and | 0.0019 | 0.0018 | 0.0018 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.002 | 0.0041 | 0.0041 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0058 | 0.052 | 0.1522 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0065 | 0.0613 | 0.0613 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0065 | 0.0613 | 0.1795 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0274 | 0.3298 | 0.9651 |
Mycobacterium ulcerans | 4'-phosphopantetheinyl transferase | 0.0028 | 0.0138 | 0.5 |
Brugia malayi | CXXC zinc finger family protein | 0.0066 | 0.0629 | 0.184 |
Schistosoma mansoni | Smad4 | 0.0019 | 0.0018 | 0.0018 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0212 | 0.2511 | 0.7349 |
Chlamydia trachomatis | holo [acyl-carrier protein] synthase | 0.0028 | 0.0138 | 0.5 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0031 | 0.0171 | 0.0171 |
Brugia malayi | mbt repeat family protein | 0.0057 | 0.0512 | 0.1498 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0066 | 0.0629 | 0.184 |
Loa Loa (eye worm) | TAR-binding protein | 0.0212 | 0.2511 | 0.7349 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.0455 | 0.0455 |
Loa Loa (eye worm) | acetyltransferase | 0.0159 | 0.1821 | 0.5328 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0053 | 0.0455 | 0.1333 |
Schistosoma mansoni | jumonji domain containing protein | 0.0017 | 0.0001 | 0.0001 |
Echinococcus multilocularis | Smad4 | 0.0019 | 0.0018 | 0.0018 |
Schistosoma mansoni | phd/f-box containing protein | 0.0017 | 0.0001 | 0.0001 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0065 | 0.0613 | 0.0613 |
Schistosoma mansoni | hypothetical protein | 0.0186 | 0.2166 | 0.2166 |
Brugia malayi | MH1 domain containing protein | 0.0019 | 0.0018 | 0.0051 |
Schistosoma mansoni | tar DNA-binding protein | 0.0212 | 0.2511 | 0.2511 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0001 | 0.0003 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0034 | 0.0214 | 0.0626 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0001 | 0.0003 |
Brugia malayi | intermediate filament protein | 0.0063 | 0.0592 | 0.1733 |
Brugia malayi | jmjC domain containing protein | 0.0017 | 0.0001 | 0.0003 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0057 | 0.0512 | 0.0512 |
Echinococcus multilocularis | phd:f box containing protein | 0.0017 | 0.0001 | 0.0001 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0028 | 0.0138 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0347 | 0.424 | 0.424 |
Echinococcus multilocularis | cpg binding protein | 0.007 | 0.0677 | 0.0677 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.0455 | 0.0455 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.014 | 0.1582 | 0.1582 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0159 | 0.1821 | 0.5328 |
Schistosoma mansoni | cpg binding protein | 0.007 | 0.0677 | 0.0677 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.002 | 0.0041 | 0.0041 |
Echinococcus granulosus | cpg binding protein | 0.007 | 0.0677 | 0.0677 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0065 | 0.0615 | 0.0615 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0047 | 0.0378 | 0.2623 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase domain-containing protein | 0.0028 | 0.0138 | 0.0949 |
Loa Loa (eye worm) | hypothetical protein | 0.0223 | 0.2642 | 0.7732 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0274 | 0.3298 | 0.9651 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.0455 | 0.0455 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0455 | 0.0455 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0225 | 0.267 | 0.267 |
Brugia malayi | MH2 domain containing protein | 0.0274 | 0.3298 | 0.9651 |
Brugia malayi | RNA binding protein | 0.0212 | 0.2511 | 0.7349 |
Echinococcus granulosus | lamin | 0.0063 | 0.0592 | 0.0592 |
Echinococcus multilocularis | tumor protein p63 | 0.0404 | 0.4977 | 0.4977 |
Mycobacterium leprae | conserved hypothetical protein | 0.0028 | 0.0138 | 0.5 |
Onchocerca volvulus | 0.0063 | 0.0592 | 0.1475 | |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0069 | 0.0664 | 0.0664 |
Echinococcus multilocularis | geminin | 0.0186 | 0.2166 | 0.2166 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0212 | 0.2511 | 0.7349 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0019 | 0.0018 | 0.0018 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0069 | 0.0664 | 0.1942 |
Schistosoma mansoni | lamin | 0.0063 | 0.0592 | 0.0592 |
Loa Loa (eye worm) | RNA binding protein | 0.0212 | 0.2511 | 0.7349 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0455 | 0.0455 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0099 | 0.1057 | 0.1057 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0065 | 0.0613 | 0.0613 |
Brugia malayi | jmjC domain containing protein | 0.0065 | 0.0615 | 0.18 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0019 | 0.0018 | 0.0051 |
Onchocerca volvulus | 0.0063 | 0.0592 | 0.1475 | |
Wolbachia endosymbiont of Brugia malayi | 4'-phosphopantetheinyl transferase | 0.0028 | 0.0138 | 0.5 |
Onchocerca volvulus | 0.0066 | 0.0629 | 0.2142 | |
Echinococcus granulosus | JmjC domain containing protein 4 | 0.0017 | 0.0001 | 0.0001 |
Brugia malayi | Smad1 | 0.0019 | 0.0018 | 0.0051 |
Echinococcus multilocularis | tar DNA binding protein | 0.0212 | 0.2511 | 0.2511 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0154 | 0.1763 | 0.1763 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0043 | 0.0328 | 0.5 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0065 | 0.0613 | 0.0613 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0019 | 0.0018 | 0.0018 |
Schistosoma mansoni | lamin | 0.0063 | 0.0592 | 0.0592 |
Mycobacterium ulcerans | phosphopantetheinyl transferase, PptII | 0.0028 | 0.0138 | 0.5 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0129 | 0.144 | 1 |
Loa Loa (eye worm) | histone methyltransferase | 0.002 | 0.0041 | 0.012 |
Echinococcus granulosus | Jumonji AT rich interactive domain 1B | 0.0021 | 0.005 | 0.005 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0225 | 0.267 | 0.267 |
Brugia malayi | MH1 domain containing protein | 0.0019 | 0.0018 | 0.0051 |
Schistosoma mansoni | protein phosphatase 2C | 0.0017 | 0.0001 | 0.0001 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.1001 | 0.293 |
Trypanosoma cruzi | JmjC domain, hydroxylase, putative | 0.0017 | 0.0001 | 0.5 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0159 | 0.1821 | 0.1821 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0001 | 0.0003 |
Echinococcus multilocularis | jumonji domain containing 1A | 0.0017 | 0.0001 | 0.0001 |
Mycobacterium tuberculosis | holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie | 0.0028 | 0.0138 | 0.5 |
Echinococcus multilocularis | JmjC domain containing protein 4 | 0.0017 | 0.0001 | 0.0001 |
Echinococcus granulosus | smad | 0.0019 | 0.0018 | 0.0018 |
Brugia malayi | hypothetical protein | 0.0283 | 0.3417 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0455 | 0.0455 |
Brugia malayi | MH2 domain containing protein | 0.0019 | 0.0018 | 0.0051 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0047 | 0.0378 | 0.2623 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0019 | 0.0018 | 0.0018 |
Brugia malayi | jmjC domain containing protein | 0.0069 | 0.0664 | 0.1942 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0019 | 0.0018 | 0.0018 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0057 | 0.0512 | 0.0512 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0171 | 0.05 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0031 | 0.0171 | 0.0171 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0055 | 0.048 | 0.1406 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0592 | 0.1733 |
Echinococcus granulosus | geminin | 0.0186 | 0.2166 | 0.2166 |
Echinococcus granulosus | phd:f box containing protein | 0.0017 | 0.0001 | 0.0001 |
Echinococcus multilocularis | lamin dm0 | 0.0063 | 0.0592 | 0.0592 |
Schistosoma mansoni | hypothetical protein | 0.0058 | 0.052 | 0.052 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0099 | 0.1057 | 0.1057 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0156 | 0.0456 |
Schistosoma mansoni | cpg binding protein | 0.007 | 0.0677 | 0.0677 |
Schistosoma mansoni | jumonji domain containing protein | 0.0065 | 0.0615 | 0.0615 |
Schistosoma mansoni | tar DNA-binding protein | 0.0212 | 0.2511 | 0.2511 |
Echinococcus granulosus | Smad4 | 0.0019 | 0.0018 | 0.0018 |
Loa Loa (eye worm) | MBCTL1 | 0.0065 | 0.0613 | 0.1795 |
Schistosoma mansoni | tar DNA-binding protein | 0.0212 | 0.2511 | 0.2511 |
Schistosoma mansoni | smad | 0.0019 | 0.0018 | 0.0018 |
Trypanosoma cruzi | JmjC domain, hydroxylase, putative | 0.0017 | 0.0001 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0613 | 0.1795 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0047 | 0.0378 | 0.0378 |
Echinococcus multilocularis | lamin | 0.0063 | 0.0592 | 0.0592 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0795 | 1 | 1 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0099 | 0.1057 | 0.1057 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0043 | 0.0328 | 1 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase superfamily protein | 0.0028 | 0.0138 | 0.0949 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0159 | 0.1821 | 0.1821 |
Plasmodium falciparum | holo-[acyl-carrier-protein] synthase, putative | 0.0028 | 0.0138 | 0.4171 |
Leishmania major | phosphopantetheinyl transferase-like protein | 0.0028 | 0.0138 | 1 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0057 | 0.0512 | 0.0512 |
Schistosoma mansoni | smad1 5 8 and | 0.0019 | 0.0018 | 0.0018 |
Schistosoma mansoni | survival motor neuron protein | 0.0058 | 0.052 | 0.052 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0057 | 0.0512 | 0.1498 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0055 | 0.048 | 0.1406 |
Schistosoma mansoni | intermediate filament proteins | 0.0063 | 0.0592 | 0.0592 |
Brugia malayi | mbt repeat family protein | 0.0057 | 0.0512 | 0.1498 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0063 | 0.0592 | 0.1733 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.0539 | 0.1577 |
Brugia malayi | jmjC domain containing protein | 0.0017 | 0.0001 | 0.0003 |
Echinococcus multilocularis | musashi | 0.0063 | 0.0592 | 0.0592 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0065 | 0.0613 | 0.0613 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0512 | 0.1498 |
Schistosoma mansoni | phosphatidylserine receptor | 0.0017 | 0.0001 | 0.0001 |
Brugia malayi | MH2 domain containing protein | 0.0019 | 0.0018 | 0.0051 |
Schistosoma mansoni | smad1 5 8 and | 0.0019 | 0.0018 | 0.0018 |
Loa Loa (eye worm) | Smad1 | 0.0019 | 0.0018 | 0.0051 |
Brugia malayi | jmjC domain containing protein | 0.0017 | 0.0001 | 0.0003 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0795 | 1 | 1 |
Onchocerca volvulus | 0.0059 | 0.0539 | 0.0496 | |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0047 | 0.0378 | 1 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0057 | 0.0512 | 0.0512 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1057 | 0.3094 |
Schistosoma mansoni | cpg binding protein | 0.0066 | 0.0629 | 0.0629 |
Echinococcus multilocularis | smad | 0.0019 | 0.0018 | 0.0018 |
Echinococcus granulosus | intermediate filament protein | 0.0063 | 0.0592 | 0.0592 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0258 | 0.0755 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0065 | 0.0615 | 0.0615 |
Echinococcus granulosus | tar DNA binding protein | 0.0212 | 0.2511 | 0.2511 |
Onchocerca volvulus | 0.0058 | 0.052 | 0.015 | |
Onchocerca volvulus | 0.0099 | 0.1057 | 1 | |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0099 | 0.1057 | 0.3094 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0057 | 0.0512 | 0.0512 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0069 | 0.0664 | 0.0664 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0185 | 0.2161 | 0.2161 |
Entamoeba histolytica | Acid sphingomyelinase-like phosphodiesterase, putative | 0.0095 | 0.1001 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0017 | 0.0001 | 0.0003 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0059 | 0.0539 | 0.0539 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.0455 | 0.0455 |
Schistosoma mansoni | tar DNA-binding protein | 0.0212 | 0.2511 | 0.2511 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0223 | 0.2642 | 0.7732 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0017 | 0.0001 | 0.0003 |
Echinococcus multilocularis | lysine specific demethylase 6a | 0.0017 | 0.0001 | 0.0001 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0063 | 0.0592 | 0.1733 |
Echinococcus granulosus | lysine specific demethylase 6a | 0.0017 | 0.0001 | 0.0001 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0043 | 0.0328 | 0.221 |
Echinococcus multilocularis | Jumonji, AT rich interactive domain 1B | 0.0021 | 0.005 | 0.005 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.0258 | 0.0755 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0053 | 0.0455 | 0.1333 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0069 | 0.0664 | 0.0664 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0034 | 0.0214 | 0.0626 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0019 | 0.0018 | 0.0018 |
Entamoeba histolytica | Acid sphingomyelinase-like phosphodiesterase, putative | 0.0095 | 0.1001 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0186 | 0.2166 | 0.2166 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0156 | 0.0456 |
Treponema pallidum | 4'-phosphopantetheinyl transferase | 0.0028 | 0.0138 | 0.5 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0185 | 0.2161 | 0.2161 |
Echinococcus granulosus | jumonji domain containing 1A | 0.0017 | 0.0001 | 0.0001 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0047 | 0.0378 | 0.5 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.002 | 0.0038 | 0.011 |
Plasmodium vivax | holo-[acyl-carrier-protein] synthase, putative | 0.0028 | 0.0138 | 0.3618 |
Schistosoma mansoni | tar DNA-binding protein | 0.0212 | 0.2511 | 0.2511 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 10.43 % | Anticancer activity against human A549 lung cancer cells assessed as decrease in cell viability at 20 uM after 48 hrs relative to control by MTT assay | ChEMBL. | 19683442 |
Activity (functional) | = 44.46 % | Anticancer activity against human A549 lung cancer cells assessed as decrease in cell viability at 10 uM after 48 hrs relative to control by MTT assay | ChEMBL. | 19683442 |
Activity (functional) | = 59.32 % | Anticancer activity against human A549 lung cancer cells assessed as decrease in cell viability at 10 uM after 24 hrs relative to control by MTT assay | ChEMBL. | 19683442 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.