Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ELOVL fatty acid elongase 6 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | Fatty acid elongase | ELOVL fatty acid elongase 6 | 265 aa | 259 aa | 34.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0036 | 0.0925 | 0.1313 |
Toxoplasma gondii | integral membrane protein, GNS1/SUR4 family protein, putative | 0.005 | 0.2901 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0742 | 0.1054 |
Leishmania major | fatty acid elongase, putative | 0.005 | 0.2901 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.312 | 0.6667 |
Brugia malayi | jmjC domain containing protein | 0.0036 | 0.0925 | 0.0925 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0042 | 0.1721 | 0.1721 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.005 | 0.2901 | 0.5 |
Leishmania major | fatty acid elongase, putative | 0.005 | 0.2901 | 0.5 |
Schistosoma mansoni | jumonji domain containing protein | 0.0078 | 0.7041 | 1 |
Trypanosoma brucei | Fatty acid elongase | 0.005 | 0.2901 | 0.5 |
Loa Loa (eye worm) | fatty acid elongation protein 3 | 0.005 | 0.2901 | 0.6198 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.312 | 0.312 |
Plasmodium falciparum | long chain fatty acid elongation enzyme, putative | 0.005 | 0.2901 | 1 |
Plasmodium falciparum | fatty acid elongation protein, GNS1/SUR4 family, putative | 0.005 | 0.2901 | 1 |
Leishmania major | fatty acid elongase, putative | 0.005 | 0.2901 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.0742 | 0.0742 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0062 | 0.468 | 1 |
Brugia malayi | GNS1/SUR4 family protein | 0.005 | 0.2901 | 0.2901 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.312 | 0.312 |
Plasmodium vivax | GNS1/SUR4 domain containing protein | 0.005 | 0.2901 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.312 | 0.6667 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0742 | 0.1586 |
Brugia malayi | Fatty acid elongation protein 3 | 0.005 | 0.2901 | 0.2901 |
Echinococcus granulosus | jumonji domain containing protein | 0.0042 | 0.1721 | 0.1721 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.314 | 0.6709 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.005 | 0.2901 | 0.5 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0036 | 0.0925 | 0.1976 |
Toxoplasma gondii | GNS1/SUR4 family protein | 0.005 | 0.2901 | 1 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0036 | 0.0925 | 0.0925 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.005 | 0.2901 | 0.5 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0036 | 0.0925 | 0.0925 |
Loa Loa (eye worm) | GNS1/SUR4 family protein | 0.005 | 0.2901 | 0.6198 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0036 | 0.0925 | 0.1313 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.005 | 0.2901 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 95 nM | Inhibition of human ELOVL6 expressed in Pichia pastoris using palmitoyl-CoA by long chain fatty acyl-CoA elongation assay | ChEMBL. | 19883081 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.