TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 284.316 | Formula: C14H16N6O
H donors: 3 H acceptors: 5 LogP: 2.25 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: OCCCCNc1nc(Nc2ccccc2)nc(n1)C#N
InChi: 1S/C14H16N6O/c15-10-12-18-13(16-8-4-5-9-21)20-14(19-12)17-11-6-2-1-3-7-11/h1-3,6-7,21H,4-5,8-9H2,(H2,16,17,18,19,20)
InChiKey: YHCATQSMTANJFQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Trypanosoma cruzi	cysteine peptidase, putative	Starlite/ChEMBL	References
Carica papaya	Papain	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Onchocerca volvulus	Cathepsin L homolog	Papain	345 aa	317 aa	33.8 %
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Papain	345 aa	328 aa	33.5 %
Echinococcus multilocularis	cathepsin L	Papain	345 aa	352 aa	36.4 %
Onchocerca volvulus		Papain	345 aa	307 aa	35.5 %
Dictyostelium discoideum	cathepsin L-like proteinase	Papain	345 aa	330 aa	37.3 %
Giardia lamblia	Dipeptidyl-peptidase I precursor	Papain	345 aa	280 aa	29.6 %
Theileria parva	cysteine proteinase, putative	Papain	345 aa	307 aa	29.0 %
Babesia bovis	papain family cysteine protease containing protein	Papain	345 aa	342 aa	31.0 %
Drosophila melanogaster	CG6347 gene product from transcript CG6347-RA	Papain	345 aa	355 aa	30.4 %
Plasmodium yoelii	cysteine proteinase precursor	Papain	345 aa	346 aa	30.6 %
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	Papain	345 aa	320 aa	28.4 %
Onchocerca volvulus		Papain	345 aa	326 aa	31.9 %
Onchocerca volvulus	Protein MCM10 homolog	Papain	345 aa	294 aa	34.7 %
Entamoeba histolytica	cysteine protease, putative	Papain	345 aa	361 aa	24.9 %
Entamoeba histolytica	cysteine protease, putative	Papain	345 aa	321 aa	29.3 %
Entamoeba histolytica	cysteine protease, putative	Papain	345 aa	351 aa	25.1 %
Brugia malayi	cathepsin B-like cysteine proteinase	Papain	345 aa	306 aa	26.1 %
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	Papain	345 aa	324 aa	35.2 %
Echinococcus granulosus	cathepsin b	Papain	345 aa	321 aa	25.9 %
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Papain	345 aa	323 aa	26.3 %
Entamoeba histolytica	cysteine protease, putative	Papain	345 aa	351 aa	25.1 %
Plasmodium vivax	vivapain-1	Papain	345 aa	360 aa	30.0 %
Plasmodium berghei	berghepain-1	Papain	345 aa	345 aa	29.9 %
Onchocerca volvulus		Papain	345 aa	344 aa	23.3 %
Onchocerca volvulus		Papain	345 aa	324 aa	32.1 %
Entamoeba histolytica	cysteine protease, putative	Papain	345 aa	357 aa	26.9 %
Entamoeba histolytica	cysteine protease, putative	Papain	345 aa	302 aa	24.8 %
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Papain	345 aa	328 aa	33.5 %
Schistosoma japonicum	Disco-interacting protein 2 homolog B, putative	Papain	345 aa	342 aa	30.7 %
Theileria parva	cysteine proteinase, putative	Papain	345 aa	324 aa	32.1 %
Neospora caninum	hypothetical protein	Papain	345 aa	297 aa	23.2 %
Entamoeba histolytica	cysteine protease, putative	Papain	345 aa	351 aa	25.1 %
Onchocerca volvulus		Papain	345 aa	312 aa	35.6 %
Theileria parva	cysteine proteinase, putative	Papain	345 aa	350 aa	29.4 %
Giardia lamblia	Dipeptidyl-peptidase I precursor	Papain	345 aa	281 aa	26.0 %
Entamoeba histolytica	cysteine protease, putative	Papain	345 aa	318 aa	22.3 %
Trypanosoma cruzi	cysteine protease, putative	Papain	345 aa	344 aa	30.8 %
Echinococcus multilocularis	cathepsin L	Papain	345 aa	355 aa	27.3 %
Trypanosoma cruzi	cysteine proteinase, putative	Papain	345 aa	298 aa	29.2 %
Schistosoma japonicum	ko:K01275 cathepsin C [EC3.4.14.1], putative	Papain	345 aa	313 aa	29.7 %
Entamoeba histolytica	cysteine protease, putative	Papain	345 aa	392 aa	23.0 %
Trypanosoma cruzi	cysteine proteinase, putative	Papain	345 aa	299 aa	30.1 %
Entamoeba histolytica	cysteine protease, putative	Papain	345 aa	373 aa	27.3 %
Plasmodium falciparum	cysteine proteinase falcipain 1	Papain	345 aa	376 aa	30.6 %
Entamoeba histolytica	cysteine protease, putative	Papain	345 aa	351 aa	25.1 %
Echinococcus granulosus	cathepsin L	Papain	345 aa	356 aa	36.0 %
Plasmodium vivax	unspecified product	Papain	345 aa	358 aa	30.2 %
Entamoeba histolytica	cysteine protease, putative	Papain	345 aa	343 aa	25.4 %
Entamoeba histolytica	cysteine protease, putative	Papain	345 aa	291 aa	24.1 %
Echinococcus granulosus	cathepsin L	Papain	345 aa	316 aa	29.1 %
Plasmodium vivax	vivapain-3	Papain	345 aa	340 aa	33.2 %
Brugia malayi	Papain family cysteine protease containing protein	Papain	345 aa	308 aa	27.6 %
Plasmodium knowlesi	knowpain-1	Papain	345 aa	396 aa	29.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0047	0.287	1
Schistosoma mansoni	hypothetical protein	0.0069	0.5631	1
Loa Loa (eye worm)	ctsf protein	0.0047	0.287	0.2923
Leishmania major	cathepsin L-like protease	0.0047	0.287	0.282
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0047	0.287	1
Onchocerca volvulus	Cathepsin L homolog	0.0047	0.287	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.287	1
Schistosoma mansoni	hypothetical protein	0.0032	0.0968	0.172
Brugia malayi	Cathepsin L-like precursor	0.0047	0.287	0.2975
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0101	0.9649	1
Loa Loa (eye worm)	fibroinase	0.0047	0.287	0.2923
Trypanosoma cruzi	cysteine peptidase, putative	0.0047	0.287	0.287
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.007	0.007
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0047	0.287	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0913	0.3182
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0032	0.0968	0.2168
Onchocerca volvulus		0.0047	0.287	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0047	0.287	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0047	0.287	1
Brugia malayi	Latrophilin receptor protein 2	0.0032	0.0968	0.1004
Schistosoma mansoni	cathepsin F (C01 family)	0.0047	0.287	0.5097
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.287	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0047	0.287	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0047	0.287	0.2923
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0968	0.0938
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.006	0.4466	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.287	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0047	0.287	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0047	0.287	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.4466	0.5
Brugia malayi	Cathepsin L-like precursor	0.0032	0.0913	0.0947
Echinococcus multilocularis	cysteine protease	0.0047	0.287	0.6428
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0032	0.0968	0.2168
Schistosoma mansoni	aldehyde dehydrogenase	0.006	0.4466	0.793
Echinococcus granulosus	GPCR family 2	0.0032	0.0968	0.2168
Entamoeba histolytica	cysteine protease, putative	0.0047	0.287	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0047	0.287	0.6428
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0047	0.287	0.6428
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0913	0.3182
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0047	0.287	0.6428
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0047	0.287	1
Leishmania major	cysteine peptidase A (CPA)	0.0047	0.287	0.282
Trypanosoma cruzi	major cysteine proteinase, putative	0.0066	0.5172	0.5172
Schistosoma mansoni	aldehyde dehydrogenase	0.006	0.4466	0.793
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0032	0.0968	0.2168
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0047	0.287	1
Echinococcus granulosus	cathepsin l1	0.0047	0.287	0.6428
Echinococcus multilocularis	cathepsin L cysteine protease	0.0047	0.287	0.6428
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.007	0.0244
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.287	1
Onchocerca volvulus		0.0047	0.287	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0101	0.9649	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0032	0.0968	0.2168
Brugia malayi	latrophilin 2 splice variant baaae	0.0069	0.5631	0.5836
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0913	0.088
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.287	1
Loa Loa (eye worm)	hypothetical protein	0.0101	0.9649	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0032	0.0913	0.0947
Entamoeba histolytica	cysteine proteinase, putative	0.0047	0.287	1
Brugia malayi	Cathepsin L-like precursor	0.0047	0.287	0.2975
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.007	0.007
Brugia malayi	Papain family cysteine protease containing protein	0.0047	0.287	0.2975
Loa Loa (eye worm)	hypothetical protein	0.0047	0.287	0.2923
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0047	0.287	1
Onchocerca volvulus		0.0047	0.287	1
Schistosoma mansoni	hypothetical protein	0.0032	0.0968	0.172
Toxoplasma gondii	aldehyde dehydrogenase	0.006	0.4466	1
Brugia malayi	Cathepsin L-like precursor	0.0032	0.0913	0.0947
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.287	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.287	1
Leishmania major	cathepsin L-like protease	0.0047	0.287	0.282
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.287	1
Schistosoma mansoni	hypothetical protein	0.0032	0.0968	0.172
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.007	0.007
Schistosoma mansoni	cathepsin F (C01 family)	0.0032	0.0913	0.1622
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0047	0.287	0.6428
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0088	0.8043	0.8043
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.287	1
Onchocerca volvulus		0.0047	0.287	1
Entamoeba histolytica	cysteine proteinase, putative	0.0047	0.287	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.007	0.0244
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0047	0.287	0.6428
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0913	0.088
Echinococcus multilocularis	GPCR, family 2	0.0032	0.0968	0.2168
Echinococcus multilocularis	cysteine protease	0.0047	0.287	0.6428
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0032	0.0968	0.1004
Onchocerca volvulus		0.0047	0.287	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0047	0.287	1
Onchocerca volvulus	Cathepsin F homolog	0.0047	0.287	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.287	1
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.006	0.4466	1
Brugia malayi	cathepsin L-like precursor	0.0032	0.0913	0.0947
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.287	1
Loa Loa (eye worm)	cysteine protease	0.0047	0.287	0.2923
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.007	0.0244
Onchocerca volvulus		0.0047	0.287	1
Leishmania major	cathepsin L-like protease	0.0047	0.287	0.282
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.4466	0.5
Brugia malayi	Cathepsin L-like precursor	0.0047	0.287	0.2975
Entamoeba histolytica	cysteine proteinase, putative	0.0032	0.0913	0.3182
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.287	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0913	0.088
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.287	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0032	0.0968	0.0938
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.006	0.4466	0.4426
Onchocerca volvulus		0.0047	0.287	1
Leishmania major	cathepsin L-like protease	0.0047	0.287	0.282
Leishmania major	cathepsin L-like protease	0.0047	0.287	0.282
Onchocerca volvulus	Cathepsin L homolog	0.0047	0.287	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.4466	0.5
Loa Loa (eye worm)	hypothetical protein	0.0069	0.5631	0.5805
Brugia malayi	Cathepsin L-like precursor	0.0047	0.287	0.2975
Plasmodium vivax	vivapain-2	0.0047	0.287	1
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.006	0.4466	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0101	0.9649	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0047	0.287	0.2923
Toxoplasma gondii	cathepsin CPL	0.0047	0.287	0.6371
Brugia malayi	hypothetical protein	0.0025	0.007	0.0073
Schistosoma mansoni	cathepsin F (C01 family)	0.0047	0.287	0.5097
Schistosoma mansoni	hypothetical protein	0.0032	0.0968	0.172
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0047	0.287	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0047	0.287	1
Plasmodium vivax	vivapain-2	0.0047	0.287	1
Echinococcus granulosus	cathepsin l1	0.0032	0.0913	0.2045
Brugia malayi	Cathepsin L-like precursor	0.0047	0.287	0.2975
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.287	1
Brugia malayi	Cathepsin L-like precursor	0.0047	0.287	0.2975

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.89 uM	Inhibition of Trypanosoma cruzi cruzain after 15 mins	ChEMBL.	19908842
Potency (functional)	= 0.8913 um	PUBCHEM_BIOASSAY: Confirmation qHTS Assay for Inhibitors of Cruzain. (Class of assay: confirmatory) [Related pubchem assays: 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1476 (cruzain qHTS without detergent), 1478 (cruzain qHTS with detergent)]	ChEMBL.	No reference
Potency (functional)	= 2.2387 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay. (Class of assay: confirmatory) [Related pubchem assays: 1476 (Cruzain without detergent), 1478 (Cruzain with detergent)]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL567137

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1067548