Detailed information for compound 1067702

Basic information

Technical information
  • TDR Targets ID: 1067702
  • Name: 1-(4-bromophenyl)-5-(phenylsulfonylmethyl)tet razole
  • MW: 379.232 | Formula: C14H11BrN4O2S
  • H donors: 0 H acceptors: 5 LogP: 2.68 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1ccc(cc1)n1nnnc1CS(=O)(=O)c1ccccc1
  • InChi: 1S/C14H11BrN4O2S/c15-11-6-8-12(9-7-11)19-14(16-17-18-19)10-22(20,21)13-4-2-1-3-5-13/h1-9H,10H2
  • InChiKey: COMOKSRDBKKMIW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(4-bromophenyl)-5-(phenylsulfonylmethyl)-1,2,3,4-tetrazole
  • ZINC06760236

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni survival motor neuron protein 0.0051 0.0806 0.1398
Loa Loa (eye worm) hypothetical protein 0.0251 0.4954 0.5113
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.1097 0.1903
Mycobacterium tuberculosis Conserved protein 0.0038 0.0532 0.1113
Schistosoma mansoni hypothetical protein 0.0033 0.0436 0.0757
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0089 0.0089
Schistosoma mansoni hypothetical protein 0.0024 0.0236 0.0409
Brugia malayi beta-lactamase 0.0038 0.0532 0.0549
Brugia malayi beta-lactamase family protein 0.0038 0.0532 0.0549
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0042 0.0617 1
Schistosoma mansoni hypothetical protein 0.017 0.328 0.5688
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0532 0.1113
Mycobacterium ulcerans acyl-CoA synthetase 0.0042 0.0617 0.107
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0072 0.1237 0.1276
Schistosoma mansoni tar DNA-binding protein 0.0134 0.2526 0.438
Brugia malayi AMP-binding enzyme family protein 0.0042 0.0617 0.0637
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0105 0.1933 0.1995
Echinococcus multilocularis geminin 0.017 0.328 0.328
Leishmania major hypothetical protein, conserved 0.0028 0.0332 0.2684
Schistosoma mansoni phd/f-box containing protein 0.0028 0.0332 0.0576
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0155 0.1411
Loa Loa (eye worm) hypothetical protein 0.0031 0.0396 0.0409
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.003 0.036 0.0754
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0841 1
Onchocerca volvulus 0.0042 0.0617 0.1209
Trypanosoma brucei unspecified product 0.0014 0.003 0.0244
Leishmania major 4-coumarate:coa ligase-like protein 0.0042 0.0617 0.4988
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0159 0.0276
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0532 0.1113
Echinococcus multilocularis lysine specific demethylase 5A 0.0106 0.195 0.195
Loa Loa (eye worm) hypothetical protein 0.0038 0.0532 0.0549
Plasmodium falciparum JmjC domain-containing protein, putative 0.0028 0.0332 0.3948
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0436 0.0436
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0031 0.0396 0.0687
Loa Loa (eye worm) hypothetical protein 0.0031 0.0396 0.0409
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0841 0.6799
Schistosoma mansoni ap endonuclease 0.002 0.0169 0.0293
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.1097 0.8873
Echinococcus multilocularis tar DNA binding protein 0.0134 0.2526 0.2526
Brugia malayi Calcitonin receptor-like protein seb-1 0.0105 0.1933 0.1995
Brugia malayi AMP-binding enzyme family protein 0.0042 0.0617 0.0637
Echinococcus multilocularis jumonji domain containing protein 0.0044 0.0667 0.0667
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0042 0.0617 0.107
Schistosoma mansoni hypothetical protein 0.017 0.328 0.5688
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1706 0.2958
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0169 0.0169
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.003 0.0244
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0159 0.1287
Mycobacterium tuberculosis Conserved protein 0.0038 0.0532 0.1113
Schistosoma mansoni hypothetical protein 0.0032 0.0407 0.0707
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0089 0.1064
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0155 0.1252
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0159 0.1287
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0159 0.1287
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0028 0.0332 0.0332
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0155 0.016
Loa Loa (eye worm) hypothetical protein 0.0038 0.0532 0.0549
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0072 0.1237 1
Echinococcus granulosus tumor protein p63 0.0358 0.7188 0.7188
Echinococcus multilocularis lysine specific demethylase 6a 0.0028 0.0332 0.0332
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0436 0.045
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0532 0.4301
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0436 0.045
Schistosoma mansoni tar DNA-binding protein 0.0134 0.2526 0.438
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0155 0.0268
Brugia malayi AMP-binding enzyme family protein 0.0042 0.0617 0.0637
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0159 0.1287
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0436 0.045
Loa Loa (eye worm) hypothetical protein 0.0258 0.5101 0.5264
Mycobacterium ulcerans lipase LipD 0.0038 0.0532 0.0922
Echinococcus granulosus tar DNA binding protein 0.0134 0.2526 0.2526
Mycobacterium ulcerans acyl-CoA synthetase 0.0042 0.0617 0.107
Schistosoma mansoni hypothetical protein 0.0072 0.124 0.2151
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0169 0.0174
Schistosoma mansoni ap endonuclease 0.002 0.0169 0.0293
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0532 0.1113
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0169 0.1366
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0105 0.1933 0.1995
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0072 0.1237 0.1276
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.0038 0.0532 0.0549
Loa Loa (eye worm) hypothetical protein 0.0032 0.0407 0.0421
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0532 0.1113
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0089 0.0723
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0032 0.0407 0.0707
Plasmodium falciparum acyl-CoA synthetase 0.0031 0.0396 0.4711
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0407 0.4845
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0089 0.0723
Brugia malayi hypothetical protein 0.0258 0.5101 0.5264
Brugia malayi Bromodomain containing protein 0.0032 0.0407 0.0421
Echinococcus granulosus geminin 0.017 0.328 0.328
Brugia malayi hypothetical protein 0.0053 0.0841 0.0868
Entamoeba histolytica acyl-CoA synthetase, putative 0.0042 0.0617 0.4988
Brugia malayi follicle stimulating hormone receptor 0.0478 0.9689 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0089 0.0089
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0532 0.0922
Brugia malayi jmjC domain containing protein 0.0172 0.3321 0.3427
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0169 0.1366
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0532 0.0922
Onchocerca volvulus Alhambra homolog 0.0032 0.0407 0.0799
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.003 0.036 0.0754
Mycobacterium leprae Probable lipase LipE 0.0038 0.0532 0.8622
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0031 0.0396 0.0829
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0833 0.1445
Loa Loa (eye worm) hypothetical protein 0.0052 0.0833 0.086
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0532 0.0922
Mycobacterium ulcerans acyl-CoA synthetase 0.0042 0.0617 0.107
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0042 0.0617 0.107
Echinococcus multilocularis tumor protein p63 0.0358 0.7188 0.7188
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0841 1
Giardia lamblia PHD finger protein 15 0.0032 0.0407 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0841 0.0868
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0169 0.1366
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0159 0.0276
Loa Loa (eye worm) glutaminase 0.029 0.5767 0.5952
Loa Loa (eye worm) hypothetical protein 0.0258 0.5101 0.5264
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0042 0.0617 0.107
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.1237 1
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0169 0.0174
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.1706 0.1761
Echinococcus multilocularis dna polymerase eta 0.002 0.0159 0.0159
Loa Loa (eye worm) hypothetical protein 0.002 0.0155 0.016
Loa Loa (eye worm) hypothetical protein 0.0042 0.0617 0.0637
Mycobacterium ulcerans hypothetical protein 0.0038 0.0532 0.0922
Schistosoma mansoni glutaminase 0.029 0.5767 1
Brugia malayi PHD-finger family protein 0.0032 0.0407 0.0421
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0532 0.0922
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0042 0.0617 0.1291
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.1097 0.1097
Echinococcus multilocularis JmjC domain containing protein 4 0.0028 0.0332 0.0332
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0169 0.0293
Schistosoma mansoni DNA helicase recq5 0.002 0.0155 0.0268
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0028 0.0332 0.3025
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0159 0.0159
Leishmania major DNA polymerase eta, putative 0.002 0.0159 0.1287
Schistosoma mansoni jumonji/arid domain-containing protein 0.0106 0.195 0.3382
Echinococcus multilocularis GPCR, family 2 0.0033 0.0436 0.0436
Leishmania major DNA polymerase kappa, putative 0.002 0.0159 0.1287
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0155 0.0268
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0532 0.1113
Echinococcus multilocularis phd:f box containing protein 0.0028 0.0332 0.0332
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0155 0.1411
Onchocerca volvulus 0.0052 0.0833 0.1634
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0134 0.2526 0.2607
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0532 0.0549
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0028 0.0332 0.2684
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0159 0.1287
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0407 0.3713
Onchocerca volvulus 0.0038 0.0532 0.1043
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0159 0.0276
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0159 0.0333
Loa Loa (eye worm) hypothetical protein 0.0038 0.0532 0.0549
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.1706 0.1706
Echinococcus granulosus lysine specific demethylase 6a 0.0028 0.0332 0.0332
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0169 0.5
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0042 0.0617 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0042 0.0617 0.4988
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0089 0.0092
Entamoeba histolytica acyl-coA synthetase, putative 0.0042 0.0617 0.4988
Leishmania major hypothetical protein, conserved 0.0038 0.0532 0.4301
Mycobacterium ulcerans hypothetical protein 0.0042 0.0617 0.107
Schistosoma mansoni hypothetical protein 0.0033 0.0436 0.0757
Plasmodium vivax acyl-CoA synthetase, putative 0.0031 0.0396 0.4711
Loa Loa (eye worm) hypothetical protein 0.0031 0.0396 0.0409
Brugia malayi jmjC domain containing protein 0.0028 0.0332 0.0343
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0089 0.0815
Mycobacterium ulcerans glutaminase 0.029 0.5767 1
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0155 0.0268
Brugia malayi hypothetical protein 0.0251 0.4954 0.5113
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0159 0.0164
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0436 0.0436
Echinococcus granulosus PHD finger protein rhinoceros 0.0032 0.0407 0.0407
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0072 0.1237 0.2145
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0028 0.0332 0.3025
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0155 0.1252
Echinococcus multilocularis jumonji domain containing 1A 0.0028 0.0332 0.0332
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0089 0.0155
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.1706 0.1706
Trichomonas vaginalis esterase, putative 0.0038 0.0532 0.0922
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0159 0.1287
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.003 0.0244
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.1097 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0532 0.0532
Schistosoma mansoni DNA helicase recq1 0.002 0.0155 0.0268
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0169 0.0354
Brugia malayi RNA binding protein 0.0134 0.2526 0.2607
Echinococcus granulosus survival motor neuron protein 1 0.0251 0.4954 0.4954
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0031 0.0396 0.5
Echinococcus granulosus bloom syndrome protein 0.002 0.0155 0.0155
Brugia malayi RNA recognition motif domain containing protein 0.0134 0.2526 0.2607
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0028 0.0332 0.2684
Brugia malayi glutaminase DH11.1 0.029 0.5767 0.5952
Trypanosoma brucei PAB1-binding protein , putative 0.0053 0.0841 0.6799
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0042 0.0617 0.1291
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0072 0.1237 0.1237
Trichomonas vaginalis glutaminase, putative 0.029 0.5767 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0236 0.0236
Echinococcus granulosus JmjC domain containing protein 4 0.0028 0.0332 0.0332
Echinococcus granulosus peregrin 0.0032 0.0407 0.0407
Loa Loa (eye worm) hypothetical protein 0.002 0.0159 0.0164
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0532 0.1113
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0028 0.0332 0.2684
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0159 0.1287
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0159 0.1287
Schistosoma mansoni jumonji domain containing protein 0.0028 0.0332 0.0576
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0169 0.0293
Loa Loa (eye worm) beta-lactamase 0.0038 0.0532 0.0549
Echinococcus granulosus lysine specific demethylase 5A 0.0106 0.195 0.195
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0159 0.0159
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0532 0.1113
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0841 0.6799
Schistosoma mansoni tar DNA-binding protein 0.0134 0.2526 0.438
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0159 0.0276
Leishmania major 4-coumarate:coa ligase-like protein 0.0042 0.0617 0.4988
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0407 0.3713
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0532 0.0922
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0089 0.0089
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.003 0.036 0.0754
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0089 0.0815
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0159 0.0276
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.124 0.128
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0532 0.4301
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.1097 0.1903
Schistosoma mansoni jumonji domain containing protein 0.0151 0.2874 0.4984
Plasmodium vivax ataxin-2 like protein, putative 0.0053 0.0841 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0169 0.201
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0169 0.1366
Loa Loa (eye worm) hypothetical protein 0.0033 0.0436 0.045
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0236 0.0236
Schistosoma mansoni hypothetical protein 0.0051 0.0806 0.1398
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.1237 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0806 0.0832
Loa Loa (eye worm) hypothetical protein 0.0038 0.0532 0.0549
Mycobacterium tuberculosis Conserved protein 0.0038 0.0532 0.1113
Loa Loa (eye worm) hypothetical protein 0.0105 0.1933 0.1995
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0169 0.1366
Echinococcus multilocularis transcription factor Dp 1 0.0042 0.0608 0.0608
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0159 0.1287
Loa Loa (eye worm) hypothetical protein 0.0031 0.0396 0.0409
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0159 0.0276
Onchocerca volvulus Huntingtin homolog 0.0258 0.5101 1
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0089 0.1064
Loa Loa (eye worm) jmjC domain-containing protein 0.0066 0.1114 0.115
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0532 0.4301
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0155 0.0155
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0089 0.0089
Loa Loa (eye worm) glutaminase 2 0.029 0.5767 0.5952
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0436 0.0436
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0436 0.0436
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0072 0.1237 0.1237
Toxoplasma gondii exonuclease III APE 0.002 0.0169 0.154
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0159 0.1287
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0169 0.5
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0172 0.3321 0.3321
Toxoplasma gondii ABC1 family protein 0.0038 0.0532 0.4847
Loa Loa (eye worm) RNA binding protein 0.0134 0.2526 0.2607
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.1237 1
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0155 0.1841
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0532 0.8622
Onchocerca volvulus 0.0051 0.0806 0.1581
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.1706 0.1706
Echinococcus granulosus jumonji domain containing 1A 0.0028 0.0332 0.0332
Loa Loa (eye worm) jmjC domain-containing protein 0.0028 0.0332 0.0343
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0159 0.1287
Loa Loa (eye worm) jmjC domain-containing protein 0.0106 0.195 0.2013
Echinococcus granulosus dna polymerase eta 0.002 0.0159 0.0159
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0089 0.0092
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0159 0.0164
Loa Loa (eye worm) hypothetical protein 0.0028 0.0332 0.0343
Loa Loa (eye worm) hypothetical protein 0.0031 0.0396 0.0409
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0532 0.0922
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1706 0.2958
Entamoeba histolytica recQ family helicase, putative 0.002 0.0155 0.1252
Echinococcus granulosus GPCR family 2 0.0033 0.0436 0.0436
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0532 0.0549
Brugia malayi jmjC domain containing protein 0.0106 0.195 0.2013
Loa Loa (eye worm) hypothetical protein 0.0042 0.0617 0.0637
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0169 0.0293
Plasmodium falciparum phd finger protein, putative 0.0032 0.0407 0.4845
Loa Loa (eye worm) TAR-binding protein 0.0134 0.2526 0.2607
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0169 0.201
Echinococcus multilocularis bloom syndrome protein 0.002 0.0155 0.0155
Schistosoma mansoni hypothetical protein 0.0033 0.0436 0.0757
Loa Loa (eye worm) hypothetical protein 0.0073 0.1256 0.1296
Schistosoma mansoni protein phosphatase 2C 0.0028 0.0332 0.0576
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0169 0.0169
Brugia malayi beta-lactamase family protein 0.0038 0.0532 0.0549
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.1097 0.2296
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0172 0.3321 0.3321
Echinococcus granulosus jumonji domain containing protein 0.0044 0.0667 0.0667
Echinococcus granulosus dna polymerase kappa 0.002 0.0159 0.0159
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0532 0.0922
Loa Loa (eye worm) hypothetical protein 0.0038 0.0532 0.0549
Loa Loa (eye worm) jmjC domain-containing protein 0.0028 0.0332 0.0343
Brugia malayi jmjC domain containing protein 0.0028 0.0332 0.0343
Giardia lamblia DINP protein human, muc B family 0.002 0.0159 0.0175
Brugia malayi jmjC domain containing protein 0.0028 0.0332 0.0343
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0042 0.0617 0.107
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0478 0.9689 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0159 0.1287
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0028 0.0332 0.0576
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0159 0.1287
Trypanosoma brucei unspecified product 0.002 0.0159 0.1287
Onchocerca volvulus 0.0038 0.0532 0.1043
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1706 0.2958
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0155 0.016
Schistosoma mansoni DNA polymerase eta 0.002 0.0159 0.0276
Schistosoma mansoni tar DNA-binding protein 0.0134 0.2526 0.438
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0155 0.1841
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0159 0.0333
Schistosoma mansoni hypothetical protein 0.0033 0.0436 0.0757
Echinococcus granulosus phd:f box containing protein 0.0028 0.0332 0.0332
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0089 0.0723
Toxoplasma gondii LsmAD domain-containing protein 0.0053 0.0841 0.7663
Onchocerca volvulus 0.0038 0.0532 0.1043
Loa Loa (eye worm) PHD-finger family protein 0.0032 0.0407 0.0421
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0159 0.1287
Echinococcus multilocularis peregrin 0.0032 0.0407 0.0407
Leishmania major 4-coumarate:coa ligase-like protein 0.0042 0.0617 0.4988
Schistosoma mansoni phosphatidylserine receptor 0.0028 0.0332 0.0576
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0532 0.0922
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0155 0.0155
Loa Loa (eye worm) RecQ helicase 0.002 0.0155 0.016
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0159 0.1287
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0242 0.478 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0159 0.1287
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0155 0.016
Plasmodium vivax JmjC domain containing protein 0.0028 0.0332 0.3948
Brugia malayi jmjC domain containing protein 0.0028 0.0332 0.0343
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.003 0.0244
Loa Loa (eye worm) jmjC domain-containing protein 0.0028 0.0332 0.0343
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.1706 0.1706
Onchocerca volvulus Huntingtin homolog 0.0258 0.5101 1
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0159 0.0164
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0089 0.0723
Echinococcus granulosus transcription factor Dp 1 0.0042 0.0608 0.0608
Trypanosoma brucei unspecified product 0.0014 0.003 0.0244
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.003 0.036 0.0754
Loa Loa (eye worm) hypothetical protein 0.0042 0.0617 0.0637
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0159 0.1287
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0532 0.6325
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.1097 0.1903
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0089 0.0089
Mycobacterium ulcerans beta-lactamase 0.0038 0.0532 0.0922
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.1706 0.1761
Schistosoma mansoni tar DNA-binding protein 0.0134 0.2526 0.438
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0159 0.1287
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0159 0.1287
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0532 0.0922
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.0028 0.0332 0.0343
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0169 0.0562
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0532 0.0532
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0155 0.016
Echinococcus multilocularis survival motor neuron protein 1 0.0251 0.4954 0.4954
Brugia malayi hypothetical protein 0.0034 0.0452 0.0466
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.1097 0.1903
Echinococcus multilocularis PHD finger protein rhinoceros 0.0032 0.0407 0.0407
Echinococcus multilocularis dna polymerase kappa 0.002 0.0159 0.0159
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0089 0.0187
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0159 0.1287
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.1097 0.1097
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.1097 0.1903
Loa Loa (eye worm) hypothetical protein 0.0072 0.124 0.128
Leishmania major hypothetical protein, conserved 0.0053 0.0841 0.6799
Brugia malayi isocitrate dehydrogenase 0.0017 0.0089 0.0092
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0089 0.0723
Brugia malayi TAR-binding protein 0.0134 0.2526 0.2607
Schistosoma mansoni jumonji/arid domain-containing protein 0.0106 0.195 0.3382
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0072 0.1237 1
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0155 0.0155
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0155 0.1252
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0028 0.0332 0.0332
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0159 0.1287

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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