Detailed information for compound 1067854

Basic information

Technical information
  • TDR Targets ID: 1067854
  • Name: 4-[2-[ethyl-[2-oxo-2-(thiophen-2-ylmethylamin o)ethyl]amino]-2-oxoethoxy]benzamide
  • MW: 375.442 | Formula: C18H21N3O4S
  • H donors: 2 H acceptors: 3 LogP: 1.22 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(C(=O)COc1ccc(cc1)C(=O)N)CC(=O)NCc1cccs1
  • InChi: 1S/C18H21N3O4S/c1-2-21(11-16(22)20-10-15-4-3-9-26-15)17(23)12-25-14-7-5-13(6-8-14)18(19)24/h3-9H,2,10-12H2,1H3,(H2,19,24)(H,20,22)
  • InChiKey: GWRGAILAPFFDBF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[2-[ethyl-[2-oxo-2-(2-thienylmethylamino)ethyl]amino]-2-oxo-ethoxy]benzamide
  • 4-[2-[ethyl-[2-oxo-2-(2-thienylmethylamino)ethyl]amino]-2-oxoethoxy]benzamide
  • 4-[2-[ethyl-[2-keto-2-(2-thienylmethylamino)ethyl]amino]-2-keto-ethoxy]benzamide
  • 4-[2-[ethyl-[2-oxo-2-(thiophen-2-ylmethylamino)ethyl]amino]-2-oxo-ethoxy]benzamide
  • ZINC07467505
  • T5608283

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0037 0.0688 0.5
Brugia malayi glutaminase DH11.1 0.0284 0.7636 0.9165
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0032 0.0541 0.0509
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0037 0.0688 0.0657
Trichomonas vaginalis glucosylceramidase, putative 0.0203 0.5342 0.6378
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0037 0.0688 0.1453
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0102 0.2505 0.248
Plasmodium vivax glutathione reductase, putative 0.0108 0.2671 1
Brugia malayi Importin beta-1 subunit 0.0035 0.0608 0.073
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0102 0.2505 0.248
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0489 0.0499
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0309 0.8331 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0037 0.0688 0.2356
Schistosoma mansoni chromobox protein 0.0062 0.1387 0.1359
Schistosoma mansoni importin beta-1 0.0035 0.0608 0.0576
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0037 0.0682 0.2333
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0346 0.0325
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0032 0.0541 0.0509
Schistosoma mansoni hypothetical protein 0.0203 0.5342 0.5326
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0681 0.0732
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0518 0.0534
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0037 0.0688 0.2356
Loa Loa (eye worm) hypothetical protein 0.0014 0.0033 0.0033
Loa Loa (eye worm) intermediate filament protein 0.0024 0.0315 0.0315
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.013 0.3279 0.3256
Echinococcus granulosus chromobox protein 1 0.0062 0.1387 0.1359
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0681 0.0732
Plasmodium vivax thioredoxin reductase, putative 0.0108 0.2671 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0045 0.089 0.089
Plasmodium falciparum thioredoxin reductase 0.0037 0.0688 0.1453
Mycobacterium tuberculosis Probable dehydrogenase 0.0246 0.6558 0.8837
Trypanosoma brucei trypanothione reductase 0.0108 0.2671 1
Trichomonas vaginalis chromobox protein, putative 0.0038 0.0693 0.0746
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0037 0.0688 0.2356
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0038 0.0708 0.1537
Loa Loa (eye worm) hypothetical protein 0.0035 0.0608 0.0608
Brugia malayi acetyltransferase, GNAT family protein 0.013 0.3279 0.3935
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0618 0.0655
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0024 0.0315 0.0315
Loa Loa (eye worm) phosphatidylinositol 3 0.0047 0.095 0.095
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0027 0.0409 0.0491
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0346 0.0325
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0345 0.0324
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0346 0.0325
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.095 0.1057
Trichomonas vaginalis glucosylceramidase, putative 0.0214 0.5649 0.675
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0099 0.2417 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0614 0.065
Plasmodium falciparum glutathione reductase 0.0037 0.0688 0.1453
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0037 0.0682 0.2333
Schistosoma mansoni hypothetical protein 0.0203 0.5342 0.5326
Brugia malayi glutathione reductase 0.0108 0.2671 0.3206
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0022 0.0258 0.0696
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0246 0.6558 0.8837
Schistosoma mansoni lamin 0.0024 0.0315 0.0282
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0047 0.095 0.3364
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0274 0.733 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0037 0.0688 0.0826
Echinococcus granulosus chromobox protein 1 0.0062 0.1387 0.1359
Entamoeba histolytica hypothetical protein 0.0032 0.0541 0.0917
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0038 0.0708 0.0764
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0688 0.2356
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0016 0.0077 0.0093
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0608 0.2045
Echinococcus granulosus histone acetyltransferase KAT2B 0.0038 0.0708 0.0677
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0037 0.0688 0.1453
Trichomonas vaginalis mercuric reductase, putative 0.0037 0.0688 0.074
Brugia malayi hypothetical protein 0.0032 0.0541 0.0649
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0309 0.8331 0.8331
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0025 0.0351 0.0319
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0019 0.0182 0.0405
Onchocerca volvulus 0.0027 0.0406 0.0182
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0614 0.065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0422 0.0417
Loa Loa (eye worm) hypothetical protein 0.0099 0.2417 0.2417
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0274 0.733 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0037 0.0688 0.2356
Leishmania major trypanothione reductase 0.0108 0.2671 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0037 0.0688 0.1453
Echinococcus multilocularis lamin 0.0024 0.0315 0.0282
Trichomonas vaginalis chromobox protein, putative 0.0038 0.0693 0.0746
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0038 0.0708 0.1537
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0037 0.0688 0.0657
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0608 0.0576
Echinococcus granulosus lamin dm0 0.0024 0.0315 0.0282
Giardia lamblia GTOR 0.0047 0.095 1
Trichomonas vaginalis glucosylceramidase, putative 0.0203 0.5342 0.6378
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0037 0.0688 0.2356
Loa Loa (eye worm) hypothetical protein 0.003 0.0493 0.0493
Loa Loa (eye worm) hypothetical protein 0.0024 0.0315 0.0315
Entamoeba histolytica acetyltransferase, GNAT family 0.0035 0.0619 0.1293
Trichomonas vaginalis glucosylceramidase, putative 0.0309 0.8331 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0614 0.065
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0693 0.0752
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0422 0.0417
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0332 0.0308
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0345 0.0324
Onchocerca volvulus 0.0051 0.1084 0.1531
Brugia malayi Thioredoxin reductase 0.0108 0.2671 0.3206
Loa Loa (eye worm) latrophilin receptor protein 2 0.0014 0.0033 0.0033
Trichomonas vaginalis glucosylceramidase, putative 0.0309 0.8331 1
Mycobacterium ulcerans glutaminase 0.0284 0.7636 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0047 0.095 0.092
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0102 0.2505 0.248
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0681 0.0732
Plasmodium falciparum thioredoxin reductase 0.0108 0.2671 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0758 0.0825
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0047 0.095 0.114
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0614 0.065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0681 0.0732
Schistosoma mansoni hypothetical protein 0.003 0.0493 0.0461
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0047 0.095 0.3364
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0037 0.0688 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.0309 0.8331 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0045 0.089 0.1068
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.095 0.1057
Echinococcus granulosus tumor protein p63 0.0352 0.9524 0.9522
Plasmodium falciparum importin beta, putative 0.0035 0.0608 0.1105
Mycobacterium tuberculosis Probable reductase 0.0246 0.6558 0.8837
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0037 0.0688 0.2356
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0345 0.0324
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0424 0.042
Trypanosoma cruzi target of rapamycin kinase 3 0.0037 0.0682 0.2333
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0424 0.042
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0047 0.095 0.3364
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0037 0.0688 0.5
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0424 0.042
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0424 0.1337
Loa Loa (eye worm) hypothetical protein 0.0027 0.0406 0.0406
Brugia malayi latrophilin 2 splice variant baaae 0.003 0.0493 0.0592
Schistosoma mansoni glutaminase 0.0284 0.7636 0.7628
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0246 0.6558 0.8837
Plasmodium vivax importin-beta 2, putative 0.0035 0.0608 0.1105
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0047 0.095 0.3364
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0108 0.2671 0.2985
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0025 0.0351 0.0422
Brugia malayi intermediate filament protein 0.0024 0.0315 0.0378
Echinococcus granulosus histone acetyltransferase KAT2B 0.0126 0.3176 0.3154
Echinococcus multilocularis chromobox protein 1 0.0062 0.1387 0.1359
Trichomonas vaginalis glucosylceramidase, putative 0.0309 0.8331 1
Schistosoma mansoni transcription factor LCR-F1 0.0032 0.0541 0.0509
Treponema pallidum NADH oxidase 0.0037 0.0688 0.5
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0035 0.0618 0.0604
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0099 0.2417 1
Trichomonas vaginalis glucosylceramidase, putative 0.0203 0.5342 0.6378
Plasmodium falciparum histone acetyltransferase GCN5 0.0035 0.0619 0.1152
Brugia malayi RNA, U transporter 1 0.0098 0.2398 0.2878
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0246 0.6558 0.8837
Toxoplasma gondii thioredoxin reductase 0.0108 0.2671 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0038 0.0708 0.1537
Brugia malayi Latrophilin receptor protein 2 0.0014 0.0033 0.004
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0688 0.2356
Schistosoma mansoni ran 0.0025 0.0351 0.0319
Trichomonas vaginalis glutaminase, putative 0.0284 0.7636 0.9157
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0332 0.0308
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0037 0.0688 0.2356
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.095 0.1057
Trichomonas vaginalis chromobox protein, putative 0.0062 0.1387 0.1587
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0102 0.2505 0.248
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0037 0.0688 0.1453
Trichomonas vaginalis glucosylceramidase, putative 0.0214 0.5649 0.675
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0014 0.0033 0.004
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0047 0.095 0.3364
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0614 0.065
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0047 0.095 0.092
Echinococcus granulosus importin subunit beta 1 0.0035 0.0608 0.0576
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0102 0.2505 0.3006
Toxoplasma gondii NADPH-glutathione reductase 0.0037 0.0688 0.1453
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0047 0.095 0.092
Loa Loa (eye worm) acetyltransferase 0.013 0.3279 0.3279
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0037 0.0688 0.0657
Trichomonas vaginalis glucosylceramidase, putative 0.0203 0.5342 0.6378
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0414 0.0408
Trichomonas vaginalis glucosylceramidase, putative 0.0309 0.8331 1
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0016 0.0077 0.0044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0422 0.0417
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0688 0.2356
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0016 0.0077 0.0044
Echinococcus granulosus intermediate filament protein 0.0024 0.0315 0.0282
Brugia malayi Intermediate filament tail domain containing protein 0.0024 0.0315 0.0378
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0037 0.0688 0.2356
Trichomonas vaginalis glucosylceramidase, putative 0.0203 0.5342 0.6378
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0414 0.0408
Trichomonas vaginalis glucosylceramidase, putative 0.0309 0.8331 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0047 0.095 0.2897
Echinococcus multilocularis musashi 0.0024 0.0315 0.0282
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0045 0.089 0.1068
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0102 0.2505 0.248
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0025 0.0351 0.0351
Brugia malayi chromobox protein homolog 3 0.0035 0.0618 0.0742
Schistosoma mansoni chromobox protein 0.0062 0.1387 0.1359
Loa Loa (eye worm) hypothetical protein 0.0024 0.0302 0.0302
Giardia lamblia Histone acetyltransferase GCN5 0.0035 0.0619 0.4465
Plasmodium falciparum glutathione reductase 0.0108 0.2671 1
Loa Loa (eye worm) glutaminase 2 0.0284 0.7636 0.7636
Onchocerca volvulus Glucosylceramidase homolog 0.0203 0.5342 1
Trichomonas vaginalis glucosylceramidase, putative 0.0203 0.5342 0.6378
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0102 0.2505 0.2505
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0047 0.095 0.2897
Echinococcus granulosus thioredoxin glutathione reductase 0.0108 0.2671 0.2647
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0102 0.2505 0.248
Schistosoma mansoni lamin 0.0024 0.0315 0.0282
Mycobacterium tuberculosis Probable oxidoreductase 0.0274 0.733 1
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0618 0.0655
Loa Loa (eye worm) heterochromatin protein 1 0.0062 0.1387 0.1387
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0688 0.2356
Entamoeba histolytica hypothetical protein 0.0032 0.0541 0.0917
Echinococcus multilocularis chromobox protein 1 0.0062 0.1387 0.1359
Brugia malayi Heterochromatin protein 1 0.0062 0.1387 0.1665
Trypanosoma cruzi trypanothione reductase, putative 0.0108 0.2671 1
Trichomonas vaginalis glucosylceramidase, putative 0.0203 0.5342 0.6378
Trichomonas vaginalis chromobox protein, putative 0.0062 0.1387 0.1587
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0608 0.1105
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0037 0.0688 0.2356
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0614 0.065
Schistosoma mansoni ran 0.0025 0.0351 0.0319
Echinococcus granulosus lamin 0.0024 0.0315 0.0282
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0025 0.0351 0.1057
Loa Loa (eye worm) phosphatidylinositol 3 0.0016 0.0077 0.0077
Loa Loa (eye worm) thioredoxin reductase 0.0108 0.2671 0.2671
Loa Loa (eye worm) glutaminase 0.0284 0.7636 0.7636
Trichomonas vaginalis bromodomain-containing protein, putative 0.0038 0.0708 0.0764
Leishmania major GTP-binding protein, putative 0.0025 0.0351 0.1057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0681 0.0732
Echinococcus multilocularis geminin 0.0203 0.5342 0.5326
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.1084 0.1054
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0688 0.2356
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0346 0.0325
Schistosoma mansoni hypothetical protein 0.0032 0.0541 0.0509
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0037 0.0688 0.1453
Echinococcus multilocularis lamin dm0 0.0024 0.0315 0.0282
Entamoeba histolytica hypothetical protein 0.0028 0.0424 0.0352
Entamoeba histolytica hypothetical protein 0.0032 0.0541 0.0917
Trichomonas vaginalis glutathione reductase, putative 0.0037 0.0688 0.074
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0274 0.733 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0025 0.0351 0.1057
Giardia lamblia NADH oxidase lateral transfer candidate 0.0037 0.0688 0.563
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0016 0.0077 0.0044
Echinococcus multilocularis tumor protein p63 0.0352 0.9524 0.9522
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0688 0.2356
Echinococcus granulosus GTP binding nuclear protein Ran 0.0025 0.0351 0.0319
Echinococcus multilocularis thioredoxin glutathione reductase 0.0108 0.2671 0.2647
Schistosoma mansoni intermediate filament proteins 0.0024 0.0315 0.0282
Entamoeba histolytica hypothetical protein 0.0032 0.0541 0.0917
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0102 0.2505 0.248
Loa Loa (eye worm) hypothetical protein 0.0051 0.1084 0.1084
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0688 0.2356
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0047 0.095 0.3364
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0246 0.6558 0.8837
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0614 0.065
Trichomonas vaginalis ran, putative 0.0025 0.0351 0.0332
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0608 0.2045
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0027 0.0409 0.0491
Toxoplasma gondii target of rapamycin (TOR), putative 0.0035 0.0614 0.113
Loa Loa (eye worm) glutathione reductase 0.0108 0.2671 0.2671
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0025 0.0351 0.1057
Loa Loa (eye worm) hypothetical protein 0.0045 0.089 0.089
Leishmania major importin beta-1 subunit, putative 0.0028 0.0424 0.1337
Loa Loa (eye worm) hypothetical protein 0.0035 0.0618 0.0618
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.013 0.3279 0.3256
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0037 0.0688 0.2356
Echinococcus granulosus geminin 0.0203 0.5342 0.5326

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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