Detailed information for compound 1068135

Basic information

Technical information
  • TDR Targets ID: 1068135
  • Name: propan-2-yl 4-methyl-6-phenyl-2-sulfanylidene -3,6-dihydro-1H-pyrimidine-5-carboxylate
  • MW: 290.381 | Formula: C15H18N2O2S
  • H donors: 2 H acceptors: 1 LogP: 2.41 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(OC(=O)C1=C(C)NC(=S)NC1c1ccccc1)C
  • InChi: 1S/C15H18N2O2S/c1-9(2)19-14(18)12-10(3)16-15(20)17-13(12)11-7-5-4-6-8-11/h4-9,13H,1-3H3,(H2,16,17,20)
  • InChiKey: ZANYRAHCEKSIBW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • isopropyl 4-methyl-6-phenyl-2-thioxo-3,6-dihydro-1H-pyrimidine-5-carboxylate
  • 4-methyl-6-phenyl-2-thioxo-3,6-dihydro-1H-pyrimidine-5-carboxylic acid isopropyl ester
  • AA-504/34071061
  • Oprea1_308094
  • STK107637
  • ChemDiv3_000604

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0105 0.0343
Trichomonas vaginalis modulator of drug activity B, putative 0.0206 0.239 0.2309
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0105 0.0343
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.006 0.0592 0.1184
Leishmania major mitochondrial DNA polymerase beta 0.0672 0.8138 1
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.013 0.1455 0.4375
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0039 0.0334 0.1089
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0321 0.0218
Loa Loa (eye worm) hypothetical protein 0.0038 0.0321 0.1048
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.033 0.0372
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0334 0.0285
Trichomonas vaginalis modulator of drug activity B, putative 0.0206 0.239 0.2309
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0321 0.0525
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0151 0.1716 0.3334
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0334 0.0648
Brugia malayi Cytochrome P450 family protein 0.0024 0.0146 0.0476
Echinococcus granulosus peptidase Clp S14 family 0.0053 0.0514 0.0997
Trichomonas vaginalis modulator of drug activity B, putative 0.0206 0.239 0.2309
Brugia malayi jmjC domain containing protein 0.0039 0.0333 0.1087
Loa Loa (eye worm) hypothetical protein 0.0038 0.0321 0.1048
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0318 0.3775 0.4621
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.0357 0.1154
Trichomonas vaginalis modulator of drug activity B, putative 0.0206 0.239 0.2309
Schistosoma mansoni dihydrofolate reductase 0.026 0.3066 0.5956
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0206 0.239 0.2309
Trichomonas vaginalis modulator of drug activity B, putative 0.0206 0.239 0.2309
Trichomonas vaginalis modulator of drug activity B, putative 0.0206 0.239 0.2309
Brugia malayi jmjC domain containing protein 0.01 0.1091 0.3558
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0592 0.1149
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0078 0.0812 0.1576
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.006 0.0592 0.1931
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0227 0.0741
Brugia malayi hypothetical protein 0.0026 0.0179 0.0584
Schistosoma mansoni cpg binding protein 0.0032 0.0248 0.0481
Loa Loa (eye worm) hypothetical protein 0.002 0.0105 0.0343
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0105 0.0203
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0321 0.0269
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0403 0.0769
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0094 0.102 0.1139
Onchocerca volvulus 0.0038 0.0321 0.0768
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0321 0.0623
Loa Loa (eye worm) hypothetical protein 0.0038 0.0321 0.1048
Echinococcus granulosus ubiquitin specific protease 41 0.0039 0.0334 0.0648
Schistosoma mansoni cpg binding protein 0.0032 0.0248 0.0481
Trichomonas vaginalis modulator of drug activity B, putative 0.0206 0.239 0.2309
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0081 0.0859 0.2783
Onchocerca volvulus 0.0038 0.0321 0.0768
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.033 0.0639
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0078 0.0812 0.3093
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0053 0.0514 0.109
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0078 0.0812 0.2648
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0321 0.1048
Brugia malayi hypothetical protein 0.0062 0.0616 0.201
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0039 0.0334 0.0648
Loa Loa (eye worm) hypothetical protein 0.0031 0.0233 0.0759
Echinococcus granulosus jumonji domain containing protein 0.0043 0.038 0.0738
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0081 0.0859 0.2783
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0262 0.3085 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0403 0.0781
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.013 0.1455 0.2825
Brugia malayi PHD-finger family protein 0.0031 0.0233 0.0759
Giardia lamblia PHD finger protein 15 0.0031 0.0233 0.0129
Brugia malayi Dihydrofolate reductase 0.026 0.3066 1
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.006 0.0592 0.0606
Loa Loa (eye worm) thymidylate synthase 0.013 0.1455 0.4745
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0333 0.1087
Echinococcus granulosus dihydrofolate reductase 0.026 0.3066 0.5956
Entamoeba histolytica modulator of drug activity B homolog, putative 0.0206 0.239 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0053 0.0514 0.0993
Trichomonas vaginalis modulator of drug activity B, putative 0.0206 0.239 0.2309
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0078 0.0812 0.1576
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0634 0.2069
Entamoeba histolytica iron-sulfur flavoprotein, putative 0.0206 0.239 1
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0334 0.0648
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0105 0.0096
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0039 0.0334 0.1001
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0312 0.0605
Mycobacterium tuberculosis Conserved hypothetical protein 0.0354 0.4218 1
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0321 0.0525
Plasmodium falciparum phd finger protein, putative 0.0031 0.0233 0.075
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0321 0.1037
Loa Loa (eye worm) beta-lactamase 0.0038 0.0321 0.1048
Echinococcus granulosus histone acetyltransferase KAT2B 0.0147 0.1664 0.3232
Loa Loa (eye worm) hypothetical protein 0.0038 0.0321 0.1048
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0262 0.3085 1
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0078 0.0812 0.0967
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0321 0.0269
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0592 0.1184
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0334 0.0378
Mycobacterium tuberculosis Conserved protein 0.0038 0.0321 0.0525
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.01 0.1091 0.2118
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.033 0.0518
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0105 0.0343
Trichomonas vaginalis conserved hypothetical protein 0.0206 0.239 0.2309
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0179 0.0092
Trichomonas vaginalis conserved hypothetical protein 0.0617 0.7465 0.7438
Loa Loa (eye worm) inositol-1 0.0038 0.033 0.1075
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0644 0.1249
Loa Loa (eye worm) hypothetical protein 0.0039 0.0334 0.1089
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0321 0.0525
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0081 0.0859 0.1669
Trichomonas vaginalis conserved hypothetical protein 0.0206 0.239 0.2309
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0334 0.0231
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0321 0.0218
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0105 0.0096
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0233 0.075
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0334 0.0231
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0201 0.0649
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.033 0.0227
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.028 0.0274
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0592 0.1149
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0081 0.0859 0.2297
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0321 0.0525
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0672 0.8138 1
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0062 0.0616 0.0636
Loa Loa (eye worm) hypothetical protein 0.0081 0.0859 0.2803
Loa Loa (eye worm) hypothetical protein 0.0038 0.0321 0.1048
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0105 0.0096
Trichomonas vaginalis FMN-dependent NADH-azoreductase, putative 0.0206 0.239 0.2309
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0078 0.0812 0.088
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0262 0.3085 0.3769
Mycobacterium ulcerans hypothetical protein 0.0354 0.4218 1
Schistosoma mansoni cpg binding protein 0.003 0.0227 0.044
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0094 0.102 0.1224
Trichomonas vaginalis modulator of drug activity B, putative 0.0206 0.239 0.2309
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0542 0.1769
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0318 0.3775 0.4569
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0321 0.1048
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.026 0.3066 1
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.0357 0.1103
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0321 0.0525
Schistosoma mansoni inositol monophosphatase 0.0038 0.033 0.0639
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0321 0.0525
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0321 0.0218
Schistosoma mansoni inositol monophosphatase 0.0038 0.033 0.0639
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0403 0.0301
Loa Loa (eye worm) hypothetical protein 0.0052 0.0502 0.1638
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0321 0.0623
Brugia malayi Probable ClpP-like protease 0.0081 0.0859 0.2803
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0672 0.8138 1
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0078 0.0812 0.2648
Schistosoma mansoni peptidase Clp (S14 family) 0.0081 0.0859 0.1669
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.026 0.3066 0.7198
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0179 0.0576
Mycobacterium ulcerans beta-lactamase 0.0038 0.0321 0.0525
Echinococcus multilocularis thymidylate synthase 0.013 0.1455 0.2825
Loa Loa (eye worm) hypothetical protein 0.0038 0.0321 0.1048
Brugia malayi thymidylate synthase 0.013 0.1455 0.4745
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0334 0.0285
Trichomonas vaginalis modulator of drug activity B, putative 0.0206 0.239 0.2309
Loa Loa (eye worm) dihydrofolate reductase 0.026 0.3066 1
Onchocerca volvulus 0.013 0.1455 1
Leishmania major hypothetical protein, conserved 0.0038 0.0321 0.0269
Echinococcus granulosus dnaJ subfamily B 0.0429 0.5147 1
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0039 0.0334 0.0231
Echinococcus multilocularis dna polymerase eta 0.002 0.0105 0.0203
Schistosoma mansoni DNA polymerase eta 0.002 0.0105 0.0203
Trichomonas vaginalis modulator of drug activity B, putative 0.0206 0.239 0.2309
Brugia malayi Bromodomain containing protein 0.0034 0.0278 0.0908
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0081 0.0859 0.1669
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0334 0.0648
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0105 0.0203
Trichomonas vaginalis modulator of drug activity B, putative 0.0206 0.239 0.2309
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.033 0.0227
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0233 0.0759
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0081 0.0859 1
Mycobacterium ulcerans lipase LipD 0.0038 0.0321 0.0525
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0146 0.0476
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.033 0.0639
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0081 0.0859 0.1834
Trichomonas vaginalis modulator of drug activity B, putative 0.0206 0.239 0.2309
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0321 0.0419
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0053 0.0514 0.0993
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0081 0.0859 1
Echinococcus granulosus dna polymerase eta 0.002 0.0105 0.0203
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.026 0.3066 0.7198
Toxoplasma gondii hypothetical protein 0.0028 0.0201 0.0077
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0333 0.0646
Toxoplasma gondii hypothetical protein 0.0108 0.1191 0.3484
Loa Loa (eye worm) acetyltransferase 0.0151 0.1716 0.5598
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0262 0.3085 0.3709
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0078 0.0812 0.088
Brugia malayi CXXC zinc finger family protein 0.003 0.0227 0.0741
Trichomonas vaginalis modulator of drug activity B, putative 0.0206 0.239 0.2309
Giardia lamblia Histone acetyltransferase GCN5 0.0041 0.0357 0.0255
Brugia malayi hypothetical protein 0.0017 0.0064 0.021
Onchocerca volvulus 0.0038 0.0321 0.0768
Loa Loa (eye worm) hypothetical protein 0.0026 0.0179 0.0584
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0233 0.0184
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0028 0.0201 0.0649
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0105 0.0096
Echinococcus multilocularis cpg binding protein 0.0032 0.0248 0.0481
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0039 0.0334 0.0648
Echinococcus multilocularis dnaJ subfamily B 0.0429 0.5147 1
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0321 0.0525
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0403 0.1301
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0233 0.0451
Onchocerca volvulus Alhambra homolog 0.0031 0.0233 0.0046
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0071 0.0137
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.006 0.0592 0.1149
Trichomonas vaginalis modulator of drug activity B, putative 0.0206 0.239 0.2309
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.033 0.0983
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0081 0.0859 0.2341
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0403 0.0301
Trichomonas vaginalis conserved hypothetical protein 0.0206 0.239 0.2309
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0105 0.0096
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0262 0.3085 1
Trichomonas vaginalis conserved hypothetical protein 0.0206 0.239 0.2309
Mycobacterium tuberculosis Conserved protein 0.0038 0.0321 0.0525
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0105 0.0203
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.01 0.1091 0.2118
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0039 0.0334 0.0285
Trichomonas vaginalis conserved hypothetical protein 0.0206 0.239 0.2309
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0179 0.0187
Brugia malayi beta-lactamase family protein 0.0038 0.0321 0.1048
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0233 0.0451
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0105 0.0096
Trichomonas vaginalis conserved hypothetical protein 0.0206 0.239 0.2309
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0078 0.0812 0.088
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0241 0.2831 0.6628
Mycobacterium tuberculosis Conserved protein 0.0038 0.0321 0.0525
Schistosoma mansoni hypothetical protein 0.0429 0.5147 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0081 0.0859 0.2341
Echinococcus multilocularis peregrin 0.0034 0.0278 0.0539
Echinococcus granulosus thymidylate synthase 0.013 0.1455 0.2825
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0179 0.0092
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0115 0.1275 0.1456
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.013 0.1455 0.3281
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0262 0.3085 0.3709
Brugia malayi Inositol-1 0.0038 0.033 0.1075
Echinococcus multilocularis peptidase Clp (S14 family) 0.0053 0.0514 0.0997
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0105 0.0096
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.033 0.0279
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0179 0.0576
Schistosoma mansoni hypothetical protein 0.0031 0.0233 0.0451
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0105 0.0203
Trichomonas vaginalis conserved hypothetical protein 0.0206 0.239 0.2309
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0081 0.0859 0.1834
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0151 0.1716 0.3334
Brugia malayi acetyltransferase, GNAT family protein 0.0151 0.1716 0.5598
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0206 0.239 0.2309
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0318 0.3775 0.4569
Trichomonas vaginalis modulator of drug activity B, putative 0.0206 0.239 0.2309
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0605 0.1466
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0321 0.0218
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0616 0.0517
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.028 0.0425
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0105 0.0096
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0321 0.0362
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0233 0.0184
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.033 0.0546
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0105 0.0096
Toxoplasma gondii ABC1 family protein 0.0038 0.0321 0.0489
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0105 0.0096
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0105 0.0096
Trichomonas vaginalis modulator of drug activity B, putative 0.0206 0.239 0.2309
Entamoeba histolytica hypothetical protein 0.0206 0.239 1
Echinococcus multilocularis transcription factor Dp 1 0.0045 0.0409 0.0794
Mycobacterium ulcerans thymidylate synthase 0.013 0.1455 0.3281
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0334 0.0648
Echinococcus granulosus transcription factor Dp 1 0.0045 0.0409 0.0794
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0105 0.0096
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0321 0.0218
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0092 0.0301
Trichomonas vaginalis modulator of drug activity B, putative 0.0206 0.239 0.2309
Mycobacterium tuberculosis Hypothetical protein 0.0062 0.0616 0.1243
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0321 0.0623
Echinococcus multilocularis dna polymerase kappa 0.002 0.0105 0.0203
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0233 0.0451
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0179 0.0576
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0672 0.8138 1
Trypanosoma brucei unspecified product 0.002 0.0105 0.0096
Echinococcus granulosus peregrin 0.0034 0.0278 0.0539
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0403 0.0769
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.033 0.0279
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0592 0.1184
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0321 0.0525
Chlamydia trachomatis dihydrofolate reductase 0.026 0.3066 1
Echinococcus granulosus dna polymerase kappa 0.002 0.0105 0.0203
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0105 0.0096
Trichomonas vaginalis modulator of drug activity B, putative 0.0206 0.239 0.2309
Echinococcus multilocularis ubiquitin specific protease 41 0.0039 0.0334 0.0648
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0094 0.102 0.1139
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.033 0.0227
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.033 0.0279
Brugia malayi beta-lactamase family protein 0.0038 0.0321 0.1048
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0078 0.0812 0.1576
Trichomonas vaginalis modulator of drug activity B, putative 0.0206 0.239 0.2309
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0333 0.0646
Brugia malayi beta-lactamase 0.0038 0.0321 0.1048
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0105 0.0096
Echinococcus multilocularis dihydrofolate reductase 0.026 0.3066 0.5956
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0321 0.0623
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0333 0.0646
Trichomonas vaginalis conserved hypothetical protein 0.0206 0.239 0.2309
Mycobacterium leprae Probable lipase LipE 0.0038 0.0321 0.0419
Schistosoma mansoni jumonji domain containing protein 0.008 0.0837 0.1625
Brugia malayi dihydrofolate reductase family protein 0.026 0.3066 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0321 0.0525
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0334 0.0231
Mycobacterium ulcerans hypothetical protein 0.0038 0.0321 0.0525
Echinococcus granulosus cpg binding protein 0.0032 0.0248 0.0481
Trichomonas vaginalis conserved hypothetical protein 0.0206 0.239 0.2309
Trichomonas vaginalis esterase, putative 0.0038 0.0321 0.0218
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.038 0.0738
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0094 0.102 0.1139
Leishmania major hypothetical protein, conserved 0.0026 0.0179 0.0092

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 50 ug ml-1 Antifungal activity against Candida albicans after 72 to 96 hrs by two fold serial dilution technique ChEMBL. 19800716
MIC (functional) = 200 ug ml-1 Antibacterial activity against Escherichia coli after 24 hrs by two fold serial dilution technique ChEMBL. 19800716

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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