TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 353.347 | Formula: C19H16FN3O3
H donors: 3 H acceptors: 3 LogP: 2.28 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1ccccc1)NCCNC(=O)C(=O)c1c[nH]c2c1c(F)ccc2
InChi: 1S/C19H16FN3O3/c20-14-7-4-8-15-16(14)13(11-23-15)17(24)19(26)22-10-9-21-18(25)12-5-2-1-3-6-12/h1-8,11,23H,9-10H2,(H,21,25)(H,22,26)
InChiKey: LKZAANXMEPZBHR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0068	0.0196
Loa Loa (eye worm)	neuropeptide F receptor	0.0045	0.0068	0.0196
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0068	0.0196
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0068	0.0196
Loa Loa (eye worm)	hypothetical protein	0.0073	0.018	0.0522
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0068	0.0196
Loa Loa (eye worm)	melatonin receptor type 1A	0.0045	0.0068	0.0196
Brugia malayi	hypothetical protein	0.0045	0.0068	0.0196
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0068	0.0196
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0068	0.0196
Echinococcus multilocularis	sodium:dicarboxylate symporter	0.0387	0.1462	0.1439
Brugia malayi	Niemann-Pick C1 protein precursor	0.0096	0.0275	0.0798
Echinococcus multilocularis	neuropeptides capa receptor	0.0045	0.0068	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0068	0.0196
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0068	0.0196
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0045	0.0068	0.0041
Echinococcus granulosus	g-protein coupled receptor	0.0045	0.0068	0.0119
Schistosoma mansoni	hypothetical protein	0.004	0.0046	0.0055
Brugia malayi	hypothetical protein	0.0045	0.0068	0.0196
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0045	0.0068	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0068	0.0196
Echinococcus multilocularis	fmrfamide receptor	0.0045	0.0068	0.0041
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0045	0.0068	0.0119
Brugia malayi	Excitatory amino acid transporter	0.0873	0.3444	1
Brugia malayi	AMP-binding enzyme family protein	0.0073	0.018	0.0522
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0068	0.0196
Onchocerca volvulus		0.0045	0.0068	0.0119
Echinococcus granulosus	g protein coupled receptor	0.0045	0.0068	0.0119
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0045	0.0068	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0073	0.018	0.0522
Loa Loa (eye worm)	hypothetical protein	0.0371	0.1396	0.4053
Schistosoma mansoni	opsin-like receptor	0.0045	0.0068	0.0119
Echinococcus granulosus	Excitatory amino acid transporter	0.0873	0.3444	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0068	0.0196
Schistosoma mansoni	survival motor neuron protein	0.0052	0.0095	0.0199
Echinococcus granulosus	neuropeptides capa receptor	0.0045	0.0068	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0105	0.0305
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0105	0.0305
Wolbachia endosymbiont of Brugia malayi	Na+/H+-dicarboxylate symporter	0.0873	0.3444	0.5
Echinococcus multilocularis	Niemann Pick C1 protein	0.0137	0.0442	0.0417
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0045	0.0068	0.0119
Echinococcus granulosus	7TM GPCR rhodopsin	0.0045	0.0068	0.0119
Echinococcus multilocularis	neutral amino acid transporter A	0.0873	0.3444	0.3426
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0045	0.0068	0.0041
Echinococcus multilocularis	G protein coupled receptor 139	0.0045	0.0068	0.0041
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0073	0.018	1
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0073	0.018	0.6171
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0045	0.0068	0.0119
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.0084	0.0167
Echinococcus multilocularis	excitatory amino acid transporter 2	0.0873	0.3444	0.3426
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0068	0.0196
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0045	0.0068	0.0196
Onchocerca volvulus		0.0045	0.0068	0.0119
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0045	0.0068	0.0041
Schistosoma mansoni	hypothetical protein	0.0045	0.0068	0.0119
Loa Loa (eye worm)	RNA binding protein	0.0064	0.0144	0.0417
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0045	0.0068	0.0119
Echinococcus multilocularis	neutral amino acid transporter A	0.0873	0.3444	0.3426
Onchocerca volvulus		0.0045	0.0068	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0105	0.0305
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0065	0.015	0.0436
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0045	0.0068	0.0119
Loa Loa (eye worm)	TAR-binding protein	0.0064	0.0144	0.0417
Brugia malayi	TAR-binding protein	0.0064	0.0144	0.0417
Echinococcus multilocularis	sterol regulatory element binding protein	0.0041	0.0052	0.0025
Echinococcus multilocularis	protein dispatched 1	0.0047	0.0075	0.0049
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0144	0.0341
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0045	0.0068	0.0041
Brugia malayi	hypothetical protein	0.0045	0.0068	0.0196
Schistosoma mansoni	hypothetical protein	0.0065	0.015	0.0361
Onchocerca volvulus		0.0045	0.0068	0.0119
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0045	0.0068	0.0119
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0045	0.0068	0.0041
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0045	0.0068	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0068	0.0196
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0027	0.0078
Brugia malayi	hypothetical protein	0.0045	0.0068	0.0196
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.0084	0.0057
Echinococcus granulosus	neutral amino acid transporter A	0.0873	0.3444	1
Schistosoma mansoni	amine GPCR	0.0045	0.0068	0.0119
Schistosoma mansoni	neuropeptide f receptor 76f	0.0045	0.0068	0.0119
Brugia malayi	larval opioid receptor	0.0045	0.0068	0.0196
Onchocerca volvulus		0.0045	0.0068	0.0119
Echinococcus multilocularis	g protein coupled receptor	0.0045	0.0068	0.0041
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0049	0.0084	0.0244
Echinococcus granulosus	expressed conserved protein	0.009	0.0251	0.0656
Echinococcus granulosus	orexin receptor type 2	0.0045	0.0068	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0027	0.0078
Onchocerca volvulus		0.0045	0.0068	0.0119
Echinococcus granulosus	tm gpcr rhodopsin	0.0045	0.0068	0.0119
Echinococcus granulosus	rhodopsin orphan GPCR	0.0045	0.0068	0.0119
Echinococcus granulosus	excitatory amino acid transporter 3	0.0873	0.3444	1
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0045	0.0068	0.0119
Brugia malayi	beta-lactamase family protein	0.0035	0.0027	0.0078
Brugia malayi	hypothetical protein	0.0045	0.0068	0.0196
Onchocerca volvulus		0.0045	0.0068	0.0119
Echinococcus multilocularis	tar DNA binding protein	0.0064	0.0144	0.0117
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0065	0.015	0.0124
Echinococcus granulosus	Protein patched homolog 1	0.0041	0.0052	0.0073
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0073	0.018	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0052	0.015
Echinococcus multilocularis	excitatory amino acid transporter 3	0.0873	0.3444	0.3426
Schistosoma mansoni	neuropeptide F-like receptor	0.0045	0.0068	0.0119
Brugia malayi	neuropeptide F receptor	0.0045	0.0068	0.0196
Echinococcus multilocularis	neuropeptide s receptor	0.0564	0.2183	0.2161
Brugia malayi	putative neuropeptide receptor	0.0045	0.0068	0.0196
Mycobacterium ulcerans	acyl-CoA synthetase	0.0073	0.018	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0073	0.018	1
Brugia malayi	AMP-binding enzyme family protein	0.0073	0.018	0.0522
Schistosoma mansoni	hypothetical protein	0.0065	0.015	0.0361
Echinococcus granulosus	rhodopsin orphan GPCR	0.0045	0.0068	0.0119
Echinococcus granulosus	tm gpcr rhodopsin	0.0045	0.0068	0.0119
Echinococcus granulosus	excitatory amino acid transporter 2	0.0873	0.3444	1
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0027	0.2568
Echinococcus granulosus	rhodopsin orphan GPCR	0.0045	0.0068	0.0119
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0045	0.0068	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0068	0.0196
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0068	0.0196
Echinococcus granulosus	tar DNA binding protein	0.0064	0.0144	0.0341
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0045	0.0068	0.0119
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0045	0.0068	0.0119
Schistosoma mansoni	adenoreceptor	0.0045	0.0068	0.0119
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0045	0.0068	0.0119
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0064	0.0144	0.0417
Loa Loa (eye worm)	TYRA-2 protein	0.0045	0.0068	0.0196
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0144	0.0341
Brugia malayi	CHE-14 protein	0.0041	0.0052	0.015
Echinococcus multilocularis	neutral amino acid transporter A	0.0873	0.3444	0.3426
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0051	0.0093	0.0193
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0045	0.0068	0.0041
Brugia malayi	AKH receptor	0.0045	0.0068	0.0196
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0073	0.018	1
Schistosoma mansoni	cellular tumor antigen P53	0.0048	0.008	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0027	0.0078
Brugia malayi	putative neuropeptide receptor NPR1	0.0045	0.0068	0.0196
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0068	0.0196
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0073	0.018	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0027	0.0078
Schistosoma mansoni	solute carrier family 1 (glial high affinity glutamate transporter	0.0873	0.3444	1
Schistosoma mansoni	biogenic amine receptor	0.0045	0.0068	0.0119
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0045	0.0068	0.0041
Brugia malayi	GnHR receptor homolog	0.0045	0.0068	0.0196
Echinococcus granulosus	neuropeptide Y receptor	0.0045	0.0068	0.0119
Echinococcus granulosus	dro:myosuppressin receptor	0.0045	0.0068	0.0119
Schistosoma mansoni	hypothetical protein	0.004	0.0046	0.0055
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0045	0.0068	0.0196
Brugia malayi	follicle stimulating hormone receptor	0.0045	0.0068	0.0196
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0371	0.1396	0.4053
Echinococcus granulosus	hypothetical protein	0.0045	0.0068	0.0119
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0045	0.0068	0.0119
Schistosoma mansoni	sodium/dicarboxylate symporter-related	0.0387	0.1462	0.42
Echinococcus granulosus	g protein coupled receptor	0.0045	0.0068	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0068	0.0196
Onchocerca volvulus		0.0045	0.0068	0.0119
Echinococcus multilocularis	excitatory amino acid transporter 2	0.0873	0.3444	0.3426
Onchocerca volvulus		0.0045	0.0068	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0068	0.0196
Echinococcus granulosus	G protein coupled receptor 139	0.0045	0.0068	0.0119
Schistosoma mansoni	amine GPCR	0.0045	0.0068	0.0119
Onchocerca volvulus		0.0073	0.018	0.0447
Brugia malayi	Serotonin receptor	0.0045	0.0068	0.0196
Echinococcus granulosus	Niemann Pick C1 protein	0.0137	0.0442	0.1216
Echinococcus multilocularis	Excitatory amino acid transporter	0.0873	0.3444	0.3426
Echinococcus multilocularis	neutral amino acid transporter excitatory amino acid transporter	0.0387	0.1462	0.1439
Onchocerca volvulus	Excitatory amino acid transporter homolog	0.0873	0.3444	1
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0045	0.0068	0.0041
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0073	0.018	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0068	0.0196
Echinococcus granulosus	fmrfamide receptor	0.0045	0.0068	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0068	0.0196
Echinococcus granulosus	allatostatin A receptor	0.0045	0.0068	0.0119
Schistosoma mansoni	hypothetical protein	0.0141	0.0459	0.1264
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0045	0.0068	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0275	0.0798
Schistosoma mansoni	biogenic amine receptor	0.0045	0.0068	0.0119
Schistosoma mansoni	hypothetical protein	0.0065	0.015	0.0361
Loa Loa (eye worm)	excitatory amino acid transporter	0.0873	0.3444	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0045	0.0068	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0068	0.0196
Leishmania major	4-coumarate:coa ligase-like protein	0.0073	0.018	1
Schistosoma mansoni	biogenic amine receptor	0.0045	0.0068	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0068	0.0196
Echinococcus multilocularis	neuropeptide receptor A26	0.0564	0.2183	0.2161
Echinococcus granulosus	excitatory amino acid transporter 2	0.0873	0.3444	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0045	0.0068	0.0041
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0045	0.0068	0.0196
Loa Loa (eye worm)	G-protein coupled receptor	0.0045	0.0068	0.0196
Onchocerca volvulus		0.0045	0.0068	0.0119
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0144	0.0341
Echinococcus multilocularis	neutral amino acid transporter excitatory amino acid transporter	0.0873	0.3444	0.3426
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0045	0.0068	0.0119
Echinococcus multilocularis	Niemann Pick C1 protein	0.0096	0.0275	0.0249
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.023	0.0821	0.0796
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0045	0.0068	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0068	0.0196
Onchocerca volvulus		0.0045	0.0068	0.0119
Mycobacterium ulcerans	acyl-CoA synthetase	0.0073	0.018	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0068	0.0196
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0206	0.0725	0.2104
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0105	0.0305
Echinococcus multilocularis	neuropeptide receptor	0.0045	0.0068	0.0041
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0049	0.0084	0.0244
Brugia malayi	Dopamine receptor	0.0045	0.0068	0.0196
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0045	0.0068	0.0119
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0045	0.0068	0.0196
Onchocerca volvulus		0.0045	0.0068	0.0119
Chlamydia trachomatis	glutamate symporter	0.0873	0.3444	1
Echinococcus multilocularis	dro:myosuppressin receptor	0.0045	0.0068	0.0041
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0073	0.018	1
Echinococcus granulosus	7tm_1 domain containing protein	0.0045	0.0068	0.0119
Echinococcus granulosus	neuropeptides capa receptor	0.0045	0.0068	0.0119
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0045	0.0068	0.0041
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0045	0.0068	0.0119
Echinococcus granulosus	neuropeptide receptor A26	0.0564	0.2183	0.6309
Loa Loa (eye worm)	hypothetical protein	0.0253	0.0917	0.2664
Echinococcus granulosus	neuropeptide receptor	0.0045	0.0068	0.0119
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0054	0.0105	0.0229
Toxoplasma gondii	ABC1 family protein	0.0035	0.0027	1
Echinococcus granulosus	neuropeptide s receptor	0.0564	0.2183	0.6309
Echinococcus granulosus	rhodopsin orphan GPCR	0.0045	0.0068	0.0119
Schistosoma mansoni	myosin xvIII	0.0045	0.0068	0.0119
Schistosoma mansoni	growth hormone secretagogue receptor	0.0045	0.0068	0.0119
Echinococcus multilocularis	serotonin receptor	0.0045	0.0068	0.0041
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0096	0.0275	1
Leishmania major	hypothetical protein, conserved	0.0035	0.0027	0.1501
Echinococcus granulosus	rhodopsin orphan GPCR	0.0045	0.0068	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0068	0.0196
Echinococcus multilocularis	neuropeptide Y receptor	0.0045	0.0068	0.0041
Echinococcus granulosus	sterol regulatory element binding protein	0.0041	0.0052	0.0073
Plasmodium vivax	acyl-CoA synthetase, putative	0.0054	0.0105	1
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0097	0.0281	0.0743
Echinococcus granulosus	g protein coupled receptor	0.0045	0.0068	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0068	0.0196
Echinococcus multilocularis	expressed conserved protein	0.009	0.0251	0.0225
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0051	0.0093	0.0193
Echinococcus granulosus	neutral amino acid transporter	0.0873	0.3444	1
Plasmodium falciparum	acyl-CoA synthetase	0.0054	0.0105	1
Echinococcus multilocularis	serotonin receptor	0.0045	0.0068	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0068	0.0196
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0027	1
Schistosoma mansoni	neuropeptide receptor	0.0045	0.0068	0.0119
Echinococcus granulosus	sodium:dicarboxylate symporter	0.0873	0.3444	1
Echinococcus granulosus	somatostatin receptor	0.0045	0.0068	0.0119
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0051	0.0093	0.0193
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0045	0.0068	0.0119
Schistosoma mansoni	opsin-like receptor	0.0045	0.0068	0.0119
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0027	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0068	0.0196
Schistosoma mansoni	hypothetical protein	0.0052	0.0095	0.0199
Brugia malayi	hypothetical protein	0.0045	0.0068	0.0196
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0068	0.0196
Echinococcus granulosus	survival motor neuron protein 1	0.0253	0.0917	0.2606
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0045	0.0068	0.0196
Echinococcus granulosus	rhodopsin orphan GPCR	0.0045	0.0068	0.0119
Brugia malayi	hypothetical protein	0.0035	0.0027	0.0078
Onchocerca volvulus		0.0045	0.0068	0.0119
Mycobacterium ulcerans	hypothetical protein	0.0073	0.018	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0045	0.0068	0.0041
Schistosoma mansoni	neuropeptide receptor	0.0045	0.0068	0.0119
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0045	0.0068	0.0041
Echinococcus multilocularis	tumor protein p63	0.0329	0.1225	0.1201
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0045	0.0068	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0068	0.0196
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0068	0.0196
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0052	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0068	0.0196
Brugia malayi	Melatonin receptor type 1A	0.0045	0.0068	0.0196
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0045	0.0068	0.0119
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.0084	0.0057
Schistosoma mansoni	amine GPCR	0.0045	0.0068	0.0119
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0045	0.0068	0.0119
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0045	0.0068	0.0041
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0144	0.0341
Echinococcus multilocularis	orexin receptor type 2	0.0045	0.0068	0.0041
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0045	0.0068	0.0041
Echinococcus granulosus	sex peptide receptor	0.0045	0.0068	0.0119
Onchocerca volvulus		0.0048	0.008	0.0156
Echinococcus granulosus	serotonin receptor	0.0045	0.0068	0.0119
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.0084	0.0167
Schistosoma mansoni	hypothetical protein	0.0065	0.015	0.0361
Brugia malayi	hypothetical protein	0.0045	0.0068	0.0196
Echinococcus multilocularis	neuropeptides capa receptor	0.0045	0.0068	0.0041
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0045	0.0068	0.0041
Brugia malayi	beta-lactamase family protein	0.0035	0.0027	0.0078
Schistosoma mansoni	hypothetical protein	0.0045	0.0068	0.0119
Brugia malayi	hypothetical protein	0.0045	0.0068	0.0196
Echinococcus multilocularis	somatostatin receptor	0.0045	0.0068	0.0041
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0054	0.0105	0.511
Schistosoma mansoni	hypothetical protein	0.004	0.0046	0.0055
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0206	0.0725	0.2104
Onchocerca volvulus		0.0045	0.0068	0.0119
Brugia malayi	Latrophilin receptor protein 2	0.0065	0.015	0.0436
Echinococcus multilocularis	g-protein coupled receptor	0.0045	0.0068	0.0041
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0084	0.0167
Brugia malayi	G protein-coupled receptor F59B2.13	0.0045	0.0068	0.0196
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0045	0.0068	0.0041
Echinococcus granulosus	Niemann Pick C1 protein	0.0096	0.0275	0.0726
Brugia malayi	Dopamine receptor protein 2	0.0045	0.0068	0.0196
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0068	0.0196
Entamoeba histolytica	acyl-coA synthetase, putative	0.0073	0.018	0.6171
Treponema pallidum	glutamate/aspartate transporter	0.0387	0.1462	0.5
Brugia malayi	neuropeptide F receptor	0.0045	0.0068	0.0196
Loa Loa (eye worm)	hypothetical protein	0.0141	0.0459	0.1332
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0224	0.0797	0.2253
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0045	0.0068	0.0119
Brugia malayi	G protein-coupled receptor	0.0045	0.0068	0.0196
Echinococcus granulosus	biogenic amine 5HT receptor	0.0045	0.0068	0.0119
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0045	0.0068	0.0119
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0045	0.0068	0.0119
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0051	0.0093	0.0193
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0045	0.0068	0.0196
Mycobacterium tuberculosis	Probable C4-dicarboxylate-transport transmembrane protein DctA	0.0873	0.3444	1
Brugia malayi	Serotonin receptor	0.0045	0.0068	0.0196
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0045	0.0068	0.0041
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0045	0.0068	0.0119
Chlamydia trachomatis	neutral amino acid transporter	0.0387	0.1462	0.4064
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.0027	1
Brugia malayi	AMP-binding enzyme family protein	0.0073	0.018	0.0522
Echinococcus granulosus	tumor protein p63	0.0329	0.1225	0.3506
Echinococcus multilocularis	allatostatin A receptor	0.0045	0.0068	0.0041
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0045	0.0068	0.0041
Onchocerca volvulus		0.0045	0.0068	0.0119
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0045	0.0068	0.0196
Brugia malayi	RE15519p	0.0045	0.0068	0.0196
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0073	0.018	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0065	0.015	0.0436
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0027	0.0078
Brugia malayi	Dopamine receptor protein 1	0.0045	0.0068	0.0196
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0041	0.0052	0.015
Echinococcus granulosus	GPCR family 2	0.0065	0.015	0.0361
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0052	0.0095	0.0276
Loa Loa (eye worm)	hypothetical protein	0.0048	0.008	0.0233
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0065	0.015	0.0361
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0045	0.0068	0.0041
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0084	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0027	0.0078
Schistosoma mansoni	amine GPCR	0.0373	0.1403	0.4027
Echinococcus multilocularis	survival motor neuron protein 1	0.0253	0.0917	0.0893
Echinococcus granulosus	tm gpcr rhodopsin	0.0045	0.0068	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0073	0.018	0.0522
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0045	0.0068	0.0041
Brugia malayi	RNA binding protein	0.0064	0.0144	0.0417
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0068	0.0196
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0045	0.0068	0.0119
Echinococcus granulosus	neuropeptide receptor	0.0045	0.0068	0.0119
Schistosoma mansoni	patched 1	0.0041	0.0052	0.0073
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0045	0.0068	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0068	0.0196
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0045	0.0068	0.0196
Loa Loa (eye worm)	G-protein coupled receptor	0.0045	0.0068	0.0196
Echinococcus multilocularis	fmrfamide receptor	0.0045	0.0068	0.0041
Loa Loa (eye worm)	neuropeptide F receptor	0.0045	0.0068	0.0196
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0073	0.018	0.6171
Brugia malayi	beta-lactamase	0.0035	0.0027	0.0078
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0045	0.0068	0.0196
Brugia malayi	latrophilin 2 splice variant baaae	0.0141	0.0459	0.1332
Brugia malayi	RNA recognition motif domain containing protein	0.0064	0.0144	0.0417
Echinococcus multilocularis	Excitatory amino acid transporter	0.0873	0.3444	0.3426
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0045	0.0068	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0068	0.0196
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0068	0.0196
Echinococcus granulosus	neutral amino acid transporter A	0.0873	0.3444	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0045	0.0068	0.0119
Schistosoma mansoni	hypothetical protein	0.0045	0.0068	0.0119
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0045	0.0068	0.0119
Echinococcus granulosus	neuropeptide FF receptor 2	0.0045	0.0068	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0068	0.0196
Schistosoma mansoni	sodium/dicarboxylate symporter-related	0.0387	0.1462	0.42
Schistosoma mansoni	amine GPCR	0.0045	0.0068	0.0119
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0045	0.0068	0.0119
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0065	0.015	0.0436
Brugia malayi	hypothetical protein	0.0253	0.0917	0.2664
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0045	0.0068	0.0119
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0084	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0068	0.0196
Brugia malayi	G-protein coupled receptor	0.0045	0.0068	0.0196
Schistosoma mansoni	neuropeptide receptor	0.0045	0.0068	0.0119
Onchocerca volvulus		0.0045	0.0068	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0068	0.0196
Onchocerca volvulus		0.0045	0.0068	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0068	0.0196
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0144	0.0341
Echinococcus granulosus	Excitatory amino acid transporter	0.0873	0.3444	1
Schistosoma mansoni	neuropeptide receptor	0.0045	0.0068	0.0119
Schistosoma mansoni	hypothetical protein	0.0045	0.0068	0.0119
Echinococcus multilocularis	sex peptide receptor	0.0045	0.0068	0.0041
Loa Loa (eye worm)	hypothetical protein	0.005	0.009	0.026
Onchocerca volvulus		0.0052	0.0095	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0068	0.0196
Echinococcus granulosus	neuropeptide Y receptor	0.0045	0.0068	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0068	0.0196
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0105	0.0305
Brugia malayi	G-protein coupled receptor	0.0045	0.0068	0.0196
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0045	0.0068	0.0196
Echinococcus multilocularis	neuropeptide receptor	0.0045	0.0068	0.0041
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0045	0.0068	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0068	0.0196
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0027	0.0078
Echinococcus granulosus	rhodopsin orphan GPCR	0.0045	0.0068	0.0119
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0045	0.0068	0.0041
Brugia malayi	ORL1-like opioid receptor	0.0045	0.0068	0.0196
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0045	0.0068	0.0041
Brugia malayi	sulfakinin receptor protein	0.0045	0.0068	0.0196
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0027	0.0078
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0045	0.0068	0.0119
Treponema pallidum	glutamate transporter	0.0387	0.1462	0.5
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0045	0.0068	0.0196
Echinococcus multilocularis	sodium:dicarboxylate symporter	0.0873	0.3444	0.3426
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0073	0.018	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0045	0.0068	0.0119
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0027	0.0078
Leishmania major	4-coumarate:coa ligase-like protein	0.0073	0.018	1
Echinococcus multilocularis	GPCR, family 2	0.0065	0.015	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0068	0.0196
Brugia malayi	hypothetical protein	0.0045	0.0068	0.0196
Echinococcus multilocularis	g protein coupled receptor	0.0045	0.0068	0.0041
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.023	0.0821	0.2324
Echinococcus multilocularis	g protein coupled receptor	0.0045	0.0068	0.0041
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0045	0.0068	0.0119
Echinococcus multilocularis	protein patched	0.0041	0.0052	0.0025
Schistosoma mansoni	hypothetical protein	0.004	0.0046	0.0055
Schistosoma mansoni	opsin-like receptor	0.0045	0.0068	0.0119
Leishmania major	4-coumarate:coa ligase-like protein	0.0073	0.018	1
Schistosoma mansoni	histamine h1 receptor	0.0045	0.0068	0.0119
Brugia malayi	hypothetical protein	0.0045	0.0068	0.0196
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0045	0.0068	0.0119

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL571364

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1068275