Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | mitogen-activated protein kinase 14 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | mitogen-activated protein kinase 14 | 360 aa | 336 aa | 33.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. | 0.1688 | 1 | 1 |
Brugia malayi | PAS domain containing protein | 0.0101 | 0.0163 | 0.0384 |
Loa Loa (eye worm) | hypothetical protein | 0.034 | 0.1644 | 0.3755 |
Schistosoma mansoni | NADH-ubiquinone oxidoreductase | 0.0762 | 0.4258 | 1 |
Mycobacterium ulcerans | NADH dehydrogenase I subunit F | 0.0762 | 0.4258 | 0.4258 |
Echinococcus granulosus | mitogen activated protein kinase 14 | 0.0152 | 0.0478 | 0.1122 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0101 | 0.0163 | 0.0218 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase I (chain H) NuoH (NADH-ubiquinone oxidoreductase chain H) | 0.0322 | 0.1531 | 0.1469 |
Brugia malayi | NADH dehydrogenase subunit 1, identical | 0.0087 | 0.0072 | 0.0169 |
Trypanosoma brucei | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial | 0.0762 | 0.4258 | 1 |
Brugia malayi | NADH-ubiquinone oxidoreductase 51 kDa subunit, mitochondrial precursor | 0.0762 | 0.4258 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/P38 protein kinase | 0.0152 | 0.0478 | 0.0969 |
Onchocerca volvulus | 0.0087 | 0.0072 | 0.0348 | |
Mycobacterium ulcerans | membrane protein ComEA | 0.017 | 0.0588 | 0.0588 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0152 | 0.0478 | 0.1122 |
Onchocerca volvulus | 0.0087 | 0.0072 | 0.0348 | |
Trypanosoma cruzi | NADH-ubiquinone oxidoreductase, mitochondrial, putative | 0.0762 | 0.4258 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 11 | 0.0152 | 0.0478 | 0.1122 |
Echinococcus multilocularis | NADH dehydrogenase (ubiquinone) flavoprotein 1 | 0.0762 | 0.4258 | 1 |
Onchocerca volvulus | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial homolog | 0.0408 | 0.2067 | 1 |
Schistosoma mansoni | single-minded | 0.0101 | 0.0163 | 0.0218 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0152 | 0.0478 | 0.1122 |
Brugia malayi | hypoxia-induced factor 1 | 0.0314 | 0.148 | 0.3477 |
Brugia malayi | hypothetical protein | 0.034 | 0.1644 | 0.386 |
Schistosoma mansoni | hypothetical protein | 0.0322 | 0.1531 | 0.3484 |
Wolbachia endosymbiont of Brugia malayi | NADH dehydrogenase I subunit F | 0.0762 | 0.4258 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0152 | 0.0478 | 0.1122 |
Trichomonas vaginalis | NADH-ubiquinone oxidoreductase flavoprotein, putative | 0.0762 | 0.4258 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0152 | 0.0478 | 0.1122 |
Trypanosoma cruzi | NADH-ubiquinone oxidoreductase, mitochondrial, putative | 0.0762 | 0.4258 | 1 |
Mycobacterium ulcerans | proteasome PrcA | 0.1688 | 1 | 1 |
Leishmania major | NADH-ubiquinone oxidoreductase, mitochondrial, putative | 0.0762 | 0.4258 | 1 |
Brugia malayi | hypothetical protein | 0.0087 | 0.0072 | 0.0169 |
Trypanosoma brucei | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial, putative | 0.0762 | 0.4258 | 1 |
Loa Loa (eye worm) | NADH-ubiquinone oxidoreductase 51 kDa subunit | 0.0762 | 0.4258 | 1 |
Echinococcus granulosus | NADH dehydrogenase ubiquinone flavoprotein 1 | 0.0762 | 0.4258 | 1 |
Brugia malayi | P38 map kinase family protein 2 | 0.0152 | 0.0478 | 0.1122 |
Mycobacterium ulcerans | NADH dehydrogenase subunit H | 0.0322 | 0.1531 | 0.1531 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0314 | 0.148 | 0.3364 |
Brugia malayi | NADH dehydrogenase subunit 1 | 0.0087 | 0.0072 | 0.0169 |
Trichomonas vaginalis | NADH-ubiquinone oxidoreductase flavoprotein, putative | 0.0762 | 0.4258 | 0.5 |
Echinococcus granulosus | NADH dehydrogenase subunit 1 | 0.0322 | 0.1531 | 0.3594 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase I (chain F) NuoF (NADH-ubiquinone oxidoreductase chain F) | 0.0762 | 0.4258 | 0.4217 |
Treponema pallidum | nitrogen fixation protein (rnfC) | 0.017 | 0.0588 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.017 | 0.0588 | 0.0519 |
Mycobacterium ulcerans | formate hydrogenlyase HycD | 0.0087 | 0.0072 | 0.0072 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.054 uM | Inhibition of LPS-stimulated TNF-alpha release from human peripheral blood mononuclear cells | ChEMBL. | 12127515 |
IC50 (functional) | = 0.054 uM | Inhibition of LPS-stimulated TNF-alpha release from human peripheral blood mononuclear cells | ChEMBL. | 12127515 |
IC50 (binding) | = 0.47 uM | In vivo inhibition of murine Mitogen-activated protein kinase p38 alpha activity, GST-ATF-2 as substrate in the presence of 120 microM ATP | ChEMBL. | 12127515 |
IC50 (binding) | = 0.47 uM | In vivo inhibition of murine Mitogen-activated protein kinase p38 alpha activity, GST-ATF-2 as substrate in the presence of 120 microM ATP | ChEMBL. | 12127515 |
IC50 (binding) | = 100 uM | In vivo inhibition of ram seminal vesicle Prostaglandin G/H synthase 1 activity by determining PGE-2 by RIA | ChEMBL. | 12127515 |
IC50 (binding) | = 100 uM | In vivo inhibition of ram seminal vesicle Prostaglandin G/H synthase 1 activity by determining PGE-2 by RIA | ChEMBL. | 12127515 |
Inhibition (functional) | 0 % | Tested for inhibition of swelling in adjuvant induced arthritis rat at 25 mg/kg per orally; NT=Not tested | ChEMBL. | 12127515 |
Inhibition (functional) | 0 % | Tested for inhibition of paw swelling in collagen induced arthritis in rat, per orally; NT=Not tested | ChEMBL. | 12127515 |
Inhibition (functional) | = 21 % | Inhibition of LPS induced TNF-alpha release in mice at 10 mg/kg peroral dose | ChEMBL. | 12127515 |
Inhibition (functional) | = 21 % | Inhibition of LPS induced TNF-alpha release in mice at 10 mg/kg peroral dose | ChEMBL. | 12127515 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 12127515 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.