Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.001 | 0.0177 | 0.0312 |
Echinococcus multilocularis | ubiquitin specific protease 41 | 0.0036 | 0.2401 | 0.4226 |
Trypanosoma brucei | ubiquitin carboxyl-terminal hydrolase, putative | 0.0036 | 0.2401 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.4411 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0074 | 0.5681 | 1 |
Echinococcus granulosus | Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 | 0.0036 | 0.2401 | 0.4226 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.1455 | 0.1455 |
Echinococcus multilocularis | lamin dm0 | 0.0054 | 0.3977 | 0.7 |
Loa Loa (eye worm) | intermediate filament protein | 0.0054 | 0.3977 | 0.3977 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0074 | 0.5681 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.2397 | 0.4219 |
Echinococcus granulosus | ubiquitin carboxyl terminal hydrolase 8 | 0.0036 | 0.2401 | 0.4226 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.0177 | 0.0312 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0177 | 0.0177 |
Echinococcus multilocularis | FTZ F1 alpha | 0.001 | 0.0177 | 0.0312 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0036 | 0.2397 | 0.4219 |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 8 | 0.0036 | 0.2401 | 0.4226 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0029 | 0.1791 | 0.1791 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0026 | 0.1541 | 0.2712 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.001 | 0.0177 | 0.0177 |
Loa Loa (eye worm) | steroid hormone receptor | 0.001 | 0.0177 | 0.0177 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0177 | 0.0177 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.3977 | 0.3977 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0177 | 0.0312 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.0177 | 0.0312 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0059 | 0.4411 | 0.7765 |
Leishmania major | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative | 0.0036 | 0.2401 | 0.0019 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.001 | 0.0177 | 0.0312 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.4411 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0177 | 0.0177 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.001 | 0.0177 | 0.0177 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.001 | 0.0177 | 0.0177 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.001 | 0.0177 | 0.0312 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0177 | 0.0177 |
Onchocerca volvulus | 0.0054 | 0.3977 | 1 | |
Echinococcus multilocularis | musashi | 0.0054 | 0.3977 | 0.7 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.001 | 0.0177 | 0.0177 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0059 | 0.4411 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.1541 | 0.1541 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0074 | 0.5681 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.0177 | 0.0312 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0177 | 0.0177 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0036 | 0.2401 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0177 | 0.0177 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0032 | 0.2069 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.4411 | 0.7765 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.4411 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0177 | 0.0177 |
Entamoeba histolytica | hypothetical protein | 0.0074 | 0.5681 | 1 |
Onchocerca volvulus | 0.0054 | 0.3977 | 1 | |
Echinococcus multilocularis | lamin | 0.0054 | 0.3977 | 0.7 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.001 | 0.0177 | 0.0177 |
Brugia malayi | nuclear hormone receptor | 0.001 | 0.0177 | 0.0177 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.001 | 0.0177 | 0.0312 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0036 | 0.2401 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.001 | 0.0177 | 0.0312 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0036 | 0.2397 | 0.4219 |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.0036 | 0.2401 | 0.0011 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0059 | 0.4411 | 0.7765 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.001 | 0.0177 | 0.0177 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0059 | 0.4411 | 1 |
Brugia malayi | intermediate filament protein | 0.0054 | 0.3977 | 0.3977 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0036 | 0.2401 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.001 | 0.0177 | 0.0177 |
Brugia malayi | steroid hormone receptor | 0.001 | 0.0177 | 0.0177 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0029 | 0.1791 | 0.1791 |
Schistosoma mansoni | lamin | 0.0054 | 0.3977 | 0.7 |
Echinococcus granulosus | ubiquitin specific protease 41 | 0.0036 | 0.2401 | 0.4226 |
Schistosoma mansoni | hypothetical protein | 0.0074 | 0.5681 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.001 | 0.0177 | 0.0312 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0036 | 0.2401 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.0177 | 0.0312 |
Entamoeba histolytica | hypothetical protein | 0.0074 | 0.5681 | 1 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0026 | 0.1541 | 0.2712 |
Brugia malayi | ecdysteroid receptor | 0.001 | 0.0177 | 0.0177 |
Loa Loa (eye worm) | inositol-1 | 0.0036 | 0.2397 | 0.2397 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.001 | 0.0177 | 0.0312 |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.0036 | 0.2401 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.001 | 0.0177 | 0.0177 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.001 | 0.0177 | 0.0312 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.001 | 0.0177 | 0.0312 |
Brugia malayi | Ubiquitin carboxyl-terminal hydrolase family protein | 0.0036 | 0.2401 | 0.2401 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.4411 | 0.7765 |
Brugia malayi | hypothetical protein | 0.0074 | 0.5681 | 0.5681 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.001 | 0.0177 | 0.0177 |
Echinococcus granulosus | lamin dm0 | 0.0054 | 0.3977 | 0.7 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0177 | 0.0177 |
Schistosoma mansoni | intermediate filament proteins | 0.0054 | 0.3977 | 0.7 |
Schistosoma mansoni | nuclear hormone receptor | 0.001 | 0.0177 | 0.0312 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.001 | 0.0177 | 0.0177 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.0177 | 0.0312 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.001 | 0.0177 | 0.0177 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.001 | 0.0177 | 0.0312 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0177 | 0.0177 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0074 | 0.5681 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.001 | 0.0177 | 0.0177 |
Echinococcus granulosus | lamin | 0.0054 | 0.3977 | 0.7 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.001 | 0.0177 | 0.0312 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0177 | 0.0177 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.0177 | 0.0312 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0054 | 0.3977 | 0.3977 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0177 | 0.0177 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0054 | 0.3977 | 0.3977 |
Schistosoma mansoni | coup transcription factor | 0.001 | 0.0177 | 0.0312 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.001 | 0.0177 | 0.0312 |
Schistosoma mansoni | lamin | 0.0054 | 0.3977 | 0.7 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.2397 | 0.4219 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.001 | 0.0177 | 0.0177 |
Schistosoma mansoni | ubiquitin-specific peptidase 2 (C19 family) | 0.0036 | 0.2401 | 0.4226 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.001 | 0.0177 | 0.0312 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0177 | 0.0177 |
Echinococcus multilocularis | Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 | 0.0036 | 0.2401 | 0.4226 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.0177 | 0.0312 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0177 | 0.0177 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.2401 | 0.2401 |
Entamoeba histolytica | hypothetical protein | 0.0074 | 0.5681 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.001 | 0.0177 | 0.0312 |
Brugia malayi | Inositol-1 | 0.0036 | 0.2397 | 0.2397 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.001 | 0.0177 | 0.0177 |
Echinococcus granulosus | intermediate filament protein | 0.0054 | 0.3977 | 0.7 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.3891 | 0.3891 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.001 | 0.0177 | 0.0312 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.001 | 0.0177 | 0.0312 |
Schistosoma mansoni | ubiquitin-specific peptidase 8 (C19 family) | 0.0036 | 0.2401 | 0.4226 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0177 | 0.0177 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.001 | 0.0177 | 0.0177 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.001 | 0.0177 | 0.0177 |
Echinococcus granulosus | FTZ F1 alpha | 0.001 | 0.0177 | 0.0312 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0036 | 0.2401 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.001 | 0.0177 | 0.0177 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0036 | 0.2397 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0177 | 0.0312 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.001 | 0.0177 | 0.0312 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.001 | 0.0177 | 0.0177 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.1455 | 0.1455 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0059 | 0.4411 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.0177 | 0.0312 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 24.1 uM | Inhibition of wild type HIV1 HXB2 protease | ChEMBL. | 19539482 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.