TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 576.573 | Formula: C32H33O8P
H donors: 0 H acceptors: 1 LogP: 6.48 Rotable bonds: 14
Rule of 5 violations (Lipinski): 2
SMILES: COc1ccc(cc1OP(=O)(OCc1ccccc1)OCc1ccccc1)/C=C\c1cc(OC)c(c(c1)OC)OC
InChi: 1S/C32H33O8P/c1-34-28-18-17-24(15-16-27-20-30(35-2)32(37-4)31(21-27)36-3)19-29(28)40-41(33,38-22-25-11-7-5-8-12-25)39-23-26-13-9-6-10-14-26/h5-21H,22-23H2,1-4H3/b16-15-
InChiKey: ZIWAAGKUCLIRAF-NXVVXOECSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0042	0.0146	0.0221
Trichomonas vaginalis	conserved hypothetical protein	0.1483	0.6596	0.6588
Schistosoma mansoni	intermediate filament proteins	0.0029	0.009	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0058	0.0058
Brugia malayi	RNA, U transporter 1	0.0081	0.0324	0.0324
Onchocerca volvulus		0.0029	0.009	0.0065
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0042	0.0146	0.0221
Loa Loa (eye worm)	hypothetical protein	0.002	0.0048	0.0047
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0014	0.0023	0.5
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0021	0.0054	0.0054
Brugia malayi	nuclear hormone receptor	0.002	0.0048	0.0048
Trichomonas vaginalis	penicillin-binding protein, putative	0.0076	0.0301	0.0278
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0021	0.0054	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0029	0.009	0.009
Echinococcus granulosus	cpg binding protein	0.0031	0.0098	0.0148
Trichomonas vaginalis	synaptic glycoprotein sc2, putative	0.1483	0.6596	0.6588
Plasmodium vivax	polyprenol reductase, putative	0.1483	0.6596	1
Brugia malayi	beta-lactamase family protein	0.0076	0.0301	0.0301
Toxoplasma gondii	3-oxo-5-alpha-steroid 4-dehydrogenase	0.1483	0.6596	0.6588
Brugia malayi	Thioredoxin reductase	0.0041	0.0143	0.0143
Mycobacterium tuberculosis	Conserved protein	0.0076	0.0301	0.1313
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0301	0.03
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0146	0.0146
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.002	0.0048	0.0072
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0093	0.0376	0.167
Trypanosoma cruzi	hypothetical protein, conserved	0.0076	0.0301	0.0278
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0103	0.0423	0.189
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0042	0.0146	0.0187
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0058	0.0058
Onchocerca volvulus		0.1483	0.6596	1
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0076	0.0301	0.0455
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0042	0.0146	0.0221
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0076	0.0301	0.03
Schistosoma mansoni	cpg binding protein	0.0031	0.0098	0.0114
Leishmania major	trypanothione reductase	0.0041	0.0143	0.012
Trichomonas vaginalis	ran, putative	0.0021	0.0054	0.0031
Schistosoma mansoni	synaptic glycoprotein sc2 related	0.1483	0.6596	1
Echinococcus multilocularis	importin subunit beta 1	0.0029	0.0088	0.0133
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.0064	0.0041
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0014	0.0023	0.0035
Schistosoma mansoni	coup transcription factor	0.0042	0.0146	0.0187
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.002	0.0048	0.0037
Schistosoma mansoni	hypothetical protein	0.007	0.0274	0.0381
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0042	0.0146	0.0187
Entamoeba histolytica	hypothetical protein	0.0035	0.0118	0.0064
Brugia malayi	beta-lactamase family protein	0.0076	0.0301	0.0301
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0103	0.0423	0.189
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0301	0.03
Trichomonas vaginalis	D-aminoacylase, putative	0.0076	0.0301	0.0278
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0088	0.0087
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0042	0.0146	0.0146
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0021	0.0054	0.0031
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0042	0.0146	0.0146
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.002	0.0048	0.0072
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0042	0.0146	0.0187
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0146	0.0146
Brugia malayi	glutathione reductase	0.0041	0.0143	0.0143
Schistosoma mansoni	lamin	0.0029	0.009	0.0102
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.002	0.0048	0.0072
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0042	0.0146	0.0146
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0041	0.0143	0.0564
Schistosoma mansoni	importin beta-1	0.0029	0.0088	0.0099
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0032	0.0105	0.0105
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.001	0.0007	0.0007
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0103	0.0419	0.0419
Echinococcus granulosus	thioredoxin glutathione reductase	0.0041	0.0145	0.0219
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0062	0.0237	0.0326
Leishmania major	GTP-binding protein, putative	0.0021	0.0054	0.0031
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0042	0.0146	0.0221
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0163	0.0213
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0021	0.0054	0.0031
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0042	0.0146	0.0146
Loa Loa (eye worm)	intermediate filament protein	0.0029	0.009	0.009
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.002	0.0048	0.0037
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0163	0.0213
Brugia malayi	Synaptic glycoprotein SC2	0.1483	0.6596	0.6596
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.002	0.0048	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0105	0.0105
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0088	0.0065
Schistosoma mansoni	hypothetical protein	0.0032	0.0105	0.0125
Brugia malayi	Nuclear hormone receptor E75	0.002	0.0048	0.0048
Mycobacterium tuberculosis	Probable esterase LipL	0.0076	0.0301	0.1313
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0014	0.0023	0.0034
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0042	0.0146	0.0221
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0021	0.0054	0.0047
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0041	0.0145	0.0219
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0055	0.0208	0.0185
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0042	0.0146	0.0187
Brugia malayi	hypothetical protein	0.002	0.0048	0.0048
Loa Loa (eye worm)	beta-lactamase	0.0076	0.0301	0.03
Trypanosoma brucei	hypothetical protein, conserved	0.0076	0.0301	0.0278
Brugia malayi	hypothetical protein	0.002	0.0048	0.0048
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0163	0.0163
Trichomonas vaginalis	conserved hypothetical protein	0.1483	0.6596	0.6588
Trichomonas vaginalis	synaptic glycoprotein sc2, putative	0.1483	0.6596	0.6588
Brugia malayi	Intermediate filament tail domain containing protein	0.0029	0.009	0.009
Brugia malayi	nuclear receptor RXR	0.0022	0.0058	0.0058
Brugia malayi	Importin beta-1 subunit	0.0029	0.0088	0.0088
Brugia malayi	nuclear hormone receptor family member odr-7	0.002	0.0048	0.0048
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0042	0.0146	0.0146
Loa Loa (eye worm)	thioredoxin reductase	0.0041	0.0143	0.0142
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0301	0.03
Mycobacterium tuberculosis	Probable hydrolase	0.0076	0.0301	0.1313
Loa Loa (eye worm)	hypothetical protein	0.002	0.0048	0.0047
Loa Loa (eye worm)	hypothetical protein	0.002	0.0048	0.0047
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0088	0.0065
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0163	0.0247
Entamoeba histolytica	hypothetical protein	0.0035	0.0118	0.0064
Loa Loa (eye worm)	hypothetical protein	0.002	0.0048	0.0047
Brugia malayi	Nuclear hormone receptor-like 1	0.0042	0.0146	0.0146
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0014	0.0023	0.5
Brugia malayi	beta-lactamase	0.0076	0.0301	0.0301
Plasmodium falciparum	importin beta, putative	0.0029	0.0088	0.0099
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.002	0.0048	0.0047
Echinococcus multilocularis	GPCR, family 2	0.0032	0.0105	0.0159
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0021	0.0054	0.0054
Loa Loa (eye worm)	hypothetical protein	0.002	0.0048	0.0047
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0042	0.0146	0.0221
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0058	0.0058
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0076	0.0301	0.0278
Mycobacterium ulcerans	hypothetical protein	0.0076	0.0301	0.0278
Echinococcus granulosus	lamin dm0	0.0029	0.009	0.0136
Schistosoma mansoni	thyroid hormone receptor	0.0042	0.0146	0.0187
Plasmodium vivax	importin-beta 2, putative	0.0029	0.0088	0.0099
Echinococcus multilocularis	FTZ F1 alpha	0.0042	0.0146	0.0221
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0103	0.0419	0.0419
Echinococcus granulosus	importin subunit beta 1	0.0029	0.0088	0.0133
Trypanosoma cruzi	hypothetical protein, conserved	0.0076	0.0301	0.0278
Trypanosoma brucei	trypanothione reductase	0.0041	0.0143	0.012
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0042	0.0146	0.0146
Brugia malayi	hypothetical protein	0.0022	0.0058	0.0058
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0042	0.0146	0.0146
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0042	0.0146	0.0146
Entamoeba histolytica	hypothetical protein	0.0023	0.0064	0.001
Plasmodium vivax	hypothetical protein, conserved	0.0076	0.0301	0.0422
Mycobacterium tuberculosis	Probable dehydrogenase	0.0093	0.0376	0.167
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0076	0.0301	0.1313
Entamoeba histolytica	hypothetical protein	0.1483	0.6596	0.6577
Echinococcus multilocularis	snurportin 1	0.0305	0.1326	0.201
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0058	0.0058
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0022	0.0058	0.0088
Brugia malayi	nuclear receptor NHR-67	0.002	0.0048	0.0048
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.002	0.0048	0.0072
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0042	0.0146	0.015
Leishmania major	hypothetical protein, conserved	0.0076	0.0301	0.0278
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0042	0.0146	0.0221
Schistosoma mansoni	cpg binding protein	0.0029	0.0091	0.0103
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.002	0.0048	0.0072
Trypanosoma cruzi	trypanothione reductase, putative	0.0041	0.0143	0.012
Brugia malayi	hypothetical protein	0.0035	0.0118	0.0118
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0091	0.009
Mycobacterium tuberculosis	Conserved protein	0.0076	0.0301	0.1313
Brugia malayi	ecdysone receptor	0.002	0.0048	0.0048
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0163	0.0163
Brugia malayi	orphan nuclear receptor NR2E1	0.002	0.0048	0.0048
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.002	0.0048	0.0048
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0064	0.0041
Brugia malayi	nuclear receptor RXR	0.002	0.0048	0.0048
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0042	0.0146	0.0146
Echinococcus multilocularis	cpg binding protein	0.0031	0.0098	0.0148
Mycobacterium tuberculosis	Conserved protein	0.0076	0.0301	0.1313
Mycobacterium tuberculosis	Probable reductase	0.0093	0.0376	0.167
Trichomonas vaginalis	synaptic glycoprotein sc2, putative	0.1483	0.6596	0.6588
Trypanosoma cruzi	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.1483	0.6596	0.6588
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0054	0.0031
Onchocerca volvulus		0.0076	0.0301	0.0386
Echinococcus granulosus	intermediate filament protein	0.0029	0.009	0.0136
Toxoplasma gondii	ABC1 family protein	0.0076	0.0301	0.0278
Onchocerca volvulus	Bile acid receptor homolog	0.0042	0.0146	0.015
Echinococcus multilocularis	ecdysone induced protein 78C	0.0042	0.0146	0.0221
Brugia malayi	latrophilin 2 splice variant baaae	0.007	0.0274	0.0274
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0042	0.0146	0.0221
Plasmodium vivax	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.1483	0.6596	1
Trichomonas vaginalis	esterase, putative	0.0076	0.0301	0.0278
Mycobacterium tuberculosis	Probable oxidoreductase	0.0103	0.0423	0.189
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.001	0.0007	0.0007
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0076	0.0301	0.0301
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0076	0.0301	0.1313
Brugia malayi	nuclear receptor NHR-88	0.0042	0.0146	0.0146
Brugia malayi	tailless protein	0.002	0.0048	0.0048
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0042	0.0146	0.0146
Echinococcus multilocularis	lamin	0.0029	0.009	0.0136
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0093	0.0376	0.167
Loa Loa (eye worm)	hypothetical protein	0.002	0.0048	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0301	0.03
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0042	0.0146	0.0187
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0146	0.0146
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0042	0.0146	0.0187
Echinococcus granulosus	ecdysone induced protein 78C	0.0042	0.0146	0.0221
Schistosoma mansoni	nuclear receptor	0.002	0.0048	0.0037
Echinococcus multilocularis	musashi	0.0029	0.009	0.0136
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0163	0.0247
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0022	0.0058	0.0088
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0076	0.0301	0.0422
Echinococcus granulosus	Nuclear hormone receptor HR96	0.002	0.0048	0.0072
Brugia malayi	conserved hypotetical protein	0.002	0.0048	0.0048
Schistosoma mansoni	thyroid hormone receptor	0.0042	0.0146	0.0187
Mycobacterium tuberculosis	Probable lipase LipD	0.0076	0.0301	0.1313
Brugia malayi	cytoplasmic intermediate filament protein	0.0016	0.003	0.003
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0042	0.0146	0.0146
Schistosoma mansoni	zinc finger protein	0.002	0.0048	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0301	0.03
Loa Loa (eye worm)	hypothetical protein	0.002	0.0048	0.0047
Onchocerca volvulus		0.0029	0.0091	0.0066
Onchocerca volvulus		0.0029	0.009	0.0065
Leishmania major	importin beta-1 subunit, putative	0.0023	0.0064	0.0041
Brugia malayi	nuclear receptor NHR-88	0.002	0.0048	0.0048
Brugia malayi	nuclear hormone receptor	0.0042	0.0146	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0023	0.0022
Schistosoma mansoni	hypothetical protein	0.0035	0.0118	0.0144
Trypanosoma brucei	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.1483	0.6596	0.6588
Echinococcus granulosus	synaptic glycoprotein sc2	0.1483	0.6596	1
Schistosoma mansoni	synaptic glycoprotein sc2 related	0.1483	0.6596	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0042	0.0146	0.0146
Schistosoma mansoni	hypothetical protein	0.0032	0.0105	0.0125
Plasmodium vivax	thioredoxin reductase, putative	0.0041	0.0143	0.0181
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0146	0.0146
Entamoeba histolytica	hypothetical protein	0.0035	0.0118	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0088	0.0088
Loa Loa (eye worm)	nuclear hormone receptor	0.002	0.0048	0.0047
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0032	0.0105	0.0159
Echinococcus multilocularis	synaptic glycoprotein sc2	0.1483	0.6596	1
Brugia malayi	nuclear hormone receptor family member nhr-6	0.002	0.0048	0.0048
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0021	0.0054	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0146	0.0146
Toxoplasma gondii	HEAT repeat-containing protein	0.0029	0.0088	0.0065
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0118	0.0178
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0032	0.0105	0.0159
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0021	0.0054	0.0081
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0022	0.0058	0.0053
Loa Loa (eye worm)	hypothetical protein	0.002	0.0048	0.0047
Loa Loa (eye worm)	hypothetical protein	0.1483	0.6596	0.6596
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0305	0.1326	0.1326
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0042	0.0146	0.0146
Echinococcus granulosus	nuclear receptor nhr 48	0.002	0.0048	0.0072
Plasmodium falciparum	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.1483	0.6596	1
Plasmodium falciparum	glutathione reductase	0.0041	0.0143	0.0181
Giardia lamblia	Synaptic glycoprotein SC2	0.1483	0.6596	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0032	0.0105	0.0159
Schistosoma mansoni	RAR-like nuclear receptor	0.0042	0.0146	0.0187
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0301	0.03
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0042	0.0146	0.0146
Loa Loa (eye worm)	hypothetical protein	0.002	0.0048	0.0047
Schistosoma mansoni	ran	0.0021	0.0054	0.0047
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0032	0.0105	0.0105
Mycobacterium ulcerans	esterase/lipase LipP	0.0076	0.0301	0.0278
Schistosoma mansoni	nuclear hormone receptor	0.002	0.0048	0.0037
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0093	0.0376	0.167
Toxoplasma gondii	3-oxo-5-alpha-steroid 4-dehydrogenase	0.1483	0.6596	0.6588
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0022	0.0058	0.0058
Loa Loa (eye worm)	hypothetical protein	0.002	0.0048	0.0047
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0042	0.0146	0.0146
Trichomonas vaginalis	D-aminoacylase, putative	0.0076	0.0301	0.0278
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0146	0.0146
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0042	0.0146	0.0146
Echinococcus granulosus	thyroid hormone receptor alpha	0.002	0.0048	0.0072
Brugia malayi	Latrophilin receptor protein 2	0.0032	0.0105	0.0105
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0064	0.0041
Echinococcus granulosus	beta LACTamase domain containing family member	0.0076	0.0301	0.0455
Entamoeba histolytica	hypothetical protein	0.0035	0.0118	0.0064
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0118	0.0178
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0042	0.0146	0.0221
Brugia malayi	photoreceptor-specific nuclear receptor	0.0042	0.0146	0.0146
Schistosoma mansoni	nuclear receptor	0.002	0.0048	0.0037
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0042	0.0146	0.0221
Loa Loa (eye worm)	hypothetical protein	0.1483	0.6596	0.6596
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0016	0.003	0.0029
Brugia malayi	hypothetical protein	0.0022	0.0058	0.0058
Loa Loa (eye worm)	DR-78	0.002	0.0048	0.0047
Brugia malayi	Steroid receptor seven-up type 2	0.0042	0.0146	0.0146
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0014	0.0023	0.0035
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0042	0.0146	0.0221
Plasmodium falciparum	polyprenol reductase, putative	0.1483	0.6596	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0048	0.0047
Schistosoma mansoni	nuclear receptor nhr-48	0.002	0.0048	0.0037
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0042	0.0146	0.0146
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0103	0.0423	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0048	0.0047
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0022	0.0058	0.0053
Echinococcus multilocularis	nuclear receptor nhr 48	0.002	0.0048	0.0072
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0487	0.2137	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0163	0.0247
Schistosoma mansoni	retinoic acid receptor RXR	0.0042	0.0146	0.0187
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0042	0.0146	0.0146
Trichomonas vaginalis	penicillin-binding protein, putative	0.0076	0.0301	0.0278
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0091	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0146	0.0146
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0076	0.0301	0.1313
Echinococcus granulosus	FTZ F1 alpha	0.0042	0.0146	0.0221
Schistosoma mansoni	nuclear hormone receptor	0.002	0.0048	0.0037
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0042	0.0146	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0014	0.002	0.002
Brugia malayi	Nuclear hormone receptor-like 1	0.0022	0.0058	0.0058
Plasmodium vivax	glutathione reductase, putative	0.0041	0.0143	0.0181
Schistosoma mansoni	cpg binding protein	0.0031	0.0098	0.0114
Onchocerca volvulus		0.0076	0.0301	0.0386
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0042	0.0146	0.0221
Loa Loa (eye worm)	hypothetical protein	0.007	0.0274	0.0273
Loa Loa (eye worm)	hypothetical protein	0.0014	0.002	0.002
Trichomonas vaginalis	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.1483	0.6596	0.6588
Loa Loa (eye worm)	hypothetical protein	0.002	0.0048	0.0047
Echinococcus granulosus	lamin	0.0029	0.009	0.0136
Plasmodium falciparum	thioredoxin reductase	0.0041	0.0143	0.0181
Treponema pallidum	NADH oxidase	0.0014	0.0023	0.5
Toxoplasma gondii	thioredoxin reductase	0.0041	0.0143	0.012
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0054	0.0031
Onchocerca volvulus		0.0042	0.0146	0.015
Schistosoma mansoni	lamin	0.0029	0.009	0.0102
Onchocerca volvulus		0.0076	0.0301	0.0386
Echinococcus multilocularis	3 oxo 5 alpha steroid 4 dehydrogenase, C terminal	0.1483	0.6596	1
Mycobacterium ulcerans	beta-lactamase	0.0076	0.0301	0.0278
Schistosoma mansoni	ran	0.0021	0.0054	0.0047
Schistosoma mansoni	hypothetical protein	0.0032	0.0105	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0419	0.0419
Brugia malayi	intermediate filament protein	0.0029	0.009	0.009
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0093	0.0376	0.6191
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0021	0.0054	0.0047
Schistosoma mansoni	nuclear hormone receptor	0.0042	0.0146	0.0187
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0064	0.0041
Loa Loa (eye worm)	nuclear receptor NHR-67	0.002	0.0048	0.0047
Brugia malayi	ecdysteroid receptor	0.0042	0.0146	0.0146
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0014	0.0023	0.0023
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0014	0.0023	0.5
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0076	0.0301	0.0422
Mycobacterium ulcerans	lipase LipD	0.0076	0.0301	0.0278
Loa Loa (eye worm)	glutathione reductase	0.0041	0.0143	0.0142
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0042	0.0146	0.0187
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0032	0.0105	0.0159
Echinococcus granulosus	snurportin 1	0.0305	0.1326	0.201
Entamoeba histolytica	3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein	0.1483	0.6596	0.6577
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0058	0.0058
Echinococcus granulosus	Nuclear hormone receptor HR96	0.002	0.0048	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0146	0.0146
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0163	0.0247
Brugia malayi	Nuclear hormone receptor E75	0.002	0.0048	0.0048
Schistosoma mansoni	hypothetical protein	0.0305	0.1326	0.1983
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0042	0.0146	0.0146
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0118	0.0144
Onchocerca volvulus	Protein ultraspiracle homolog	0.0042	0.0146	0.015
Echinococcus multilocularis	lamin dm0	0.0029	0.009	0.0136
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0042	0.0146	0.0221
Mycobacterium tuberculosis	Probable lipase LipE	0.0076	0.0301	0.1313
Loa Loa (eye worm)	steroid hormone receptor	0.0042	0.0146	0.0146
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0093	0.0376	0.167
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0163	0.0213
Echinococcus granulosus	3 oxo 5 alpha steroid 4 dehydrogenase C terminal	0.1483	0.6596	1
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.002	0.0048	0.0072
Echinococcus granulosus	GPCR family 2	0.0032	0.0105	0.0159
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0042	0.0146	0.0221
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0103	0.0419	0.0419
Trichomonas vaginalis	D-aminoacylase, putative	0.0076	0.0301	0.0278
Entamoeba histolytica	trans-2,3-enoyl-CoA reductase, putative	0.1483	0.6596	0.6577
Brugia malayi	steroid hormone receptor	0.0042	0.0146	0.0146
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0029	0.009	0.009
Schistosoma mansoni	hypothetical protein	0.0032	0.0105	0.0125
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0014	0.0023	0.0034
Brugia malayi	Nuclear hormone receptor-like 1	0.0022	0.0058	0.0058

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 0.246 uM	Cytotoxicity against human HeLa cells by MTT assay	ChEMBL.	19879758
IC50 (functional)	= 1.17 uM	Cytotoxicity against human MCF7 cells by MTT assay	ChEMBL.	19879758

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	19879758

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL571189

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1068732